Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH77_LEIBR

TriTrypDb:

LbrM.29.0710 , LBRM2903_290013300

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HH77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH77

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	625	631	PF00089	0.521
CLV_NRD_NRD_1	365	367	PF00675	0.474
CLV_NRD_NRD_1	483	485	PF00675	0.433
CLV_NRD_NRD_1	555	557	PF00675	0.498
CLV_NRD_NRD_1	97	99	PF00675	0.734
CLV_PCSK_FUR_1	95	99	PF00082	0.768
CLV_PCSK_KEX2_1	365	367	PF00082	0.511
CLV_PCSK_KEX2_1	451	453	PF00082	0.573
CLV_PCSK_KEX2_1	483	485	PF00082	0.569
CLV_PCSK_KEX2_1	555	557	PF00082	0.584
CLV_PCSK_KEX2_1	97	99	PF00082	0.765
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.512
CLV_PCSK_PC7_1	93	99	PF00082	0.663
CLV_PCSK_SKI1_1	423	427	PF00082	0.545
CLV_PCSK_SKI1_1	428	432	PF00082	0.481
CLV_PCSK_SKI1_1	555	559	PF00082	0.555
CLV_PCSK_SKI1_1	73	77	PF00082	0.652
CLV_PCSK_SKI1_1	80	84	PF00082	0.574
DEG_COP1_1	369	377	PF00400	0.491
DEG_SPOP_SBC_1	46	50	PF00917	0.656
DEG_SPOP_SBC_1	690	694	PF00917	0.533
DOC_CKS1_1	261	266	PF01111	0.646
DOC_CKS1_1	88	93	PF01111	0.530
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.671
DOC_CYCLIN_yCln2_LP_2	482	488	PF00134	0.699
DOC_MAPK_gen_1	451	458	PF00069	0.577
DOC_MAPK_gen_1	581	590	PF00069	0.533
DOC_MAPK_MEF2A_6	635	643	PF00069	0.510
DOC_MAPK_RevD_3	543	556	PF00069	0.352
DOC_PP1_RVXF_1	190	197	PF00149	0.550
DOC_PP1_RVXF_1	530	537	PF00149	0.596
DOC_USP7_MATH_1	117	121	PF00917	0.551
DOC_USP7_MATH_1	131	135	PF00917	0.497
DOC_USP7_MATH_1	140	144	PF00917	0.509
DOC_USP7_MATH_1	168	172	PF00917	0.606
DOC_USP7_MATH_1	173	177	PF00917	0.519
DOC_USP7_MATH_1	18	22	PF00917	0.635
DOC_USP7_MATH_1	26	30	PF00917	0.616
DOC_USP7_MATH_1	266	270	PF00917	0.564
DOC_USP7_MATH_1	402	406	PF00917	0.566
DOC_USP7_MATH_1	407	411	PF00917	0.546
DOC_USP7_MATH_1	51	55	PF00917	0.698
DOC_USP7_MATH_1	527	531	PF00917	0.484
DOC_USP7_MATH_1	606	610	PF00917	0.554
DOC_USP7_MATH_1	639	643	PF00917	0.683
DOC_USP7_MATH_1	656	660	PF00917	0.620
DOC_WW_Pin1_4	13	18	PF00397	0.674
DOC_WW_Pin1_4	260	265	PF00397	0.617
DOC_WW_Pin1_4	300	305	PF00397	0.488
DOC_WW_Pin1_4	614	619	PF00397	0.553
DOC_WW_Pin1_4	87	92	PF00397	0.588
LIG_14-3-3_CanoR_1	139	145	PF00244	0.805
LIG_14-3-3_CanoR_1	229	237	PF00244	0.684
LIG_14-3-3_CanoR_1	240	244	PF00244	0.720
LIG_14-3-3_CanoR_1	251	259	PF00244	0.749
LIG_14-3-3_CanoR_1	282	286	PF00244	0.610
LIG_14-3-3_CanoR_1	365	371	PF00244	0.456
LIG_14-3-3_CanoR_1	445	454	PF00244	0.449
LIG_Actin_WH2_2	267	284	PF00022	0.644
LIG_Actin_WH2_2	28	46	PF00022	0.405
LIG_Actin_WH2_2	414	430	PF00022	0.585
LIG_Actin_WH2_2	622	637	PF00022	0.513
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_BRCT_BRCA1_1	168	172	PF00533	0.639
LIG_deltaCOP1_diTrp_1	288	296	PF00928	0.435
LIG_FHA_1	160	166	PF00498	0.612
LIG_FHA_1	305	311	PF00498	0.562
LIG_FHA_1	356	362	PF00498	0.595
LIG_FHA_1	369	375	PF00498	0.453
LIG_FHA_1	442	448	PF00498	0.472
LIG_FHA_1	615	621	PF00498	0.622
LIG_FHA_1	74	80	PF00498	0.661
LIG_FHA_2	605	611	PF00498	0.744
LIG_FHA_2	69	75	PF00498	0.543
LIG_LIR_Apic_2	500	505	PF02991	0.587
LIG_LIR_Apic_2	537	543	PF02991	0.467
LIG_LIR_Nem_3	19	25	PF02991	0.633
LIG_LIR_Nem_3	242	246	PF02991	0.701
LIG_LYPXL_yS_3	243	246	PF13949	0.766
LIG_NRBOX	311	317	PF00104	0.467
LIG_PCNA_yPIPBox_3	282	290	PF02747	0.557
LIG_Pex14_2	536	540	PF04695	0.468
LIG_RPA_C_Fungi	172	184	PF08784	0.452
LIG_RPA_C_Insects	172	187	PF08784	0.438
LIG_SH2_CRK	367	371	PF00017	0.632
LIG_SH2_NCK_1	23	27	PF00017	0.635
LIG_SH2_SRC	502	505	PF00017	0.693
LIG_SH2_STAP1	23	27	PF00017	0.652
LIG_SH2_STAT5	27	30	PF00017	0.575
LIG_SH2_STAT5	442	445	PF00017	0.514
LIG_SH2_STAT5	502	505	PF00017	0.680
LIG_SH3_2	88	93	PF14604	0.530
LIG_SH3_3	113	119	PF00018	0.544
LIG_SH3_3	150	156	PF00018	0.646
LIG_SH3_3	241	247	PF00018	0.668
LIG_SH3_3	258	264	PF00018	0.721
LIG_SH3_3	371	377	PF00018	0.518
LIG_SH3_3	464	470	PF00018	0.749
LIG_SH3_3	484	490	PF00018	0.377
LIG_SH3_3	638	644	PF00018	0.658
LIG_SH3_3	85	91	PF00018	0.658
LIG_SUMO_SIM_anti_2	313	319	PF11976	0.461
LIG_SUMO_SIM_par_1	313	319	PF11976	0.423
LIG_TRAF2_1	109	112	PF00917	0.778
LIG_TRAF2_1	344	347	PF00917	0.552
LIG_TRAF2_1	557	560	PF00917	0.573
LIG_TRAF2_1	683	686	PF00917	0.606
LIG_UBA3_1	544	550	PF00899	0.474
MOD_CDK_SPxK_1	87	93	PF00069	0.524
MOD_CK1_1	134	140	PF00069	0.694
MOD_CK1_1	166	172	PF00069	0.566
MOD_CK1_1	21	27	PF00069	0.641
MOD_CK1_1	239	245	PF00069	0.683
MOD_CK1_1	369	375	PF00069	0.447
MOD_CK1_1	4	10	PF00069	0.684
MOD_CK1_1	446	452	PF00069	0.592
MOD_CK1_1	45	51	PF00069	0.668
MOD_CK1_1	642	648	PF00069	0.724
MOD_CK1_1	691	697	PF00069	0.771
MOD_CK2_1	13	19	PF00069	0.422
MOD_CK2_1	604	610	PF00069	0.703
MOD_CK2_1	68	74	PF00069	0.552
MOD_GlcNHglycan	222	226	PF01048	0.706
MOD_GlcNHglycan	254	258	PF01048	0.723
MOD_GlcNHglycan	28	31	PF01048	0.635
MOD_GlcNHglycan	629	632	PF01048	0.552
MOD_GlcNHglycan	636	639	PF01048	0.545
MOD_GlcNHglycan	644	647	PF01048	0.558
MOD_GlcNHglycan	662	665	PF01048	0.381
MOD_GlcNHglycan	694	697	PF01048	0.807
MOD_GlcNHglycan	99	103	PF01048	0.729
MOD_GSK3_1	131	138	PF00069	0.755
MOD_GSK3_1	159	166	PF00069	0.572
MOD_GSK3_1	246	253	PF00069	0.703
MOD_GSK3_1	300	307	PF00069	0.615
MOD_GSK3_1	353	360	PF00069	0.633
MOD_GSK3_1	42	49	PF00069	0.655
MOD_GSK3_1	504	511	PF00069	0.675
MOD_GSK3_1	6	13	PF00069	0.652
MOD_GSK3_1	656	663	PF00069	0.565
MOD_GSK3_1	688	695	PF00069	0.625
MOD_N-GLC_1	266	271	PF02516	0.502
MOD_NEK2_1	1	6	PF00069	0.712
MOD_NEK2_1	158	163	PF00069	0.524
MOD_NEK2_1	281	286	PF00069	0.573
MOD_NEK2_1	311	316	PF00069	0.512
MOD_NEK2_1	355	360	PF00069	0.646
MOD_NEK2_1	634	639	PF00069	0.597
MOD_NEK2_2	18	23	PF00069	0.635
MOD_NEK2_2	266	271	PF00069	0.474
MOD_NEK2_2	51	56	PF00069	0.688
MOD_PIKK_1	131	137	PF00454	0.552
MOD_PIKK_1	228	234	PF00454	0.705
MOD_PIKK_1	246	252	PF00454	0.482
MOD_PIKK_1	304	310	PF00454	0.571
MOD_PIKK_1	389	395	PF00454	0.568
MOD_PIKK_1	407	413	PF00454	0.402
MOD_PIKK_1	465	471	PF00454	0.648
MOD_PIKK_1	573	579	PF00454	0.515
MOD_PIKK_1	695	701	PF00454	0.810
MOD_PK_1	366	372	PF00069	0.377
MOD_PKA_2	135	141	PF00069	0.737
MOD_PKA_2	228	234	PF00069	0.646
MOD_PKA_2	239	245	PF00069	0.660
MOD_PKA_2	250	256	PF00069	0.660
MOD_PKA_2	281	287	PF00069	0.525
MOD_PKA_2	627	633	PF00069	0.689
MOD_PKB_1	66	74	PF00069	0.617
MOD_Plk_1	18	24	PF00069	0.635
MOD_Plk_1	266	272	PF00069	0.497
MOD_Plk_1	423	429	PF00069	0.614
MOD_Plk_2-3	216	222	PF00069	0.516
MOD_Plk_4	18	24	PF00069	0.614
MOD_Plk_4	281	287	PF00069	0.573
MOD_Plk_4	311	317	PF00069	0.520
MOD_Plk_4	409	415	PF00069	0.613
MOD_Plk_4	42	48	PF00069	0.665
MOD_Plk_4	497	503	PF00069	0.645
MOD_Plk_4	504	510	PF00069	0.619
MOD_Plk_4	51	57	PF00069	0.700
MOD_Plk_4	656	662	PF00069	0.708
MOD_Plk_4	7	13	PF00069	0.709
MOD_ProDKin_1	13	19	PF00069	0.674
MOD_ProDKin_1	260	266	PF00069	0.615
MOD_ProDKin_1	300	306	PF00069	0.481
MOD_ProDKin_1	614	620	PF00069	0.554
MOD_ProDKin_1	87	93	PF00069	0.595
MOD_SUMO_rev_2	566	572	PF00179	0.562
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.530
TRG_ENDOCYTIC_2	243	246	PF00928	0.752
TRG_ENDOCYTIC_2	299	302	PF00928	0.538
TRG_ENDOCYTIC_2	367	370	PF00928	0.601
TRG_ER_diArg_1	124	127	PF00400	0.720
TRG_ER_diArg_1	365	367	PF00400	0.515
TRG_ER_diArg_1	482	484	PF00400	0.426
TRG_ER_diArg_1	65	68	PF00400	0.655
TRG_ER_diArg_1	95	98	PF00400	0.773
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE66	Leptomonas seymouri	42%	100%
A0A1X0NZK2	Trypanosomatidae	26%	100%
A0A3Q8IEA8	Leishmania donovani	67%	99%
A0A3R7NL89	Trypanosoma rangeli	27%	100%
A4I4C3	Leishmania infantum	67%	99%
C9ZL45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ADS2	Leishmania major	68%	98%
E9AM08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	98%
V5BUN1	Trypanosoma cruzi	25%	100%