Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH49_LEIBR

TriTrypDb:

LbrM.29.0420 , LBRM2903_290010900

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.464
CLV_NRD_NRD_1	197	199	PF00675	0.510
CLV_NRD_NRD_1	281	283	PF00675	0.483
CLV_NRD_NRD_1	83	85	PF00675	0.498
CLV_PCSK_KEX2_1	196	198	PF00082	0.502
CLV_PCSK_KEX2_1	281	283	PF00082	0.413
CLV_PCSK_KEX2_1	3	5	PF00082	0.467
CLV_PCSK_KEX2_1	83	85	PF00082	0.498
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.467
CLV_PCSK_SKI1_1	126	130	PF00082	0.443
CLV_PCSK_SKI1_1	233	237	PF00082	0.562
DEG_SPOP_SBC_1	64	68	PF00917	0.626
DOC_CYCLIN_RxL_1	115	123	PF00134	0.501
DOC_MAPK_gen_1	279	286	PF00069	0.530
DOC_MAPK_MEF2A_6	197	206	PF00069	0.596
DOC_PP2B_LxvP_1	215	218	PF13499	0.583
DOC_USP7_MATH_1	141	145	PF00917	0.515
DOC_USP7_MATH_1	58	62	PF00917	0.679
DOC_USP7_UBL2_3	175	179	PF12436	0.396
DOC_WW_Pin1_4	166	171	PF00397	0.714
LIG_14-3-3_CanoR_1	118	123	PF00244	0.463
LIG_14-3-3_CanoR_1	28	35	PF00244	0.585
LIG_14-3-3_CanoR_1	285	293	PF00244	0.421
LIG_14-3-3_CanoR_1	4	10	PF00244	0.474
LIG_14-3-3_CanoR_1	63	73	PF00244	0.630
LIG_14-3-3_CanoR_1	98	102	PF00244	0.697
LIG_FHA_1	117	123	PF00498	0.574
LIG_FHA_1	30	36	PF00498	0.470
LIG_FHA_2	167	173	PF00498	0.586
LIG_LIR_Apic_2	86	90	PF02991	0.467
LIG_LIR_Gen_1	201	211	PF02991	0.587
LIG_LIR_Nem_3	201	206	PF02991	0.586
LIG_NRP_CendR_1	295	298	PF00754	0.463
LIG_SH2_CRK	274	278	PF00017	0.418
LIG_SH2_PTP2	203	206	PF00017	0.584
LIG_SH2_STAP1	274	278	PF00017	0.418
LIG_SH2_STAT3	181	184	PF00017	0.525
LIG_SH2_STAT5	106	109	PF00017	0.545
LIG_SH2_STAT5	203	206	PF00017	0.584
LIG_SH2_STAT5	221	224	PF00017	0.566
LIG_SUMO_SIM_par_1	118	123	PF11976	0.434
MOD_CK1_1	65	71	PF00069	0.789
MOD_CK1_1	97	103	PF00069	0.685
MOD_CK2_1	166	172	PF00069	0.599
MOD_Cter_Amidation	1	4	PF01082	0.479
MOD_Cter_Amidation	81	84	PF01082	0.508
MOD_GlcNHglycan	56	59	PF01048	0.719
MOD_GlcNHglycan	67	70	PF01048	0.660
MOD_GSK3_1	54	61	PF00069	0.710
MOD_GSK3_1	97	104	PF00069	0.596
MOD_LATS_1	116	122	PF00433	0.435
MOD_NEK2_1	101	106	PF00069	0.600
MOD_NEK2_1	211	216	PF00069	0.443
MOD_NEK2_1	62	67	PF00069	0.740
MOD_NEK2_2	141	146	PF00069	0.492
MOD_PKA_1	3	9	PF00069	0.436
MOD_PKA_2	29	35	PF00069	0.600
MOD_PKA_2	3	9	PF00069	0.442
MOD_PKA_2	62	68	PF00069	0.628
MOD_PKA_2	92	98	PF00069	0.702
MOD_Plk_1	101	107	PF00069	0.413
MOD_Plk_1	190	196	PF00069	0.518
MOD_Plk_4	102	108	PF00069	0.545
MOD_ProDKin_1	166	172	PF00069	0.707
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.582
TRG_ENDOCYTIC_2	203	206	PF00928	0.584
TRG_ENDOCYTIC_2	274	277	PF00928	0.427
TRG_ER_diArg_1	195	198	PF00400	0.545
TRG_ER_diArg_1	27	30	PF00400	0.513
TRG_ER_diArg_1	295	298	PF00400	0.606
TRG_ER_diArg_1	83	85	PF00400	0.498
TRG_NES_CRM1_1	112	123	PF08389	0.423
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Y3	Leptomonas seymouri	56%	95%
A0A1X0NZJ3	Trypanosomatidae	34%	100%
A0A3S7X240	Leishmania donovani	69%	94%
A4I4A0	Leishmania infantum	69%	94%
E9ADP9	Leishmania major	69%	100%
E9AM31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%