Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triple RNA binding domain protein 3

Species:

Leishmania braziliensis

UniProt:

A4HH75_LEIBR

TriTrypDb:

LbrM.29.0690 , LBRM2903_290013100

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HH75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH75

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.533
CLV_NRD_NRD_1	150	152	PF00675	0.750
CLV_NRD_NRD_1	271	273	PF00675	0.486
CLV_NRD_NRD_1	348	350	PF00675	0.494
CLV_NRD_NRD_1	376	378	PF00675	0.494
CLV_NRD_NRD_1	454	456	PF00675	0.708
CLV_NRD_NRD_1	514	516	PF00675	0.341
CLV_NRD_NRD_1	598	600	PF00675	0.680
CLV_NRD_NRD_1	644	646	PF00675	0.747
CLV_NRD_NRD_1	659	661	PF00675	0.498
CLV_NRD_NRD_1	669	671	PF00675	0.495
CLV_NRD_NRD_1	92	94	PF00675	0.694
CLV_PCSK_KEX2_1	150	152	PF00082	0.750
CLV_PCSK_KEX2_1	33	35	PF00082	0.740
CLV_PCSK_KEX2_1	376	378	PF00082	0.494
CLV_PCSK_KEX2_1	454	456	PF00082	0.708
CLV_PCSK_KEX2_1	598	600	PF00082	0.691
CLV_PCSK_KEX2_1	642	644	PF00082	0.750
CLV_PCSK_KEX2_1	659	661	PF00082	0.490
CLV_PCSK_KEX2_1	669	671	PF00082	0.733
CLV_PCSK_KEX2_1	92	94	PF00082	0.694
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.740
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.691
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.750
CLV_PCSK_PC1ET2_1	659	661	PF00082	0.490
CLV_PCSK_SKI1_1	186	190	PF00082	0.591
CLV_PCSK_SKI1_1	242	246	PF00082	0.471
CLV_PCSK_SKI1_1	272	276	PF00082	0.489
CLV_PCSK_SKI1_1	308	312	PF00082	0.423
CLV_PCSK_SKI1_1	325	329	PF00082	0.459
CLV_PCSK_SKI1_1	349	353	PF00082	0.448
CLV_PCSK_SKI1_1	600	604	PF00082	0.641
CLV_PCSK_SKI1_1	716	720	PF00082	0.646
CLV_PCSK_SKI1_1	734	738	PF00082	0.761
CLV_Separin_Metazoa	326	330	PF03568	0.463
DEG_APCC_DBOX_1	324	332	PF00400	0.458
DEG_SPOP_SBC_1	134	138	PF00917	0.548
DOC_ANK_TNKS_1	114	121	PF00023	0.575
DOC_CKS1_1	52	57	PF01111	0.667
DOC_MAPK_gen_1	200	208	PF00069	0.537
DOC_MAPK_gen_1	349	355	PF00069	0.443
DOC_MAPK_gen_1	515	521	PF00069	0.560
DOC_MAPK_gen_1	553	561	PF00069	0.560
DOC_MAPK_RevD_3	363	377	PF00069	0.531
DOC_PP1_RVXF_1	531	537	PF00149	0.480
DOC_PP4_FxxP_1	103	106	PF00568	0.750
DOC_PP4_FxxP_1	536	539	PF00568	0.501
DOC_USP7_MATH_1	130	134	PF00917	0.715
DOC_USP7_MATH_1	24	28	PF00917	0.735
DOC_USP7_MATH_1	396	400	PF00917	0.674
DOC_USP7_MATH_1	417	421	PF00917	0.717
DOC_USP7_MATH_1	447	451	PF00917	0.561
DOC_USP7_MATH_1	633	637	PF00917	0.770
DOC_USP7_MATH_1	665	669	PF00917	0.631
DOC_USP7_MATH_1	679	683	PF00917	0.740
DOC_USP7_MATH_1	702	706	PF00917	0.721
DOC_USP7_MATH_1	718	722	PF00917	0.731
DOC_USP7_MATH_2	458	464	PF00917	0.513
DOC_USP7_UBL2_3	201	205	PF12436	0.563
DOC_USP7_UBL2_3	287	291	PF12436	0.599
DOC_USP7_UBL2_3	299	303	PF12436	0.591
DOC_USP7_UBL2_3	596	600	PF12436	0.589
DOC_USP7_UBL2_3	638	642	PF12436	0.737
DOC_USP7_UBL2_3	715	719	PF12436	0.655
DOC_USP7_UBL2_3	730	734	PF12436	0.747
DOC_WW_Pin1_4	105	110	PF00397	0.537
DOC_WW_Pin1_4	142	147	PF00397	0.792
DOC_WW_Pin1_4	255	260	PF00397	0.463
DOC_WW_Pin1_4	411	416	PF00397	0.764
DOC_WW_Pin1_4	51	56	PF00397	0.662
DOC_WW_Pin1_4	71	76	PF00397	0.660
DOC_WW_Pin1_4	81	86	PF00397	0.570
LIG_14-3-3_CanoR_1	125	135	PF00244	0.777
LIG_14-3-3_CanoR_1	186	192	PF00244	0.589
LIG_AP2alpha_1	367	371	PF02296	0.473
LIG_APCC_ABBA_1	519	524	PF00400	0.560
LIG_BRCT_BRCA1_1	131	135	PF00533	0.644
LIG_BRCT_BRCA1_1	444	448	PF00533	0.510
LIG_FHA_1	183	189	PF00498	0.628
LIG_FHA_1	276	282	PF00498	0.564
LIG_FHA_1	305	311	PF00498	0.497
LIG_FHA_1	694	700	PF00498	0.716
LIG_FHA_1	82	88	PF00498	0.532
LIG_FHA_2	221	227	PF00498	0.593
LIG_FHA_2	355	361	PF00498	0.498
LIG_FHA_2	364	370	PF00498	0.455
LIG_Integrin_isoDGR_2	270	272	PF01839	0.474
LIG_Integrin_RGD_1	117	119	PF01839	0.652
LIG_Integrin_RGD_1	645	647	PF01839	0.609
LIG_LIR_Apic_2	535	539	PF02991	0.528
LIG_LIR_Gen_1	369	378	PF02991	0.488
LIG_LIR_Gen_1	477	487	PF02991	0.570
LIG_LIR_Nem_3	369	374	PF02991	0.477
LIG_LIR_Nem_3	477	483	PF02991	0.578
LIG_NRP_CendR_1	737	739	PF00754	0.795
LIG_Pex14_2	231	235	PF04695	0.472
LIG_Pex14_2	367	371	PF04695	0.473
LIG_RPA_C_Fungi	372	384	PF08784	0.490
LIG_SH2_STAP1	541	545	PF00017	0.357
LIG_SH2_STAP1	584	588	PF00017	0.648
LIG_SH2_STAT5	213	216	PF00017	0.591
LIG_SH2_STAT5	491	494	PF00017	0.391
LIG_SH2_STAT5	601	604	PF00017	0.589
LIG_SH3_3	103	109	PF00018	0.552
LIG_SH3_3	216	222	PF00018	0.653
LIG_SH3_3	234	240	PF00018	0.379
LIG_SH3_3	278	284	PF00018	0.476
LIG_SH3_3	315	321	PF00018	0.485
LIG_SH3_3	35	41	PF00018	0.728
LIG_SH3_3	409	415	PF00018	0.617
LIG_SH3_3	46	52	PF00018	0.733
LIG_SUMO_SIM_anti_2	426	435	PF11976	0.710
LIG_TRAF2_1	168	171	PF00917	0.812
LIG_TRAF2_1	223	226	PF00917	0.584
LIG_TRAF2_1	96	99	PF00917	0.739
LIG_UBA3_1	311	317	PF00899	0.440
LIG_WRC_WIRS_1	352	357	PF05994	0.470
MOD_CDK_SPK_2	142	147	PF00069	0.637
MOD_CDK_SPxxK_3	411	418	PF00069	0.751
MOD_CK1_1	129	135	PF00069	0.800
MOD_CK1_1	258	264	PF00069	0.458
MOD_CK1_1	450	456	PF00069	0.666
MOD_CK1_1	471	477	PF00069	0.599
MOD_CK1_1	709	715	PF00069	0.747
MOD_CK1_1	9	15	PF00069	0.820
MOD_CK2_1	165	171	PF00069	0.769
MOD_CK2_1	191	197	PF00069	0.613
MOD_CK2_1	220	226	PF00069	0.570
MOD_CK2_1	354	360	PF00069	0.524
MOD_CK2_1	619	625	PF00069	0.749
MOD_CK2_1	679	685	PF00069	0.630
MOD_Cter_Amidation	270	273	PF01082	0.482
MOD_Cter_Amidation	374	377	PF01082	0.509
MOD_Cter_Amidation	640	643	PF01082	0.756
MOD_GlcNHglycan	128	131	PF01048	0.748
MOD_GlcNHglycan	137	140	PF01048	0.744
MOD_GlcNHglycan	176	179	PF01048	0.714
MOD_GlcNHglycan	19	22	PF01048	0.760
MOD_GlcNHglycan	193	196	PF01048	0.641
MOD_GlcNHglycan	232	235	PF01048	0.610
MOD_GlcNHglycan	26	29	PF01048	0.763
MOD_GlcNHglycan	378	381	PF01048	0.437
MOD_GlcNHglycan	408	411	PF01048	0.688
MOD_GlcNHglycan	444	447	PF01048	0.707
MOD_GlcNHglycan	449	452	PF01048	0.695
MOD_GlcNHglycan	462	465	PF01048	0.698
MOD_GlcNHglycan	55	58	PF01048	0.760
MOD_GlcNHglycan	567	570	PF01048	0.601
MOD_GlcNHglycan	664	668	PF01048	0.653
MOD_GlcNHglycan	703	707	PF01048	0.630
MOD_GlcNHglycan	720	723	PF01048	0.542
MOD_GlcNHglycan	89	92	PF01048	0.822
MOD_GSK3_1	125	132	PF00069	0.807
MOD_GSK3_1	182	189	PF00069	0.629
MOD_GSK3_1	385	392	PF00069	0.568
MOD_GSK3_1	442	449	PF00069	0.623
MOD_GSK3_1	460	467	PF00069	0.767
MOD_GSK3_1	522	529	PF00069	0.373
MOD_GSK3_1	53	60	PF00069	0.646
MOD_GSK3_1	702	709	PF00069	0.796
MOD_N-GLC_1	174	179	PF02516	0.537
MOD_N-GLC_1	460	465	PF02516	0.723
MOD_N-GLC_1	471	476	PF02516	0.572
MOD_N-GLC_1	633	638	PF02516	0.788
MOD_N-GLC_1	679	684	PF02516	0.740
MOD_NEK2_1	135	140	PF00069	0.647
MOD_NEK2_1	174	179	PF00069	0.656
MOD_NEK2_1	275	280	PF00069	0.530
MOD_NEK2_1	602	607	PF00069	0.580
MOD_NEK2_1	710	715	PF00069	0.532
MOD_NEK2_2	130	135	PF00069	0.547
MOD_NEK2_2	706	711	PF00069	0.627
MOD_PIKK_1	343	349	PF00454	0.590
MOD_PKA_1	376	382	PF00069	0.491
MOD_PKA_1	660	666	PF00069	0.672
MOD_PKA_2	376	382	PF00069	0.491
MOD_PKA_2	396	402	PF00069	0.434
MOD_PKA_2	417	423	PF00069	0.586
MOD_PKA_2	6	12	PF00069	0.815
MOD_PKA_2	706	712	PF00069	0.574
MOD_PKB_1	184	192	PF00069	0.627
MOD_Plk_1	460	466	PF00069	0.520
MOD_Plk_2-3	165	171	PF00069	0.700
MOD_Plk_4	130	136	PF00069	0.546
MOD_Plk_4	706	712	PF00069	0.535
MOD_ProDKin_1	105	111	PF00069	0.543
MOD_ProDKin_1	142	148	PF00069	0.790
MOD_ProDKin_1	255	261	PF00069	0.457
MOD_ProDKin_1	411	417	PF00069	0.769
MOD_ProDKin_1	51	57	PF00069	0.664
MOD_ProDKin_1	71	77	PF00069	0.661
MOD_ProDKin_1	81	87	PF00069	0.572
MOD_SUMO_for_1	96	99	PF00179	0.552
MOD_SUMO_rev_2	282	286	PF00179	0.593
MOD_SUMO_rev_2	330	339	PF00179	0.511
TRG_DiLeu_BaEn_1	478	483	PF01217	0.575
TRG_DiLeu_BaEn_3	98	104	PF01217	0.745
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.510
TRG_ENDOCYTIC_2	480	483	PF00928	0.568
TRG_ER_diArg_1	149	151	PF00400	0.651
TRG_ER_diArg_1	184	187	PF00400	0.641
TRG_ER_diArg_1	376	378	PF00400	0.494
TRG_ER_diArg_1	643	645	PF00400	0.560
TRG_ER_diLys_1	735	739	PF00400	0.767
TRG_NES_CRM1_1	197	209	PF08389	0.555
TRG_NLS_Bipartite_1	642	663	PF00514	0.814
TRG_NLS_Bipartite_1	719	738	PF00514	0.749
TRG_NLS_MonoCore_2	641	646	PF00514	0.560
TRG_NLS_MonoCore_2	658	663	PF00514	0.483
TRG_NLS_MonoExtC_3	641	647	PF00514	0.650
TRG_NLS_MonoExtC_3	658	664	PF00514	0.735
TRG_NLS_MonoExtN_4	640	646	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	277	282	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C3	Leptomonas seymouri	60%	98%
A0A0S4JB85	Bodo saltans	47%	100%
A0A3S7X2A3	Leishmania donovani	73%	95%
A4I4C1	Leishmania infantum	74%	95%
C9ZL47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ADS0	Leishmania major	83%	100%
E9AM10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	96%