1TM protein with a basic N-terminus that might be a mitochondrial transit signal.. Though conservative, not found outside Kinetoplastida
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 10 |
| NetGPI | no | yes: 0, no: 10 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 9 |
| GO:0110165 | cellular anatomical entity | 1 | 9 |
| GO:0005737 | cytoplasm | 2 | 1 |
| GO:0005739 | mitochondrion | 5 | 1 |
| GO:0031974 | membrane-enclosed lumen | 2 | 1 |
| GO:0031981 | nuclear lumen | 5 | 1 |
| GO:0032838 | plasma membrane bounded cell projection cytoplasm | 4 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
| GO:0043233 | organelle lumen | 3 | 1 |
| GO:0070013 | intracellular organelle lumen | 4 | 1 |
| GO:0097014 | ciliary plasm | 5 | 1 |
| GO:0099568 | cytoplasmic region | 3 | 1 |
Related structures:
AlphaFold database: A4HH74
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 10 | 12 | PF00675 | 0.466 |
| CLV_NRD_NRD_1 | 14 | 16 | PF00675 | 0.480 |
| CLV_NRD_NRD_1 | 20 | 22 | PF00675 | 0.408 |
| CLV_PCSK_KEX2_1 | 20 | 22 | PF00082 | 0.408 |
| CLV_PCSK_KEX2_1 | 9 | 11 | PF00082 | 0.429 |
| CLV_PCSK_SKI1_1 | 11 | 15 | PF00082 | 0.428 |
| DOC_CYCLIN_yClb5_NLxxxL_5 | 117 | 123 | PF00134 | 0.442 |
| DOC_CYCLIN_yCln2_LP_2 | 119 | 125 | PF00134 | 0.426 |
| DOC_MAPK_gen_1 | 23 | 33 | PF00069 | 0.628 |
| DOC_MAPK_gen_1 | 37 | 45 | PF00069 | 0.633 |
| DOC_MAPK_MEF2A_6 | 26 | 33 | PF00069 | 0.633 |
| DOC_PP4_FxxP_1 | 49 | 52 | PF00568 | 0.355 |
| DOC_USP7_MATH_1 | 62 | 66 | PF00917 | 0.356 |
| DOC_WW_Pin1_4 | 111 | 116 | PF00397 | 0.427 |
| LIG_14-3-3_CanoR_1 | 20 | 26 | PF00244 | 0.637 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.551 |
| LIG_BRCT_BRCA1_1 | 99 | 103 | PF00533 | 0.477 |
| LIG_FHA_1 | 126 | 132 | PF00498 | 0.378 |
| LIG_FHA_1 | 61 | 67 | PF00498 | 0.283 |
| LIG_LIR_Apic_2 | 109 | 115 | PF02991 | 0.404 |
| LIG_LIR_Gen_1 | 100 | 111 | PF02991 | 0.461 |
| LIG_LIR_Gen_1 | 128 | 135 | PF02991 | 0.448 |
| LIG_LIR_Nem_3 | 100 | 106 | PF02991 | 0.468 |
| LIG_LIR_Nem_3 | 128 | 132 | PF02991 | 0.478 |
| LIG_LIR_Nem_3 | 22 | 28 | PF02991 | 0.606 |
| LIG_LIR_Nem_3 | 3 | 7 | PF02991 | 0.630 |
| LIG_SH2_CRK | 4 | 8 | PF00017 | 0.538 |
| LIG_SH2_STAP1 | 82 | 86 | PF00017 | 0.395 |
| LIG_SH2_STAP1 | 88 | 92 | PF00017 | 0.411 |
| LIG_SH2_STAT5 | 68 | 71 | PF00017 | 0.412 |
| LIG_SH3_2 | 122 | 127 | PF14604 | 0.447 |
| LIG_SH3_3 | 119 | 125 | PF00018 | 0.448 |
| MOD_CDC14_SPxK_1 | 114 | 117 | PF00782 | 0.423 |
| MOD_CDK_SPxK_1 | 111 | 117 | PF00069 | 0.421 |
| MOD_CK1_1 | 5 | 11 | PF00069 | 0.695 |
| MOD_GSK3_1 | 71 | 78 | PF00069 | 0.501 |
| MOD_N-GLC_1 | 33 | 38 | PF02516 | 0.420 |
| MOD_NEK2_1 | 33 | 38 | PF00069 | 0.620 |
| MOD_NEK2_1 | 60 | 65 | PF00069 | 0.290 |
| MOD_NEK2_1 | 75 | 80 | PF00069 | 0.365 |
| MOD_NEK2_2 | 62 | 67 | PF00069 | 0.361 |
| MOD_PIKK_1 | 97 | 103 | PF00454 | 0.482 |
| MOD_PKA_2 | 19 | 25 | PF00069 | 0.636 |
| MOD_PKB_1 | 9 | 17 | PF00069 | 0.546 |
| MOD_Plk_1 | 2 | 8 | PF00069 | 0.553 |
| MOD_Plk_4 | 2 | 8 | PF00069 | 0.704 |
| MOD_Plk_4 | 62 | 68 | PF00069 | 0.330 |
| MOD_Plk_4 | 71 | 77 | PF00069 | 0.379 |
| MOD_ProDKin_1 | 111 | 117 | PF00069 | 0.429 |
| MOD_SUMO_rev_2 | 130 | 138 | PF00179 | 0.440 |
| TRG_ENDOCYTIC_2 | 4 | 7 | PF00928 | 0.636 |
| TRG_ENDOCYTIC_2 | 67 | 70 | PF00928 | 0.410 |
| TRG_ER_diArg_1 | 19 | 21 | PF00400 | 0.615 |
| TRG_ER_diArg_1 | 9 | 11 | PF00400 | 0.680 |
| TRG_Pf-PMV_PEXEL_1 | 26 | 30 | PF00026 | 0.431 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I9D3 | Leptomonas seymouri | 74% | 100% |
| A0A0S4JF31 | Bodo saltans | 54% | 84% |
| A0A1X0NZT9 | Trypanosomatidae | 74% | 100% |
| A0A3Q8IH51 | Leishmania donovani | 91% | 100% |
| A0A3S5IRQ2 | Trypanosoma rangeli | 67% | 100% |
| A4I4C0 | Leishmania infantum | 91% | 100% |
| C9ZL48 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 71% | 100% |
| E9ADR9 | Leishmania major | 90% | 100% |
| E9AM11 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 90% | 100% |