Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH50_LEIBR

TriTrypDb:

LbrM.29.0430 , LBRM2903_290011000

Length:

364

Annotations

LeishMANIAdb annotations

Specific to Kinetoplastids, with fairly unique fold and uncertain topology

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HH50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	241	243	PF00675	0.481
CLV_NRD_NRD_1	70	72	PF00675	0.433
CLV_PCSK_KEX2_1	189	191	PF00082	0.627
CLV_PCSK_KEX2_1	241	243	PF00082	0.472
CLV_PCSK_KEX2_1	50	52	PF00082	0.543
CLV_PCSK_KEX2_1	70	72	PF00082	0.507
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.601
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.543
CLV_PCSK_SKI1_1	20	24	PF00082	0.539
CLV_PCSK_SKI1_1	242	246	PF00082	0.481
DEG_Nend_Nbox_1	1	3	PF02207	0.643
DOC_AGCK_PIF_2	164	169	PF00069	0.429
DOC_MAPK_gen_1	47	56	PF00069	0.653
DOC_MAPK_MEF2A_6	107	115	PF00069	0.610
DOC_MAPK_MEF2A_6	47	56	PF00069	0.649
DOC_USP7_MATH_1	125	129	PF00917	0.627
DOC_USP7_MATH_1	203	207	PF00917	0.337
DOC_USP7_MATH_1	265	269	PF00917	0.727
DOC_WW_Pin1_4	181	186	PF00397	0.443
DOC_WW_Pin1_4	55	60	PF00397	0.730
LIG_14-3-3_CanoR_1	202	208	PF00244	0.403
LIG_14-3-3_CanoR_1	249	255	PF00244	0.596
LIG_14-3-3_CanoR_1	294	300	PF00244	0.608
LIG_APCC_ABBA_1	88	93	PF00400	0.556
LIG_BRCT_BRCA1_1	102	106	PF00533	0.631
LIG_BRCT_BRCA1_1	247	251	PF00533	0.688
LIG_BRCT_BRCA1_1	56	60	PF00533	0.695
LIG_FHA_1	100	106	PF00498	0.627
LIG_FHA_1	310	316	PF00498	0.705
LIG_FHA_2	21	27	PF00498	0.740
LIG_FHA_2	297	303	PF00498	0.608
LIG_IBAR_NPY_1	324	326	PF08397	0.612
LIG_LIR_Apic_2	346	351	PF02991	0.622
LIG_LIR_Gen_1	166	175	PF02991	0.376
LIG_LIR_Gen_1	57	65	PF02991	0.688
LIG_LIR_Nem_3	166	170	PF02991	0.376
LIG_LIR_Nem_3	206	211	PF02991	0.290
LIG_LIR_Nem_3	233	239	PF02991	0.559
LIG_LIR_Nem_3	248	254	PF02991	0.664
LIG_LIR_Nem_3	57	63	PF02991	0.634
LIG_LIR_Nem_3	86	90	PF02991	0.549
LIG_Pex14_1	116	120	PF04695	0.584
LIG_Pex14_2	216	220	PF04695	0.447
LIG_PTB_Apo_2	321	328	PF02174	0.589
LIG_REV1ctd_RIR_1	213	223	PF16727	0.510
LIG_SH2_CRK	252	256	PF00017	0.687
LIG_SH2_GRB2like	117	120	PF00017	0.605
LIG_SH2_GRB2like	326	329	PF00017	0.623
LIG_SH2_PTP2	41	44	PF00017	0.570
LIG_SH2_SRC	237	240	PF00017	0.564
LIG_SH2_SRC	41	44	PF00017	0.570
LIG_SH2_STAP1	165	169	PF00017	0.366
LIG_SH2_STAP1	213	217	PF00017	0.292
LIG_SH2_STAP1	252	256	PF00017	0.627
LIG_SH2_STAT3	72	75	PF00017	0.653
LIG_SH2_STAT5	120	123	PF00017	0.605
LIG_SH2_STAT5	163	166	PF00017	0.369
LIG_SH2_STAT5	169	172	PF00017	0.366
LIG_SH2_STAT5	199	202	PF00017	0.410
LIG_SH2_STAT5	254	257	PF00017	0.638
LIG_SH2_STAT5	292	295	PF00017	0.617
LIG_SH2_STAT5	326	329	PF00017	0.641
LIG_SH2_STAT5	41	44	PF00017	0.570
LIG_SH2_STAT5	96	99	PF00017	0.638
LIG_SH3_3	15	21	PF00018	0.725
LIG_SH3_3	327	333	PF00018	0.654
LIG_SH3_3	53	59	PF00018	0.634
LIG_SUMO_SIM_par_1	52	58	PF11976	0.635
LIG_TYR_ITIM	250	255	PF00017	0.686
MOD_CK1_1	99	105	PF00069	0.588
MOD_CK2_1	20	26	PF00069	0.737
MOD_CK2_1	80	86	PF00069	0.661
MOD_GlcNHglycan	127	130	PF01048	0.437
MOD_GlcNHglycan	222	225	PF01048	0.438
MOD_GlcNHglycan	245	248	PF01048	0.442
MOD_GlcNHglycan	296	299	PF01048	0.411
MOD_GlcNHglycan	360	363	PF01048	0.473
MOD_GSK3_1	125	132	PF00069	0.712
MOD_GSK3_1	296	303	PF00069	0.595
MOD_GSK3_1	96	103	PF00069	0.648
MOD_N-GLC_1	129	134	PF02516	0.437
MOD_N-GLC_1	283	288	PF02516	0.412
MOD_N-GLC_1	306	311	PF02516	0.435
MOD_NEK2_1	139	144	PF00069	0.625
MOD_NEK2_1	227	232	PF00069	0.537
MOD_NEK2_1	245	250	PF00069	0.552
MOD_NEK2_1	293	298	PF00069	0.589
MOD_NEK2_1	300	305	PF00069	0.585
MOD_NEK2_1	358	363	PF00069	0.641
MOD_NEK2_1	63	68	PF00069	0.611
MOD_NEK2_2	203	208	PF00069	0.337
MOD_PIKK_1	257	263	PF00454	0.681
MOD_PIKK_1	309	315	PF00454	0.675
MOD_PK_1	283	289	PF00069	0.634
MOD_PKA_2	293	299	PF00069	0.589
MOD_PKA_2	358	364	PF00069	0.659
MOD_Plk_1	283	289	PF00069	0.652
MOD_Plk_4	203	209	PF00069	0.296
MOD_Plk_4	250	256	PF00069	0.708
MOD_Plk_4	300	306	PF00069	0.597
MOD_ProDKin_1	181	187	PF00069	0.437
MOD_ProDKin_1	55	61	PF00069	0.728
MOD_SUMO_for_1	11	14	PF00179	0.692
MOD_SUMO_rev_2	43	52	PF00179	0.561
TRG_ENDOCYTIC_2	167	170	PF00928	0.362
TRG_ENDOCYTIC_2	213	216	PF00928	0.277
TRG_ENDOCYTIC_2	252	255	PF00928	0.686
TRG_ENDOCYTIC_2	292	295	PF00928	0.606
TRG_ENDOCYTIC_2	39	42	PF00928	0.665
TRG_ER_diArg_1	70	72	PF00400	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I199	Leptomonas seymouri	76%	100%
A0A0S4JHX1	Bodo saltans	44%	100%
A0A1X0P043	Trypanosomatidae	65%	99%
A0A3Q8IE98	Leishmania donovani	91%	100%
A0A422NUJ6	Trypanosoma rangeli	61%	99%
A4I4A1	Leishmania infantum	91%	100%
C9ZKM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ADQ0	Leishmania major	91%	100%
E9AM30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DLE6	Trypanosoma cruzi	63%	99%