RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH68_LEIBR

TriTrypDb:

LbrM.29.0610 , LBRM2903_290012300

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	22
GO:0043226	organelle	2	22
GO:0043227	membrane-bounded organelle	3	22
GO:0043229	intracellular organelle	3	22
GO:0043231	intracellular membrane-bounded organelle	4	22
GO:0110165	cellular anatomical entity	1	22
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HH68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH68

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003700	DNA-binding transcription factor activity	2	22
GO:0005488	binding	1	22
GO:0008270	zinc ion binding	6	22
GO:0043167	ion binding	2	22
GO:0043169	cation binding	3	22
GO:0046872	metal ion binding	4	22
GO:0046914	transition metal ion binding	5	22
GO:0140110	transcription regulator activity	1	22
GO:0003676	nucleic acid binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1
GO:0000976	transcription cis-regulatory region binding	5	2
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	6	2
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	3	2
GO:0001067	transcription regulatory region nucleic acid binding	4	2
GO:0003677	DNA binding	4	2
GO:0003690	double-stranded DNA binding	5	2
GO:0043565	sequence-specific DNA binding	5	2
GO:1990837	sequence-specific double-stranded DNA binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.464
CLV_NRD_NRD_1	124	126	PF00675	0.397
CLV_NRD_NRD_1	219	221	PF00675	0.426
CLV_NRD_NRD_1	397	399	PF00675	0.414
CLV_NRD_NRD_1	424	426	PF00675	0.537
CLV_NRD_NRD_1	458	460	PF00675	0.377
CLV_NRD_NRD_1	532	534	PF00675	0.483
CLV_PCSK_FUR_1	217	221	PF00082	0.479
CLV_PCSK_KEX2_1	124	126	PF00082	0.378
CLV_PCSK_KEX2_1	219	221	PF00082	0.454
CLV_PCSK_KEX2_1	263	265	PF00082	0.526
CLV_PCSK_KEX2_1	397	399	PF00082	0.346
CLV_PCSK_KEX2_1	561	563	PF00082	0.396
CLV_PCSK_KEX2_1	571	573	PF00082	0.721
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.526
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.396
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.487
CLV_PCSK_SKI1_1	397	401	PF00082	0.526
CLV_PCSK_SKI1_1	425	429	PF00082	0.258
DOC_CKS1_1	284	289	PF01111	0.448
DOC_CKS1_1	345	350	PF01111	0.528
DOC_PP2B_LxvP_1	320	323	PF13499	0.519
DOC_PP4_FxxP_1	45	48	PF00568	0.410
DOC_PP4_FxxP_1	520	523	PF00568	0.510
DOC_PP4_FxxP_1	80	83	PF00568	0.338
DOC_USP7_MATH_1	249	253	PF00917	0.502
DOC_USP7_MATH_1	310	314	PF00917	0.413
DOC_USP7_MATH_1	380	384	PF00917	0.493
DOC_USP7_MATH_1	390	394	PF00917	0.514
DOC_USP7_MATH_1	510	514	PF00917	0.500
DOC_WW_Pin1_4	1	6	PF00397	0.647
DOC_WW_Pin1_4	283	288	PF00397	0.427
DOC_WW_Pin1_4	333	338	PF00397	0.515
DOC_WW_Pin1_4	344	349	PF00397	0.444
DOC_WW_Pin1_4	355	360	PF00397	0.451
LIG_14-3-3_CanoR_1	134	138	PF00244	0.547
LIG_14-3-3_CanoR_1	159	165	PF00244	0.263
LIG_14-3-3_CanoR_1	304	312	PF00244	0.392
LIG_14-3-3_CanoR_1	354	359	PF00244	0.441
LIG_14-3-3_CanoR_1	457	463	PF00244	0.367
LIG_14-3-3_CanoR_1	63	71	PF00244	0.628
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_BRCT_BRCA1_1	357	361	PF00533	0.336
LIG_BRCT_BRCA1_1	559	563	PF00533	0.591
LIG_FHA_1	201	207	PF00498	0.597
LIG_FHA_1	303	309	PF00498	0.452
LIG_FHA_1	315	321	PF00498	0.462
LIG_FHA_1	6	12	PF00498	0.467
LIG_FHA_1	66	72	PF00498	0.592
LIG_FHA_2	233	239	PF00498	0.462
LIG_FHA_2	329	335	PF00498	0.557
LIG_FHA_2	411	417	PF00498	0.471
LIG_FHA_2	426	432	PF00498	0.415
LIG_FHA_2	459	465	PF00498	0.395
LIG_FHA_2	563	569	PF00498	0.610
LIG_FHA_2	71	77	PF00498	0.428
LIG_LIR_Apic_2	281	287	PF02991	0.578
LIG_LIR_Apic_2	461	465	PF02991	0.359
LIG_LIR_Apic_2	78	83	PF02991	0.356
LIG_LIR_Gen_1	450	455	PF02991	0.391
LIG_LIR_Nem_3	252	257	PF02991	0.294
LIG_LIR_Nem_3	358	364	PF02991	0.311
LIG_LIR_Nem_3	450	454	PF02991	0.379
LIG_LIR_Nem_3	560	566	PF02991	0.502
LIG_Pex14_1	156	160	PF04695	0.263
LIG_Rb_LxCxE_1	21	34	PF01857	0.264
LIG_SH2_CRK	284	288	PF00017	0.374
LIG_SH2_STAP1	160	164	PF00017	0.261
LIG_SH2_STAP1	20	24	PF00017	0.364
LIG_SH2_STAP1	451	455	PF00017	0.411
LIG_SH2_STAT5	100	103	PF00017	0.353
LIG_SH2_STAT5	364	367	PF00017	0.376
LIG_SH2_STAT5	455	458	PF00017	0.427
LIG_SH3_2	129	134	PF14604	0.427
LIG_SH3_2	337	342	PF14604	0.547
LIG_SH3_3	126	132	PF00018	0.436
LIG_SH3_3	334	340	PF00018	0.459
LIG_SH3_3	342	348	PF00018	0.375
LIG_SH3_3	460	466	PF00018	0.389
LIG_SH3_3	487	493	PF00018	0.452
LIG_SH3_3	495	501	PF00018	0.534
LIG_SUMO_SIM_par_1	202	208	PF11976	0.504
LIG_TRAF2_1	241	244	PF00917	0.448
LIG_TYR_ITIM	449	454	PF00017	0.469
MOD_CDK_SPxK_1	283	289	PF00069	0.439
MOD_CK1_1	383	389	PF00069	0.438
MOD_CK1_1	87	93	PF00069	0.375
MOD_CK2_1	365	371	PF00069	0.514
MOD_CK2_1	410	416	PF00069	0.480
MOD_CK2_1	425	431	PF00069	0.426
MOD_CK2_1	458	464	PF00069	0.280
MOD_CK2_1	70	76	PF00069	0.411
MOD_Cter_Amidation	531	534	PF01082	0.396
MOD_GlcNHglycan	1	4	PF01048	0.550
MOD_GlcNHglycan	551	554	PF01048	0.442
MOD_GlcNHglycan	68	71	PF01048	0.507
MOD_GSK3_1	1	8	PF00069	0.584
MOD_GSK3_1	160	167	PF00069	0.382
MOD_GSK3_1	200	207	PF00069	0.437
MOD_GSK3_1	310	317	PF00069	0.402
MOD_GSK3_1	380	387	PF00069	0.585
MOD_GSK3_1	66	73	PF00069	0.467
MOD_N-GLC_1	557	562	PF02516	0.177
MOD_N-GLC_2	409	411	PF02516	0.340
MOD_NEK2_1	65	70	PF00069	0.621
MOD_NEK2_1	84	89	PF00069	0.407
MOD_NEK2_2	166	171	PF00069	0.395
MOD_NEK2_2	328	333	PF00069	0.438
MOD_OFUCOSY	307	314	PF10250	0.377
MOD_OFUCOSY	396	402	PF10250	0.370
MOD_OFUCOSY	412	419	PF10250	0.381
MOD_OFUCOSY	423	429	PF10250	0.281
MOD_OFUCOSY	438	443	PF10250	0.270
MOD_OFUCOSY	524	531	PF10250	0.350
MOD_OGLYCOS	550	555	PF02709	0.433
MOD_PIKK_1	233	239	PF00454	0.748
MOD_PIKK_1	390	396	PF00454	0.260
MOD_PIKK_1	5	11	PF00454	0.442
MOD_PIKK_1	53	59	PF00454	0.454
MOD_PIKK_1	70	76	PF00454	0.414
MOD_PKA_1	425	431	PF00069	0.320
MOD_PKA_2	133	139	PF00069	0.427
MOD_PKA_2	158	164	PF00069	0.267
MOD_PKA_2	303	309	PF00069	0.378
MOD_PKA_2	405	411	PF00069	0.427
MOD_PKA_2	458	464	PF00069	0.365
MOD_Plk_1	415	421	PF00069	0.439
MOD_Plk_4	133	139	PF00069	0.321
MOD_Plk_4	200	206	PF00069	0.371
MOD_Plk_4	458	464	PF00069	0.529
MOD_ProDKin_1	1	7	PF00069	0.631
MOD_ProDKin_1	283	289	PF00069	0.429
MOD_ProDKin_1	333	339	PF00069	0.382
MOD_ProDKin_1	344	350	PF00069	0.445
MOD_ProDKin_1	355	361	PF00069	0.446
TRG_ENDOCYTIC_2	20	23	PF00928	0.407
TRG_ENDOCYTIC_2	42	45	PF00928	0.345
TRG_ENDOCYTIC_2	451	454	PF00928	0.378
TRG_ER_diArg_1	217	220	PF00400	0.449
TRG_ER_diArg_1	397	399	PF00400	0.346
TRG_NLS_Bipartite_1	561	575	PF00514	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT0	Leptomonas seymouri	36%	75%
A0A0N1I9N1	Leptomonas seymouri	75%	100%
A0A0S4INQ1	Bodo saltans	47%	96%
A0A1X0NUI9	Trypanosomatidae	38%	72%
A0A1X0NZM6	Trypanosomatidae	53%	100%
A0A3R7M581	Trypanosoma rangeli	52%	100%
A0A3R7MD54	Trypanosoma rangeli	35%	70%
A0A3S5H7A4	Leishmania donovani	36%	75%
A0A3S7X2B6	Leishmania donovani	85%	100%
A4HC58	Leishmania braziliensis	35%	100%
A4I4B2	Leishmania infantum	85%	100%
C9ZKS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZSC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	72%
E9ADR2	Leishmania major	85%	100%
E9AGY6	Leishmania infantum	36%	75%
E9AM18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AVJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	75%
Q4QBY8	Leishmania major	36%	100%
V5BFS7	Trypanosoma cruzi	37%	71%
V5BUH3	Trypanosoma cruzi	51%	100%