DNA repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA repair protein

Gene product:

recA bacterial DNA recombination protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HH46_LEIBR

TriTrypDb:

LbrM.29.0390 , LBRM2903_290010600

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH46

Function

Biological processes
Term	Name	Level	Count
GO:0000730	DNA recombinase assembly	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006310	DNA recombination	5	1
GO:0006312	mitotic recombination	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042148	strand invasion	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090735	DNA repair complex assembly	6	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000150	DNA strand exchange activity	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0003697	single-stranded DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0140657	ATP-dependent activity	1	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	475	479	PF00656	0.337
CLV_NRD_NRD_1	121	123	PF00675	0.613
CLV_NRD_NRD_1	162	164	PF00675	0.586
CLV_NRD_NRD_1	229	231	PF00675	0.519
CLV_NRD_NRD_1	464	466	PF00675	0.525
CLV_NRD_NRD_1	598	600	PF00675	0.269
CLV_NRD_NRD_1	7	9	PF00675	0.549
CLV_PCSK_KEX2_1	121	123	PF00082	0.613
CLV_PCSK_KEX2_1	162	164	PF00082	0.566
CLV_PCSK_KEX2_1	229	231	PF00082	0.487
CLV_PCSK_KEX2_1	560	562	PF00082	0.269
CLV_PCSK_KEX2_1	7	9	PF00082	0.549
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.269
CLV_PCSK_PC7_1	225	231	PF00082	0.502
CLV_PCSK_SKI1_1	155	159	PF00082	0.643
CLV_PCSK_SKI1_1	163	167	PF00082	0.566
CLV_PCSK_SKI1_1	229	233	PF00082	0.675
CLV_PCSK_SKI1_1	595	599	PF00082	0.316
CLV_Separin_Metazoa	438	442	PF03568	0.443
DEG_APCC_DBOX_1	161	169	PF00400	0.592
DEG_MDM2_SWIB_1	281	289	PF02201	0.469
DEG_SPOP_SBC_1	471	475	PF00917	0.495
DEG_SPOP_SBC_1	571	575	PF00917	0.450
DOC_CYCLIN_RxL_1	592	601	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	442	448	PF00134	0.533
DOC_MAPK_DCC_7	578	586	PF00069	0.472
DOC_MAPK_MEF2A_6	578	586	PF00069	0.472
DOC_PP1_RVXF_1	454	460	PF00149	0.507
DOC_PP2B_LxvP_1	166	169	PF13499	0.649
DOC_PP4_FxxP_1	247	250	PF00568	0.593
DOC_PP4_MxPP_1	168	171	PF00568	0.520
DOC_USP7_MATH_1	17	21	PF00917	0.494
DOC_USP7_MATH_1	182	186	PF00917	0.534
DOC_USP7_MATH_1	254	258	PF00917	0.566
DOC_USP7_MATH_1	452	456	PF00917	0.599
DOC_USP7_MATH_1	46	50	PF00917	0.554
DOC_USP7_MATH_1	493	497	PF00917	0.414
DOC_USP7_MATH_1	565	569	PF00917	0.466
DOC_USP7_MATH_1	571	575	PF00917	0.474
DOC_USP7_MATH_1	620	624	PF00917	0.516
DOC_USP7_MATH_1	77	81	PF00917	0.587
DOC_WW_Pin1_4	124	129	PF00397	0.531
DOC_WW_Pin1_4	187	192	PF00397	0.427
DOC_WW_Pin1_4	223	228	PF00397	0.606
DOC_WW_Pin1_4	326	331	PF00397	0.456
DOC_WW_Pin1_4	342	347	PF00397	0.605
DOC_WW_Pin1_4	42	47	PF00397	0.595
DOC_WW_Pin1_4	561	566	PF00397	0.479
LIG_14-3-3_CanoR_1	135	141	PF00244	0.563
LIG_14-3-3_CanoR_1	201	207	PF00244	0.492
LIG_14-3-3_CanoR_1	230	240	PF00244	0.536
LIG_14-3-3_CanoR_1	242	248	PF00244	0.550
LIG_14-3-3_CanoR_1	431	437	PF00244	0.438
LIG_14-3-3_CanoR_1	456	460	PF00244	0.592
LIG_14-3-3_CanoR_1	472	477	PF00244	0.438
LIG_14-3-3_CanoR_1	52	59	PF00244	0.497
LIG_14-3-3_CanoR_1	599	609	PF00244	0.469
LIG_14-3-3_CanoR_1	98	106	PF00244	0.408
LIG_Actin_WH2_2	140	157	PF00022	0.453
LIG_BIR_III_2	259	263	PF00653	0.341
LIG_BIR_III_4	9	13	PF00653	0.497
LIG_DLG_GKlike_1	472	480	PF00625	0.434
LIG_EH1_1	603	611	PF00400	0.516
LIG_EVH1_1	166	170	PF00568	0.650
LIG_FAT_LD_1	140	148	PF03623	0.514
LIG_FHA_1	265	271	PF00498	0.414
LIG_FHA_1	35	41	PF00498	0.555
LIG_FHA_1	374	380	PF00498	0.408
LIG_FHA_1	382	388	PF00498	0.360
LIG_FHA_1	416	422	PF00498	0.394
LIG_FHA_1	42	48	PF00498	0.515
LIG_FHA_1	472	478	PF00498	0.412
LIG_FHA_1	575	581	PF00498	0.453
LIG_FHA_2	127	133	PF00498	0.509
LIG_FHA_2	174	180	PF00498	0.678
LIG_FHA_2	334	340	PF00498	0.473
LIG_FHA_2	43	49	PF00498	0.523
LIG_FHA_2	52	58	PF00498	0.348
LIG_LIR_Apic_2	244	250	PF02991	0.580
LIG_LIR_Gen_1	409	416	PF02991	0.297
LIG_LIR_Gen_1	531	542	PF02991	0.500
LIG_LIR_Nem_3	409	415	PF02991	0.428
LIG_LIR_Nem_3	531	537	PF02991	0.500
LIG_MYND_1	70	74	PF01753	0.539
LIG_NRBOX	301	307	PF00104	0.469
LIG_PCNA_yPIPBox_3	297	306	PF02747	0.469
LIG_PDZ_Class_3	629	634	PF00595	0.469
LIG_Pex14_2	281	285	PF04695	0.469
LIG_RPA_C_Fungi	358	370	PF08784	0.414
LIG_SH2_STAP1	202	206	PF00017	0.370
LIG_SH2_STAT5	146	149	PF00017	0.375
LIG_SH2_STAT5	368	371	PF00017	0.343
LIG_SH2_STAT5	624	627	PF00017	0.304
LIG_SH3_1	612	618	PF00018	0.272
LIG_SH3_3	11	17	PF00018	0.519
LIG_SH3_3	164	170	PF00018	0.662
LIG_SH3_3	612	618	PF00018	0.352
LIG_SH3_3	67	73	PF00018	0.481
LIG_SUMO_SIM_anti_2	192	200	PF11976	0.434
LIG_SUMO_SIM_anti_2	236	246	PF11976	0.536
LIG_SUMO_SIM_anti_2	53	61	PF11976	0.349
LIG_SUMO_SIM_par_1	420	426	PF11976	0.296
LIG_SUMO_SIM_par_1	490	496	PF11976	0.304
MOD_CDK_SPxK_1	223	229	PF00069	0.517
MOD_CDK_SPxxK_3	223	230	PF00069	0.603
MOD_CDK_SPxxK_3	342	349	PF00069	0.628
MOD_CK1_1	133	139	PF00069	0.582
MOD_CK1_1	173	179	PF00069	0.535
MOD_CK1_1	243	249	PF00069	0.504
MOD_CK1_1	417	423	PF00069	0.297
MOD_CK1_1	455	461	PF00069	0.629
MOD_CK1_1	564	570	PF00069	0.308
MOD_CK1_1	572	578	PF00069	0.298
MOD_CK1_1	587	593	PF00069	0.242
MOD_CK1_1	80	86	PF00069	0.608
MOD_CK2_1	126	132	PF00069	0.516
MOD_CK2_1	173	179	PF00069	0.786
MOD_CK2_1	333	339	PF00069	0.458
MOD_CK2_1	410	416	PF00069	0.290
MOD_CK2_1	432	438	PF00069	0.451
MOD_CK2_1	90	96	PF00069	0.464
MOD_DYRK1A_RPxSP_1	561	565	PF00069	0.369
MOD_GlcNHglycan	132	135	PF01048	0.557
MOD_GlcNHglycan	172	175	PF01048	0.648
MOD_GlcNHglycan	179	182	PF01048	0.521
MOD_GlcNHglycan	282	285	PF01048	0.304
MOD_GlcNHglycan	336	339	PF01048	0.481
MOD_GlcNHglycan	567	570	PF01048	0.314
MOD_GlcNHglycan	574	577	PF01048	0.294
MOD_GlcNHglycan	589	592	PF01048	0.366
MOD_GlcNHglycan	79	82	PF01048	0.554
MOD_GlcNHglycan	92	95	PF01048	0.682
MOD_GSK3_1	126	133	PF00069	0.529
MOD_GSK3_1	173	180	PF00069	0.624
MOD_GSK3_1	183	190	PF00069	0.469
MOD_GSK3_1	236	243	PF00069	0.593
MOD_GSK3_1	280	287	PF00069	0.304
MOD_GSK3_1	410	417	PF00069	0.335
MOD_GSK3_1	42	49	PF00069	0.579
MOD_GSK3_1	455	462	PF00069	0.625
MOD_GSK3_1	561	568	PF00069	0.497
MOD_GSK3_1	570	577	PF00069	0.314
MOD_GSK3_1	620	627	PF00069	0.304
MOD_GSK3_1	73	80	PF00069	0.509
MOD_GSK3_1	90	97	PF00069	0.671
MOD_N-GLC_1	41	46	PF02516	0.579
MOD_N-GLC_2	533	535	PF02516	0.304
MOD_NEK2_1	115	120	PF00069	0.472
MOD_NEK2_1	240	245	PF00069	0.603
MOD_NEK2_1	340	345	PF00069	0.696
MOD_NEK2_1	40	45	PF00069	0.545
MOD_NEK2_1	459	464	PF00069	0.527
MOD_NEK2_1	483	488	PF00069	0.304
MOD_NEK2_1	50	55	PF00069	0.394
MOD_NEK2_1	584	589	PF00069	0.313
MOD_NEK2_1	598	603	PF00069	0.282
MOD_NEK2_2	116	121	PF00069	0.473
MOD_NEK2_2	17	22	PF00069	0.496
MOD_NEK2_2	46	51	PF00069	0.507
MOD_OFUCOSY	414	419	PF10250	0.426
MOD_PIKK_1	295	301	PF00454	0.304
MOD_PIKK_1	483	489	PF00454	0.227
MOD_PKA_2	136	142	PF00069	0.595
MOD_PKA_2	241	247	PF00069	0.590
MOD_PKA_2	455	461	PF00069	0.581
MOD_PKA_2	471	477	PF00069	0.463
MOD_PKA_2	51	57	PF00069	0.390
MOD_PKA_2	598	604	PF00069	0.304
MOD_PKA_2	97	103	PF00069	0.398
MOD_PKB_1	561	569	PF00069	0.304
MOD_Plk_1	514	520	PF00069	0.304
MOD_Plk_2-3	126	132	PF00069	0.516
MOD_Plk_4	139	145	PF00069	0.386
MOD_Plk_4	202	208	PF00069	0.401
MOD_Plk_4	236	242	PF00069	0.524
MOD_Plk_4	407	413	PF00069	0.456
MOD_Plk_4	46	52	PF00069	0.515
MOD_Plk_4	472	478	PF00069	0.447
MOD_Plk_4	620	626	PF00069	0.315
MOD_Plk_4	81	87	PF00069	0.668
MOD_ProDKin_1	124	130	PF00069	0.532
MOD_ProDKin_1	187	193	PF00069	0.419
MOD_ProDKin_1	223	229	PF00069	0.605
MOD_ProDKin_1	326	332	PF00069	0.454
MOD_ProDKin_1	342	348	PF00069	0.597
MOD_ProDKin_1	42	48	PF00069	0.591
MOD_ProDKin_1	561	567	PF00069	0.317
TRG_DiLeu_BaEn_1	438	443	PF01217	0.443
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.301
TRG_DiLeu_LyEn_5	438	443	PF01217	0.443
TRG_ER_diArg_1	120	122	PF00400	0.611
TRG_ER_diArg_1	135	138	PF00400	0.589
TRG_ER_diArg_1	229	231	PF00400	0.487
TRG_ER_diArg_1	523	526	PF00400	0.313
TRG_ER_diArg_1	6	8	PF00400	0.568
TRG_NLS_MonoExtN_4	558	564	PF00514	0.313
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U1	Leptomonas seymouri	45%	100%
A0A3Q8IE59	Leishmania donovani	71%	98%
A4I499	Leishmania infantum	70%	98%
E9ADP6	Leishmania major	71%	100%
E9AM34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%