Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH66_LEIBR

TriTrypDb:

LbrM.29.0590 , LBRM2903_290012000

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.448
CLV_NRD_NRD_1	131	133	PF00675	0.546
CLV_NRD_NRD_1	146	148	PF00675	0.360
CLV_NRD_NRD_1	184	186	PF00675	0.640
CLV_NRD_NRD_1	255	257	PF00675	0.627
CLV_NRD_NRD_1	286	288	PF00675	0.557
CLV_NRD_NRD_1	358	360	PF00675	0.546
CLV_NRD_NRD_1	365	367	PF00675	0.613
CLV_NRD_NRD_1	397	399	PF00675	0.714
CLV_NRD_NRD_1	430	432	PF00675	0.582
CLV_NRD_NRD_1	442	444	PF00675	0.562
CLV_NRD_NRD_1	448	450	PF00675	0.590
CLV_NRD_NRD_1	466	468	PF00675	0.486
CLV_PCSK_KEX2_1	125	127	PF00082	0.443
CLV_PCSK_KEX2_1	131	133	PF00082	0.543
CLV_PCSK_KEX2_1	145	147	PF00082	0.360
CLV_PCSK_KEX2_1	184	186	PF00082	0.640
CLV_PCSK_KEX2_1	286	288	PF00082	0.556
CLV_PCSK_KEX2_1	358	360	PF00082	0.546
CLV_PCSK_KEX2_1	365	367	PF00082	0.613
CLV_PCSK_KEX2_1	396	398	PF00082	0.709
CLV_PCSK_KEX2_1	430	432	PF00082	0.587
CLV_PCSK_KEX2_1	448	450	PF00082	0.590
CLV_PCSK_KEX2_1	466	468	PF00082	0.517
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.517
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.559
CLV_PCSK_SKI1_1	117	121	PF00082	0.386
CLV_PCSK_SKI1_1	226	230	PF00082	0.654
CLV_PCSK_SKI1_1	369	373	PF00082	0.533
CLV_PCSK_SKI1_1	404	408	PF00082	0.529
DEG_SPOP_SBC_1	35	39	PF00917	0.554
DEG_SPOP_SBC_1	371	375	PF00917	0.512
DEG_SPOP_SBC_1	389	393	PF00917	0.711
DOC_MAPK_gen_1	113	121	PF00069	0.438
DOC_MAPK_gen_1	184	195	PF00069	0.531
DOC_MAPK_RevD_3	417	431	PF00069	0.556
DOC_PP2B_LxvP_1	233	236	PF13499	0.512
DOC_USP7_MATH_1	13	17	PF00917	0.676
DOC_USP7_MATH_1	2	6	PF00917	0.612
DOC_USP7_MATH_1	200	204	PF00917	0.517
DOC_USP7_MATH_1	261	265	PF00917	0.619
DOC_USP7_MATH_1	269	273	PF00917	0.644
DOC_USP7_MATH_1	279	283	PF00917	0.611
DOC_USP7_MATH_1	305	309	PF00917	0.544
DOC_USP7_MATH_1	35	39	PF00917	0.627
DOC_USP7_MATH_1	352	356	PF00917	0.481
DOC_USP7_MATH_1	367	371	PF00917	0.662
DOC_USP7_MATH_1	389	393	PF00917	0.716
DOC_USP7_MATH_1	451	455	PF00917	0.675
DOC_USP7_MATH_1	79	83	PF00917	0.604
DOC_USP7_UBL2_3	284	288	PF12436	0.566
DOC_WW_Pin1_4	263	268	PF00397	0.745
DOC_WW_Pin1_4	288	293	PF00397	0.636
DOC_WW_Pin1_4	447	452	PF00397	0.509
DOC_WW_Pin1_4	5	10	PF00397	0.673
DOC_WW_Pin1_4	80	85	PF00397	0.669
LIG_14-3-3_CanoR_1	226	233	PF00244	0.542
LIG_14-3-3_CanoR_1	369	379	PF00244	0.648
LIG_14-3-3_CanoR_1	472	479	PF00244	0.557
LIG_eIF4E_1	171	177	PF01652	0.517
LIG_FHA_1	167	173	PF00498	0.593
LIG_FHA_1	455	461	PF00498	0.676
LIG_FHA_2	118	124	PF00498	0.378
LIG_FHA_2	244	250	PF00498	0.552
LIG_FHA_2	35	41	PF00498	0.665
LIG_FHA_2	436	442	PF00498	0.552
LIG_GBD_Chelix_1	452	460	PF00786	0.525
LIG_LIR_Gen_1	415	424	PF02991	0.607
LIG_LIR_Gen_1	51	61	PF02991	0.528
LIG_LIR_Nem_3	339	345	PF02991	0.568
LIG_LIR_Nem_3	415	419	PF02991	0.601
LIG_LIR_Nem_3	51	57	PF02991	0.569
LIG_MYND_1	190	194	PF01753	0.501
LIG_SH2_CRK	342	346	PF00017	0.587
LIG_SH2_NCK_1	94	98	PF00017	0.447
LIG_SH2_SRC	171	174	PF00017	0.514
LIG_SH2_STAP1	50	54	PF00017	0.623
LIG_SH2_STAP1	94	98	PF00017	0.544
LIG_SH2_STAT5	171	174	PF00017	0.514
LIG_SH2_STAT5	63	66	PF00017	0.503
LIG_SH2_STAT5	94	97	PF00017	0.555
LIG_SH3_3	184	190	PF00018	0.600
LIG_SH3_3	191	197	PF00018	0.580
LIG_SH3_3	418	424	PF00018	0.447
LIG_SUMO_SIM_par_1	10	16	PF11976	0.535
LIG_SUMO_SIM_par_1	343	349	PF11976	0.486
LIG_TRAF2_1	39	42	PF00917	0.648
MOD_CK1_1	18	24	PF00069	0.629
MOD_CK1_1	221	227	PF00069	0.536
MOD_CK1_1	272	278	PF00069	0.708
MOD_CK1_1	370	376	PF00069	0.501
MOD_CK1_1	391	397	PF00069	0.648
MOD_CK1_1	44	50	PF00069	0.660
MOD_CK1_1	454	460	PF00069	0.686
MOD_CK1_1	5	11	PF00069	0.677
MOD_CK1_1	59	65	PF00069	0.541
MOD_CK1_1	70	76	PF00069	0.713
MOD_CK1_1	93	99	PF00069	0.624
MOD_CK2_1	117	123	PF00069	0.464
MOD_CK2_1	196	202	PF00069	0.592
MOD_CK2_1	36	42	PF00069	0.805
MOD_CK2_1	371	377	PF00069	0.574
MOD_CK2_1	435	441	PF00069	0.552
MOD_Cter_Amidation	123	126	PF01082	0.353
MOD_Cter_Amidation	284	287	PF01082	0.550
MOD_GlcNHglycan	15	18	PF01048	0.743
MOD_GlcNHglycan	198	201	PF01048	0.744
MOD_GlcNHglycan	220	223	PF01048	0.656
MOD_GlcNHglycan	271	274	PF01048	0.556
MOD_GlcNHglycan	28	31	PF01048	0.598
MOD_GlcNHglycan	281	284	PF01048	0.689
MOD_GlcNHglycan	295	298	PF01048	0.709
MOD_GlcNHglycan	354	357	PF01048	0.495
MOD_GlcNHglycan	369	372	PF01048	0.490
MOD_GlcNHglycan	4	7	PF01048	0.674
MOD_GSK3_1	1	8	PF00069	0.802
MOD_GSK3_1	13	20	PF00069	0.706
MOD_GSK3_1	196	203	PF00069	0.504
MOD_GSK3_1	263	270	PF00069	0.687
MOD_GSK3_1	288	295	PF00069	0.655
MOD_GSK3_1	367	374	PF00069	0.517
MOD_GSK3_1	385	392	PF00069	0.612
MOD_GSK3_1	447	454	PF00069	0.584
MOD_GSK3_1	467	474	PF00069	0.524
MOD_GSK3_1	86	93	PF00069	0.543
MOD_NEK2_1	26	31	PF00069	0.604
MOD_PIKK_1	166	172	PF00454	0.600
MOD_PIKK_1	200	206	PF00454	0.517
MOD_PIKK_1	243	249	PF00454	0.588
MOD_PKA_2	324	330	PF00069	0.500
MOD_PKA_2	462	468	PF00069	0.565
MOD_PKA_2	471	477	PF00069	0.601
MOD_PKB_1	115	123	PF00069	0.387
MOD_Plk_1	229	235	PF00069	0.531
MOD_Plk_1	305	311	PF00069	0.535
MOD_Plk_1	41	47	PF00069	0.654
MOD_Plk_1	435	441	PF00069	0.628
MOD_Plk_1	467	473	PF00069	0.549
MOD_Plk_1	59	65	PF00069	0.408
MOD_Plk_2-3	435	441	PF00069	0.628
MOD_Plk_4	117	123	PF00069	0.385
MOD_Plk_4	238	244	PF00069	0.511
MOD_Plk_4	299	305	PF00069	0.534
MOD_Plk_4	324	330	PF00069	0.506
MOD_ProDKin_1	263	269	PF00069	0.740
MOD_ProDKin_1	288	294	PF00069	0.631
MOD_ProDKin_1	447	453	PF00069	0.509
MOD_ProDKin_1	5	11	PF00069	0.677
MOD_ProDKin_1	80	86	PF00069	0.668
MOD_SUMO_rev_2	312	322	PF00179	0.627
TRG_ENDOCYTIC_2	342	345	PF00928	0.545
TRG_ER_diArg_1	125	128	PF00400	0.443
TRG_ER_diArg_1	146	148	PF00400	0.381
TRG_ER_diArg_1	364	366	PF00400	0.647
TRG_ER_diArg_1	430	432	PF00400	0.614
TRG_NLS_Bipartite_1	131	149	PF00514	0.348
TRG_NLS_MonoCore_2	395	400	PF00514	0.550
TRG_NLS_MonoExtC_3	395	400	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCW8	Leptomonas seymouri	38%	97%
A0A3Q8IF08	Leishmania donovani	65%	99%
A4I4B0	Leishmania infantum	64%	99%
E9ADR0	Leishmania major	64%	100%
E9AM20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%