Putative BET1-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BET1-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HH70_LEIBR

TriTrypDb:

LbrM.29.0640 , LBRM2903_290012600

Length:

139

Annotations

LeishMANIAdb annotations

A SNARE-like tail-anchored coil-coil protein required for ER-to-Golgi transport. Probably not GPI anchored due to reverse topology. Localization: Golgi (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH70

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.529
CLV_NRD_NRD_1	66	68	PF00675	0.430
CLV_PCSK_KEX2_1	10	12	PF00082	0.536
CLV_PCSK_KEX2_1	66	68	PF00082	0.423
CLV_PCSK_SKI1_1	66	70	PF00082	0.412
DEG_MDM2_SWIB_1	115	123	PF02201	0.532
DEG_Nend_Nbox_1	1	3	PF02207	0.697
DOC_MAPK_MEF2A_6	116	125	PF00069	0.441
DOC_PP1_RVXF_1	107	113	PF00149	0.632
DOC_PP4_FxxP_1	22	25	PF00568	0.592
DOC_USP7_MATH_1	38	42	PF00917	0.763
DOC_USP7_MATH_1	46	50	PF00917	0.621
DOC_USP7_MATH_1	68	72	PF00917	0.655
DOC_USP7_MATH_1	96	100	PF00917	0.596
DOC_WW_Pin1_4	21	26	PF00397	0.740
LIG_14-3-3_CanoR_1	101	105	PF00244	0.581
LIG_14-3-3_CanoR_1	67	73	PF00244	0.661
LIG_14-3-3_CanoR_1	88	94	PF00244	0.607
LIG_BRCT_BRCA1_1	5	9	PF00533	0.663
LIG_LIR_Apic_2	19	25	PF02991	0.592
LIG_LIR_Gen_1	71	79	PF02991	0.688
LIG_NRP_CendR_1	137	139	PF00754	0.548
LIG_Pex14_2	115	119	PF04695	0.486
LIG_Pex14_2	124	128	PF04695	0.278
LIG_SH2_STAT5	133	136	PF00017	0.322
LIG_TRAF2_1	48	51	PF00917	0.616
LIG_TYR_ITIM	131	136	PF00017	0.287
LIG_UBA3_1	61	70	PF00899	0.667
MOD_CK1_1	23	29	PF00069	0.749
MOD_CK1_1	92	98	PF00069	0.690
MOD_GlcNHglycan	40	43	PF01048	0.403
MOD_GSK3_1	20	27	PF00069	0.743
MOD_GSK3_1	92	99	PF00069	0.592
MOD_NEK2_1	100	105	PF00069	0.579
MOD_NEK2_1	89	94	PF00069	0.608
MOD_NEK2_2	4	9	PF00069	0.636
MOD_NEK2_2	96	101	PF00069	0.587
MOD_PIKK_1	46	52	PF00454	0.541
MOD_PKA_2	100	106	PF00069	0.643
MOD_PKA_2	89	95	PF00069	0.612
MOD_Plk_4	4	10	PF00069	0.639
MOD_Plk_4	89	95	PF00069	0.604
MOD_ProDKin_1	21	27	PF00069	0.740
TRG_DiLeu_BaEn_1	53	58	PF01217	0.606
TRG_ENDOCYTIC_2	133	136	PF00928	0.287
TRG_ER_diArg_1	65	67	PF00400	0.628
TRG_ER_diArg_1	9	12	PF00400	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG6	Leptomonas seymouri	62%	100%
A0A1X0NZJ5	Trypanosomatidae	42%	100%
A0A3Q8IIL2	Leishmania donovani	81%	100%
A0A422NUM6	Trypanosoma rangeli	36%	100%
A4I4B6	Leishmania infantum	82%	100%
C9ZL52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ADR5	Leishmania major	83%	100%
E9AM15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%