Putative flagellar radial spoke protein-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar radial spoke protein-like, putative

Species:

Leishmania braziliensis

UniProt:

A4HH73_LEIBR

TriTrypDb:

LbrM.29.0670 , LBRM2903_290012900

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0001534	radial spoke	2	12
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4HH73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH73

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	12
GO:0006996	organelle organization	4	12
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	11
GO:0030031	cell projection assembly	5	11
GO:0044782	cilium organization	5	11
GO:0060271	cilium assembly	6	11
GO:0060294	cilium movement involved in cell motility	5	12
GO:0070925	organelle assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	11
GO:0120036	plasma membrane bounded cell projection organization	5	11
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0001578	microtubule bundle formation	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0035082	axoneme assembly	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.433
CLV_MEL_PAP_1	289	295	PF00089	0.197
CLV_NRD_NRD_1	240	242	PF00675	0.276
CLV_NRD_NRD_1	484	486	PF00675	0.205
CLV_NRD_NRD_1	94	96	PF00675	0.225
CLV_NRD_NRD_1	97	99	PF00675	0.218
CLV_PCSK_FUR_1	95	99	PF00082	0.269
CLV_PCSK_KEX2_1	240	242	PF00082	0.278
CLV_PCSK_KEX2_1	94	96	PF00082	0.225
CLV_PCSK_KEX2_1	97	99	PF00082	0.218
DEG_COP1_1	333	343	PF00400	0.447
DEG_MDM2_SWIB_1	559	567	PF02201	0.355
DEG_SCF_FBW7_2	245	251	PF00400	0.433
DEG_SPOP_SBC_1	512	516	PF00917	0.355
DOC_CDC14_PxL_1	361	369	PF14671	0.415
DOC_CKS1_1	245	250	PF01111	0.433
DOC_CYCLIN_yCln2_LP_2	465	471	PF00134	0.447
DOC_PP1_RVXF_1	499	506	PF00149	0.509
DOC_PP2B_LxvP_1	147	150	PF13499	0.509
DOC_PP2B_LxvP_1	465	468	PF13499	0.447
DOC_PP2B_LxvP_1	544	547	PF13499	0.509
DOC_PP2B_LxvP_1	87	90	PF13499	0.405
DOC_PP4_FxxP_1	297	300	PF00568	0.355
DOC_USP7_MATH_1	169	173	PF00917	0.440
DOC_USP7_MATH_1	243	247	PF00917	0.500
DOC_USP7_MATH_1	263	267	PF00917	0.322
DOC_USP7_MATH_1	441	445	PF00917	0.447
DOC_USP7_MATH_1	519	523	PF00917	0.485
DOC_USP7_MATH_1	70	74	PF00917	0.486
DOC_WW_Pin1_4	244	249	PF00397	0.433
DOC_WW_Pin1_4	276	281	PF00397	0.429
LIG_14-3-3_CanoR_1	10	18	PF00244	0.497
LIG_14-3-3_CanoR_1	321	330	PF00244	0.405
LIG_14-3-3_CanoR_1	518	524	PF00244	0.472
LIG_APCC_ABBAyCdc20_2	54	60	PF00400	0.502
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_BRCT_BRCA1_1	171	175	PF00533	0.440
LIG_BRCT_BRCA1_1	293	297	PF00533	0.355
LIG_eIF4E_1	391	397	PF01652	0.405
LIG_FHA_1	17	23	PF00498	0.472
LIG_FHA_1	376	382	PF00498	0.374
LIG_FHA_1	414	420	PF00498	0.529
LIG_FHA_1	508	514	PF00498	0.426
LIG_FHA_2	129	135	PF00498	0.355
LIG_FHA_2	245	251	PF00498	0.374
LIG_FHA_2	263	269	PF00498	0.490
LIG_FHA_2	564	570	PF00498	0.414
LIG_LIR_Apic_2	294	300	PF02991	0.355
LIG_LIR_Apic_2	570	576	PF02991	0.472
LIG_LIR_Gen_1	270	280	PF02991	0.416
LIG_LIR_Gen_1	399	410	PF02991	0.439
LIG_LIR_Gen_1	522	528	PF02991	0.427
LIG_LIR_Nem_3	153	158	PF02991	0.438
LIG_LIR_Nem_3	172	178	PF02991	0.328
LIG_LIR_Nem_3	182	187	PF02991	0.391
LIG_LIR_Nem_3	270	275	PF02991	0.447
LIG_LIR_Nem_3	399	405	PF02991	0.400
LIG_MYND_1	365	369	PF01753	0.415
LIG_PDZ_Class_3	587	592	PF00595	0.665
LIG_Pex14_1	387	391	PF04695	0.405
LIG_Pex14_2	293	297	PF04695	0.355
LIG_Pex14_2	559	563	PF04695	0.355
LIG_RPA_C_Fungi	316	328	PF08784	0.384
LIG_SH2_CRK	155	159	PF00017	0.384
LIG_SH2_CRK	361	365	PF00017	0.253
LIG_SH2_CRK	540	544	PF00017	0.413
LIG_SH2_CRK	573	577	PF00017	0.487
LIG_SH2_GRB2like	141	144	PF00017	0.297
LIG_SH2_NCK_1	361	365	PF00017	0.277
LIG_SH2_NCK_1	573	577	PF00017	0.487
LIG_SH2_PTP2	58	61	PF00017	0.168
LIG_SH2_SRC	540	543	PF00017	0.384
LIG_SH2_SRC	552	555	PF00017	0.384
LIG_SH2_SRC	573	576	PF00017	0.502
LIG_SH2_SRC	58	61	PF00017	0.272
LIG_SH2_STAP1	184	188	PF00017	0.238
LIG_SH2_STAT5	141	144	PF00017	0.297
LIG_SH2_STAT5	187	190	PF00017	0.238
LIG_SH2_STAT5	314	317	PF00017	0.238
LIG_SH2_STAT5	498	501	PF00017	0.238
LIG_SH2_STAT5	552	555	PF00017	0.297
LIG_SH2_STAT5	58	61	PF00017	0.189
LIG_SH3_1	539	545	PF00018	0.384
LIG_SH3_1	572	578	PF00018	0.620
LIG_SH3_2	89	94	PF14604	0.238
LIG_SH3_3	242	248	PF00018	0.297
LIG_SH3_3	347	353	PF00018	0.253
LIG_SH3_3	360	366	PF00018	0.246
LIG_SH3_3	443	449	PF00018	0.396
LIG_SH3_3	539	545	PF00018	0.266
LIG_SH3_3	550	556	PF00018	0.243
LIG_SH3_3	572	578	PF00018	0.476
LIG_SH3_3	86	92	PF00018	0.291
LIG_TRAF2_1	248	251	PF00917	0.384
LIG_TRAF2_1	343	346	PF00917	0.167
LIG_TRAF2_1	373	376	PF00917	0.251
LIG_TRAF2_1	392	395	PF00917	0.253
LIG_TRAF2_1	420	423	PF00917	0.333
LIG_TRAF2_1	582	585	PF00917	0.593
LIG_WRC_WIRS_1	331	336	PF05994	0.297
LIG_WRC_WIRS_1	71	76	PF05994	0.297
LIG_WW_2	542	545	PF00397	0.384
LIG_WW_3	576	580	PF00397	0.651
LIG_WW_3	88	92	PF00397	0.338
MOD_CK1_1	38	44	PF00069	0.376
MOD_CK1_1	408	414	PF00069	0.376
MOD_CK1_1	493	499	PF00069	0.237
MOD_CK1_1	73	79	PF00069	0.218
MOD_CK2_1	244	250	PF00069	0.182
MOD_CK2_1	389	395	PF00069	0.297
MOD_CK2_1	439	445	PF00069	0.417
MOD_CK2_1	563	569	PF00069	0.378
MOD_DYRK1A_RPxSP_1	244	248	PF00069	0.168
MOD_GlcNHglycan	108	114	PF01048	0.271
MOD_GlcNHglycan	11	14	PF01048	0.297
MOD_GlcNHglycan	265	268	PF01048	0.224
MOD_GlcNHglycan	293	296	PF01048	0.360
MOD_GlcNHglycan	323	326	PF01048	0.297
MOD_GlcNHglycan	37	40	PF01048	0.306
MOD_GlcNHglycan	45	48	PF01048	0.346
MOD_GSK3_1	164	171	PF00069	0.447
MOD_GSK3_1	263	270	PF00069	0.234
MOD_GSK3_1	396	403	PF00069	0.234
MOD_GSK3_1	507	514	PF00069	0.343
MOD_GSK3_1	70	77	PF00069	0.344
MOD_NEK2_1	396	401	PF00069	0.273
MOD_NEK2_1	45	50	PF00069	0.343
MOD_NEK2_1	469	474	PF00069	0.229
MOD_NEK2_1	74	79	PF00069	0.318
MOD_NEK2_2	169	174	PF00069	0.332
MOD_NEK2_2	480	485	PF00069	0.222
MOD_PIKK_1	16	22	PF00454	0.398
MOD_PIKK_1	490	496	PF00454	0.297
MOD_PKA_2	243	249	PF00069	0.384
MOD_PKA_2	291	297	PF00069	0.384
MOD_PKA_2	320	326	PF00069	0.253
MOD_PKA_2	413	419	PF00069	0.332
MOD_PKA_2	61	67	PF00069	0.358
MOD_PKA_2	9	15	PF00069	0.297
MOD_Plk_1	461	467	PF00069	0.297
MOD_Plk_1	563	569	PF00069	0.332
MOD_Plk_4	359	365	PF00069	0.277
MOD_Plk_4	405	411	PF00069	0.243
MOD_Plk_4	493	499	PF00069	0.280
MOD_ProDKin_1	244	250	PF00069	0.277
MOD_ProDKin_1	276	282	PF00069	0.272
TRG_DiLeu_BaEn_1	153	158	PF01217	0.195
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.332
TRG_DiLeu_LyEn_5	153	158	PF01217	0.168
TRG_ENDOCYTIC_2	141	144	PF00928	0.440
TRG_ENDOCYTIC_2	155	158	PF00928	0.287
TRG_ENDOCYTIC_2	361	364	PF00928	0.238
TRG_ENDOCYTIC_2	523	526	PF00928	0.286
TRG_ER_diArg_1	235	238	PF00400	0.328
TRG_ER_diArg_1	289	292	PF00400	0.272
TRG_ER_diArg_1	93	95	PF00400	0.272
TRG_ER_diArg_1	96	98	PF00400	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q1	Leptomonas seymouri	69%	100%
A0A0S4JES8	Bodo saltans	40%	100%
A0A1X0P128	Trypanosomatidae	47%	100%
A0A3Q8IE67	Leishmania donovani	83%	83%
A0A3R7KK84	Trypanosoma rangeli	46%	100%
A4H732	Leishmania braziliensis	24%	100%
A4I4B9	Leishmania infantum	83%	84%
C9ZL49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ADR8	Leishmania major	84%	100%
E9AM12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q01656	Chlamydomonas reinhardtii	23%	100%
Q5TD94	Homo sapiens	25%	83%
Q8CDR2	Mus musculus	29%	84%
Q9H0K4	Homo sapiens	29%	83%
V5B4W9	Trypanosoma cruzi	45%	100%