FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH57_LEIBR

TriTrypDb:

LbrM.29.0500 , LBRM2903_290008800

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HH57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.441
CLV_NRD_NRD_1	188	190	PF00675	0.470
CLV_NRD_NRD_1	343	345	PF00675	0.411
CLV_NRD_NRD_1	71	73	PF00675	0.552
CLV_PCSK_KEX2_1	114	116	PF00082	0.462
CLV_PCSK_KEX2_1	71	73	PF00082	0.552
CLV_PCSK_SKI1_1	101	105	PF00082	0.442
CLV_PCSK_SKI1_1	231	235	PF00082	0.417
CLV_PCSK_SKI1_1	272	276	PF00082	0.322
CLV_PCSK_SKI1_1	51	55	PF00082	0.441
DEG_APCC_DBOX_1	135	143	PF00400	0.387
DEG_Nend_UBRbox_4	1	3	PF02207	0.488
DEG_SPOP_SBC_1	122	126	PF00917	0.447
DOC_ANK_TNKS_1	39	46	PF00023	0.440
DOC_PP1_RVXF_1	49	56	PF00149	0.574
DOC_PP2B_LxvP_1	41	44	PF13499	0.613
DOC_PP2B_LxvP_1	60	63	PF13499	0.366
DOC_PP4_FxxP_1	175	178	PF00568	0.473
DOC_USP7_MATH_1	166	170	PF00917	0.679
DOC_USP7_MATH_1	219	223	PF00917	0.307
DOC_USP7_MATH_1	250	254	PF00917	0.203
DOC_USP7_MATH_1	274	278	PF00917	0.381
DOC_USP7_UBL2_3	186	190	PF12436	0.483
DOC_WW_Pin1_4	118	123	PF00397	0.413
DOC_WW_Pin1_4	130	135	PF00397	0.341
DOC_WW_Pin1_4	257	262	PF00397	0.385
LIG_14-3-3_CanoR_1	276	286	PF00244	0.230
LIG_14-3-3_CterR_2	350	352	PF00244	0.350
LIG_BRCT_BRCA1_1	172	176	PF00533	0.476
LIG_Clathr_ClatBox_1	307	311	PF01394	0.203
LIG_eIF4E_1	21	27	PF01652	0.617
LIG_FHA_1	123	129	PF00498	0.622
LIG_FHA_1	142	148	PF00498	0.291
LIG_FHA_1	172	178	PF00498	0.446
LIG_FHA_1	22	28	PF00498	0.516
LIG_FHA_1	300	306	PF00498	0.417
LIG_FHA_1	327	333	PF00498	0.307
LIG_FHA_1	48	54	PF00498	0.392
LIG_FHA_1	85	91	PF00498	0.384
LIG_FHA_2	102	108	PF00498	0.460
LIG_FHA_2	12	18	PF00498	0.465
LIG_FHA_2	328	334	PF00498	0.288
LIG_LIR_Apic_2	173	178	PF02991	0.488
LIG_LIR_Gen_1	193	202	PF02991	0.441
LIG_LIR_Gen_1	280	290	PF02991	0.357
LIG_LIR_Gen_1	98	106	PF02991	0.451
LIG_LIR_Nem_3	179	183	PF02991	0.329
LIG_LIR_Nem_3	193	197	PF02991	0.435
LIG_LIR_Nem_3	198	202	PF02991	0.453
LIG_LIR_Nem_3	237	243	PF02991	0.385
LIG_LIR_Nem_3	280	286	PF02991	0.357
LIG_LIR_Nem_3	98	102	PF02991	0.453
LIG_LYPXL_yS_3	56	59	PF13949	0.527
LIG_MLH1_MIPbox_1	172	176	PF16413	0.485
LIG_NRBOX	26	32	PF00104	0.404
LIG_SH2_CRK	143	147	PF00017	0.477
LIG_SH2_CRK	180	184	PF00017	0.435
LIG_SH2_CRK	194	198	PF00017	0.420
LIG_SH2_GRB2like	194	197	PF00017	0.486
LIG_SH2_STAP1	143	147	PF00017	0.412
LIG_SH2_STAT5	143	146	PF00017	0.449
LIG_SH2_STAT5	243	246	PF00017	0.378
LIG_SH2_STAT5	346	349	PF00017	0.329
LIG_SH2_STAT5	99	102	PF00017	0.454
LIG_SH3_2	131	136	PF14604	0.354
LIG_SH3_3	125	131	PF00018	0.518
LIG_SH3_3	253	259	PF00018	0.329
LIG_SH3_3	33	39	PF00018	0.654
LIG_SH3_3	41	47	PF00018	0.671
LIG_SUMO_SIM_par_1	306	313	PF11976	0.288
LIG_TRAF2_2	63	68	PF00917	0.514
LIG_TYR_ITIM	97	102	PF00017	0.465
LIG_UBA3_1	182	190	PF00899	0.490
MOD_CDC14_SPxK_1	133	136	PF00782	0.351
MOD_CDK_SPK_2	257	262	PF00069	0.203
MOD_CDK_SPxK_1	130	136	PF00069	0.372
MOD_CK1_1	121	127	PF00069	0.575
MOD_CK1_1	156	162	PF00069	0.645
MOD_CK1_1	170	176	PF00069	0.575
MOD_CK1_1	220	226	PF00069	0.203
MOD_CK1_1	277	283	PF00069	0.378
MOD_CK1_1	58	64	PF00069	0.375
MOD_CK1_1	84	90	PF00069	0.548
MOD_CK1_1	92	98	PF00069	0.371
MOD_CK2_1	101	107	PF00069	0.462
MOD_CK2_1	11	17	PF00069	0.470
MOD_CK2_1	321	327	PF00069	0.213
MOD_CMANNOS	113	116	PF00535	0.454
MOD_GlcNHglycan	155	158	PF01048	0.560
MOD_GlcNHglycan	162	165	PF01048	0.621
MOD_GlcNHglycan	291	294	PF01048	0.351
MOD_GlcNHglycan	296	300	PF01048	0.301
MOD_GlcNHglycan	323	326	PF01048	0.298
MOD_GlcNHglycan	73	77	PF01048	0.547
MOD_GlcNHglycan	83	86	PF01048	0.590
MOD_GSK3_1	101	108	PF00069	0.383
MOD_GSK3_1	118	125	PF00069	0.667
MOD_GSK3_1	156	163	PF00069	0.548
MOD_GSK3_1	166	173	PF00069	0.645
MOD_GSK3_1	21	28	PF00069	0.612
MOD_GSK3_1	220	227	PF00069	0.279
MOD_GSK3_1	274	281	PF00069	0.203
MOD_GSK3_1	295	302	PF00069	0.387
MOD_GSK3_1	309	316	PF00069	0.288
MOD_GSK3_1	327	334	PF00069	0.338
MOD_GSK3_1	81	88	PF00069	0.724
MOD_N-GLC_1	195	200	PF02516	0.497
MOD_N-GLC_1	313	318	PF02516	0.288
MOD_NEK2_1	167	172	PF00069	0.519
MOD_NEK2_1	26	31	PF00069	0.577
MOD_NEK2_1	268	273	PF00069	0.378
MOD_NEK2_1	278	283	PF00069	0.264
MOD_NEK2_1	286	291	PF00069	0.172
MOD_NEK2_1	310	315	PF00069	0.307
MOD_NEK2_1	326	331	PF00069	0.375
MOD_NEK2_1	339	344	PF00069	0.268
MOD_PIKK_1	168	174	PF00454	0.389
MOD_PIKK_1	220	226	PF00454	0.459
MOD_Plk_1	195	201	PF00069	0.457
MOD_Plk_1	286	292	PF00069	0.421
MOD_Plk_1	295	301	PF00069	0.381
MOD_Plk_1	326	332	PF00069	0.378
MOD_Plk_2-3	327	333	PF00069	0.367
MOD_Plk_4	105	111	PF00069	0.328
MOD_Plk_4	11	17	PF00069	0.474
MOD_Plk_4	171	177	PF00069	0.535
MOD_Plk_4	26	32	PF00069	0.374
MOD_Plk_4	278	284	PF00069	0.217
MOD_Plk_4	327	333	PF00069	0.312
MOD_Plk_4	55	61	PF00069	0.414
MOD_Plk_4	92	98	PF00069	0.509
MOD_ProDKin_1	118	124	PF00069	0.419
MOD_ProDKin_1	130	136	PF00069	0.340
MOD_ProDKin_1	257	263	PF00069	0.385
MOD_SUMO_rev_2	187	192	PF00179	0.330
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.617
TRG_ENDOCYTIC_2	143	146	PF00928	0.478
TRG_ENDOCYTIC_2	180	183	PF00928	0.440
TRG_ENDOCYTIC_2	194	197	PF00928	0.379
TRG_ENDOCYTIC_2	346	349	PF00928	0.329
TRG_ENDOCYTIC_2	56	59	PF00928	0.527
TRG_ENDOCYTIC_2	99	102	PF00928	0.370
TRG_ER_diArg_1	113	115	PF00400	0.447
TRG_ER_diArg_1	38	41	PF00400	0.619
TRG_ER_diArg_1	70	72	PF00400	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9L3	Leptomonas seymouri	56%	100%
A0A1X0NZG4	Trypanosomatidae	34%	100%
A0A3S7X221	Leishmania donovani	80%	100%
A0A422N067	Trypanosoma rangeli	33%	100%
A4I483	Leishmania infantum	80%	100%
C9ZKP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ADN2	Leishmania major	78%	100%
E9AM48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5BPX7	Trypanosoma cruzi	32%	100%