ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HH65_LEIBR

TriTrypDb:

LbrM.29.0580 , LBRM2903_290011900

Length:

831

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.507
CLV_C14_Caspase3-7	407	411	PF00656	0.468
CLV_C14_Caspase3-7	507	511	PF00656	0.497
CLV_C14_Caspase3-7	51	55	PF00656	0.487
CLV_C14_Caspase3-7	551	555	PF00656	0.700
CLV_C14_Caspase3-7	815	819	PF00656	0.512
CLV_NRD_NRD_1	436	438	PF00675	0.611
CLV_NRD_NRD_1	478	480	PF00675	0.638
CLV_NRD_NRD_1	552	554	PF00675	0.498
CLV_NRD_NRD_1	785	787	PF00675	0.387
CLV_PCSK_KEX2_1	436	438	PF00082	0.611
CLV_PCSK_KEX2_1	478	480	PF00082	0.631
CLV_PCSK_KEX2_1	552	554	PF00082	0.498
CLV_PCSK_KEX2_1	785	787	PF00082	0.539
CLV_PCSK_SKI1_1	132	136	PF00082	0.545
CLV_PCSK_SKI1_1	593	597	PF00082	0.346
CLV_PCSK_SKI1_1	61	65	PF00082	0.529
CLV_PCSK_SKI1_1	78	82	PF00082	0.366
DEG_APCC_DBOX_1	477	485	PF00400	0.660
DEG_APCC_DBOX_1	73	81	PF00400	0.512
DEG_APCC_DBOX_1	810	818	PF00400	0.643
DEG_SCF_FBW7_2	258	263	PF00400	0.473
DOC_CKS1_1	563	568	PF01111	0.790
DOC_CYCLIN_yClb5_NLxxxL_5	378	387	PF00134	0.613
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	394	400	PF00134	0.568
DOC_MAPK_MEF2A_6	142	149	PF00069	0.336
DOC_PP2B_LxvP_1	340	343	PF13499	0.347
DOC_PP4_FxxP_1	519	522	PF00568	0.509
DOC_USP7_MATH_1	192	196	PF00917	0.699
DOC_USP7_MATH_1	198	202	PF00917	0.488
DOC_USP7_MATH_1	231	235	PF00917	0.762
DOC_USP7_MATH_1	269	273	PF00917	0.614
DOC_USP7_MATH_1	274	278	PF00917	0.521
DOC_USP7_MATH_1	348	352	PF00917	0.379
DOC_USP7_MATH_1	406	410	PF00917	0.508
DOC_USP7_MATH_1	474	478	PF00917	0.759
DOC_USP7_MATH_1	482	486	PF00917	0.449
DOC_USP7_MATH_1	557	561	PF00917	0.763
DOC_USP7_MATH_1	723	727	PF00917	0.597
DOC_USP7_MATH_1	732	736	PF00917	0.558
DOC_WW_Pin1_4	137	142	PF00397	0.454
DOC_WW_Pin1_4	256	261	PF00397	0.652
DOC_WW_Pin1_4	449	454	PF00397	0.677
DOC_WW_Pin1_4	466	471	PF00397	0.767
DOC_WW_Pin1_4	562	567	PF00397	0.749
DOC_WW_Pin1_4	617	622	PF00397	0.341
DOC_WW_Pin1_4	680	685	PF00397	0.584
DOC_WW_Pin1_4	86	91	PF00397	0.560
LIG_14-3-3_CanoR_1	221	230	PF00244	0.684
LIG_14-3-3_CanoR_1	294	301	PF00244	0.597
LIG_14-3-3_CanoR_1	326	332	PF00244	0.547
LIG_14-3-3_CanoR_1	479	485	PF00244	0.408
LIG_14-3-3_CanoR_1	590	596	PF00244	0.325
LIG_14-3-3_CanoR_1	767	776	PF00244	0.540
LIG_Actin_WH2_2	105	122	PF00022	0.522
LIG_Actin_WH2_2	413	430	PF00022	0.528
LIG_Actin_WH2_2	704	721	PF00022	0.561
LIG_Actin_WH2_2	813	831	PF00022	0.451
LIG_BIR_III_2	54	58	PF00653	0.353
LIG_BIR_III_4	818	822	PF00653	0.648
LIG_BRCT_BRCA1_1	394	398	PF00533	0.558
LIG_BRCT_BRCA1_1	515	519	PF00533	0.369
LIG_CtBP_PxDLS_1	10	14	PF00389	0.532
LIG_CtBP_PxDLS_1	633	637	PF00389	0.480
LIG_eIF4E_1	364	370	PF01652	0.404
LIG_eIF4E_1	685	691	PF01652	0.613
LIG_FHA_1	109	115	PF00498	0.463
LIG_FHA_1	122	128	PF00498	0.489
LIG_FHA_1	149	155	PF00498	0.363
LIG_FHA_1	248	254	PF00498	0.781
LIG_FHA_1	47	53	PF00498	0.509
LIG_FHA_1	557	563	PF00498	0.724
LIG_FHA_1	618	624	PF00498	0.368
LIG_FHA_1	684	690	PF00498	0.488
LIG_FHA_1	712	718	PF00498	0.610
LIG_FHA_1	79	85	PF00498	0.591
LIG_FHA_2	249	255	PF00498	0.757
LIG_FHA_2	305	311	PF00498	0.602
LIG_FHA_2	328	334	PF00498	0.508
LIG_FHA_2	405	411	PF00498	0.457
LIG_FHA_2	454	460	PF00498	0.620
LIG_FHA_2	734	740	PF00498	0.596
LIG_FHA_2	767	773	PF00498	0.529
LIG_LIR_Apic_2	516	522	PF02991	0.497
LIG_LIR_Apic_2	682	688	PF02991	0.631
LIG_LIR_Gen_1	283	293	PF02991	0.502
LIG_LIR_Gen_1	332	342	PF02991	0.453
LIG_LIR_Gen_1	395	406	PF02991	0.556
LIG_LIR_Gen_1	503	513	PF02991	0.540
LIG_LIR_Nem_3	283	289	PF02991	0.495
LIG_LIR_Nem_3	332	337	PF02991	0.499
LIG_LIR_Nem_3	371	376	PF02991	0.475
LIG_LIR_Nem_3	395	401	PF02991	0.541
LIG_LIR_Nem_3	503	508	PF02991	0.543
LIG_LIR_Nem_3	60	66	PF02991	0.470
LIG_LIR_Nem_3	616	622	PF02991	0.384
LIG_LIR_Nem_3	656	662	PF02991	0.335
LIG_MYND_1	29	33	PF01753	0.621
LIG_NRBOX	145	151	PF00104	0.406
LIG_NRBOX	365	371	PF00104	0.403
LIG_PCNA_yPIPBox_3	137	150	PF02747	0.376
LIG_Pex14_2	515	519	PF04695	0.496
LIG_PTB_Apo_2	176	183	PF02174	0.474
LIG_PTB_Phospho_1	176	182	PF10480	0.470
LIG_SH2_CRK	685	689	PF00017	0.617
LIG_SH2_NCK_1	660	664	PF00017	0.366
LIG_SH2_SRC	660	663	PF00017	0.362
LIG_SH2_STAP1	364	368	PF00017	0.346
LIG_SH2_STAP1	666	670	PF00017	0.349
LIG_SH2_STAP1	724	728	PF00017	0.544
LIG_SH2_STAP1	802	806	PF00017	0.659
LIG_SH2_STAT3	364	367	PF00017	0.560
LIG_SH2_STAT3	802	805	PF00017	0.694
LIG_SH2_STAT5	125	128	PF00017	0.476
LIG_SH2_STAT5	292	295	PF00017	0.420
LIG_SH2_STAT5	308	311	PF00017	0.488
LIG_SH2_STAT5	400	403	PF00017	0.554
LIG_SH2_STAT5	416	419	PF00017	0.446
LIG_SH2_STAT5	486	489	PF00017	0.558
LIG_SH2_STAT5	591	594	PF00017	0.335
LIG_SH2_STAT5	685	688	PF00017	0.618
LIG_SH3_2	566	571	PF14604	0.523
LIG_SH3_3	111	117	PF00018	0.423
LIG_SH3_3	29	35	PF00018	0.575
LIG_SH3_3	336	342	PF00018	0.550
LIG_SH3_3	369	375	PF00018	0.494
LIG_SH3_3	428	434	PF00018	0.418
LIG_SH3_3	560	566	PF00018	0.737
LIG_SH3_3	623	629	PF00018	0.359
LIG_SUMO_SIM_anti_2	111	116	PF11976	0.515
LIG_SUMO_SIM_anti_2	332	339	PF11976	0.519
LIG_SUMO_SIM_anti_2	632	638	PF11976	0.447
LIG_SUMO_SIM_anti_2	725	732	PF11976	0.588
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.504
LIG_SUMO_SIM_par_1	124	131	PF11976	0.527
LIG_SUMO_SIM_par_1	145	151	PF11976	0.299
LIG_SUMO_SIM_par_1	359	365	PF11976	0.445
LIG_SUMO_SIM_par_1	544	551	PF11976	0.519
LIG_SUMO_SIM_par_1	729	736	PF11976	0.561
LIG_TRAF2_1	224	227	PF00917	0.517
LIG_TRAF2_1	330	333	PF00917	0.586
LIG_TRAF2_1	501	504	PF00917	0.655
LIG_WRC_WIRS_1	213	218	PF05994	0.493
MOD_CDC14_SPxK_1	568	571	PF00782	0.522
MOD_CDK_SPK_2	137	142	PF00069	0.454
MOD_CDK_SPxK_1	565	571	PF00069	0.556
MOD_CK1_1	362	368	PF00069	0.442
MOD_CK1_1	404	410	PF00069	0.460
MOD_CK1_1	465	471	PF00069	0.736
MOD_CK1_1	489	495	PF00069	0.617
MOD_CK1_1	547	553	PF00069	0.748
MOD_CK1_1	683	689	PF00069	0.511
MOD_CK2_1	221	227	PF00069	0.731
MOD_CK2_1	231	237	PF00069	0.706
MOD_CK2_1	304	310	PF00069	0.515
MOD_CK2_1	327	333	PF00069	0.565
MOD_CK2_1	56	62	PF00069	0.470
MOD_CK2_1	733	739	PF00069	0.508
MOD_CK2_1	747	753	PF00069	0.515
MOD_CK2_1	766	772	PF00069	0.553
MOD_CMANNOS	810	813	PF00535	0.645
MOD_GlcNHglycan	194	197	PF01048	0.776
MOD_GlcNHglycan	223	226	PF01048	0.753
MOD_GlcNHglycan	42	45	PF01048	0.592
MOD_GlcNHglycan	527	530	PF01048	0.504
MOD_GlcNHglycan	577	580	PF01048	0.534
MOD_GlcNHglycan	750	753	PF01048	0.607
MOD_GlcNHglycan	763	766	PF01048	0.495
MOD_GlcNHglycan	86	89	PF01048	0.531
MOD_GSK3_1	194	201	PF00069	0.725
MOD_GSK3_1	212	219	PF00069	0.671
MOD_GSK3_1	240	247	PF00069	0.665
MOD_GSK3_1	449	456	PF00069	0.739
MOD_GSK3_1	462	469	PF00069	0.722
MOD_GSK3_1	480	487	PF00069	0.436
MOD_GSK3_1	552	559	PF00069	0.749
MOD_GSK3_1	613	620	PF00069	0.415
MOD_GSK3_1	676	683	PF00069	0.550
MOD_LATS_1	76	82	PF00433	0.378
MOD_N-GLC_1	392	397	PF02516	0.336
MOD_NEK2_1	108	113	PF00069	0.473
MOD_NEK2_1	216	221	PF00069	0.498
MOD_NEK2_1	401	406	PF00069	0.537
MOD_NEK2_1	527	532	PF00069	0.685
MOD_NEK2_1	733	738	PF00069	0.551
MOD_NEK2_2	359	364	PF00069	0.444
MOD_NEK2_2	824	829	PF00069	0.663
MOD_PIKK_1	468	474	PF00454	0.762
MOD_PKA_1	552	558	PF00069	0.512
MOD_PKA_2	174	180	PF00069	0.680
MOD_PKA_2	220	226	PF00069	0.705
MOD_PKA_2	293	299	PF00069	0.498
MOD_PKA_2	489	495	PF00069	0.417
MOD_PKA_2	5	11	PF00069	0.582
MOD_PKA_2	535	541	PF00069	0.567
MOD_PKA_2	552	558	PF00069	0.446
MOD_PKA_2	759	765	PF00069	0.676
MOD_PKA_2	766	772	PF00069	0.607
MOD_Plk_1	653	659	PF00069	0.421
MOD_Plk_1	724	730	PF00069	0.545
MOD_Plk_2-3	304	310	PF00069	0.378
MOD_Plk_2-3	504	510	PF00069	0.504
MOD_Plk_4	108	114	PF00069	0.493
MOD_Plk_4	121	127	PF00069	0.533
MOD_Plk_4	212	218	PF00069	0.647
MOD_Plk_4	304	310	PF00069	0.406
MOD_Plk_4	333	339	PF00069	0.525
MOD_Plk_4	348	354	PF00069	0.484
MOD_Plk_4	368	374	PF00069	0.505
MOD_Plk_4	544	550	PF00069	0.601
MOD_Plk_4	557	563	PF00069	0.591
MOD_Plk_4	599	605	PF00069	0.368
MOD_Plk_4	733	739	PF00069	0.600
MOD_ProDKin_1	137	143	PF00069	0.443
MOD_ProDKin_1	256	262	PF00069	0.652
MOD_ProDKin_1	449	455	PF00069	0.676
MOD_ProDKin_1	466	472	PF00069	0.766
MOD_ProDKin_1	562	568	PF00069	0.747
MOD_ProDKin_1	617	623	PF00069	0.341
MOD_ProDKin_1	680	686	PF00069	0.578
MOD_ProDKin_1	86	92	PF00069	0.551
MOD_SUMO_rev_2	51	58	PF00179	0.589
MOD_SUMO_rev_2	59	66	PF00179	0.534
MOD_SUMO_rev_2	735	742	PF00179	0.574
TRG_DiLeu_BaEn_1	333	338	PF01217	0.306
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.335
TRG_DiLeu_BaLyEn_6	685	690	PF01217	0.545
TRG_DiLeu_BaLyEn_6	751	756	PF01217	0.425
TRG_ENDOCYTIC_2	155	158	PF00928	0.327
TRG_ENDOCYTIC_2	182	185	PF00928	0.514
TRG_ENDOCYTIC_2	400	403	PF00928	0.554
TRG_ENDOCYTIC_2	659	662	PF00928	0.335
TRG_ER_diArg_1	436	439	PF00400	0.651
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	754	759	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G5	Leptomonas seymouri	57%	93%
A0A1X0NZT3	Trypanosomatidae	34%	100%
A0A3Q8IF85	Leishmania donovani	73%	98%
A0A3R7NNU5	Trypanosoma rangeli	35%	100%
A4I4A9	Leishmania infantum	73%	98%
C9ZKL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ADQ9	Leishmania major	73%	100%
E9AM21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
V5BKD9	Trypanosoma cruzi	38%	100%