zf-C2HE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Scavenger mRNA decapping enzyme C-term binding, putative

Species:

Leishmania braziliensis

UniProt:

A4HH71_LEIBR

TriTrypDb:

LbrM.29.0650 , LBRM2903_290012700

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HH71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH71

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004527	exonuclease activity	5	11
GO:0004529	DNA exonuclease activity	5	11
GO:0004536	DNA nuclease activity	4	11
GO:0005488	binding	1	11
GO:0008409	5'-3' exonuclease activity	6	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0033699	DNA 5'-adenosine monophosphate hydrolase activity	8	11
GO:0035312	5'-3' DNA exonuclease activity	7	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.584
CLV_NRD_NRD_1	157	159	PF00675	0.303
CLV_PCSK_KEX2_1	13	15	PF00082	0.637
CLV_PCSK_KEX2_1	157	159	PF00082	0.303
CLV_PCSK_SKI1_1	144	148	PF00082	0.269
DEG_APCC_DBOX_1	24	32	PF00400	0.374
DEG_Nend_UBRbox_3	1	3	PF02207	0.649
DEG_SPOP_SBC_1	50	54	PF00917	0.605
DOC_CDC14_PxL_1	163	171	PF14671	0.399
DOC_CDC14_PxL_1	69	77	PF14671	0.384
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.423
DOC_MAPK_gen_1	25	34	PF00069	0.464
DOC_MAPK_RevD_3	174	190	PF00069	0.365
DOC_PP2B_LxvP_1	110	113	PF13499	0.399
DOC_USP7_MATH_1	16	20	PF00917	0.474
DOC_USP7_MATH_1	165	169	PF00917	0.423
DOC_USP7_MATH_1	38	42	PF00917	0.511
DOC_USP7_MATH_1	50	54	PF00917	0.575
DOC_USP7_MATH_1	83	87	PF00917	0.326
DOC_USP7_UBL2_3	249	253	PF12436	0.266
DOC_USP7_UBL2_3	36	40	PF12436	0.480
DOC_WW_Pin1_4	180	185	PF00397	0.421
DOC_WW_Pin1_4	46	51	PF00397	0.623
LIG_14-3-3_CanoR_1	117	122	PF00244	0.500
LIG_14-3-3_CanoR_1	144	154	PF00244	0.513
LIG_14-3-3_CanoR_1	215	219	PF00244	0.294
LIG_Actin_WH2_2	131	149	PF00022	0.503
LIG_BIR_III_2	100	104	PF00653	0.399
LIG_CtBP_PxDLS_1	113	117	PF00389	0.423
LIG_DLG_GKlike_1	117	124	PF00625	0.503
LIG_FHA_1	1	7	PF00498	0.435
LIG_LIR_Gen_1	194	201	PF02991	0.378
LIG_LIR_Nem_3	140	145	PF02991	0.424
LIG_LIR_Nem_3	194	198	PF02991	0.342
LIG_LYPXL_yS_3	72	75	PF13949	0.365
LIG_PAM2_1	60	72	PF00658	0.270
LIG_Pex14_2	159	163	PF04695	0.432
LIG_Pex14_2	195	199	PF04695	0.233
LIG_PTB_Apo_2	96	103	PF02174	0.399
LIG_SH2_STAT5	137	140	PF00017	0.403
LIG_SH2_STAT5	142	145	PF00017	0.395
LIG_SH3_1	70	76	PF00018	0.249
LIG_SH3_3	164	170	PF00018	0.399
LIG_SH3_3	70	76	PF00018	0.249
LIG_TRFH_1	72	76	PF08558	0.364
LIG_WRC_WIRS_1	192	197	PF05994	0.254
LIG_WRPW_2	69	72	PF00400	0.400
MOD_CDK_SPxxK_3	180	187	PF00069	0.424
MOD_CK1_1	19	25	PF00069	0.428
MOD_CK1_1	194	200	PF00069	0.247
MOD_CK1_1	41	47	PF00069	0.438
MOD_CK1_1	53	59	PF00069	0.611
MOD_CK1_1	77	83	PF00069	0.535
MOD_CK2_1	55	61	PF00069	0.643
MOD_GlcNHglycan	18	21	PF01048	0.315
MOD_GlcNHglycan	3	6	PF01048	0.549
MOD_GlcNHglycan	40	43	PF01048	0.450
MOD_GlcNHglycan	55	58	PF01048	0.536
MOD_GlcNHglycan	76	79	PF01048	0.420
MOD_GSK3_1	1	8	PF00069	0.594
MOD_GSK3_1	12	19	PF00069	0.528
MOD_GSK3_1	146	153	PF00069	0.415
MOD_GSK3_1	247	254	PF00069	0.250
MOD_GSK3_1	38	45	PF00069	0.455
MOD_GSK3_1	46	53	PF00069	0.574
MOD_GSK3_1	56	63	PF00069	0.593
MOD_N-GLC_1	42	47	PF02516	0.313
MOD_NEK2_1	1	6	PF00069	0.482
MOD_NEK2_1	146	151	PF00069	0.458
MOD_PKA_2	12	18	PF00069	0.558
MOD_PKA_2	214	220	PF00069	0.294
MOD_Plk_4	102	108	PF00069	0.399
MOD_Plk_4	194	200	PF00069	0.344
MOD_Plk_4	60	66	PF00069	0.306
MOD_Plk_4	84	90	PF00069	0.344
MOD_ProDKin_1	180	186	PF00069	0.421
MOD_ProDKin_1	46	52	PF00069	0.626
MOD_SUMO_rev_2	77	83	PF00179	0.417
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.441
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.463
TRG_ENDOCYTIC_2	192	195	PF00928	0.246
TRG_ENDOCYTIC_2	72	75	PF00928	0.365
TRG_ER_diArg_1	12	14	PF00400	0.617
TRG_ER_diArg_1	157	159	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB39	Leptomonas seymouri	68%	100%
A0A0S4IR98	Bodo saltans	40%	100%
A0A0S4JC46	Bodo saltans	30%	85%
A0A0S4JGA0	Bodo saltans	39%	100%
A0A1X0NZZ4	Trypanosomatidae	50%	100%
A0A3S7X266	Leishmania donovani	84%	100%
A4I4B7	Leishmania infantum	84%	100%
C9ZL51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AM14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O74859	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
P61798	Gallus gallus	34%	84%
Q08702	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
V5BUM6	Trypanosoma cruzi	50%	100%