Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania braziliensis

UniProt:

A4HH55_LEIBR

TriTrypDb:

LbrM.29.0480 , LBRM2903_290011600

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HH55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH55

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.656
CLV_C14_Caspase3-7	139	143	PF00656	0.611
CLV_C14_Caspase3-7	347	351	PF00656	0.516
CLV_NRD_NRD_1	146	148	PF00675	0.631
CLV_NRD_NRD_1	151	153	PF00675	0.630
CLV_NRD_NRD_1	341	343	PF00675	0.276
CLV_NRD_NRD_1	373	375	PF00675	0.248
CLV_NRD_NRD_1	427	429	PF00675	0.298
CLV_NRD_NRD_1	496	498	PF00675	0.558
CLV_NRD_NRD_1	506	508	PF00675	0.490
CLV_PCSK_KEX2_1	219	221	PF00082	0.483
CLV_PCSK_KEX2_1	341	343	PF00082	0.293
CLV_PCSK_KEX2_1	373	375	PF00082	0.293
CLV_PCSK_KEX2_1	427	429	PF00082	0.288
CLV_PCSK_KEX2_1	491	493	PF00082	0.630
CLV_PCSK_KEX2_1	496	498	PF00082	0.668
CLV_PCSK_KEX2_1	505	507	PF00082	0.630
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.437
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.611
CLV_PCSK_PC7_1	215	221	PF00082	0.522
CLV_PCSK_PC7_1	492	498	PF00082	0.527
CLV_PCSK_PC7_1	501	507	PF00082	0.484
CLV_PCSK_SKI1_1	152	156	PF00082	0.634
CLV_PCSK_SKI1_1	219	223	PF00082	0.464
DEG_APCC_DBOX_1	120	128	PF00400	0.579
DEG_SPOP_SBC_1	41	45	PF00917	0.525
DEG_SPOP_SBC_1	78	82	PF00917	0.644
DOC_CKS1_1	206	211	PF01111	0.472
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.375
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.398
DOC_PP2B_LxvP_1	105	108	PF13499	0.535
DOC_SPAK_OSR1_1	131	135	PF12202	0.522
DOC_USP7_MATH_1	157	161	PF00917	0.652
DOC_USP7_MATH_1	184	188	PF00917	0.665
DOC_USP7_MATH_1	239	243	PF00917	0.467
DOC_USP7_MATH_1	27	31	PF00917	0.625
DOC_USP7_MATH_1	34	38	PF00917	0.559
DOC_USP7_MATH_1	354	358	PF00917	0.476
DOC_USP7_MATH_1	41	45	PF00917	0.644
DOC_USP7_MATH_1	78	82	PF00917	0.646
DOC_WW_Pin1_4	19	24	PF00397	0.590
DOC_WW_Pin1_4	205	210	PF00397	0.477
DOC_WW_Pin1_4	53	58	PF00397	0.642
DOC_WW_Pin1_4	67	72	PF00397	0.561
DOC_WW_Pin1_4	79	84	PF00397	0.638
LIG_14-3-3_CanoR_1	3	8	PF00244	0.543
LIG_14-3-3_CanoR_1	399	403	PF00244	0.479
LIG_14-3-3_CanoR_1	412	420	PF00244	0.479
LIG_14-3-3_CanoR_1	79	83	PF00244	0.532
LIG_Actin_WH2_2	249	265	PF00022	0.486
LIG_Actin_WH2_2	369	385	PF00022	0.476
LIG_APCC_ABBAyCdc20_2	341	347	PF00400	0.486
LIG_BIR_II_1	1	5	PF00653	0.431
LIG_BRCT_BRCA1_1	402	406	PF00533	0.476
LIG_BRCT_BRCA1_1	420	424	PF00533	0.380
LIG_BRCT_BRCA1_1	81	85	PF00533	0.523
LIG_deltaCOP1_diTrp_1	367	375	PF00928	0.479
LIG_FHA_1	167	173	PF00498	0.534
LIG_FHA_1	257	263	PF00498	0.480
LIG_FHA_1	412	418	PF00498	0.447
LIG_FHA_1	433	439	PF00498	0.486
LIG_FHA_1	99	105	PF00498	0.526
LIG_HP1_1	253	257	PF01393	0.486
LIG_Integrin_RGD_1	463	465	PF01839	0.467
LIG_LIR_Gen_1	130	136	PF02991	0.527
LIG_LIR_Nem_3	130	135	PF02991	0.522
LIG_LIR_Nem_3	251	255	PF02991	0.448
LIG_LIR_Nem_3	267	271	PF02991	0.592
LIG_LIR_Nem_3	387	391	PF02991	0.488
LIG_PCNA_yPIPBox_3	407	417	PF02747	0.486
LIG_Pex14_1	323	327	PF04695	0.486
LIG_SH2_CRK	393	397	PF00017	0.486
LIG_SH2_GRB2like	395	398	PF00017	0.486
LIG_SH2_PTP2	271	274	PF00017	0.455
LIG_SH2_PTP2	395	398	PF00017	0.486
LIG_SH2_SRC	395	398	PF00017	0.522
LIG_SH2_STAP1	402	406	PF00017	0.486
LIG_SH2_STAT5	271	274	PF00017	0.464
LIG_SH2_STAT5	395	398	PF00017	0.522
LIG_SH3_3	196	202	PF00018	0.656
LIG_SH3_3	20	26	PF00018	0.576
LIG_SH3_3	210	216	PF00018	0.511
LIG_SH3_3	240	246	PF00018	0.505
LIG_SH3_3	383	389	PF00018	0.580
LIG_SH3_3	80	86	PF00018	0.572
LIG_SUMO_SIM_par_1	251	259	PF11976	0.508
LIG_SUMO_SIM_par_1	293	299	PF11976	0.509
LIG_TRAF2_1	183	186	PF00917	0.542
LIG_TRAF2_1	473	476	PF00917	0.472
LIG_TYR_ITIM	391	396	PF00017	0.479
MOD_CDK_SPK_2	53	58	PF00069	0.609
MOD_CK1_1	165	171	PF00069	0.554
MOD_CK1_1	22	28	PF00069	0.616
MOD_CK1_1	490	496	PF00069	0.615
MOD_CK1_1	51	57	PF00069	0.626
MOD_CK1_1	81	87	PF00069	0.653
MOD_CK1_1	98	104	PF00069	0.521
MOD_CK2_1	165	171	PF00069	0.778
MOD_CK2_1	179	185	PF00069	0.623
MOD_Cter_Amidation	425	428	PF01082	0.286
MOD_Cter_Amidation	503	506	PF01082	0.517
MOD_DYRK1A_RPxSP_1	79	83	PF00069	0.532
MOD_GlcNHglycan	159	162	PF01048	0.658
MOD_GlcNHglycan	164	167	PF01048	0.614
MOD_GlcNHglycan	181	184	PF01048	0.571
MOD_GlcNHglycan	191	194	PF01048	0.790
MOD_GlcNHglycan	239	242	PF01048	0.260
MOD_GlcNHglycan	29	32	PF01048	0.611
MOD_GlcNHglycan	356	359	PF01048	0.276
MOD_GlcNHglycan	429	432	PF01048	0.255
MOD_GlcNHglycan	64	67	PF01048	0.649
MOD_GlcNHglycan	89	92	PF01048	0.577
MOD_GSK3_1	152	159	PF00069	0.602
MOD_GSK3_1	162	169	PF00069	0.676
MOD_GSK3_1	185	192	PF00069	0.634
MOD_GSK3_1	278	285	PF00069	0.479
MOD_GSK3_1	463	470	PF00069	0.442
MOD_GSK3_1	47	54	PF00069	0.678
MOD_GSK3_1	77	84	PF00069	0.653
MOD_GSK3_1	95	102	PF00069	0.546
MOD_N-GLC_1	117	122	PF02516	0.572
MOD_N-GLC_1	354	359	PF02516	0.276
MOD_NEK2_1	127	132	PF00069	0.596
MOD_NEK2_1	136	141	PF00069	0.565
MOD_NEK2_1	234	239	PF00069	0.486
MOD_NEK2_1	35	40	PF00069	0.521
MOD_NEK2_1	467	472	PF00069	0.394
MOD_NEK2_1	484	489	PF00069	0.463
MOD_NEK2_1	96	101	PF00069	0.519
MOD_NEK2_2	239	244	PF00069	0.486
MOD_OFUCOSY	232	238	PF10250	0.247
MOD_PIKK_1	146	152	PF00454	0.612
MOD_PIKK_1	170	176	PF00454	0.637
MOD_PIKK_1	288	294	PF00454	0.488
MOD_PIKK_1	99	105	PF00454	0.656
MOD_PKA_1	152	158	PF00069	0.613
MOD_PKA_1	427	433	PF00069	0.451
MOD_PKA_2	146	152	PF00069	0.643
MOD_PKA_2	398	404	PF00069	0.479
MOD_PKA_2	411	417	PF00069	0.479
MOD_PKA_2	427	433	PF00069	0.474
MOD_PKA_2	78	84	PF00069	0.530
MOD_Plk_1	184	190	PF00069	0.557
MOD_Plk_1	377	383	PF00069	0.430
MOD_Plk_1	48	54	PF00069	0.512
MOD_Plk_1	484	490	PF00069	0.490
MOD_Plk_2-3	185	191	PF00069	0.570
MOD_Plk_4	185	191	PF00069	0.692
MOD_Plk_4	377	383	PF00069	0.450
MOD_Plk_4	463	469	PF00069	0.400
MOD_ProDKin_1	19	25	PF00069	0.595
MOD_ProDKin_1	205	211	PF00069	0.474
MOD_ProDKin_1	53	59	PF00069	0.641
MOD_ProDKin_1	67	73	PF00069	0.559
MOD_ProDKin_1	79	85	PF00069	0.638
MOD_SUMO_for_1	336	339	PF00179	0.486
MOD_SUMO_for_1	46	49	PF00179	0.512
TRG_DiLeu_BaEn_1	185	190	PF01217	0.573
TRG_DiLeu_BaEn_2	338	344	PF01217	0.486
TRG_DiLeu_BaEn_4	185	191	PF01217	0.504
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.496
TRG_ENDOCYTIC_2	345	348	PF00928	0.463
TRG_ENDOCYTIC_2	393	396	PF00928	0.479
TRG_ENDOCYTIC_2	481	484	PF00928	0.457
TRG_ER_diArg_1	341	343	PF00400	0.476
TRG_ER_diArg_1	372	374	PF00400	0.486
TRG_ER_diArg_1	505	507	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.247
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G3	Leptomonas seymouri	61%	96%
A0A3R7M512	Trypanosoma rangeli	45%	100%
A0A3S7X262	Leishmania donovani	79%	100%
A4I4A6	Leishmania infantum	78%	100%
E9ADQ5	Leishmania major	78%	99%
E9AM22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AM25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%