Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HH72_LEIBR

TriTrypDb:

LbrM.29.0660 , LBRM2903_290012800

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HH72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH72

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006811	monoatomic ion transport	4	6
GO:0006817	phosphate ion transport	7	6
GO:0006820	monoatomic anion transport	5	6
GO:0015698	inorganic anion transport	6	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0009987	cellular process	1	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0035435	phosphate ion transmembrane transport	6	1
GO:0055085	transmembrane transport	2	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098661	inorganic anion transmembrane transport	5	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	6
GO:0005315	inorganic phosphate transmembrane transporter activity	4	6
GO:0015291	secondary active transmembrane transporter activity	4	6
GO:0015293	symporter activity	5	6
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	6
GO:0022804	active transmembrane transporter activity	3	6
GO:0022857	transmembrane transporter activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.440
CLV_C14_Caspase3-7	353	357	PF00656	0.420
CLV_C14_Caspase3-7	405	409	PF00656	0.486
CLV_NRD_NRD_1	175	177	PF00675	0.242
CLV_NRD_NRD_1	412	414	PF00675	0.229
CLV_PCSK_KEX2_1	175	177	PF00082	0.242
CLV_PCSK_KEX2_1	53	55	PF00082	0.191
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.191
CLV_PCSK_SKI1_1	176	180	PF00082	0.242
CLV_PCSK_SKI1_1	414	418	PF00082	0.191
DEG_Nend_UBRbox_2	1	3	PF02207	0.334
DEG_SPOP_SBC_1	277	281	PF00917	0.391
DOC_CKS1_1	387	392	PF01111	0.417
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	537	543	PF00134	0.442
DOC_MAPK_DCC_7	417	425	PF00069	0.391
DOC_MAPK_DCC_7	79	88	PF00069	0.286
DOC_MAPK_gen_1	182	190	PF00069	0.443
DOC_MAPK_gen_1	413	420	PF00069	0.416
DOC_MAPK_MEF2A_6	145	154	PF00069	0.242
DOC_MAPK_MEF2A_6	184	192	PF00069	0.443
DOC_MAPK_MEF2A_6	92	99	PF00069	0.248
DOC_PP1_RVXF_1	527	534	PF00149	0.391
DOC_PP2B_LxvP_1	157	160	PF13499	0.325
DOC_PP2B_LxvP_1	340	343	PF13499	0.486
DOC_PP4_FxxP_1	116	119	PF00568	0.442
DOC_PP4_FxxP_1	290	293	PF00568	0.421
DOC_USP7_MATH_1	214	218	PF00917	0.248
DOC_USP7_MATH_1	277	281	PF00917	0.391
DOC_USP7_MATH_1	295	299	PF00917	0.360
DOC_USP7_MATH_1	343	347	PF00917	0.465
DOC_USP7_MATH_1	382	386	PF00917	0.491
DOC_USP7_MATH_1	481	485	PF00917	0.426
DOC_USP7_MATH_1	706	710	PF00917	0.282
DOC_WW_Pin1_4	341	346	PF00397	0.585
DOC_WW_Pin1_4	378	383	PF00397	0.540
DOC_WW_Pin1_4	386	391	PF00397	0.528
DOC_WW_Pin1_4	504	509	PF00397	0.442
DOC_WW_Pin1_4	626	631	PF00397	0.442
LIG_14-3-3_CanoR_1	286	291	PF00244	0.392
LIG_14-3-3_CanoR_1	300	305	PF00244	0.378
LIG_14-3-3_CanoR_1	435	440	PF00244	0.403
LIG_APCC_ABBA_1	509	514	PF00400	0.391
LIG_BRCT_BRCA1_1	112	116	PF00533	0.276
LIG_BRCT_BRCA1_1	216	220	PF00533	0.191
LIG_BRCT_BRCA1_1	37	41	PF00533	0.442
LIG_CtBP_PxDLS_1	653	657	PF00389	0.242
LIG_DLG_GKlike_1	435	443	PF00625	0.391
LIG_EVH1_1	386	390	PF00568	0.391
LIG_FHA_1	12	18	PF00498	0.242
LIG_FHA_1	121	127	PF00498	0.276
LIG_FHA_1	144	150	PF00498	0.280
LIG_FHA_1	165	171	PF00498	0.281
LIG_FHA_1	269	275	PF00498	0.487
LIG_FHA_1	299	305	PF00498	0.481
LIG_FHA_1	335	341	PF00498	0.483
LIG_FHA_1	4	10	PF00498	0.331
LIG_FHA_1	432	438	PF00498	0.396
LIG_FHA_1	441	447	PF00498	0.407
LIG_FHA_1	448	454	PF00498	0.364
LIG_FHA_1	642	648	PF00498	0.296
LIG_FHA_1	690	696	PF00498	0.269
LIG_FHA_1	697	703	PF00498	0.265
LIG_FHA_2	279	285	PF00498	0.391
LIG_FHA_2	58	64	PF00498	0.276
LIG_FHA_2	582	588	PF00498	0.242
LIG_GSK3_LRP6_1	341	346	PF00069	0.391
LIG_IRF3_LxIS_1	691	696	PF10401	0.277
LIG_LIR_Apic_2	113	119	PF02991	0.442
LIG_LIR_Apic_2	289	293	PF02991	0.418
LIG_LIR_Gen_1	138	149	PF02991	0.199
LIG_LIR_Gen_1	204	215	PF02991	0.276
LIG_LIR_Gen_1	38	45	PF02991	0.442
LIG_LIR_Gen_1	573	583	PF02991	0.263
LIG_LIR_Gen_1	594	604	PF02991	0.248
LIG_LIR_Gen_1	60	70	PF02991	0.276
LIG_LIR_Gen_1	641	650	PF02991	0.328
LIG_LIR_Gen_1	678	687	PF02991	0.391
LIG_LIR_Nem_3	138	144	PF02991	0.199
LIG_LIR_Nem_3	204	210	PF02991	0.276
LIG_LIR_Nem_3	38	44	PF02991	0.442
LIG_LIR_Nem_3	546	552	PF02991	0.446
LIG_LIR_Nem_3	573	579	PF02991	0.263
LIG_LIR_Nem_3	594	600	PF02991	0.248
LIG_LIR_Nem_3	60	65	PF02991	0.276
LIG_LIR_Nem_3	678	682	PF02991	0.442
LIG_NRBOX	169	175	PF00104	0.205
LIG_NRBOX	197	203	PF00104	0.338
LIG_PTB_Apo_2	284	291	PF02174	0.387
LIG_REV1ctd_RIR_1	288	292	PF16727	0.442
LIG_SH2_CRK	58	62	PF00017	0.276
LIG_SH2_STAT5	111	114	PF00017	0.276
LIG_SH2_STAT5	143	146	PF00017	0.253
LIG_SH2_STAT5	172	175	PF00017	0.276
LIG_SH2_STAT5	227	230	PF00017	0.255
LIG_SH2_STAT5	3	6	PF00017	0.310
LIG_SH2_STAT5	547	550	PF00017	0.486
LIG_SH2_STAT5	58	61	PF00017	0.276
LIG_SH3_2	342	347	PF14604	0.391
LIG_SH3_3	325	331	PF00018	0.404
LIG_SH3_3	335	341	PF00018	0.480
LIG_SH3_3	384	390	PF00018	0.427
LIG_SH3_3	499	505	PF00018	0.448
LIG_SH3_3	524	530	PF00018	0.442
LIG_SH3_3	537	543	PF00018	0.442
LIG_SH3_3	647	653	PF00018	0.205
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.338
LIG_SUMO_SIM_par_1	118	123	PF11976	0.442
LIG_SUMO_SIM_par_1	149	155	PF11976	0.187
LIG_SUMO_SIM_par_1	434	440	PF11976	0.391
LIG_SUMO_SIM_par_1	507	516	PF11976	0.391
LIG_SUMO_SIM_par_1	624	629	PF11976	0.442
LIG_SUMO_SIM_par_1	652	657	PF11976	0.242
LIG_SUMO_SIM_par_1	691	696	PF11976	0.276
LIG_TYR_ITIM	56	61	PF00017	0.276
LIG_WRC_WIRS_1	23	28	PF05994	0.276
LIG_WRC_WIRS_1	559	564	PF05994	0.276
LIG_WRC_WIRS_1	580	585	PF05994	0.191
MOD_CDC14_SPxK_1	344	347	PF00782	0.391
MOD_CDK_SPxK_1	341	347	PF00069	0.391
MOD_CDK_SPxK_1	626	632	PF00069	0.442
MOD_CK1_1	298	304	PF00069	0.391
MOD_CK1_1	373	379	PF00069	0.587
MOD_CK1_1	402	408	PF00069	0.568
MOD_CK1_1	440	446	PF00069	0.521
MOD_CK1_1	484	490	PF00069	0.455
MOD_CK1_1	558	564	PF00069	0.279
MOD_CK1_1	595	601	PF00069	0.255
MOD_CK1_1	696	702	PF00069	0.276
MOD_CK2_1	278	284	PF00069	0.391
MOD_CK2_1	510	516	PF00069	0.442
MOD_CK2_1	57	63	PF00069	0.276
MOD_CK2_1	581	587	PF00069	0.242
MOD_GlcNHglycan	322	325	PF01048	0.245
MOD_GlcNHglycan	328	331	PF01048	0.243
MOD_GlcNHglycan	36	40	PF01048	0.242
MOD_GlcNHglycan	363	366	PF01048	0.277
MOD_GlcNHglycan	429	432	PF01048	0.203
MOD_GlcNHglycan	46	49	PF01048	0.242
MOD_GlcNHglycan	475	478	PF01048	0.292
MOD_GlcNHglycan	489	492	PF01048	0.196
MOD_GlcNHglycan	495	498	PF01048	0.157
MOD_GlcNHglycan	573	576	PF01048	0.486
MOD_GlcNHglycan	695	698	PF01048	0.313
MOD_GlcNHglycan	79	82	PF01048	0.486
MOD_GSK3_1	118	125	PF00069	0.442
MOD_GSK3_1	135	142	PF00069	0.276
MOD_GSK3_1	18	25	PF00069	0.205
MOD_GSK3_1	295	302	PF00069	0.433
MOD_GSK3_1	341	348	PF00069	0.489
MOD_GSK3_1	350	357	PF00069	0.415
MOD_GSK3_1	370	377	PF00069	0.509
MOD_GSK3_1	378	385	PF00069	0.443
MOD_GSK3_1	395	402	PF00069	0.383
MOD_GSK3_1	403	410	PF00069	0.442
MOD_GSK3_1	427	434	PF00069	0.447
MOD_GSK3_1	435	442	PF00069	0.452
MOD_GSK3_1	481	488	PF00069	0.424
MOD_GSK3_1	591	598	PF00069	0.255
MOD_GSK3_1	613	620	PF00069	0.321
MOD_GSK3_1	641	648	PF00069	0.276
MOD_GSK3_1	652	659	PF00069	0.242
MOD_GSK3_1	689	696	PF00069	0.276
MOD_GSK3_1	706	713	PF00069	0.367
MOD_LATS_1	433	439	PF00433	0.391
MOD_N-GLC_1	11	16	PF02516	0.550
MOD_N-GLC_1	286	291	PF02516	0.187
MOD_N-GLC_1	395	400	PF02516	0.290
MOD_N-GLC_1	440	445	PF02516	0.228
MOD_N-GLC_1	570	575	PF02516	0.442
MOD_NEK2_1	110	115	PF00069	0.276
MOD_NEK2_1	135	140	PF00069	0.338
MOD_NEK2_1	188	193	PF00069	0.474
MOD_NEK2_1	197	202	PF00069	0.297
MOD_NEK2_1	216	221	PF00069	0.344
MOD_NEK2_1	399	404	PF00069	0.486
MOD_NEK2_1	439	444	PF00069	0.448
MOD_NEK2_1	461	466	PF00069	0.445
MOD_NEK2_1	579	584	PF00069	0.191
MOD_NEK2_1	613	618	PF00069	0.313
MOD_NEK2_1	638	643	PF00069	0.328
MOD_NEK2_1	645	650	PF00069	0.314
MOD_NEK2_1	656	661	PF00069	0.297
MOD_NEK2_1	693	698	PF00069	0.313
MOD_NEK2_2	111	116	PF00069	0.199
MOD_NEK2_2	3	8	PF00069	0.298
MOD_PIKK_1	214	220	PF00454	0.242
MOD_PIKK_1	312	318	PF00454	0.391
MOD_PIKK_1	592	598	PF00454	0.242
MOD_PIKK_1	654	660	PF00454	0.276
MOD_PKA_2	299	305	PF00069	0.391
MOD_Plk_1	11	17	PF00069	0.286
MOD_Plk_1	277	283	PF00069	0.469
MOD_Plk_1	286	292	PF00069	0.422
MOD_Plk_1	395	401	PF00069	0.442
MOD_Plk_1	407	413	PF00069	0.442
MOD_Plk_1	440	446	PF00069	0.454
MOD_Plk_2-3	278	284	PF00069	0.421
MOD_Plk_4	111	117	PF00069	0.239
MOD_Plk_4	122	128	PF00069	0.330
MOD_Plk_4	188	194	PF00069	0.476
MOD_Plk_4	19	25	PF00069	0.276
MOD_Plk_4	197	203	PF00069	0.304
MOD_Plk_4	258	264	PF00069	0.509
MOD_Plk_4	354	360	PF00069	0.427
MOD_Plk_4	395	401	PF00069	0.442
MOD_Plk_4	407	413	PF00069	0.442
MOD_Plk_4	441	447	PF00069	0.411
MOD_Plk_4	558	564	PF00069	0.276
MOD_Plk_4	57	63	PF00069	0.276
MOD_Plk_4	613	619	PF00069	0.311
MOD_Plk_4	638	644	PF00069	0.311
MOD_Plk_4	689	695	PF00069	0.325
MOD_Plk_4	700	706	PF00069	0.325
MOD_ProDKin_1	341	347	PF00069	0.585
MOD_ProDKin_1	378	384	PF00069	0.540
MOD_ProDKin_1	386	392	PF00069	0.528
MOD_ProDKin_1	504	510	PF00069	0.442
MOD_ProDKin_1	626	632	PF00069	0.442
MOD_SUMO_rev_2	464	474	PF00179	0.391
TRG_ENDOCYTIC_2	58	61	PF00928	0.276
TRG_ENDOCYTIC_2	580	583	PF00928	0.277
TRG_ER_diArg_1	174	176	PF00400	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C5	Leptomonas seymouri	62%	100%
A0A3S7X2A5	Leishmania donovani	76%	100%
A4I4B8	Leishmania infantum	77%	100%
E9ADR7	Leishmania major	76%	99%
Q6NV12	Danio rerio	23%	100%