Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania braziliensis

UniProt:

A4HH64_LEIBR

TriTrypDb:

LbrM.29.0570 , LBRM2903_290011800

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HH64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH64

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.465
CLV_NRD_NRD_1	18	20	PF00675	0.516
CLV_NRD_NRD_1	227	229	PF00675	0.276
CLV_NRD_NRD_1	285	287	PF00675	0.407
CLV_NRD_NRD_1	342	344	PF00675	0.473
CLV_PCSK_KEX2_1	18	20	PF00082	0.450
CLV_PCSK_KEX2_1	285	287	PF00082	0.383
CLV_PCSK_KEX2_1	303	305	PF00082	0.389
CLV_PCSK_KEX2_1	341	343	PF00082	0.472
CLV_PCSK_KEX2_1	6	8	PF00082	0.462
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.454
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.476
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.458
CLV_PCSK_SKI1_1	167	171	PF00082	0.247
DEG_APCC_DBOX_1	356	364	PF00400	0.401
DEG_SCF_FBW7_1	127	134	PF00400	0.534
DOC_MAPK_gen_1	228	234	PF00069	0.473
DOC_MAPK_gen_1	352	360	PF00069	0.536
DOC_MAPK_MEF2A_6	214	223	PF00069	0.522
DOC_MAPK_MEF2A_6	354	362	PF00069	0.461
DOC_USP7_MATH_1	146	150	PF00917	0.564
DOC_USP7_UBL2_3	11	15	PF12436	0.622
DOC_WW_Pin1_4	127	132	PF00397	0.498
LIG_14-3-3_CanoR_1	113	118	PF00244	0.453
LIG_14-3-3_CanoR_1	208	212	PF00244	0.442
LIG_14-3-3_CanoR_1	250	254	PF00244	0.511
LIG_14-3-3_CanoR_1	342	348	PF00244	0.567
LIG_14-3-3_CanoR_1	357	361	PF00244	0.371
LIG_BIR_II_1	1	5	PF00653	0.719
LIG_BIR_III_2	145	149	PF00653	0.536
LIG_deltaCOP1_diTrp_1	176	184	PF00928	0.425
LIG_FHA_1	106	112	PF00498	0.536
LIG_FHA_1	149	155	PF00498	0.467
LIG_FHA_1	321	327	PF00498	0.606
LIG_FHA_1	357	363	PF00498	0.323
LIG_FHA_1	384	390	PF00498	0.439
LIG_FHA_1	63	69	PF00498	0.661
LIG_FHA_2	59	65	PF00498	0.763
LIG_LIR_Apic_2	119	123	PF02991	0.442
LIG_LIR_Gen_1	199	207	PF02991	0.455
LIG_LIR_Gen_1	365	374	PF02991	0.197
LIG_LIR_Gen_1	74	83	PF02991	0.445
LIG_LIR_Nem_3	116	120	PF02991	0.482
LIG_LIR_Nem_3	180	184	PF02991	0.452
LIG_LIR_Nem_3	199	205	PF02991	0.380
LIG_LIR_Nem_3	309	313	PF02991	0.583
LIG_LIR_Nem_3	365	369	PF02991	0.455
LIG_LIR_Nem_3	74	78	PF02991	0.486
LIG_MYND_1	127	131	PF01753	0.471
LIG_Pex14_2	197	201	PF04695	0.442
LIG_SH2_PTP2	120	123	PF00017	0.380
LIG_SH2_PTP2	75	78	PF00017	0.503
LIG_SH2_SRC	204	207	PF00017	0.492
LIG_SH2_SRC	75	78	PF00017	0.537
LIG_SH2_STAT3	29	32	PF00017	0.742
LIG_SH2_STAT3	373	376	PF00017	0.355
LIG_SH2_STAT5	120	123	PF00017	0.380
LIG_SH2_STAT5	204	207	PF00017	0.442
LIG_SH2_STAT5	310	313	PF00017	0.610
LIG_SH2_STAT5	373	376	PF00017	0.334
LIG_SH2_STAT5	46	49	PF00017	0.712
LIG_SH2_STAT5	75	78	PF00017	0.485
LIG_SH3_3	192	198	PF00018	0.460
LIG_SUMO_SIM_anti_2	359	365	PF11976	0.323
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.442
LIG_SUMO_SIM_par_1	102	108	PF11976	0.453
LIG_SUMO_SIM_par_1	359	365	PF11976	0.346
LIG_SUMO_SIM_par_1	74	80	PF11976	0.442
LIG_TYR_ITIM	200	205	PF00017	0.442
LIG_WRC_WIRS_1	363	368	PF05994	0.197
MOD_CK1_1	116	122	PF00069	0.456
MOD_CK1_1	387	393	PF00069	0.502
MOD_CK1_1	396	402	PF00069	0.499
MOD_CK1_1	42	48	PF00069	0.791
MOD_CK2_1	146	152	PF00069	0.484
MOD_GlcNHglycan	239	242	PF01048	0.252
MOD_GlcNHglycan	288	292	PF01048	0.442
MOD_GlcNHglycan	386	389	PF01048	0.593
MOD_GlcNHglycan	399	402	PF01048	0.570
MOD_GlcNHglycan	41	44	PF01048	0.555
MOD_GlcNHglycan	51	54	PF01048	0.579
MOD_GSK3_1	127	134	PF00069	0.550
MOD_GSK3_1	31	38	PF00069	0.745
MOD_GSK3_1	383	390	PF00069	0.480
MOD_GSK3_1	393	400	PF00069	0.376
MOD_GSK3_1	42	49	PF00069	0.710
MOD_GSK3_1	58	65	PF00069	0.768
MOD_LATS_1	328	334	PF00433	0.683
MOD_NEK2_1	394	399	PF00069	0.339
MOD_NEK2_2	168	173	PF00069	0.496
MOD_PIKK_1	131	137	PF00454	0.483
MOD_PKA_1	341	347	PF00069	0.602
MOD_PKA_2	161	167	PF00069	0.469
MOD_PKA_2	207	213	PF00069	0.442
MOD_PKA_2	249	255	PF00069	0.408
MOD_PKA_2	34	40	PF00069	0.695
MOD_PKA_2	341	347	PF00069	0.593
MOD_PKA_2	356	362	PF00069	0.502
MOD_Plk_4	116	122	PF00069	0.536
MOD_Plk_4	168	174	PF00069	0.553
MOD_Plk_4	196	202	PF00069	0.463
MOD_Plk_4	356	362	PF00069	0.536
MOD_Plk_4	390	396	PF00069	0.329
MOD_Plk_4	42	48	PF00069	0.712
MOD_ProDKin_1	127	133	PF00069	0.498
MOD_SUMO_rev_2	176	184	PF00179	0.442
TRG_ENDOCYTIC_2	202	205	PF00928	0.451
TRG_ENDOCYTIC_2	310	313	PF00928	0.594
TRG_ENDOCYTIC_2	75	78	PF00928	0.525
TRG_ER_diArg_1	284	286	PF00400	0.561
TRG_ER_diArg_1	352	355	PF00400	0.485
TRG_NES_CRM1_1	70	82	PF08389	0.498
TRG_NLS_MonoExtC_3	14	19	PF00514	0.670
TRG_NLS_MonoExtN_4	3	10	PF00514	0.749
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS5	Leptomonas seymouri	75%	99%
A0A1X0P115	Trypanosomatidae	57%	100%
A0A3R7MWK6	Trypanosoma rangeli	59%	100%
A0A3S7X264	Leishmania donovani	87%	100%
A4I4A8	Leishmania infantum	87%	100%
C9ZKL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	90%
E9ADQ8	Leishmania major	86%	100%
E9AM22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BUL7	Trypanosoma cruzi	57%	100%