Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisomal targeting signal 2 receptor, putative

Species:

Leishmania braziliensis

UniProt:

A4HH81_LEIBR

TriTrypDb:

LbrM.29.0760 , LBRM2903_290013800

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	12
GO:0005782	peroxisomal matrix	6	1
GO:0005829	cytosol	2	1
GO:0005840	ribosome	5	12
GO:0020015	glycosome	7	1
GO:0031907	microbody lumen	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0032991	protein-containing complex	1	12
GO:0042579	microbody	5	12

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Expansion

Sequence features

A4HH81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH81

Function

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Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006625	protein targeting to peroxisome	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006996	organelle organization	4	12
GO:0007031	peroxisome organization	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0015919	peroxisomal membrane transport	5	12

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Molecular functions
Term	Name	Level	Count
GO:0000268	peroxisome targeting sequence binding	5	12
GO:0005048	signal sequence binding	4	12
GO:0005053	peroxisome matrix targeting signal-2 binding	6	12
GO:0005488	binding	1	12
GO:0033218	amide binding	2	12
GO:0042277	peptide binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.525
CLV_NRD_NRD_1	233	235	PF00675	0.449
CLV_NRD_NRD_1	250	252	PF00675	0.267
CLV_PCSK_KEX2_1	125	127	PF00082	0.525
CLV_PCSK_KEX2_1	212	214	PF00082	0.288
CLV_PCSK_KEX2_1	233	235	PF00082	0.449
CLV_PCSK_KEX2_1	250	252	PF00082	0.267
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.288
CLV_PCSK_SKI1_1	192	196	PF00082	0.448
DEG_APCC_DBOX_1	191	199	PF00400	0.447

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	25%	71%
A0A0N1IM97	Leptomonas seymouri	85%	100%
A0A0S4JHX6	Bodo saltans	52%	92%
A0A1X0P138	Trypanosomatidae	63%	100%
A0A3Q8IF18	Leishmania donovani	90%	100%
A0A3Q8IGC4	Leishmania donovani	26%	71%
A0A422NRU1	Trypanosoma rangeli	66%	100%
A4HDT7	Leishmania braziliensis	26%	71%
A4I135	Leishmania infantum	26%	71%
A4I4C7	Leishmania infantum	90%	100%

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