Peptidase_S15 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH53_LEIBR

TriTrypDb:

LbrM.29.0460 , LBRM2903_290011300

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.566
CLV_PCSK_SKI1_1	216	220	PF00082	0.609
CLV_PCSK_SKI1_1	45	49	PF00082	0.528
DEG_Nend_UBRbox_3	1	3	PF02207	0.687
DEG_ODPH_VHL_1	126	139	PF01847	0.496
DEG_SPOP_SBC_1	207	211	PF00917	0.609
DEG_SPOP_SBC_1	80	84	PF00917	0.526
DOC_CDC14_PxL_1	126	134	PF14671	0.619
DOC_CDC14_PxL_1	30	38	PF14671	0.646
DOC_CYCLIN_RxL_1	213	222	PF00134	0.606
DOC_USP7_MATH_1	156	160	PF00917	0.663
DOC_USP7_MATH_1	18	22	PF00917	0.619
DOC_USP7_MATH_1	207	211	PF00917	0.574
DOC_WW_Pin1_4	167	172	PF00397	0.569
DOC_WW_Pin1_4	81	86	PF00397	0.524
LIG_BRCT_BRCA1_1	210	214	PF00533	0.588
LIG_eIF4E_1	134	140	PF01652	0.613
LIG_EVH1_2	34	38	PF00568	0.649
LIG_FHA_1	121	127	PF00498	0.547
LIG_FHA_1	181	187	PF00498	0.586
LIG_FHA_1	210	216	PF00498	0.592
LIG_FHA_1	26	32	PF00498	0.487
LIG_FHA_1	68	74	PF00498	0.595
LIG_FHA_2	46	52	PF00498	0.533
LIG_LIR_Apic_2	98	102	PF02991	0.510
LIG_LIR_Gen_1	15	25	PF02991	0.602
LIG_LIR_Nem_3	15	20	PF02991	0.651
LIG_LIR_Nem_3	32	36	PF02991	0.510
LIG_LYPXL_yS_3	33	36	PF13949	0.649
LIG_MYND_1	190	194	PF01753	0.507
LIG_SH2_NCK_1	134	138	PF00017	0.508
LIG_SH2_NCK_1	46	50	PF00017	0.564
LIG_SH2_SRC	134	137	PF00017	0.642
LIG_SH2_SRC	144	147	PF00017	0.653
LIG_SH2_STAP1	46	50	PF00017	0.529
LIG_SH2_STAT5	144	147	PF00017	0.691
LIG_SH2_STAT5	152	155	PF00017	0.602
LIG_SH3_3	122	128	PF00018	0.523
LIG_SH3_3	150	156	PF00018	0.609
LIG_SH3_3	183	189	PF00018	0.599
LIG_SH3_3	196	202	PF00018	0.479
LIG_TYR_ITIM	132	137	PF00017	0.487
LIG_TYR_ITIM	31	36	PF00017	0.681
MOD_CDK_SPxxK_3	167	174	PF00069	0.571
MOD_CK1_1	209	215	PF00069	0.592
MOD_CK2_1	160	166	PF00069	0.701
MOD_GlcNHglycan	147	150	PF01048	0.713
MOD_GlcNHglycan	158	161	PF01048	0.632
MOD_GSK3_1	156	163	PF00069	0.677
MOD_GSK3_1	188	195	PF00069	0.556
MOD_GSK3_1	37	44	PF00069	0.637
MOD_GSK3_1	57	64	PF00069	0.709
MOD_GSK3_1	8	15	PF00069	0.617
MOD_NEK2_1	208	213	PF00069	0.598
MOD_NEK2_1	214	219	PF00069	0.545
MOD_PIKK_1	192	198	PF00454	0.497
MOD_PIKK_1	57	63	PF00454	0.711
MOD_PIKK_1	67	73	PF00454	0.588
MOD_Plk_1	18	24	PF00069	0.685
MOD_Plk_4	12	18	PF00069	0.583
MOD_ProDKin_1	167	173	PF00069	0.573
MOD_ProDKin_1	81	87	PF00069	0.529
MOD_SUMO_for_1	78	81	PF00179	0.583
TRG_DiLeu_BaEn_1	135	140	PF01217	0.584
TRG_ENDOCYTIC_2	134	137	PF00928	0.586
TRG_ENDOCYTIC_2	22	25	PF00928	0.665
TRG_ENDOCYTIC_2	33	36	PF00928	0.661
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IR44	Leishmania donovani	65%	96%
A4I4A4	Leishmania infantum	65%	96%
E9ADQ3	Leishmania major	61%	96%
E9AM27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	96%