DNA damage-binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 7 protein

Species:

Leishmania braziliensis

UniProt:

A4HH78_LEIBR

TriTrypDb:

LbrM.29.0720 , LBRM2903_290013400

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1

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Expansion

Sequence features

A4HH78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH78

Function

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Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.496
CLV_C14_Caspase3-7	405	409	PF00656	0.439
CLV_C14_Caspase3-7	620	624	PF00656	0.575
CLV_C14_Caspase3-7	852	856	PF00656	0.500
CLV_NRD_NRD_1	108	110	PF00675	0.391
CLV_NRD_NRD_1	13	15	PF00675	0.474
CLV_NRD_NRD_1	246	248	PF00675	0.447
CLV_NRD_NRD_1	688	690	PF00675	0.547
CLV_PCSK_KEX2_1	13	15	PF00082	0.504
CLV_PCSK_KEX2_1	246	248	PF00082	0.288

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W9	Leptomonas seymouri	61%	100%
A0A1X0NZL6	Trypanosomatidae	33%	100%
A0A3Q8IR58	Leishmania donovani	81%	100%
A0A422NRV6	Trypanosoma rangeli	32%	100%
A4I4C4	Leishmania infantum	81%	100%
C9ZL44	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ADS3	Leishmania major	81%	100%
E9AM07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q8IWZ6	Homo sapiens	23%	100%
Q8K2G4	Mus musculus	23%	100%

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