Putative U3 small nucleolar ribonucleoprotein protein MPP10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 small nucleolar ribonucleoprotein protein MPP10, putative

Species:

Leishmania braziliensis

UniProt:

A4HH82_LEIBR

TriTrypDb:

LbrM.29.0770 , LBRM2903_290014000

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0034457	Mpp10 complex	3	8
GO:0140513	nuclear protein-containing complex	2	8
GO:1990904	ribonucleoprotein complex	2	8
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HH82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH82

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006364	rRNA processing	8	8
GO:0006396	RNA processing	6	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0016072	rRNA metabolic process	7	8
GO:0034470	ncRNA processing	7	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034660	ncRNA metabolic process	6	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.353
CLV_C14_Caspase3-7	260	264	PF00656	0.394
CLV_NRD_NRD_1	134	136	PF00675	0.418
CLV_NRD_NRD_1	191	193	PF00675	0.389
CLV_NRD_NRD_1	241	243	PF00675	0.384
CLV_NRD_NRD_1	420	422	PF00675	0.317
CLV_NRD_NRD_1	46	48	PF00675	0.592
CLV_NRD_NRD_1	492	494	PF00675	0.372
CLV_NRD_NRD_1	649	651	PF00675	0.363
CLV_NRD_NRD_1	661	663	PF00675	0.327
CLV_NRD_NRD_1	673	675	PF00675	0.525
CLV_NRD_NRD_1	81	83	PF00675	0.614
CLV_PCSK_FUR_1	236	240	PF00082	0.383
CLV_PCSK_KEX2_1	190	192	PF00082	0.395
CLV_PCSK_KEX2_1	238	240	PF00082	0.367
CLV_PCSK_KEX2_1	241	243	PF00082	0.357
CLV_PCSK_KEX2_1	426	428	PF00082	0.354
CLV_PCSK_KEX2_1	443	445	PF00082	0.225
CLV_PCSK_KEX2_1	46	48	PF00082	0.592
CLV_PCSK_KEX2_1	492	494	PF00082	0.382
CLV_PCSK_KEX2_1	649	651	PF00082	0.322
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.482
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.225
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.434
CLV_PCSK_PC7_1	236	242	PF00082	0.383
CLV_PCSK_PC7_1	645	651	PF00082	0.363
CLV_PCSK_SKI1_1	101	105	PF00082	0.303
CLV_PCSK_SKI1_1	135	139	PF00082	0.274
CLV_PCSK_SKI1_1	161	165	PF00082	0.392
CLV_PCSK_SKI1_1	209	213	PF00082	0.286
CLV_PCSK_SKI1_1	308	312	PF00082	0.377
CLV_PCSK_SKI1_1	426	430	PF00082	0.383
CLV_PCSK_SKI1_1	446	450	PF00082	0.171
CLV_PCSK_SKI1_1	494	498	PF00082	0.249
CLV_PCSK_SKI1_1	527	531	PF00082	0.383
CLV_PCSK_SKI1_1	85	89	PF00082	0.331
DEG_APCC_DBOX_1	100	108	PF00400	0.383
DEG_APCC_DBOX_1	445	453	PF00400	0.383
DEG_APCC_DBOX_1	53	61	PF00400	0.475
DEG_APCC_KENBOX_2	213	217	PF00400	0.221
DEG_MDM2_SWIB_1	429	436	PF02201	0.383
DEG_SCF_FBW7_1	461	468	PF00400	0.221
DOC_MAPK_gen_1	443	452	PF00069	0.383
DOC_MAPK_gen_1	516	524	PF00069	0.303
DOC_MAPK_MEF2A_6	66	74	PF00069	0.564
DOC_USP7_MATH_1	2	6	PF00917	0.692
DOC_USP7_MATH_1	514	518	PF00917	0.443
DOC_USP7_UBL2_3	422	426	PF12436	0.383
DOC_USP7_UBL2_3	653	657	PF12436	0.425
DOC_WW_Pin1_4	461	466	PF00397	0.221
DOC_WW_Pin1_4	578	583	PF00397	0.303
DOC_WW_Pin1_4	638	643	PF00397	0.383
DOC_WW_Pin1_4	66	71	PF00397	0.541
DOC_WW_Pin1_4	7	12	PF00397	0.693
LIG_14-3-3_CanoR_1	25	31	PF00244	0.488
LIG_14-3-3_CanoR_1	33	43	PF00244	0.610
LIG_14-3-3_CanoR_1	427	436	PF00244	0.363
LIG_14-3-3_CanoR_1	626	635	PF00244	0.426
LIG_14-3-3_CanoR_1	645	649	PF00244	0.181
LIG_14-3-3_CanoR_1	85	93	PF00244	0.305
LIG_Actin_WH2_2	60	75	PF00022	0.541
LIG_Actin_WH2_2	633	651	PF00022	0.215
LIG_BIR_III_2	285	289	PF00653	0.221
LIG_BRCT_BRCA1_1	628	632	PF00533	0.383
LIG_Clathr_ClatBox_1	449	453	PF01394	0.383
LIG_deltaCOP1_diTrp_1	205	212	PF00928	0.305
LIG_FHA_1	166	172	PF00498	0.363
LIG_FHA_1	462	468	PF00498	0.312
LIG_FHA_1	470	476	PF00498	0.297
LIG_FHA_1	87	93	PF00498	0.383
LIG_FHA_2	139	145	PF00498	0.260
LIG_FHA_2	497	503	PF00498	0.305
LIG_FHA_2	550	556	PF00498	0.303
LIG_FHA_2	611	617	PF00498	0.363
LIG_FHA_2	639	645	PF00498	0.383
LIG_FHA_2	79	85	PF00498	0.586
LIG_LIR_Gen_1	430	441	PF02991	0.376
LIG_LIR_Gen_1	485	496	PF02991	0.215
LIG_LIR_Gen_1	629	640	PF02991	0.363
LIG_LIR_Nem_3	430	436	PF02991	0.376
LIG_LIR_Nem_3	485	491	PF02991	0.303
LIG_LIR_Nem_3	629	635	PF02991	0.388
LIG_LIR_Nem_3	90	96	PF02991	0.363
LIG_Pex14_1	208	212	PF04695	0.303
LIG_Pex14_2	429	433	PF04695	0.363
LIG_PTB_Apo_2	451	458	PF02174	0.383
LIG_PTB_Apo_2	574	581	PF02174	0.303
LIG_PTB_Phospho_1	574	580	PF10480	0.363
LIG_SH2_NCK_1	61	65	PF00017	0.488
LIG_SH2_SRC	488	491	PF00017	0.363
LIG_SH2_STAP1	508	512	PF00017	0.383
LIG_SH2_STAP1	525	529	PF00017	0.171
LIG_SH2_STAT5	346	349	PF00017	0.363
LIG_SH2_STAT5	580	583	PF00017	0.363
LIG_SH3_4	583	590	PF00018	0.363
LIG_SUMO_SIM_par_1	447	453	PF11976	0.383
LIG_TRAF2_1	217	220	PF00917	0.365
LIG_UBA3_1	521	527	PF00899	0.303
MOD_CDC14_SPxK_1	10	13	PF00782	0.696
MOD_CDK_SPK_2	578	583	PF00069	0.303
MOD_CDK_SPK_2	638	643	PF00069	0.383
MOD_CDK_SPxK_1	7	13	PF00069	0.703
MOD_CDK_SPxxK_3	638	645	PF00069	0.383
MOD_CDK_SPxxK_3	66	73	PF00069	0.560
MOD_CK1_1	165	171	PF00069	0.398
MOD_CK1_1	3	9	PF00069	0.638
MOD_CK1_1	45	51	PF00069	0.523
MOD_CK1_1	517	523	PF00069	0.377
MOD_CK1_1	62	68	PF00069	0.450
MOD_CK2_1	147	153	PF00069	0.246
MOD_CK2_1	371	377	PF00069	0.276
MOD_CK2_1	402	408	PF00069	0.320
MOD_CK2_1	549	555	PF00069	0.325
MOD_CK2_1	610	616	PF00069	0.363
MOD_CK2_1	638	644	PF00069	0.387
MOD_CK2_1	648	654	PF00069	0.419
MOD_CK2_1	74	80	PF00069	0.570
MOD_Cter_Amidation	655	658	PF01082	0.383
MOD_GlcNHglycan	120	123	PF01048	0.499
MOD_GlcNHglycan	125	128	PF01048	0.452
MOD_GlcNHglycan	148	152	PF01048	0.396
MOD_GlcNHglycan	373	376	PF01048	0.283
MOD_GlcNHglycan	47	50	PF01048	0.527
MOD_GlcNHglycan	6	9	PF01048	0.679
MOD_GlcNHglycan	679	682	PF01048	0.566
MOD_GSK3_1	123	130	PF00069	0.404
MOD_GSK3_1	162	169	PF00069	0.390
MOD_GSK3_1	2	9	PF00069	0.630
MOD_GSK3_1	427	434	PF00069	0.304
MOD_GSK3_1	461	468	PF00069	0.308
MOD_GSK3_1	55	62	PF00069	0.483
MOD_GSK3_1	644	651	PF00069	0.302
MOD_GSK3_1	74	81	PF00069	0.549
MOD_N-GLC_1	3	8	PF02516	0.544
MOD_NEK2_1	34	39	PF00069	0.595
MOD_NEK2_1	42	47	PF00069	0.538
MOD_NEK2_1	53	58	PF00069	0.389
MOD_NEK2_1	648	653	PF00069	0.383
MOD_NEK2_1	74	79	PF00069	0.562
MOD_PIKK_1	127	133	PF00454	0.278
MOD_PKA_2	166	172	PF00069	0.395
MOD_PKA_2	24	30	PF00069	0.566
MOD_PKA_2	32	38	PF00069	0.629
MOD_PKA_2	371	377	PF00069	0.208
MOD_PKA_2	45	51	PF00069	0.544
MOD_PKA_2	53	59	PF00069	0.520
MOD_PKA_2	625	631	PF00069	0.330
MOD_PKA_2	644	650	PF00069	0.363
MOD_Plk_1	204	210	PF00069	0.353
MOD_Plk_1	431	437	PF00069	0.507
MOD_Plk_1	501	507	PF00069	0.221
MOD_Plk_2-3	402	408	PF00069	0.383
MOD_Plk_2-3	549	555	PF00069	0.303
MOD_Plk_4	179	185	PF00069	0.221
MOD_Plk_4	517	523	PF00069	0.303
MOD_ProDKin_1	461	467	PF00069	0.221
MOD_ProDKin_1	578	584	PF00069	0.303
MOD_ProDKin_1	638	644	PF00069	0.383
MOD_ProDKin_1	66	72	PF00069	0.549
MOD_ProDKin_1	7	13	PF00069	0.692
MOD_SUMO_for_1	473	476	PF00179	0.363
MOD_SUMO_rev_2	244	249	PF00179	0.221
MOD_SUMO_rev_2	388	393	PF00179	0.221
MOD_SUMO_rev_2	659	665	PF00179	0.317
TRG_DiLeu_BaEn_1	179	184	PF01217	0.363
TRG_DiLeu_BaEn_4	322	328	PF01217	0.383
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.221
TRG_ENDOCYTIC_2	488	491	PF00928	0.363
TRG_ER_diArg_1	113	116	PF00400	0.405
TRG_ER_diArg_1	190	192	PF00400	0.317
TRG_ER_diArg_1	236	239	PF00400	0.367
TRG_ER_diArg_1	240	242	PF00400	0.357
TRG_ER_diArg_1	648	650	PF00400	0.303
TRG_NLS_Bipartite_1	657	678	PF00514	0.562
TRG_NLS_MonoExtN_4	133	139	PF00514	0.221
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	296	301	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JKJ8	Bodo saltans	39%	100%
A0A3S7X283	Leishmania donovani	82%	100%
A4I4C8	Leishmania infantum	82%	100%
C9ZL36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ADS7	Leishmania major	82%	99%
E9AM03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%