Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH80_LEIBR

TriTrypDb:

LbrM.29.0750 , LBRM2903_290013700

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	153	159	PF00089	0.561
CLV_NRD_NRD_1	36	38	PF00675	0.447
CLV_NRD_NRD_1	48	50	PF00675	0.489
CLV_NRD_NRD_1	80	82	PF00675	0.584
CLV_PCSK_KEX2_1	36	38	PF00082	0.447
CLV_PCSK_KEX2_1	48	50	PF00082	0.489
CLV_PCSK_KEX2_1	80	82	PF00082	0.598
CLV_PCSK_SKI1_1	210	214	PF00082	0.530
DEG_SPOP_SBC_1	125	129	PF00917	0.579
DEG_SPOP_SBC_1	157	161	PF00917	0.572
DOC_MAPK_MEF2A_6	67	76	PF00069	0.506
DOC_PP2B_LxvP_1	174	177	PF13499	0.576
DOC_USP7_MATH_1	124	128	PF00917	0.705
DOC_USP7_MATH_1	155	159	PF00917	0.601
DOC_USP7_UBL2_3	216	220	PF12436	0.571
DOC_WW_Pin1_4	113	118	PF00397	0.632
DOC_WW_Pin1_4	159	164	PF00397	0.740
DOC_WW_Pin1_4	4	9	PF00397	0.698
LIG_14-3-3_CanoR_1	156	163	PF00244	0.633
LIG_14-3-3_CanoR_1	210	219	PF00244	0.466
LIG_BIR_III_4	109	113	PF00653	0.559
LIG_BRCT_BRCA1_1	126	130	PF00533	0.541
LIG_EVH1_1	174	178	PF00568	0.534
LIG_FHA_1	21	27	PF00498	0.692
LIG_FHA_1	38	44	PF00498	0.529
LIG_FHA_2	159	165	PF00498	0.565
LIG_FHA_2	30	36	PF00498	0.444
LIG_FHA_2	55	61	PF00498	0.612
LIG_LIR_Gen_1	192	203	PF02991	0.595
LIG_LIR_Nem_3	151	157	PF02991	0.575
LIG_LIR_Nem_3	192	198	PF02991	0.595
LIG_LIR_Nem_3	201	206	PF02991	0.590
LIG_SH2_CRK	154	158	PF00017	0.573
LIG_SH2_NCK_1	154	158	PF00017	0.563
LIG_SH2_STAP1	182	186	PF00017	0.613
LIG_SH2_STAT3	68	71	PF00017	0.493
LIG_SH3_3	172	178	PF00018	0.552
LIG_SH3_3	188	194	PF00018	0.548
LIG_TYR_ITSM	150	157	PF00017	0.550
MOD_CK1_1	115	121	PF00069	0.699
MOD_CK1_1	158	164	PF00069	0.735
MOD_CK1_1	20	26	PF00069	0.441
MOD_CK1_1	7	13	PF00069	0.556
MOD_CK2_1	159	165	PF00069	0.818
MOD_Cter_Amidation	78	81	PF01082	0.559
MOD_GlcNHglycan	103	106	PF01048	0.671
MOD_GlcNHglycan	186	189	PF01048	0.714
MOD_GlcNHglycan	19	22	PF01048	0.545
MOD_GlcNHglycan	195	198	PF01048	0.535
MOD_GlcNHglycan	88	91	PF01048	0.808
MOD_GlcNHglycan	9	12	PF01048	0.661
MOD_GSK3_1	111	118	PF00069	0.671
MOD_GSK3_1	120	127	PF00069	0.641
MOD_GSK3_1	155	162	PF00069	0.694
MOD_GSK3_1	189	196	PF00069	0.563
MOD_GSK3_1	25	32	PF00069	0.715
MOD_GSK3_1	88	95	PF00069	0.704
MOD_GSK3_1	97	104	PF00069	0.601
MOD_LATS_1	147	153	PF00433	0.533
MOD_LATS_1	92	98	PF00433	0.692
MOD_N-GLC_1	119	124	PF02516	0.552
MOD_N-GLC_1	43	48	PF02516	0.593
MOD_N-GLC_1	92	97	PF02516	0.559
MOD_NEK2_1	212	217	PF00069	0.463
MOD_NEK2_1	29	34	PF00069	0.650
MOD_NEK2_1	43	48	PF00069	0.461
MOD_NEK2_1	54	59	PF00069	0.553
MOD_PIKK_1	43	49	PF00454	0.580
MOD_PKA_2	155	161	PF00069	0.567
MOD_PKA_2	93	99	PF00069	0.604
MOD_Plk_1	149	155	PF00069	0.652
MOD_Plk_4	149	155	PF00069	0.543
MOD_Plk_4	169	175	PF00069	0.583
MOD_Plk_4	70	76	PF00069	0.756
MOD_ProDKin_1	113	119	PF00069	0.632
MOD_ProDKin_1	159	165	PF00069	0.738
MOD_ProDKin_1	4	10	PF00069	0.698
TRG_DiLeu_BaEn_1	201	206	PF01217	0.439
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.582
TRG_ENDOCYTIC_2	154	157	PF00928	0.573
TRG_ENDOCYTIC_2	203	206	PF00928	0.584
TRG_ER_diArg_1	36	38	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I154	Leptomonas seymouri	40%	98%
A0A3Q8IF96	Leishmania donovani	62%	100%
A4I4C6	Leishmania infantum	61%	100%
E9ADS5	Leishmania major	61%	100%
E9AM05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%