Zinc-finger of a C2HC-type family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type, putative

Species:

Leishmania braziliensis

UniProt:

A4HH62_LEIBR

TriTrypDb:

LbrM.29.0550 , LBRM2903_290008600 , LBRM2903_290008700

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.656
CLV_C14_Caspase3-7	67	71	PF00656	0.698
CLV_NRD_NRD_1	163	165	PF00675	0.814
CLV_NRD_NRD_1	191	193	PF00675	0.828
CLV_NRD_NRD_1	320	322	PF00675	0.678
CLV_NRD_NRD_1	332	334	PF00675	0.543
CLV_NRD_NRD_1	362	364	PF00675	0.274
CLV_NRD_NRD_1	99	101	PF00675	0.626
CLV_PCSK_KEX2_1	163	165	PF00082	0.714
CLV_PCSK_KEX2_1	191	193	PF00082	0.828
CLV_PCSK_KEX2_1	319	321	PF00082	0.641
CLV_PCSK_KEX2_1	362	364	PF00082	0.274
CLV_PCSK_KEX2_1	99	101	PF00082	0.626
CLV_PCSK_SKI1_1	20	24	PF00082	0.643
CLV_PCSK_SKI1_1	263	267	PF00082	0.415
CLV_PCSK_SKI1_1	28	32	PF00082	0.504
CLV_PCSK_SKI1_1	285	289	PF00082	0.644
DEG_APCC_DBOX_1	284	292	PF00400	0.496
DEG_SPOP_SBC_1	304	308	PF00917	0.549
DOC_CYCLIN_RxL_1	25	34	PF00134	0.358
DOC_MAPK_gen_1	270	278	PF00069	0.431
DOC_MAPK_gen_1	283	290	PF00069	0.484
DOC_MAPK_MEF2A_6	231	238	PF00069	0.759
DOC_USP7_MATH_1	139	143	PF00917	0.508
DOC_USP7_MATH_1	158	162	PF00917	0.550
DOC_USP7_MATH_1	180	184	PF00917	0.773
DOC_USP7_MATH_1	303	307	PF00917	0.762
DOC_USP7_MATH_1	344	348	PF00917	0.740
DOC_USP7_MATH_1	356	360	PF00917	0.377
DOC_USP7_MATH_1	88	92	PF00917	0.523
DOC_WW_Pin1_4	147	152	PF00397	0.599
DOC_WW_Pin1_4	31	36	PF00397	0.534
LIG_14-3-3_CanoR_1	10	17	PF00244	0.641
LIG_14-3-3_CanoR_1	100	108	PF00244	0.523
LIG_14-3-3_CanoR_1	191	196	PF00244	0.612
LIG_14-3-3_CanoR_1	20	30	PF00244	0.541
LIG_14-3-3_CanoR_1	285	291	PF00244	0.638
LIG_14-3-3_CanoR_1	319	329	PF00244	0.789
LIG_14-3-3_CanoR_1	362	369	PF00244	0.349
LIG_14-3-3_CanoR_1	53	61	PF00244	0.553
LIG_14-3-3_CanoR_1	78	85	PF00244	0.572
LIG_Actin_WH2_2	34	49	PF00022	0.637
LIG_APCC_ABBAyCdc20_2	8	14	PF00400	0.503
LIG_BIR_II_1	1	5	PF00653	0.785
LIG_BIR_III_2	117	121	PF00653	0.514
LIG_BRCT_BRCA1_1	149	153	PF00533	0.533
LIG_FHA_1	170	176	PF00498	0.765
LIG_FHA_1	25	31	PF00498	0.630
LIG_FHA_1	253	259	PF00498	0.244
LIG_FHA_1	92	98	PF00498	0.558
LIG_FHA_2	150	156	PF00498	0.528
LIG_FHA_2	264	270	PF00498	0.342
LIG_FHA_2	32	38	PF00498	0.639
LIG_LIR_Gen_1	150	160	PF02991	0.691
LIG_LIR_Gen_1	37	48	PF02991	0.538
LIG_LIR_LC3C_4	172	176	PF02991	0.544
LIG_LIR_Nem_3	37	43	PF02991	0.547
LIG_SH2_NCK_1	203	207	PF00017	0.675
LIG_SH2_NCK_1	212	216	PF00017	0.663
LIG_SH3_1	242	248	PF00018	0.244
LIG_SH3_2	315	320	PF14604	0.728
LIG_SH3_3	229	235	PF00018	0.649
LIG_SH3_3	242	248	PF00018	0.352
LIG_SH3_3	312	318	PF00018	0.725
LIG_SH3_3	352	358	PF00018	0.411
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.547
LIG_SUMO_SIM_par_1	172	178	PF11976	0.547
LIG_SUMO_SIM_par_1	234	240	PF11976	0.750
MOD_CK1_1	112	118	PF00069	0.698
MOD_CK1_1	126	132	PF00069	0.716
MOD_CK1_1	24	30	PF00069	0.539
MOD_CK1_1	378	384	PF00069	0.485
MOD_CK1_1	91	97	PF00069	0.613
MOD_CK2_1	263	269	PF00069	0.342
MOD_Cter_Amidation	360	363	PF01082	0.274
MOD_Cter_Amidation	97	100	PF01082	0.628
MOD_GlcNHglycan	125	128	PF01048	0.517
MOD_GlcNHglycan	141	144	PF01048	0.461
MOD_GlcNHglycan	177	180	PF01048	0.817
MOD_GlcNHglycan	213	216	PF01048	0.500
MOD_GlcNHglycan	335	338	PF01048	0.542
MOD_GlcNHglycan	48	51	PF01048	0.503
MOD_GlcNHglycan	72	75	PF01048	0.527
MOD_GSK3_1	207	214	PF00069	0.644
MOD_GSK3_1	277	284	PF00069	0.510
MOD_GSK3_1	66	73	PF00069	0.596
MOD_NEK2_1	208	213	PF00069	0.749
MOD_NEK2_1	30	35	PF00069	0.530
MOD_NEK2_1	46	51	PF00069	0.514
MOD_NEK2_1	72	77	PF00069	0.463
MOD_NEK2_2	158	163	PF00069	0.549
MOD_PIKK_1	186	192	PF00454	0.821
MOD_PIKK_1	76	82	PF00454	0.479
MOD_PKA_1	191	197	PF00069	0.806
MOD_PKA_1	319	325	PF00069	0.638
MOD_PKA_1	333	339	PF00069	0.538
MOD_PKA_1	362	368	PF00069	0.244
MOD_PKA_2	191	197	PF00069	0.737
MOD_PKA_2	319	325	PF00069	0.735
MOD_PKA_2	362	368	PF00069	0.312
MOD_PKA_2	378	384	PF00069	0.394
MOD_PKA_2	46	52	PF00069	0.426
MOD_PKB_1	8	16	PF00069	0.484
MOD_Plk_1	109	115	PF00069	0.653
MOD_Plk_4	109	115	PF00069	0.525
MOD_Plk_4	286	292	PF00069	0.506
MOD_Plk_4	344	350	PF00069	0.472
MOD_ProDKin_1	147	153	PF00069	0.601
MOD_ProDKin_1	31	37	PF00069	0.531
MOD_SUMO_for_1	327	330	PF00179	0.636
MOD_SUMO_rev_2	237	244	PF00179	0.655
MOD_SUMO_rev_2	280	284	PF00179	0.456
TRG_AP2beta_CARGO_1	37	47	PF09066	0.541
TRG_DiLeu_BaEn_1	170	175	PF01217	0.538
TRG_DiLeu_BaEn_1	25	30	PF01217	0.524
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.386
TRG_ER_diArg_1	162	164	PF00400	0.552
TRG_ER_diArg_1	191	193	PF00400	0.828
TRG_ER_diArg_1	318	321	PF00400	0.632
TRG_ER_diArg_1	362	364	PF00400	0.274
TRG_ER_diArg_1	8	11	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM20	Leptomonas seymouri	36%	100%
A0A3S7X263	Leishmania donovani	67%	100%
A4I482	Leishmania infantum	67%	100%
E9ADN1	Leishmania major	65%	100%
E9AM49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%