Piwi domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HH63_LEIBR

TriTrypDb:

LbrM.29.0560 , LBRM2903_110008400

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH63

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.887
CLV_NRD_NRD_1	218	220	PF00675	0.825
CLV_NRD_NRD_1	31	33	PF00675	0.905
CLV_PCSK_KEX2_1	177	179	PF00082	0.841
CLV_PCSK_KEX2_1	31	33	PF00082	0.905
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.841
CLV_PCSK_SKI1_1	141	145	PF00082	0.850
CLV_PCSK_SKI1_1	225	229	PF00082	0.850
CLV_PCSK_SKI1_1	48	52	PF00082	0.859
DEG_SCF_FBW7_1	149	155	PF00400	0.847
DOC_CKS1_1	149	154	PF01111	0.845
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.833
DOC_MAPK_DCC_7	201	211	PF00069	0.834
DOC_MAPK_gen_1	177	184	PF00069	0.824
DOC_MAPK_gen_1	59	67	PF00069	0.878
DOC_MAPK_JIP1_4	201	207	PF00069	0.836
DOC_MAPK_MEF2A_6	201	209	PF00069	0.834
DOC_PP2B_LxvP_1	205	208	PF13499	0.835
DOC_USP7_MATH_1	152	156	PF00917	0.849
DOC_USP7_MATH_1	18	22	PF00917	0.881
DOC_USP7_MATH_2	118	124	PF00917	0.852
DOC_USP7_UBL2_3	55	59	PF12436	0.878
DOC_WW_Pin1_4	148	153	PF00397	0.842
LIG_14-3-3_CanoR_1	133	143	PF00244	0.852
LIG_14-3-3_CanoR_1	69	79	PF00244	0.873
LIG_BIR_III_2	203	207	PF00653	0.840
LIG_FHA_1	169	175	PF00498	0.843
LIG_FHA_1	25	31	PF00498	0.909
LIG_FHA_1	62	68	PF00498	0.882
LIG_FHA_1	94	100	PF00498	0.871
LIG_FHA_2	149	155	PF00498	0.847
LIG_FHA_2	71	77	PF00498	0.872
LIG_LIR_Nem_3	123	128	PF02991	0.861
LIG_LIR_Nem_3	147	153	PF02991	0.845
LIG_LIR_Nem_3	171	175	PF02991	0.847
LIG_Pex14_2	107	111	PF04695	0.874
LIG_PTB_Apo_2	37	44	PF02174	0.862
LIG_SH2_CRK	125	129	PF00017	0.864
LIG_SH2_CRK	196	200	PF00017	0.840
LIG_SH2_CRK	221	225	PF00017	0.840
LIG_SH2_NCK_1	150	154	PF00017	0.850
LIG_SH2_SRC	13	16	PF00017	0.891
LIG_SH2_SRC	215	218	PF00017	0.821
LIG_SH2_STAP1	217	221	PF00017	0.824
LIG_SH2_STAT3	173	176	PF00017	0.848
LIG_SH2_STAT5	150	153	PF00017	0.849
LIG_SH2_STAT5	157	160	PF00017	0.714
LIG_SH2_STAT5	173	176	PF00017	0.568
LIG_SH3_1	196	202	PF00018	0.837
LIG_SH3_3	146	152	PF00018	0.844
LIG_SH3_3	196	202	PF00018	0.837
LIG_SH3_3	97	103	PF00018	0.862
LIG_SUMO_SIM_anti_2	181	186	PF11976	0.809
LIG_UBA3_1	184	189	PF00899	0.810
LIG_WRC_WIRS_1	153	158	PF05994	0.855
MOD_CK1_1	21	27	PF00069	0.901
MOD_CK1_1	223	229	PF00069	0.849
MOD_CK1_1	61	67	PF00069	0.877
MOD_CK2_1	223	229	PF00069	0.849
MOD_CK2_1	70	76	PF00069	0.870
MOD_GlcNHglycan	122	125	PF01048	0.852
MOD_GlcNHglycan	158	161	PF01048	0.826
MOD_GSK3_1	13	20	PF00069	0.888
MOD_GSK3_1	144	151	PF00069	0.846
MOD_GSK3_1	152	159	PF00069	0.709
MOD_GSK3_1	22	29	PF00069	0.747
MOD_N-GLC_1	161	166	PF02516	0.825
MOD_N-GLC_2	193	195	PF02516	0.814
MOD_NEK2_1	156	161	PF00069	0.835
MOD_NEK2_1	23	28	PF00069	0.907
MOD_NEK2_2	152	157	PF00069	0.851
MOD_PK_1	178	184	PF00069	0.819
MOD_PKA_2	234	240	PF00069	0.839
MOD_Plk_1	161	167	PF00069	0.828
MOD_Plk_4	112	118	PF00069	0.556
MOD_Plk_4	152	158	PF00069	0.851
MOD_Plk_4	168	174	PF00069	0.559
MOD_Plk_4	61	67	PF00069	0.877
MOD_Plk_4	95	101	PF00069	0.868
MOD_ProDKin_1	148	154	PF00069	0.845
MOD_SUMO_for_1	5	8	PF00179	0.877
TRG_ENDOCYTIC_2	125	128	PF00928	0.863
TRG_ENDOCYTIC_2	150	153	PF00928	0.849
TRG_ENDOCYTIC_2	172	175	PF00928	0.843
TRG_ENDOCYTIC_2	221	224	PF00928	0.835
TRG_ER_diArg_1	233	236	PF00400	0.830
TRG_ER_diArg_1	30	32	PF00400	0.913