Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HH76_LEIBR

TriTrypDb:

LbrM.29.0700 , LBRM2903_290013200

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0020023	kinetoplast	2	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HH76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.744
CLV_PCSK_SKI1_1	149	153	PF00082	0.553
CLV_PCSK_SKI1_1	191	195	PF00082	0.532
CLV_PCSK_SKI1_1	242	246	PF00082	0.410
DEG_APCC_DBOX_1	22	30	PF00400	0.490
DEG_MDM2_SWIB_1	38	46	PF02201	0.687
DEG_Nend_Nbox_1	1	3	PF02207	0.651
DOC_CKS1_1	157	162	PF01111	0.533
DOC_USP7_MATH_1	220	224	PF00917	0.497
DOC_USP7_MATH_1	7	11	PF00917	0.712
DOC_USP7_MATH_1	75	79	PF00917	0.659
DOC_USP7_UBL2_3	187	191	PF12436	0.490
DOC_WW_Pin1_4	119	124	PF00397	0.362
DOC_WW_Pin1_4	156	161	PF00397	0.542
DOC_WW_Pin1_4	257	262	PF00397	0.549
DOC_WW_Pin1_4	97	102	PF00397	0.652
LIG_14-3-3_CanoR_1	111	121	PF00244	0.580
LIG_14-3-3_CanoR_1	4	11	PF00244	0.714
LIG_BRCT_BRCA1_1	189	193	PF00533	0.564
LIG_BRCT_BRCA1_1	90	94	PF00533	0.617
LIG_deltaCOP1_diTrp_1	143	154	PF00928	0.538
LIG_FHA_1	113	119	PF00498	0.526
LIG_FHA_1	257	263	PF00498	0.521
LIG_FHA_2	224	230	PF00498	0.564
LIG_FHA_2	245	251	PF00498	0.455
LIG_FXI_DFP_1	151	155	PF00024	0.343
LIG_LIR_Gen_1	170	180	PF02991	0.433
LIG_LIR_Gen_1	204	212	PF02991	0.344
LIG_LIR_Nem_3	105	110	PF02991	0.563
LIG_LIR_Nem_3	144	150	PF02991	0.435
LIG_LIR_Nem_3	170	176	PF02991	0.466
LIG_LIR_Nem_3	204	208	PF02991	0.361
LIG_LIR_Nem_3	229	235	PF02991	0.333
LIG_LIR_Nem_3	97	102	PF02991	0.571
LIG_Pex14_1	169	173	PF04695	0.487
LIG_Pex14_2	165	169	PF04695	0.412
LIG_Pex14_2	38	42	PF04695	0.695
LIG_PTB_Apo_2	61	68	PF02174	0.720
LIG_PTB_Phospho_1	61	67	PF10480	0.680
LIG_SH2_CRK	107	111	PF00017	0.610
LIG_SH2_NCK_1	173	177	PF00017	0.530
LIG_SH2_STAP1	205	209	PF00017	0.517
LIG_SH2_STAP1	228	232	PF00017	0.375
LIG_SH2_STAT5	173	176	PF00017	0.413
LIG_SH2_STAT5	202	205	PF00017	0.515
LIG_SH3_1	117	123	PF00018	0.528
LIG_SH3_3	117	123	PF00018	0.528
LIG_SH3_4	191	198	PF00018	0.307
LIG_TRAF2_1	254	257	PF00917	0.673
LIG_TYR_ITIM	203	208	PF00017	0.529
MOD_CDK_SPxxK_3	97	104	PF00069	0.653
MOD_CK1_1	156	162	PF00069	0.600
MOD_CK1_1	17	23	PF00069	0.652
MOD_CK1_1	223	229	PF00069	0.326
MOD_CK1_1	44	50	PF00069	0.562
MOD_CK1_1	6	12	PF00069	0.683
MOD_CK2_1	223	229	PF00069	0.569
MOD_CK2_1	97	103	PF00069	0.564
MOD_GlcNHglycan	175	179	PF01048	0.438
MOD_GlcNHglycan	19	22	PF01048	0.595
MOD_GlcNHglycan	43	46	PF01048	0.641
MOD_GlcNHglycan	5	8	PF01048	0.683
MOD_GlcNHglycan	73	76	PF01048	0.620
MOD_GlcNHglycan	83	86	PF01048	0.721
MOD_GSK3_1	106	113	PF00069	0.751
MOD_GSK3_1	17	24	PF00069	0.673
MOD_GSK3_1	3	10	PF00069	0.688
MOD_GSK3_1	71	78	PF00069	0.612
MOD_NEK2_1	110	115	PF00069	0.725
MOD_NEK2_1	193	198	PF00069	0.510
MOD_NEK2_1	244	249	PF00069	0.493
MOD_NEK2_1	3	8	PF00069	0.722
MOD_NEK2_2	7	12	PF00069	0.754
MOD_PIKK_1	193	199	PF00454	0.497
MOD_PIKK_1	47	53	PF00454	0.539
MOD_PKA_2	110	116	PF00069	0.718
MOD_PKA_2	238	244	PF00069	0.389
MOD_PKA_2	3	9	PF00069	0.721
MOD_PKB_1	12	20	PF00069	0.727
MOD_Plk_1	223	229	PF00069	0.364
MOD_Plk_1	62	68	PF00069	0.466
MOD_Plk_4	223	229	PF00069	0.578
MOD_ProDKin_1	119	125	PF00069	0.351
MOD_ProDKin_1	156	162	PF00069	0.539
MOD_ProDKin_1	257	263	PF00069	0.550
MOD_ProDKin_1	97	103	PF00069	0.651
TRG_ENDOCYTIC_2	107	110	PF00928	0.621
TRG_ENDOCYTIC_2	173	176	PF00928	0.280
TRG_ENDOCYTIC_2	205	208	PF00928	0.487
TRG_ER_diArg_1	11	14	PF00400	0.694
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P4	Leptomonas seymouri	69%	100%
A0A0S4JHC6	Bodo saltans	36%	100%
A0A1X0P070	Trypanosomatidae	59%	100%
A0A3S7X260	Leishmania donovani	83%	100%
A4I4C2	Leishmania infantum	83%	100%
C9ZL46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ADS1	Leishmania major	83%	100%
E9AM09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BQ11	Trypanosoma cruzi	58%	100%