Tubulin-tyrosine ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin-tyrosine ligase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HH59_LEIBR

TriTrypDb:

LbrM.29.0520 , LBRM2903_290008300

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HH59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH59

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0018095	protein polyglutamylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018200	peptidyl-glutamic acid modification	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0016874	ligase activity	2	5
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016881	acid-amino acid ligase activity	4	1
GO:0070739	protein-glutamic acid ligase activity	3	1
GO:0070740	tubulin-glutamic acid ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.479
CLV_MEL_PAP_1	137	143	PF00089	0.430
CLV_NRD_NRD_1	160	162	PF00675	0.244
CLV_NRD_NRD_1	167	169	PF00675	0.244
CLV_NRD_NRD_1	185	187	PF00675	0.188
CLV_NRD_NRD_1	277	279	PF00675	0.323
CLV_NRD_NRD_1	315	317	PF00675	0.625
CLV_NRD_NRD_1	453	455	PF00675	0.364
CLV_NRD_NRD_1	471	473	PF00675	0.442
CLV_NRD_NRD_1	588	590	PF00675	0.455
CLV_NRD_NRD_1	631	633	PF00675	0.512
CLV_PCSK_KEX2_1	167	169	PF00082	0.273
CLV_PCSK_KEX2_1	185	187	PF00082	0.273
CLV_PCSK_KEX2_1	276	278	PF00082	0.335
CLV_PCSK_KEX2_1	315	317	PF00082	0.625
CLV_PCSK_KEX2_1	45	47	PF00082	0.648
CLV_PCSK_KEX2_1	452	454	PF00082	0.399
CLV_PCSK_KEX2_1	471	473	PF00082	0.460
CLV_PCSK_KEX2_1	588	590	PF00082	0.455
CLV_PCSK_KEX2_1	631	633	PF00082	0.531
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.339
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.685
CLV_PCSK_PC7_1	273	279	PF00082	0.339
CLV_PCSK_SKI1_1	161	165	PF00082	0.260
CLV_PCSK_SKI1_1	204	208	PF00082	0.171
CLV_PCSK_SKI1_1	228	232	PF00082	0.340
CLV_PCSK_SKI1_1	241	245	PF00082	0.310
CLV_PCSK_SKI1_1	288	292	PF00082	0.318
CLV_PCSK_SKI1_1	315	319	PF00082	0.464
CLV_PCSK_SKI1_1	332	336	PF00082	0.539
CLV_PCSK_SKI1_1	382	386	PF00082	0.317
CLV_PCSK_SKI1_1	588	592	PF00082	0.440
CLV_Separin_Metazoa	344	348	PF03568	0.502
CLV_Separin_Metazoa	468	472	PF03568	0.507
DEG_APCC_DBOX_1	29	37	PF00400	0.642
DEG_APCC_DBOX_1	338	346	PF00400	0.627
DEG_Nend_Nbox_1	1	3	PF02207	0.613
DEG_SPOP_SBC_1	58	62	PF00917	0.611
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.552
DOC_MAPK_DCC_7	501	510	PF00069	0.539
DOC_MAPK_gen_1	167	175	PF00069	0.422
DOC_MAPK_gen_1	276	284	PF00069	0.506
DOC_MAPK_gen_1	28	35	PF00069	0.558
DOC_MAPK_gen_1	295	303	PF00069	0.447
DOC_MAPK_gen_1	452	461	PF00069	0.235
DOC_MAPK_HePTP_8	451	463	PF00069	0.241
DOC_MAPK_MEF2A_6	277	286	PF00069	0.493
DOC_MAPK_MEF2A_6	295	303	PF00069	0.358
DOC_MAPK_MEF2A_6	347	356	PF00069	0.446
DOC_MAPK_MEF2A_6	454	463	PF00069	0.221
DOC_MAPK_NFAT4_5	296	304	PF00069	0.552
DOC_PP1_RVXF_1	160	167	PF00149	0.473
DOC_PP1_RVXF_1	239	246	PF00149	0.552
DOC_PP1_RVXF_1	88	95	PF00149	0.492
DOC_PP2B_LxvP_1	124	127	PF13499	0.280
DOC_PP2B_LxvP_1	208	211	PF13499	0.552
DOC_PP2B_LxvP_1	328	331	PF13499	0.475
DOC_PP2B_LxvP_1	395	398	PF13499	0.565
DOC_PP4_FxxP_1	326	329	PF00568	0.480
DOC_USP7_MATH_1	16	20	PF00917	0.538
DOC_USP7_MATH_1	322	326	PF00917	0.685
DOC_USP7_MATH_1	434	438	PF00917	0.504
DOC_USP7_MATH_1	527	531	PF00917	0.518
DOC_USP7_MATH_1	58	62	PF00917	0.755
DOC_USP7_MATH_1	596	600	PF00917	0.589
DOC_USP7_MATH_1	7	11	PF00917	0.647
DOC_WW_Pin1_4	197	202	PF00397	0.501
DOC_WW_Pin1_4	318	323	PF00397	0.722
DOC_WW_Pin1_4	512	517	PF00397	0.447
LIG_14-3-3_CanoR_1	119	123	PF00244	0.506
LIG_14-3-3_CanoR_1	204	209	PF00244	0.454
LIG_14-3-3_CanoR_1	259	264	PF00244	0.539
LIG_14-3-3_CanoR_1	315	320	PF00244	0.717
LIG_14-3-3_CanoR_1	339	349	PF00244	0.414
LIG_14-3-3_CanoR_1	9	17	PF00244	0.415
LIG_Actin_WH2_2	487	503	PF00022	0.505
LIG_Actin_WH2_2	521	536	PF00022	0.520
LIG_APCC_ABBA_1	282	287	PF00400	0.539
LIG_APCC_ABBA_1	354	359	PF00400	0.444
LIG_BRCT_BRCA1_1	4	8	PF00533	0.414
LIG_Clathr_ClatBox_1	493	497	PF01394	0.462
LIG_eIF4E_1	285	291	PF01652	0.500
LIG_FHA_1	100	106	PF00498	0.573
LIG_FHA_1	119	125	PF00498	0.444
LIG_FHA_1	205	211	PF00498	0.471
LIG_FHA_1	534	540	PF00498	0.518
LIG_FHA_2	249	255	PF00498	0.539
LIG_FHA_2	267	273	PF00498	0.382
LIG_FHA_2	520	526	PF00498	0.473
LIG_FHA_2	93	99	PF00498	0.514
LIG_LIR_Apic_2	325	329	PF02991	0.477
LIG_LIR_Apic_2	367	372	PF02991	0.414
LIG_LIR_Gen_1	203	212	PF02991	0.552
LIG_LIR_Gen_1	213	220	PF02991	0.518
LIG_LIR_Gen_1	489	499	PF02991	0.522
LIG_LIR_Gen_1	80	89	PF02991	0.371
LIG_LIR_Nem_3	203	208	PF02991	0.552
LIG_LIR_Nem_3	213	217	PF02991	0.518
LIG_LIR_Nem_3	489	494	PF02991	0.521
LIG_LIR_Nem_3	535	540	PF02991	0.452
LIG_LIR_Nem_3	80	85	PF02991	0.354
LIG_NRBOX	168	174	PF00104	0.371
LIG_NRBOX	300	306	PF00104	0.552
LIG_PCNA_PIPBox_1	199	208	PF02747	0.371
LIG_REV1ctd_RIR_1	242	248	PF16727	0.500
LIG_SH2_CRK	147	151	PF00017	0.518
LIG_SH2_CRK	17	21	PF00017	0.425
LIG_SH2_CRK	369	373	PF00017	0.462
LIG_SH2_CRK	82	86	PF00017	0.353
LIG_SH2_NCK_1	369	373	PF00017	0.453
LIG_SH2_PTP2	302	305	PF00017	0.526
LIG_SH2_SRC	396	399	PF00017	0.560
LIG_SH2_STAP1	557	561	PF00017	0.547
LIG_SH2_STAT3	51	54	PF00017	0.482
LIG_SH2_STAT5	17	20	PF00017	0.627
LIG_SH2_STAT5	285	288	PF00017	0.448
LIG_SH2_STAT5	302	305	PF00017	0.444
LIG_SH2_STAT5	396	399	PF00017	0.560
LIG_SH3_1	412	418	PF00018	0.432
LIG_SH3_3	107	113	PF00018	0.311
LIG_SH3_3	117	123	PF00018	0.639
LIG_SH3_3	283	289	PF00018	0.444
LIG_SH3_3	316	322	PF00018	0.557
LIG_SH3_3	327	333	PF00018	0.641
LIG_SH3_3	412	418	PF00018	0.675
LIG_SUMO_SIM_anti_2	465	471	PF11976	0.342
LIG_SUMO_SIM_par_1	302	308	PF11976	0.536
LIG_SUMO_SIM_par_1	506	511	PF11976	0.371
LIG_SUMO_SIM_par_1	625	630	PF11976	0.531
LIG_TRAF2_1	269	272	PF00917	0.466
LIG_TYR_ITSM	78	85	PF00017	0.380
LIG_UBA3_1	169	178	PF00899	0.482
LIG_WRC_WIRS_1	3	8	PF05994	0.415
MOD_CDK_SPxxK_3	197	204	PF00069	0.371
MOD_CK1_1	135	141	PF00069	0.358
MOD_CK1_1	213	219	PF00069	0.457
MOD_CK2_1	197	203	PF00069	0.560
MOD_CK2_1	248	254	PF00069	0.557
MOD_CK2_1	266	272	PF00069	0.404
MOD_CK2_1	462	468	PF00069	0.268
MOD_CK2_1	486	492	PF00069	0.539
MOD_CK2_1	57	63	PF00069	0.681
MOD_Cter_Amidation	293	296	PF01082	0.300
MOD_GlcNHglycan	432	435	PF01048	0.477
MOD_GlcNHglycan	464	467	PF01048	0.339
MOD_GlcNHglycan	594	597	PF01048	0.571
MOD_GSK3_1	132	139	PF00069	0.439
MOD_GSK3_1	16	23	PF00069	0.688
MOD_GSK3_1	231	238	PF00069	0.371
MOD_GSK3_1	311	318	PF00069	0.642
MOD_GSK3_1	430	437	PF00069	0.495
MOD_GSK3_1	592	599	PF00069	0.453
MOD_GSK3_1	92	99	PF00069	0.476
MOD_N-GLC_1	512	517	PF02516	0.253
MOD_N-GLC_2	376	378	PF02516	0.291
MOD_NEK2_1	20	25	PF00069	0.510
MOD_NEK2_1	305	310	PF00069	0.444
MOD_NEK2_1	317	322	PF00069	0.578
MOD_NEK2_1	438	443	PF00069	0.515
MOD_NEK2_1	519	524	PF00069	0.482
MOD_NEK2_1	533	538	PF00069	0.450
MOD_NEK2_1	539	544	PF00069	0.518
MOD_NEK2_1	8	13	PF00069	0.652
MOD_NEK2_2	447	452	PF00069	0.255
MOD_OFUCOSY	15	22	PF10250	0.420
MOD_PKA_1	315	321	PF00069	0.718
MOD_PKA_2	118	124	PF00069	0.551
MOD_PKA_2	258	264	PF00069	0.539
MOD_PKA_2	315	321	PF00069	0.705
MOD_PKA_2	533	539	PF00069	0.552
MOD_PKA_2	77	83	PF00069	0.526
MOD_PKA_2	8	14	PF00069	0.417
MOD_Plk_1	132	138	PF00069	0.399
MOD_Plk_1	228	234	PF00069	0.371
MOD_Plk_2-3	266	272	PF00069	0.513
MOD_Plk_4	132	138	PF00069	0.375
MOD_Plk_4	20	26	PF00069	0.425
MOD_Plk_4	391	397	PF00069	0.552
MOD_Plk_4	434	440	PF00069	0.492
MOD_Plk_4	459	465	PF00069	0.325
MOD_Plk_4	514	520	PF00069	0.462
MOD_Plk_4	528	534	PF00069	0.460
MOD_ProDKin_1	197	203	PF00069	0.501
MOD_ProDKin_1	318	324	PF00069	0.724
MOD_ProDKin_1	512	518	PF00069	0.447
MOD_SUMO_rev_2	558	567	PF00179	0.562
TRG_DiLeu_BaEn_1	572	577	PF01217	0.455
TRG_DiLeu_BaEn_3	570	576	PF01217	0.420
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.500
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.486
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.484
TRG_ENDOCYTIC_2	147	150	PF00928	0.518
TRG_ENDOCYTIC_2	153	156	PF00928	0.518
TRG_ENDOCYTIC_2	17	20	PF00928	0.426
TRG_ENDOCYTIC_2	302	305	PF00928	0.444
TRG_ENDOCYTIC_2	82	85	PF00928	0.341
TRG_ER_diArg_1	166	168	PF00400	0.505
TRG_ER_diArg_1	315	317	PF00400	0.527
TRG_ER_diArg_1	451	454	PF00400	0.387
TRG_ER_diArg_1	470	472	PF00400	0.438
TRG_ER_diArg_1	587	589	PF00400	0.455
TRG_ER_diArg_1	631	633	PF00400	0.542
TRG_NES_CRM1_1	457	473	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH77	Leptomonas seymouri	55%	100%
A0A0S4IUG9	Bodo saltans	26%	68%
A0A0S4JH38	Bodo saltans	33%	100%
A0A1X0P0Y5	Trypanosomatidae	38%	100%
A0A3S7X261	Leishmania donovani	76%	100%
A0A422N064	Trypanosoma rangeli	44%	100%
A4H9E1	Leishmania braziliensis	22%	100%
A4HXR2	Leishmania infantum	22%	100%
A4I479	Leishmania infantum	75%	100%
A4Q9E4	Mus musculus	22%	100%
A4Q9F6	Mus musculus	26%	79%
B6DTF7	Bodo saltans	24%	100%
C9ZI96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	93%
C9ZKP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZPR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZYH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	96%
D0A044	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ADM8	Leishmania major	76%	100%
E9AM52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9ARH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
Q4QE05	Leishmania major	22%	100%
Q8N841	Homo sapiens	26%	75%
V5ARK1	Trypanosoma cruzi	26%	100%
V5B4U2	Trypanosoma cruzi	42%	100%