Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania braziliensis

UniProt:

A4HH56_LEIBR

TriTrypDb:

LbrM.29.0490 , LBRM2903_290011700

Length:

881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HH56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH56

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	446	450	PF00656	0.605
CLV_NRD_NRD_1	150	152	PF00675	0.494
CLV_NRD_NRD_1	270	272	PF00675	0.326
CLV_NRD_NRD_1	293	295	PF00675	0.446
CLV_NRD_NRD_1	553	555	PF00675	0.565
CLV_PCSK_FUR_1	680	684	PF00082	0.313
CLV_PCSK_KEX2_1	293	295	PF00082	0.446
CLV_PCSK_KEX2_1	552	554	PF00082	0.535
CLV_PCSK_KEX2_1	682	684	PF00082	0.313
CLV_PCSK_KEX2_1	690	692	PF00082	0.261
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.313
CLV_PCSK_PC1ET2_1	690	692	PF00082	0.261
CLV_PCSK_PC7_1	678	684	PF00082	0.313
CLV_PCSK_SKI1_1	151	155	PF00082	0.449
CLV_PCSK_SKI1_1	22	26	PF00082	0.524
CLV_PCSK_SKI1_1	272	276	PF00082	0.350
CLV_PCSK_SKI1_1	485	489	PF00082	0.544
CLV_PCSK_SKI1_1	690	694	PF00082	0.237
CLV_PCSK_SKI1_1	726	730	PF00082	0.268
CLV_PCSK_SKI1_1	779	783	PF00082	0.374
CLV_Separin_Metazoa	268	272	PF03568	0.472
CLV_Separin_Metazoa	549	553	PF03568	0.534
DEG_APCC_DBOX_1	150	158	PF00400	0.423
DEG_SCF_FBW7_1	383	390	PF00400	0.580
DEG_SCF_FBW7_2	29	35	PF00400	0.550
DEG_SCF_FBW7_2	507	513	PF00400	0.575
DEG_SPOP_SBC_1	373	377	PF00917	0.672
DEG_SPOP_SBC_1	382	386	PF00917	0.583
DEG_SPOP_SBC_1	402	406	PF00917	0.515
DEG_SPOP_SBC_1	458	462	PF00917	0.655
DEG_SPOP_SBC_1	534	538	PF00917	0.511
DOC_ANK_TNKS_1	87	94	PF00023	0.686
DOC_CKS1_1	29	34	PF01111	0.602
DOC_CKS1_1	357	362	PF01111	0.631
DOC_CKS1_1	507	512	PF01111	0.573
DOC_CKS1_1	92	97	PF01111	0.676
DOC_CYCLIN_RxL_1	149	160	PF00134	0.569
DOC_CYCLIN_RxL_1	266	279	PF00134	0.420
DOC_CYCLIN_yClb1_LxF_4	822	827	PF00134	0.381
DOC_CYCLIN_yCln2_LP_2	626	632	PF00134	0.587
DOC_MAPK_gen_1	206	215	PF00069	0.521
DOC_MAPK_gen_1	293	301	PF00069	0.487
DOC_MAPK_MEF2A_6	801	810	PF00069	0.468
DOC_PP1_RVXF_1	433	440	PF00149	0.541
DOC_PP2B_LxvP_1	785	788	PF13499	0.459
DOC_PP2B_LxvP_1	844	847	PF13499	0.576
DOC_PP4_FxxP_1	676	679	PF00568	0.468
DOC_USP7_MATH_1	111	115	PF00917	0.535
DOC_USP7_MATH_1	117	121	PF00917	0.526
DOC_USP7_MATH_1	146	150	PF00917	0.715
DOC_USP7_MATH_1	207	211	PF00917	0.633
DOC_USP7_MATH_1	231	235	PF00917	0.574
DOC_USP7_MATH_1	246	250	PF00917	0.647
DOC_USP7_MATH_1	317	321	PF00917	0.674
DOC_USP7_MATH_1	340	344	PF00917	0.674
DOC_USP7_MATH_1	373	377	PF00917	0.567
DOC_USP7_MATH_1	382	386	PF00917	0.577
DOC_USP7_MATH_1	442	446	PF00917	0.585
DOC_USP7_MATH_1	458	462	PF00917	0.707
DOC_USP7_MATH_1	48	52	PF00917	0.534
DOC_USP7_MATH_1	520	524	PF00917	0.646
DOC_USP7_MATH_1	534	538	PF00917	0.515
DOC_USP7_MATH_1	563	567	PF00917	0.700
DOC_WW_Pin1_4	107	112	PF00397	0.507
DOC_WW_Pin1_4	115	120	PF00397	0.668
DOC_WW_Pin1_4	128	133	PF00397	0.552
DOC_WW_Pin1_4	199	204	PF00397	0.623
DOC_WW_Pin1_4	28	33	PF00397	0.625
DOC_WW_Pin1_4	294	299	PF00397	0.629
DOC_WW_Pin1_4	332	337	PF00397	0.500
DOC_WW_Pin1_4	356	361	PF00397	0.633
DOC_WW_Pin1_4	383	388	PF00397	0.596
DOC_WW_Pin1_4	406	411	PF00397	0.699
DOC_WW_Pin1_4	422	427	PF00397	0.559
DOC_WW_Pin1_4	437	442	PF00397	0.698
DOC_WW_Pin1_4	471	476	PF00397	0.611
DOC_WW_Pin1_4	485	490	PF00397	0.719
DOC_WW_Pin1_4	506	511	PF00397	0.580
DOC_WW_Pin1_4	525	530	PF00397	0.740
DOC_WW_Pin1_4	57	62	PF00397	0.647
DOC_WW_Pin1_4	580	585	PF00397	0.564
DOC_WW_Pin1_4	611	616	PF00397	0.721
DOC_WW_Pin1_4	618	623	PF00397	0.531
DOC_WW_Pin1_4	861	866	PF00397	0.566
DOC_WW_Pin1_4	91	96	PF00397	0.624
LIG_14-3-3_CanoR_1	18	22	PF00244	0.541
LIG_14-3-3_CanoR_1	209	216	PF00244	0.517
LIG_14-3-3_CanoR_1	235	243	PF00244	0.531
LIG_14-3-3_CanoR_1	293	298	PF00244	0.611
LIG_14-3-3_CanoR_1	374	383	PF00244	0.551
LIG_14-3-3_CanoR_1	435	440	PF00244	0.763
LIG_14-3-3_CanoR_1	552	561	PF00244	0.555
LIG_14-3-3_CanoR_1	715	722	PF00244	0.513
LIG_14-3-3_CanoR_1	857	865	PF00244	0.555
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_BIR_III_2	862	866	PF00653	0.489
LIG_BRCT_BRCA1_1	435	439	PF00533	0.686
LIG_BRCT_BRCA1_1	538	542	PF00533	0.592
LIG_BRCT_BRCA1_1	67	71	PF00533	0.540
LIG_Clathr_ClatBox_1	633	637	PF01394	0.365
LIG_CtBP_PxDLS_1	734	738	PF00389	0.468
LIG_deltaCOP1_diTrp_1	256	267	PF00928	0.513
LIG_FHA_1	279	285	PF00498	0.485
LIG_FHA_1	387	393	PF00498	0.590
LIG_FHA_1	569	575	PF00498	0.551
LIG_FHA_1	618	624	PF00498	0.451
LIG_FHA_1	85	91	PF00498	0.683
LIG_FHA_2	161	167	PF00498	0.393
LIG_FHA_2	252	258	PF00498	0.543
LIG_FHA_2	295	301	PF00498	0.680
LIG_FHA_2	386	392	PF00498	0.520
LIG_FHA_2	493	499	PF00498	0.752
LIG_FHA_2	544	550	PF00498	0.612
LIG_FHA_2	639	645	PF00498	0.468
LIG_FHA_2	814	820	PF00498	0.303
LIG_FHA_2	873	879	PF00498	0.508
LIG_Integrin_isoDGR_2	81	83	PF01839	0.653
LIG_LIR_Apic_2	618	622	PF02991	0.529
LIG_LIR_Gen_1	257	267	PF02991	0.446
LIG_LIR_Gen_1	500	511	PF02991	0.517
LIG_LIR_Gen_1	631	640	PF02991	0.303
LIG_LIR_Gen_1	672	681	PF02991	0.468
LIG_LIR_Gen_1	766	771	PF02991	0.458
LIG_LIR_Gen_1	816	825	PF02991	0.382
LIG_LIR_Nem_3	257	263	PF02991	0.466
LIG_LIR_Nem_3	500	506	PF02991	0.531
LIG_LIR_Nem_3	631	635	PF02991	0.301
LIG_LIR_Nem_3	656	660	PF02991	0.503
LIG_LIR_Nem_3	672	676	PF02991	0.503
LIG_LIR_Nem_3	766	770	PF02991	0.482
LIG_LIR_Nem_3	816	820	PF02991	0.388
LIG_Pex14_2	71	75	PF04695	0.569
LIG_Pex14_2	713	717	PF04695	0.413
LIG_Pex14_2	753	757	PF04695	0.468
LIG_Pex14_2	767	771	PF04695	0.468
LIG_SH2_CRK	619	623	PF00017	0.531
LIG_SH2_NCK_1	176	180	PF00017	0.359
LIG_SH2_SRC	518	521	PF00017	0.654
LIG_SH2_STAP1	304	308	PF00017	0.542
LIG_SH2_STAP1	54	58	PF00017	0.553
LIG_SH2_STAP1	630	634	PF00017	0.330
LIG_SH2_STAT5	619	622	PF00017	0.668
LIG_SH2_STAT5	632	635	PF00017	0.298
LIG_SH2_STAT5	650	653	PF00017	0.468
LIG_SH3_3	306	312	PF00018	0.593
LIG_SH3_3	34	40	PF00018	0.597
LIG_SH3_3	343	349	PF00018	0.608
LIG_SH3_3	354	360	PF00018	0.624
LIG_SH3_3	367	373	PF00018	0.610
LIG_SH3_3	438	444	PF00018	0.639
LIG_SH3_3	504	510	PF00018	0.584
LIG_SH3_3	514	520	PF00018	0.578
LIG_SH3_3	591	597	PF00018	0.523
LIG_SH3_3	609	615	PF00018	0.529
LIG_SH3_3	89	95	PF00018	0.621
LIG_SH3_CIN85_PxpxPR_1	489	494	PF14604	0.542
LIG_SUMO_SIM_anti_2	631	637	PF11976	0.303
LIG_SUMO_SIM_par_1	631	637	PF11976	0.303
LIG_SUMO_SIM_par_1	656	663	PF11976	0.509
LIG_TRAF2_1	254	257	PF00917	0.560
LIG_TRAF2_1	546	549	PF00917	0.544
LIG_TRAF2_1	641	644	PF00917	0.468
LIG_TRAF2_1	705	708	PF00917	0.468
LIG_TYR_ITIM	756	761	PF00017	0.503
LIG_WRC_WIRS_1	685	690	PF05994	0.433
MOD_CDK_SPK_2	525	530	PF00069	0.501
MOD_CDK_SPxxK_3	199	206	PF00069	0.545
MOD_CK1_1	138	144	PF00069	0.618
MOD_CK1_1	177	183	PF00069	0.517
MOD_CK1_1	234	240	PF00069	0.608
MOD_CK1_1	358	364	PF00069	0.571
MOD_CK1_1	376	382	PF00069	0.612
MOD_CK1_1	385	391	PF00069	0.576
MOD_CK1_1	406	412	PF00069	0.533
MOD_CK1_1	445	451	PF00069	0.613
MOD_CK1_1	467	473	PF00069	0.747
MOD_CK1_1	523	529	PF00069	0.646
MOD_CK1_1	568	574	PF00069	0.515
MOD_CK1_1	57	63	PF00069	0.629
MOD_CK1_1	579	585	PF00069	0.640
MOD_CK1_1	618	624	PF00069	0.526
MOD_CK1_1	849	855	PF00069	0.597
MOD_CK1_1	861	867	PF00069	0.562
MOD_CK1_1	869	875	PF00069	0.538
MOD_CK2_1	160	166	PF00069	0.405
MOD_CK2_1	190	196	PF00069	0.528
MOD_CK2_1	251	257	PF00069	0.559
MOD_CK2_1	492	498	PF00069	0.744
MOD_CK2_1	543	549	PF00069	0.556
MOD_CK2_1	638	644	PF00069	0.468
MOD_CK2_1	702	708	PF00069	0.513
MOD_CK2_1	71	77	PF00069	0.586
MOD_CK2_1	813	819	PF00069	0.383
MOD_CK2_1	870	876	PF00069	0.575
MOD_DYRK1A_RPxSP_1	128	132	PF00069	0.605
MOD_DYRK1A_RPxSP_1	294	298	PF00069	0.482
MOD_GlcNHglycan	1	4	PF01048	0.748
MOD_GlcNHglycan	102	105	PF01048	0.619
MOD_GlcNHglycan	107	110	PF01048	0.628
MOD_GlcNHglycan	144	147	PF01048	0.565
MOD_GlcNHglycan	148	151	PF01048	0.507
MOD_GlcNHglycan	168	171	PF01048	0.299
MOD_GlcNHglycan	224	227	PF01048	0.573
MOD_GlcNHglycan	231	234	PF01048	0.543
MOD_GlcNHglycan	332	335	PF01048	0.520
MOD_GlcNHglycan	361	364	PF01048	0.605
MOD_GlcNHglycan	379	382	PF01048	0.578
MOD_GlcNHglycan	405	408	PF01048	0.656
MOD_GlcNHglycan	468	472	PF01048	0.711
MOD_GlcNHglycan	520	523	PF01048	0.666
MOD_GlcNHglycan	538	541	PF01048	0.520
MOD_GlcNHglycan	554	557	PF01048	0.468
MOD_GlcNHglycan	567	570	PF01048	0.648
MOD_GlcNHglycan	603	606	PF01048	0.514
MOD_GlcNHglycan	794	797	PF01048	0.303
MOD_GlcNHglycan	840	843	PF01048	0.661
MOD_GlcNHglycan	851	854	PF01048	0.553
MOD_GlcNHglycan	868	871	PF01048	0.672
MOD_GlcNHglycan	872	875	PF01048	0.777
MOD_GSK3_1	107	114	PF00069	0.576
MOD_GSK3_1	122	129	PF00069	0.776
MOD_GSK3_1	138	145	PF00069	0.661
MOD_GSK3_1	227	234	PF00069	0.735
MOD_GSK3_1	355	362	PF00069	0.636
MOD_GSK3_1	372	379	PF00069	0.600
MOD_GSK3_1	38	45	PF00069	0.771
MOD_GSK3_1	381	388	PF00069	0.773
MOD_GSK3_1	402	409	PF00069	0.688
MOD_GSK3_1	433	440	PF00069	0.592
MOD_GSK3_1	443	450	PF00069	0.647
MOD_GSK3_1	467	474	PF00069	0.548
MOD_GSK3_1	505	512	PF00069	0.582
MOD_GSK3_1	520	527	PF00069	0.585
MOD_GSK3_1	56	63	PF00069	0.585
MOD_GSK3_1	561	568	PF00069	0.549
MOD_GSK3_1	576	583	PF00069	0.722
MOD_GSK3_1	597	604	PF00069	0.547
MOD_GSK3_1	607	614	PF00069	0.675
MOD_GSK3_1	65	72	PF00069	0.630
MOD_GSK3_1	830	837	PF00069	0.557
MOD_GSK3_1	866	873	PF00069	0.606
MOD_LATS_1	98	104	PF00433	0.528
MOD_N-GLC_1	396	401	PF02516	0.674
MOD_N-GLC_1	601	606	PF02516	0.500
MOD_NEK2_1	102	107	PF00069	0.535
MOD_NEK2_1	27	32	PF00069	0.641
MOD_NEK2_1	524	529	PF00069	0.681
MOD_NEK2_1	535	540	PF00069	0.620
MOD_NEK2_1	561	566	PF00069	0.568
MOD_NEK2_1	601	606	PF00069	0.570
MOD_NEK2_1	617	622	PF00069	0.666
MOD_NEK2_1	71	76	PF00069	0.588
MOD_NEK2_1	717	722	PF00069	0.468
MOD_NEK2_1	771	776	PF00069	0.468
MOD_NEK2_1	830	835	PF00069	0.657
MOD_NEK2_2	17	22	PF00069	0.477
MOD_NEK2_2	459	464	PF00069	0.679
MOD_PIKK_1	473	479	PF00454	0.606
MOD_PIKK_1	492	498	PF00454	0.687
MOD_PIKK_1	771	777	PF00454	0.513
MOD_PKA_1	293	299	PF00069	0.479
MOD_PKA_1	552	558	PF00069	0.554
MOD_PKA_1	690	696	PF00069	0.453
MOD_PKA_2	17	23	PF00069	0.560
MOD_PKA_2	208	214	PF00069	0.557
MOD_PKA_2	234	240	PF00069	0.527
MOD_PKA_2	293	299	PF00069	0.479
MOD_PKA_2	373	379	PF00069	0.675
MOD_PKA_2	552	558	PF00069	0.550
MOD_PKA_2	690	696	PF00069	0.413
MOD_PKA_2	858	864	PF00069	0.570
MOD_Plk_1	54	60	PF00069	0.638
MOD_Plk_1	683	689	PF00069	0.433
MOD_Plk_2-3	160	166	PF00069	0.405
MOD_Plk_4	102	108	PF00069	0.536
MOD_Plk_4	340	346	PF00069	0.576
MOD_Plk_4	520	526	PF00069	0.761
MOD_Plk_4	583	589	PF00069	0.591
MOD_Plk_4	71	77	PF00069	0.609
MOD_Plk_4	802	808	PF00069	0.468
MOD_ProDKin_1	107	113	PF00069	0.505
MOD_ProDKin_1	115	121	PF00069	0.670
MOD_ProDKin_1	128	134	PF00069	0.553
MOD_ProDKin_1	199	205	PF00069	0.615
MOD_ProDKin_1	28	34	PF00069	0.626
MOD_ProDKin_1	294	300	PF00069	0.633
MOD_ProDKin_1	332	338	PF00069	0.500
MOD_ProDKin_1	356	362	PF00069	0.633
MOD_ProDKin_1	383	389	PF00069	0.596
MOD_ProDKin_1	406	412	PF00069	0.699
MOD_ProDKin_1	422	428	PF00069	0.560
MOD_ProDKin_1	437	443	PF00069	0.698
MOD_ProDKin_1	471	477	PF00069	0.611
MOD_ProDKin_1	485	491	PF00069	0.720
MOD_ProDKin_1	506	512	PF00069	0.578
MOD_ProDKin_1	525	531	PF00069	0.742
MOD_ProDKin_1	57	63	PF00069	0.648
MOD_ProDKin_1	580	586	PF00069	0.565
MOD_ProDKin_1	611	617	PF00069	0.548
MOD_ProDKin_1	618	624	PF00069	0.529
MOD_ProDKin_1	861	867	PF00069	0.569
MOD_ProDKin_1	91	97	PF00069	0.624
TRG_DiLeu_BaEn_2	671	677	PF01217	0.468
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.489
TRG_ENDOCYTIC_2	562	565	PF00928	0.565
TRG_ENDOCYTIC_2	630	633	PF00928	0.335
TRG_ENDOCYTIC_2	758	761	PF00928	0.478
TRG_ER_diArg_1	292	294	PF00400	0.400
TRG_ER_diArg_1	416	419	PF00400	0.551
TRG_ER_diArg_1	551	554	PF00400	0.537
TRG_ER_diArg_1	677	680	PF00400	0.468
TRG_ER_diArg_1	857	860	PF00400	0.503
TRG_NES_CRM1_1	653	667	PF08389	0.424
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U4	Leptomonas seymouri	49%	77%
A0A3S7X257	Leishmania donovani	74%	100%
A4I4A7	Leishmania infantum	74%	100%
E9ADQ6	Leishmania major	73%	100%
E9AM24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%