Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH48_LEIBR

TriTrypDb:

LbrM.29.0410 , LBRM2903_290010800

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HH48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.725
CLV_C14_Caspase3-7	394	398	PF00656	0.735
CLV_C14_Caspase3-7	91	95	PF00656	0.652
CLV_MEL_PAP_1	64	70	PF00089	0.358
CLV_NRD_NRD_1	217	219	PF00675	0.431
CLV_NRD_NRD_1	225	227	PF00675	0.464
CLV_PCSK_KEX2_1	101	103	PF00082	0.415
CLV_PCSK_KEX2_1	216	218	PF00082	0.436
CLV_PCSK_KEX2_1	225	227	PF00082	0.465
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.415
CLV_PCSK_SKI1_1	102	106	PF00082	0.411
CLV_PCSK_SKI1_1	23	27	PF00082	0.404
CLV_PCSK_SKI1_1	413	417	PF00082	0.460
DEG_Nend_UBRbox_3	1	3	PF02207	0.698
DEG_SPOP_SBC_1	377	381	PF00917	0.630
DOC_CKS1_1	70	75	PF01111	0.558
DOC_CYCLIN_RxL_1	99	109	PF00134	0.613
DOC_MAPK_gen_1	144	152	PF00069	0.560
DOC_MAPK_gen_1	216	224	PF00069	0.566
DOC_MAPK_MEF2A_6	225	232	PF00069	0.566
DOC_MAPK_MEF2A_6	340	347	PF00069	0.729
DOC_MAPK_MEF2A_6	58	65	PF00069	0.607
DOC_MAPK_NFAT4_5	225	233	PF00069	0.567
DOC_MAPK_NFAT4_5	58	66	PF00069	0.551
DOC_PP1_RVXF_1	72	79	PF00149	0.543
DOC_USP7_MATH_1	100	104	PF00917	0.607
DOC_USP7_MATH_1	178	182	PF00917	0.491
DOC_USP7_MATH_1	190	194	PF00917	0.351
DOC_USP7_MATH_1	377	381	PF00917	0.660
DOC_USP7_MATH_1	95	99	PF00917	0.583
DOC_WW_Pin1_4	247	252	PF00397	0.700
DOC_WW_Pin1_4	304	309	PF00397	0.681
DOC_WW_Pin1_4	339	344	PF00397	0.721
DOC_WW_Pin1_4	35	40	PF00397	0.639
DOC_WW_Pin1_4	69	74	PF00397	0.556
LIG_14-3-3_CanoR_1	149	153	PF00244	0.670
LIG_14-3-3_CanoR_1	365	371	PF00244	0.715
LIG_14-3-3_CanoR_1	389	399	PF00244	0.633
LIG_14-3-3_CanoR_1	413	420	PF00244	0.562
LIG_14-3-3_CanoR_1	67	71	PF00244	0.623
LIG_14-3-3_CanoR_1	7	16	PF00244	0.708
LIG_BIR_III_4	373	377	PF00653	0.630
LIG_Clathr_ClatBox_1	241	245	PF01394	0.588
LIG_deltaCOP1_diTrp_1	294	302	PF00928	0.690
LIG_FHA_1	121	127	PF00498	0.622
LIG_FHA_1	130	136	PF00498	0.610
LIG_FHA_1	248	254	PF00498	0.721
LIG_FHA_1	255	261	PF00498	0.817
LIG_FHA_1	36	42	PF00498	0.631
LIG_FHA_1	377	383	PF00498	0.630
LIG_FHA_1	8	14	PF00498	0.681
LIG_FHA_1	91	97	PF00498	0.592
LIG_FHA_2	278	284	PF00498	0.831
LIG_FHA_2	401	407	PF00498	0.735
LIG_LIR_Gen_1	161	171	PF02991	0.395
LIG_LIR_Gen_1	296	303	PF02991	0.687
LIG_LIR_Nem_3	103	108	PF02991	0.658
LIG_LIR_Nem_3	161	167	PF02991	0.315
LIG_LIR_Nem_3	189	194	PF02991	0.395
LIG_LIR_Nem_3	296	302	PF02991	0.688
LIG_NRBOX	75	81	PF00104	0.595
LIG_PDZ_Class_2	436	441	PF00595	0.677
LIG_SH2_CRK	164	168	PF00017	0.315
LIG_SH2_NCK_1	164	168	PF00017	0.395
LIG_SH2_SRC	202	205	PF00017	0.315
LIG_SH2_STAP1	370	374	PF00017	0.676
LIG_SH2_STAT5	164	167	PF00017	0.315
LIG_SH2_STAT5	202	205	PF00017	0.315
LIG_SH2_STAT5	206	209	PF00017	0.531
LIG_SH2_STAT5	414	417	PF00017	0.629
LIG_SH3_3	249	255	PF00018	0.742
LIG_SH3_3	310	316	PF00018	0.648
LIG_Sin3_3	25	32	PF02671	0.647
LIG_SUMO_SIM_anti_2	10	18	PF11976	0.678
LIG_SUMO_SIM_anti_2	344	349	PF11976	0.731
LIG_SUMO_SIM_par_1	378	387	PF11976	0.628
LIG_TRAF2_1	243	246	PF00917	0.663
LIG_TRAF2_2	229	234	PF00917	0.572
LIG_WRC_WIRS_1	108	113	PF05994	0.659
MOD_CDK_SPK_2	69	74	PF00069	0.560
MOD_CK1_1	11	17	PF00069	0.677
MOD_CK1_1	116	122	PF00069	0.616
MOD_CK1_1	148	154	PF00069	0.662
MOD_CK1_1	162	168	PF00069	0.268
MOD_CK1_1	236	242	PF00069	0.587
MOD_CK1_1	277	283	PF00069	0.691
MOD_CK1_1	317	323	PF00069	0.739
MOD_CK1_1	361	367	PF00069	0.736
MOD_CK1_1	384	390	PF00069	0.679
MOD_CK1_1	48	54	PF00069	0.633
MOD_CK1_1	69	75	PF00069	0.554
MOD_CK2_1	240	246	PF00069	0.662
MOD_CK2_1	365	371	PF00069	0.781
MOD_CK2_1	372	378	PF00069	0.682
MOD_CK2_1	400	406	PF00069	0.736
MOD_CK2_1	415	421	PF00069	0.557
MOD_DYRK1A_RPxSP_1	304	308	PF00069	0.691
MOD_GlcNHglycan	115	118	PF01048	0.423
MOD_GlcNHglycan	30	33	PF01048	0.409
MOD_GlcNHglycan	373	377	PF01048	0.523
MOD_GlcNHglycan	386	389	PF01048	0.470
MOD_GlcNHglycan	417	420	PF01048	0.352
MOD_GlcNHglycan	90	93	PF01048	0.480
MOD_GSK3_1	11	18	PF00069	0.642
MOD_GSK3_1	116	123	PF00069	0.606
MOD_GSK3_1	131	138	PF00069	0.621
MOD_GSK3_1	158	165	PF00069	0.477
MOD_GSK3_1	186	193	PF00069	0.315
MOD_GSK3_1	236	243	PF00069	0.655
MOD_GSK3_1	3	10	PF00069	0.634
MOD_GSK3_1	307	314	PF00069	0.715
MOD_GSK3_1	346	353	PF00069	0.721
MOD_GSK3_1	361	368	PF00069	0.685
MOD_GSK3_1	372	379	PF00069	0.704
MOD_GSK3_1	383	390	PF00069	0.678
MOD_GSK3_1	90	97	PF00069	0.602
MOD_LATS_1	363	369	PF00433	0.631
MOD_N-GLC_1	329	334	PF02516	0.429
MOD_NEK2_1	113	118	PF00069	0.734
MOD_NEK2_1	135	140	PF00069	0.620
MOD_NEK2_1	15	20	PF00069	0.618
MOD_NEK2_1	159	164	PF00069	0.315
MOD_NEK2_1	302	307	PF00069	0.673
MOD_NEK2_1	334	339	PF00069	0.737
MOD_NEK2_1	46	51	PF00069	0.636
MOD_NEK2_2	100	105	PF00069	0.666
MOD_NEK2_2	358	363	PF00069	0.624
MOD_PIKK_1	346	352	PF00454	0.626
MOD_PKA_2	145	151	PF00069	0.658
MOD_PKA_2	350	356	PF00069	0.657
MOD_PKA_2	66	72	PF00069	0.620
MOD_PKB_1	411	419	PF00069	0.598
MOD_Plk_1	236	242	PF00069	0.587
MOD_Plk_1	255	261	PF00069	0.608
MOD_Plk_1	329	335	PF00069	0.627
MOD_Plk_1	377	383	PF00069	0.648
MOD_Plk_4	11	17	PF00069	0.677
MOD_Plk_4	131	137	PF00069	0.585
MOD_Plk_4	159	165	PF00069	0.315
MOD_Plk_4	178	184	PF00069	0.458
MOD_Plk_4	190	196	PF00069	0.244
MOD_Plk_4	236	242	PF00069	0.587
MOD_Plk_4	277	283	PF00069	0.647
MOD_Plk_4	307	313	PF00069	0.635
MOD_Plk_4	378	384	PF00069	0.635
MOD_ProDKin_1	247	253	PF00069	0.702
MOD_ProDKin_1	304	310	PF00069	0.684
MOD_ProDKin_1	339	345	PF00069	0.722
MOD_ProDKin_1	35	41	PF00069	0.642
MOD_ProDKin_1	69	75	PF00069	0.554
TRG_DiLeu_BaEn_1	237	242	PF01217	0.584
TRG_DiLeu_BaEn_1	59	64	PF01217	0.665
TRG_DiLeu_LyEn_5	59	64	PF01217	0.665
TRG_ENDOCYTIC_2	157	160	PF00928	0.575
TRG_ENDOCYTIC_2	164	167	PF00928	0.315
TRG_ER_diArg_1	216	218	PF00400	0.637
TRG_ER_diArg_1	224	226	PF00400	0.659
TRG_ER_diArg_1	411	414	PF00400	0.625
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	389	394	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G2	Leptomonas seymouri	57%	100%
A0A3S7X253	Leishmania donovani	74%	98%
A4I492	Leishmania infantum	74%	98%
E9ADP8	Leishmania major	74%	100%
E9AM32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	98%