DNA damage-binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 7 protein

Species:

Leishmania braziliensis

UniProt:

A4HH78_LEIBR

TriTrypDb:

LbrM.29.0720 , LBRM2903_290013400

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0032991	protein-containing complex	1	1
GO:0034464	BBSome	2	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HH78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH78

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.496
CLV_C14_Caspase3-7	405	409	PF00656	0.439
CLV_C14_Caspase3-7	620	624	PF00656	0.575
CLV_C14_Caspase3-7	852	856	PF00656	0.500
CLV_NRD_NRD_1	108	110	PF00675	0.391
CLV_NRD_NRD_1	13	15	PF00675	0.474
CLV_NRD_NRD_1	246	248	PF00675	0.447
CLV_NRD_NRD_1	688	690	PF00675	0.547
CLV_PCSK_KEX2_1	13	15	PF00082	0.504
CLV_PCSK_KEX2_1	246	248	PF00082	0.288
CLV_PCSK_KEX2_1	504	506	PF00082	0.455
CLV_PCSK_KEX2_1	57	59	PF00082	0.561
CLV_PCSK_KEX2_1	644	646	PF00082	0.404
CLV_PCSK_KEX2_1	688	690	PF00082	0.547
CLV_PCSK_KEX2_1	738	740	PF00082	0.530
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.524
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.490
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.561
CLV_PCSK_PC1ET2_1	644	646	PF00082	0.409
CLV_PCSK_PC1ET2_1	738	740	PF00082	0.530
CLV_PCSK_SKI1_1	112	116	PF00082	0.417
CLV_PCSK_SKI1_1	15	19	PF00082	0.455
CLV_PCSK_SKI1_1	223	227	PF00082	0.484
CLV_PCSK_SKI1_1	368	372	PF00082	0.356
CLV_PCSK_SKI1_1	602	606	PF00082	0.472
CLV_PCSK_SKI1_1	629	633	PF00082	0.370
CLV_PCSK_SKI1_1	739	743	PF00082	0.379
CLV_PCSK_SKI1_1	811	815	PF00082	0.467
CLV_PCSK_SKI1_1	84	88	PF00082	0.492
DEG_SCF_FBW7_1	427	434	PF00400	0.285
DEG_SPOP_SBC_1	473	477	PF00917	0.741
DEG_SPOP_SBC_1	801	805	PF00917	0.671
DOC_CDC14_PxL_1	397	405	PF14671	0.624
DOC_CKS1_1	130	135	PF01111	0.362
DOC_CKS1_1	305	310	PF01111	0.286
DOC_CKS1_1	4	9	PF01111	0.394
DOC_CKS1_1	423	428	PF01111	0.486
DOC_CYCLIN_RxL_1	219	229	PF00134	0.502
DOC_CYCLIN_yClb5_NLxxxL_5	216	225	PF00134	0.237
DOC_MAPK_gen_1	35	43	PF00069	0.409
DOC_MAPK_gen_1	415	424	PF00069	0.287
DOC_MAPK_gen_1	504	512	PF00069	0.422
DOC_MAPK_gen_1	57	65	PF00069	0.485
DOC_MAPK_HePTP_8	412	424	PF00069	0.412
DOC_MAPK_MEF2A_6	415	424	PF00069	0.445
DOC_MAPK_MEF2A_6	501	510	PF00069	0.545
DOC_MAPK_MEF2A_6	57	65	PF00069	0.523
DOC_PP1_RVXF_1	148	155	PF00149	0.483
DOC_PP1_RVXF_1	221	227	PF00149	0.503
DOC_PP1_RVXF_1	627	633	PF00149	0.260
DOC_PP2B_LxvP_1	815	818	PF13499	0.492
DOC_PP4_FxxP_1	155	158	PF00568	0.523
DOC_USP7_MATH_1	168	172	PF00917	0.351
DOC_USP7_MATH_1	292	296	PF00917	0.531
DOC_USP7_MATH_1	652	656	PF00917	0.510
DOC_USP7_MATH_1	678	682	PF00917	0.504
DOC_USP7_MATH_1	800	804	PF00917	0.651
DOC_USP7_MATH_1	851	855	PF00917	0.582
DOC_WW_Pin1_4	129	134	PF00397	0.372
DOC_WW_Pin1_4	154	159	PF00397	0.396
DOC_WW_Pin1_4	19	24	PF00397	0.239
DOC_WW_Pin1_4	3	8	PF00397	0.634
DOC_WW_Pin1_4	304	309	PF00397	0.416
DOC_WW_Pin1_4	422	427	PF00397	0.416
DOC_WW_Pin1_4	474	479	PF00397	0.754
DOC_WW_Pin1_4	494	499	PF00397	0.399
DOC_WW_Pin1_4	847	852	PF00397	0.617
LIG_14-3-3_CanoR_1	14	23	PF00244	0.269
LIG_14-3-3_CanoR_1	417	423	PF00244	0.278
LIG_14-3-3_CanoR_1	521	525	PF00244	0.538
LIG_14-3-3_CanoR_1	602	610	PF00244	0.457
LIG_14-3-3_CanoR_1	739	748	PF00244	0.456
LIG_Actin_WH2_2	181	198	PF00022	0.454
LIG_Actin_WH2_2	230	248	PF00022	0.388
LIG_Clathr_ClatBox_1	613	617	PF01394	0.243
LIG_EH1_1	417	425	PF00400	0.295
LIG_FHA_1	120	126	PF00498	0.401
LIG_FHA_1	130	136	PF00498	0.348
LIG_FHA_1	147	153	PF00498	0.429
LIG_FHA_1	212	218	PF00498	0.407
LIG_FHA_1	231	237	PF00498	0.247
LIG_FHA_1	282	288	PF00498	0.412
LIG_FHA_1	301	307	PF00498	0.475
LIG_FHA_1	392	398	PF00498	0.454
LIG_FHA_1	428	434	PF00498	0.437
LIG_FHA_1	482	488	PF00498	0.550
LIG_FHA_1	530	536	PF00498	0.427
LIG_FHA_1	613	619	PF00498	0.440
LIG_FHA_1	759	765	PF00498	0.422
LIG_FHA_1	802	808	PF00498	0.640
LIG_FHA_1	810	816	PF00498	0.685
LIG_FHA_2	143	149	PF00498	0.475
LIG_FHA_2	171	177	PF00498	0.433
LIG_FHA_2	377	383	PF00498	0.582
LIG_FHA_2	423	429	PF00498	0.487
LIG_FHA_2	788	794	PF00498	0.642
LIG_LIR_Gen_1	131	142	PF02991	0.425
LIG_LIR_Gen_1	215	226	PF02991	0.367
LIG_LIR_Gen_1	712	720	PF02991	0.421
LIG_LIR_Gen_1	747	756	PF02991	0.537
LIG_LIR_LC3C_4	434	437	PF02991	0.504
LIG_LIR_Nem_3	131	137	PF02991	0.462
LIG_LIR_Nem_3	215	221	PF02991	0.373
LIG_LIR_Nem_3	47	53	PF02991	0.474
LIG_LIR_Nem_3	712	716	PF02991	0.422
LIG_LIR_Nem_3	742	748	PF02991	0.455
LIG_LYPXL_S_1	676	680	PF13949	0.480
LIG_LYPXL_yS_3	677	680	PF13949	0.487
LIG_NRBOX	220	226	PF00104	0.244
LIG_NRBOX	609	615	PF00104	0.250
LIG_PCNA_yPIPBox_3	191	202	PF02747	0.467
LIG_Pex14_2	605	609	PF04695	0.429
LIG_SH2_CRK	167	171	PF00017	0.463
LIG_SH2_CRK	218	222	PF00017	0.470
LIG_SH2_CRK	444	448	PF00017	0.250
LIG_SH2_GRB2like	218	221	PF00017	0.278
LIG_SH2_NCK_1	167	171	PF00017	0.271
LIG_SH2_NCK_1	546	550	PF00017	0.385
LIG_SH2_PTP2	537	540	PF00017	0.492
LIG_SH2_SRC	280	283	PF00017	0.423
LIG_SH2_STAP1	525	529	PF00017	0.567
LIG_SH2_STAT3	227	230	PF00017	0.454
LIG_SH2_STAT3	525	528	PF00017	0.525
LIG_SH2_STAT5	184	187	PF00017	0.364
LIG_SH2_STAT5	537	540	PF00017	0.492
LIG_SH2_STAT5	736	739	PF00017	0.380
LIG_SH2_STAT5	750	753	PF00017	0.406
LIG_SH2_STAT5	98	101	PF00017	0.491
LIG_SH3_3	1	7	PF00018	0.431
LIG_SH3_3	245	251	PF00018	0.463
LIG_SH3_3	845	851	PF00018	0.490
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.497
LIG_SUMO_SIM_par_1	60	67	PF11976	0.283
LIG_SUMO_SIM_par_1	612	617	PF11976	0.460
LIG_SUMO_SIM_par_1	636	642	PF11976	0.333
LIG_TRAF2_1	712	715	PF00917	0.463
LIG_TRAF2_1	719	722	PF00917	0.484
LIG_TRAF2_1	731	734	PF00917	0.470
LIG_TRAF2_1	790	793	PF00917	0.664
LIG_TRFH_1	154	158	PF08558	0.500
LIG_TYR_ITIM	216	221	PF00017	0.456
LIG_TYR_ITIM	535	540	PF00017	0.497
LIG_WRC_WIRS_1	337	342	PF05994	0.364
LIG_WRC_WIRS_1	745	750	PF05994	0.505
MOD_CDC14_SPxK_1	157	160	PF00782	0.387
MOD_CDK_SPxK_1	154	160	PF00069	0.397
MOD_CDK_SPxxK_3	494	501	PF00069	0.538
MOD_CK1_1	295	301	PF00069	0.487
MOD_CK1_1	3	9	PF00069	0.571
MOD_CK1_1	458	464	PF00069	0.427
MOD_CK1_1	477	483	PF00069	0.693
MOD_CK1_1	555	561	PF00069	0.551
MOD_CK1_1	612	618	PF00069	0.476
MOD_CK1_1	636	642	PF00069	0.371
MOD_CK1_1	657	663	PF00069	0.350
MOD_CK1_1	681	687	PF00069	0.511
MOD_CK1_1	809	815	PF00069	0.625
MOD_CK1_1	849	855	PF00069	0.732
MOD_CK2_1	142	148	PF00069	0.466
MOD_CK2_1	376	382	PF00069	0.575
MOD_CK2_1	422	428	PF00069	0.513
MOD_CK2_1	656	662	PF00069	0.461
MOD_CK2_1	709	715	PF00069	0.458
MOD_CK2_1	716	722	PF00069	0.458
MOD_CK2_1	787	793	PF00069	0.643
MOD_CK2_1	851	857	PF00069	0.658
MOD_Cter_Amidation	55	58	PF01082	0.528
MOD_GlcNHglycan	170	173	PF01048	0.456
MOD_GlcNHglycan	230	233	PF01048	0.403
MOD_GlcNHglycan	241	244	PF01048	0.445
MOD_GlcNHglycan	292	295	PF01048	0.414
MOD_GlcNHglycan	340	343	PF01048	0.357
MOD_GlcNHglycan	437	440	PF01048	0.484
MOD_GlcNHglycan	460	463	PF01048	0.321
MOD_GlcNHglycan	525	528	PF01048	0.490
MOD_GlcNHglycan	550	553	PF01048	0.542
MOD_GlcNHglycan	718	721	PF01048	0.541
MOD_GSK3_1	142	149	PF00069	0.347
MOD_GSK3_1	15	22	PF00069	0.396
MOD_GSK3_1	226	233	PF00069	0.393
MOD_GSK3_1	290	297	PF00069	0.548
MOD_GSK3_1	300	307	PF00069	0.442
MOD_GSK3_1	391	398	PF00069	0.548
MOD_GSK3_1	418	425	PF00069	0.420
MOD_GSK3_1	427	434	PF00069	0.399
MOD_GSK3_1	452	459	PF00069	0.476
MOD_GSK3_1	472	479	PF00069	0.723
MOD_GSK3_1	483	490	PF00069	0.634
MOD_GSK3_1	516	523	PF00069	0.450
MOD_GSK3_1	548	555	PF00069	0.545
MOD_GSK3_1	621	628	PF00069	0.455
MOD_GSK3_1	652	659	PF00069	0.387
MOD_GSK3_1	678	685	PF00069	0.493
MOD_GSK3_1	802	809	PF00069	0.603
MOD_GSK3_1	833	840	PF00069	0.709
MOD_GSK3_1	842	849	PF00069	0.745
MOD_GSK3_1	851	858	PF00069	0.517
MOD_N-GLC_1	119	124	PF02516	0.407
MOD_N-GLC_1	219	224	PF02516	0.275
MOD_N-GLC_1	704	709	PF02516	0.333
MOD_N-GLC_1	838	843	PF02516	0.483
MOD_NEK2_1	141	146	PF00069	0.373
MOD_NEK2_1	226	231	PF00069	0.490
MOD_NEK2_1	256	261	PF00069	0.534
MOD_NEK2_1	296	301	PF00069	0.608
MOD_NEK2_1	336	341	PF00069	0.355
MOD_NEK2_1	418	423	PF00069	0.405
MOD_NEK2_1	481	486	PF00069	0.608
MOD_NEK2_1	520	525	PF00069	0.416
MOD_NEK2_1	603	608	PF00069	0.460
MOD_NEK2_1	609	614	PF00069	0.358
MOD_NEK2_1	656	661	PF00069	0.444
MOD_NEK2_1	665	670	PF00069	0.401
MOD_NEK2_1	679	684	PF00069	0.354
MOD_NEK2_1	737	742	PF00069	0.375
MOD_NEK2_1	744	749	PF00069	0.377
MOD_NEK2_1	758	763	PF00069	0.421
MOD_NEK2_1	802	807	PF00069	0.574
MOD_NEK2_1	837	842	PF00069	0.620
MOD_NEK2_2	170	175	PF00069	0.324
MOD_NEK2_2	410	415	PF00069	0.400
MOD_NEK2_2	8	13	PF00069	0.542
MOD_PIKK_1	226	232	PF00454	0.434
MOD_PIKK_1	324	330	PF00454	0.446
MOD_PIKK_1	376	382	PF00454	0.573
MOD_PIKK_1	683	689	PF00454	0.520
MOD_PK_1	317	323	PF00069	0.460
MOD_PK_1	51	57	PF00069	0.486
MOD_PK_1	654	660	PF00069	0.274
MOD_PKA_2	500	506	PF00069	0.528
MOD_PKA_2	520	526	PF00069	0.495
MOD_PKB_1	393	401	PF00069	0.623
MOD_Plk_1	219	225	PF00069	0.443
MOD_Plk_1	552	558	PF00069	0.632
MOD_Plk_1	652	658	PF00069	0.315
MOD_Plk_1	704	710	PF00069	0.433
MOD_Plk_1	787	793	PF00069	0.590
MOD_Plk_2-3	833	839	PF00069	0.480
MOD_Plk_4	212	218	PF00069	0.388
MOD_Plk_4	368	374	PF00069	0.610
MOD_Plk_4	418	424	PF00069	0.453
MOD_Plk_4	431	437	PF00069	0.425
MOD_Plk_4	452	458	PF00069	0.484
MOD_Plk_4	520	526	PF00069	0.463
MOD_Plk_4	552	558	PF00069	0.645
MOD_Plk_4	609	615	PF00069	0.394
MOD_Plk_4	633	639	PF00069	0.367
MOD_Plk_4	665	671	PF00069	0.506
MOD_Plk_4	704	710	PF00069	0.433
MOD_Plk_4	802	808	PF00069	0.576
MOD_Plk_4	87	93	PF00069	0.382
MOD_Plk_4	99	105	PF00069	0.352
MOD_ProDKin_1	129	135	PF00069	0.366
MOD_ProDKin_1	154	160	PF00069	0.397
MOD_ProDKin_1	19	25	PF00069	0.242
MOD_ProDKin_1	3	9	PF00069	0.628
MOD_ProDKin_1	304	310	PF00069	0.414
MOD_ProDKin_1	422	428	PF00069	0.423
MOD_ProDKin_1	474	480	PF00069	0.755
MOD_ProDKin_1	494	500	PF00069	0.406
MOD_ProDKin_1	847	853	PF00069	0.619
MOD_SUMO_rev_2	147	152	PF00179	0.560
MOD_SUMO_rev_2	76	86	PF00179	0.654
TRG_DiLeu_BaEn_2	150	156	PF01217	0.550
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.492
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.510
TRG_ENDOCYTIC_2	218	221	PF00928	0.491
TRG_ENDOCYTIC_2	444	447	PF00928	0.255
TRG_ENDOCYTIC_2	537	540	PF00928	0.422
TRG_ENDOCYTIC_2	546	549	PF00928	0.338
TRG_ENDOCYTIC_2	677	680	PF00928	0.466
TRG_ENDOCYTIC_2	745	748	PF00928	0.408
TRG_ER_diArg_1	245	247	PF00400	0.283
TRG_ER_diArg_1	414	417	PF00400	0.339
TRG_ER_diArg_1	688	690	PF00400	0.547
TRG_NLS_MonoExtC_3	108	113	PF00514	0.434
TRG_NLS_MonoExtN_4	32	39	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	387	392	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W9	Leptomonas seymouri	61%	100%
A0A1X0NZL6	Trypanosomatidae	33%	100%
A0A3Q8IR58	Leishmania donovani	81%	100%
A0A422NRV6	Trypanosoma rangeli	32%	100%
A4I4C4	Leishmania infantum	81%	100%
C9ZL44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ADS3	Leishmania major	81%	100%
E9AM07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q8IWZ6	Homo sapiens	23%	100%
Q8K2G4	Mus musculus	23%	100%
V5BKF4	Trypanosoma cruzi	32%	100%