Histone H1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H1

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH60_LEIBR

TriTrypDb:

LbrM.29.0530 , LBRM2903_290008400

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005643	nuclear pore	3	1
GO:0020023	kinetoplast	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HH60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.596
CLV_NRD_NRD_1	137	139	PF00675	0.689
CLV_NRD_NRD_1	142	144	PF00675	0.652
CLV_NRD_NRD_1	152	154	PF00675	0.505
CLV_NRD_NRD_1	192	194	PF00675	0.621
CLV_NRD_NRD_1	47	49	PF00675	0.612
CLV_PCSK_KEX2_1	107	109	PF00082	0.592
CLV_PCSK_KEX2_1	191	193	PF00082	0.626
CLV_PCSK_KEX2_1	47	49	PF00082	0.612
CLV_PCSK_SKI1_1	143	147	PF00082	0.548
CLV_PCSK_SKI1_1	80	84	PF00082	0.498
DEG_SPOP_SBC_1	100	104	PF00917	0.662
DOC_CKS1_1	81	86	PF01111	0.670
DOC_PP2B_LxvP_1	19	22	PF13499	0.426
DOC_USP7_MATH_1	100	104	PF00917	0.582
DOC_USP7_MATH_1	129	133	PF00917	0.613
DOC_USP7_MATH_1	152	156	PF00917	0.758
DOC_USP7_MATH_1	206	210	PF00917	0.660
DOC_USP7_UBL2_3	144	148	PF12436	0.591
DOC_USP7_UBL2_3	182	186	PF12436	0.639
DOC_USP7_UBL2_3	222	226	PF12436	0.469
DOC_USP7_UBL2_3	87	91	PF12436	0.519
DOC_WW_Pin1_4	101	106	PF00397	0.594
DOC_WW_Pin1_4	111	116	PF00397	0.608
DOC_WW_Pin1_4	121	126	PF00397	0.652
DOC_WW_Pin1_4	133	138	PF00397	0.631
DOC_WW_Pin1_4	148	153	PF00397	0.631
DOC_WW_Pin1_4	158	163	PF00397	0.678
DOC_WW_Pin1_4	166	171	PF00397	0.612
DOC_WW_Pin1_4	172	177	PF00397	0.708
DOC_WW_Pin1_4	184	189	PF00397	0.666
DOC_WW_Pin1_4	210	215	PF00397	0.542
DOC_WW_Pin1_4	59	64	PF00397	0.569
DOC_WW_Pin1_4	80	85	PF00397	0.619
DOC_WW_Pin1_4	93	98	PF00397	0.538
LIG_14-3-3_CanoR_1	107	115	PF00244	0.604
LIG_14-3-3_CanoR_1	121	125	PF00244	0.692
LIG_14-3-3_CanoR_1	153	162	PF00244	0.596
LIG_14-3-3_CanoR_1	47	54	PF00244	0.503
LIG_FHA_1	38	44	PF00498	0.600
LIG_FHA_1	49	55	PF00498	0.599
LIG_FHA_2	121	127	PF00498	0.570
LIG_FHA_2	8	14	PF00498	0.557
LIG_Pex14_2	3	7	PF04695	0.414
LIG_Rb_pABgroove_1	21	29	PF01858	0.456
LIG_SH2_CRK	70	74	PF00017	0.486
LIG_SH2_NCK_1	9	13	PF00017	0.551
LIG_SH2_STAP1	70	74	PF00017	0.446
LIG_SH2_STAT5	9	12	PF00017	0.524
LIG_SH3_2	81	86	PF14604	0.507
LIG_SH3_3	175	181	PF00018	0.633
LIG_SH3_3	202	208	PF00018	0.517
LIG_SH3_3	78	84	PF00018	0.502
LIG_SH3_4	182	189	PF00018	0.586
MOD_CDC14_SPxK_1	104	107	PF00782	0.515
MOD_CDC14_SPxK_1	114	117	PF00782	0.612
MOD_CDC14_SPxK_1	118	121	PF00782	0.629
MOD_CDC14_SPxK_1	151	154	PF00782	0.653
MOD_CDC14_SPxK_1	161	164	PF00782	0.712
MOD_CDC14_SPxK_1	169	172	PF00782	0.572
MOD_CDC14_SPxK_1	96	99	PF00782	0.648
MOD_CDK_SPK_2	133	138	PF00069	0.600
MOD_CDK_SPK_2	148	153	PF00069	0.555
MOD_CDK_SPK_2	158	163	PF00069	0.742
MOD_CDK_SPK_2	210	215	PF00069	0.545
MOD_CDK_SPxK_1	101	107	PF00069	0.643
MOD_CDK_SPxK_1	111	117	PF00069	0.589
MOD_CDK_SPxK_1	133	139	PF00069	0.601
MOD_CDK_SPxK_1	148	154	PF00069	0.559
MOD_CDK_SPxK_1	158	164	PF00069	0.681
MOD_CDK_SPxK_1	166	172	PF00069	0.566
MOD_CDK_SPxK_1	80	86	PF00069	0.668
MOD_CDK_SPxK_1	93	99	PF00069	0.634
MOD_CDK_SPxxK_3	101	108	PF00069	0.515
MOD_CDK_SPxxK_3	184	191	PF00069	0.525
MOD_CDK_SPxxK_3	80	87	PF00069	0.507
MOD_CK1_1	103	109	PF00069	0.575
MOD_CK1_1	132	138	PF00069	0.684
MOD_CK1_1	157	163	PF00069	0.676
MOD_CK1_1	49	55	PF00069	0.670
MOD_CK1_1	76	82	PF00069	0.662
MOD_CK1_1	93	99	PF00069	0.652
MOD_CK2_1	120	126	PF00069	0.561
MOD_CK2_1	7	13	PF00069	0.566
MOD_Cter_Amidation	189	192	PF01082	0.528
MOD_DYRK1A_RPxSP_1	121	125	PF00069	0.617
MOD_DYRK1A_RPxSP_1	172	176	PF00069	0.675
MOD_GlcNHglycan	242	245	PF01048	0.435
MOD_GlcNHglycan	55	58	PF01048	0.608
MOD_GlcNHglycan	75	78	PF01048	0.544
MOD_GSK3_1	107	114	PF00069	0.527
MOD_GSK3_1	128	135	PF00069	0.702
MOD_GSK3_1	148	155	PF00069	0.657
MOD_GSK3_1	191	198	PF00069	0.779
MOD_GSK3_1	206	213	PF00069	0.516
MOD_GSK3_1	46	53	PF00069	0.626
MOD_GSK3_1	59	66	PF00069	0.521
MOD_GSK3_1	69	76	PF00069	0.640
MOD_GSK3_1	91	98	PF00069	0.617
MOD_GSK3_1	99	106	PF00069	0.671
MOD_NEK2_1	7	12	PF00069	0.432
MOD_NEK2_1	73	78	PF00069	0.605
MOD_NEK2_1	90	95	PF00069	0.590
MOD_PIKK_1	63	69	PF00454	0.589
MOD_PK_1	226	232	PF00069	0.552
MOD_PKA_1	107	113	PF00069	0.518
MOD_PKA_1	153	159	PF00069	0.745
MOD_PKA_1	191	197	PF00069	0.681
MOD_PKA_1	47	53	PF00069	0.605
MOD_PKA_2	107	113	PF00069	0.534
MOD_PKA_2	120	126	PF00069	0.655
MOD_PKA_2	152	158	PF00069	0.600
MOD_PKA_2	191	197	PF00069	0.654
MOD_PKA_2	46	52	PF00069	0.619
MOD_PKB_1	191	199	PF00069	0.627
MOD_Plk_1	226	232	PF00069	0.552
MOD_Plk_4	237	243	PF00069	0.407
MOD_Plk_4	69	75	PF00069	0.584
MOD_ProDKin_1	101	107	PF00069	0.596
MOD_ProDKin_1	111	117	PF00069	0.613
MOD_ProDKin_1	121	127	PF00069	0.651
MOD_ProDKin_1	133	139	PF00069	0.633
MOD_ProDKin_1	148	154	PF00069	0.635
MOD_ProDKin_1	158	164	PF00069	0.681
MOD_ProDKin_1	166	172	PF00069	0.613
MOD_ProDKin_1	184	190	PF00069	0.666
MOD_ProDKin_1	210	216	PF00069	0.536
MOD_ProDKin_1	59	65	PF00069	0.567
MOD_ProDKin_1	80	86	PF00069	0.622
MOD_ProDKin_1	93	99	PF00069	0.542
MOD_SUMO_for_1	33	36	PF00179	0.465
TRG_ENDOCYTIC_2	24	27	PF00928	0.715
TRG_ENDOCYTIC_2	70	73	PF00928	0.486
TRG_ER_diArg_1	191	193	PF00400	0.708
TRG_ER_diArg_1	46	48	PF00400	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS3	Leptomonas seymouri	45%	97%
A0A1X0NZQ5	Trypanosomatidae	31%	77%
A0A3S5H7K5	Leishmania donovani	74%	100%
E9ADM9	Leishmania major	73%	100%
E9AM51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
V5DLD7	Trypanosoma cruzi	36%	94%