LeishMANIAdb
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Metallophos domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Metallophos domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HH45_LEIBR
TriTrypDb:
LbrM.29.0380 , LBRM2903_290010500
Length:
379

Annotations

LeishMANIAdb annotations

A metalloenzyme with the catalytic domain facing outwards. Related to plant Shewanella-like protein phosphatases. Kinetoplastids have multiple copies of these genes but probably from a very ancient gene duplication.. The cluster might merge two separate, very distantly related groups.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 13, no: 12
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0016020 membrane 2 15
GO:0110165 cellular anatomical entity 1 15

Expansion

Sequence features

A4HH45
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH45

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 26
GO:0016787 hydrolase activity 2 26

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 16 18 PF00675 0.439
CLV_NRD_NRD_1 288 290 PF00675 0.475
CLV_NRD_NRD_1 350 352 PF00675 0.602
CLV_NRD_NRD_1 4 6 PF00675 0.523
CLV_NRD_NRD_1 56 58 PF00675 0.595
CLV_PCSK_KEX2_1 288 290 PF00082 0.510
CLV_PCSK_KEX2_1 345 347 PF00082 0.627
CLV_PCSK_KEX2_1 350 352 PF00082 0.599
CLV_PCSK_KEX2_1 4 6 PF00082 0.297
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.510
CLV_PCSK_PC1ET2_1 345 347 PF00082 0.490
CLV_PCSK_PC7_1 346 352 PF00082 0.461
CLV_PCSK_SKI1_1 101 105 PF00082 0.161
CLV_PCSK_SKI1_1 158 162 PF00082 0.300
CLV_PCSK_SKI1_1 317 321 PF00082 0.463
CLV_PCSK_SKI1_1 327 331 PF00082 0.448
CLV_PCSK_SKI1_1 345 349 PF00082 0.657
CLV_PCSK_SKI1_1 351 355 PF00082 0.603
DEG_SPOP_SBC_1 246 250 PF00917 0.150
DOC_ANK_TNKS_1 85 92 PF00023 0.514
DOC_CKS1_1 47 52 PF01111 0.355
DOC_CKS1_1 68 73 PF01111 0.221
DOC_CYCLIN_RxL_1 178 189 PF00134 0.398
DOC_MAPK_gen_1 288 299 PF00069 0.328
DOC_MAPK_HePTP_8 287 299 PF00069 0.198
DOC_MAPK_MEF2A_6 288 297 PF00069 0.382
DOC_MAPK_MEF2A_6 317 325 PF00069 0.351
DOC_MAPK_NFAT4_5 292 300 PF00069 0.150
DOC_PP1_SILK_1 77 82 PF00149 0.155
DOC_USP7_MATH_1 152 156 PF00917 0.493
DOC_USP7_MATH_1 214 218 PF00917 0.374
DOC_USP7_MATH_1 271 275 PF00917 0.284
DOC_USP7_MATH_1 368 372 PF00917 0.389
DOC_WW_Pin1_4 258 263 PF00397 0.251
DOC_WW_Pin1_4 300 305 PF00397 0.319
DOC_WW_Pin1_4 46 51 PF00397 0.430
DOC_WW_Pin1_4 67 72 PF00397 0.221
LIG_14-3-3_CanoR_1 158 163 PF00244 0.512
LIG_14-3-3_CanoR_1 4 8 PF00244 0.536
LIG_Actin_WH2_2 90 107 PF00022 0.443
LIG_BIR_II_1 1 5 PF00653 0.550
LIG_Clathr_ClatBox_1 318 322 PF01394 0.248
LIG_EH_1 253 257 PF12763 0.150
LIG_FHA_1 120 126 PF00498 0.453
LIG_FHA_1 318 324 PF00498 0.368
LIG_FHA_1 35 41 PF00498 0.356
LIG_FHA_1 47 53 PF00498 0.364
LIG_FHA_1 68 74 PF00498 0.358
LIG_FHA_2 114 120 PF00498 0.422
LIG_LIR_Gen_1 331 342 PF02991 0.361
LIG_LIR_Nem_3 331 337 PF02991 0.358
LIG_PDZ_Class_1 374 379 PF00595 0.347
LIG_SH2_SRC 194 197 PF00017 0.521
LIG_SH2_STAP1 334 338 PF00017 0.367
LIG_SH2_STAT5 194 197 PF00017 0.445
LIG_SH2_STAT5 328 331 PF00017 0.375
LIG_SH2_STAT5 48 51 PF00017 0.538
LIG_SH3_3 133 139 PF00018 0.398
LIG_SH3_3 58 64 PF00018 0.344
LIG_SH3_3 65 71 PF00018 0.221
LIG_SUMO_SIM_anti_2 28 34 PF11976 0.217
LIG_SUMO_SIM_par_1 158 163 PF11976 0.398
LIG_SUMO_SIM_par_1 167 172 PF11976 0.354
LIG_SUMO_SIM_par_1 319 324 PF11976 0.248
LIG_SUMO_SIM_par_1 86 92 PF11976 0.468
LIG_UBA3_1 141 149 PF00899 0.428
LIG_WRC_WIRS_1 337 342 PF05994 0.224
MOD_CDK_SPK_2 67 72 PF00069 0.155
MOD_CDK_SPxK_1 300 306 PF00069 0.228
MOD_CK1_1 186 192 PF00069 0.443
MOD_CK1_1 247 253 PF00069 0.316
MOD_CK1_1 66 72 PF00069 0.155
MOD_CK2_1 113 119 PF00069 0.449
MOD_Cter_Amidation 348 351 PF01082 0.471
MOD_GlcNHglycan 154 157 PF01048 0.322
MOD_GlcNHglycan 162 165 PF01048 0.245
MOD_GlcNHglycan 171 174 PF01048 0.234
MOD_GlcNHglycan 185 188 PF01048 0.260
MOD_GlcNHglycan 21 24 PF01048 0.223
MOD_GlcNHglycan 273 276 PF01048 0.554
MOD_GlcNHglycan 280 283 PF01048 0.516
MOD_GlcNHglycan 330 333 PF01048 0.451
MOD_GSK3_1 317 324 PF00069 0.269
MOD_GSK3_1 34 41 PF00069 0.377
MOD_GSK3_1 349 356 PF00069 0.427
MOD_GSK3_1 63 70 PF00069 0.334
MOD_GSK3_1 9 16 PF00069 0.542
MOD_N-GLC_1 183 188 PF02516 0.308
MOD_N-GLC_1 374 379 PF02516 0.556
MOD_NEK2_1 169 174 PF00069 0.531
MOD_NEK2_1 183 188 PF00069 0.457
MOD_NEK2_1 25 30 PF00069 0.414
MOD_NEK2_1 263 268 PF00069 0.218
MOD_NEK2_1 309 314 PF00069 0.311
MOD_NEK2_1 34 39 PF00069 0.327
MOD_NEK2_2 336 341 PF00069 0.171
MOD_NEK2_2 368 373 PF00069 0.229
MOD_PKA_2 3 9 PF00069 0.534
MOD_PKA_2 349 355 PF00069 0.270
MOD_Plk_1 113 119 PF00069 0.562
MOD_Plk_1 264 270 PF00069 0.353
MOD_Plk_1 321 327 PF00069 0.369
MOD_Plk_2-3 113 119 PF00069 0.350
MOD_Plk_4 264 270 PF00069 0.343
MOD_Plk_4 34 40 PF00069 0.437
MOD_ProDKin_1 258 264 PF00069 0.251
MOD_ProDKin_1 300 306 PF00069 0.319
MOD_ProDKin_1 46 52 PF00069 0.431
MOD_ProDKin_1 67 73 PF00069 0.221
MOD_SUMO_for_1 111 114 PF00179 0.350
MOD_SUMO_rev_2 146 150 PF00179 0.372
TRG_DiLeu_BaLyEn_6 155 160 PF01217 0.551
TRG_DiLeu_BaLyEn_6 178 183 PF01217 0.544
TRG_ENDOCYTIC_2 202 205 PF00928 0.391
TRG_ENDOCYTIC_2 334 337 PF00928 0.308
TRG_ER_diArg_1 3 5 PF00400 0.505
TRG_NLS_MonoExtN_4 342 349 PF00514 0.282
TRG_Pf-PMV_PEXEL_1 351 355 PF00026 0.616

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3V2 Leptomonas seymouri 27% 100%
A0A0N1P9R1 Leptomonas seymouri 25% 100%
A0A0S4JMN0 Bodo saltans 34% 94%
A0A0S4KJG1 Bodo saltans 28% 100%
A0A1X0NU01 Trypanosomatidae 25% 100%
A0A1X0NZX7 Trypanosomatidae 33% 85%
A0A1X0P2G6 Trypanosomatidae 29% 100%
A0A3Q8IBB4 Leishmania donovani 29% 100%
A0A3Q8IIK0 Leishmania donovani 73% 100%
A0A3R7NTC0 Trypanosoma rangeli 30% 100%
A0A3S5IRW3 Trypanosoma rangeli 31% 92%
A0A3S7X3U9 Leishmania donovani 29% 100%
A4HCJ2 Leishmania braziliensis 28% 100%
A4HIR7 Leishmania braziliensis 29% 90%
A4I008 Leishmania infantum 29% 100%
A4I498 Leishmania infantum 73% 100%
A4I612 Leishmania infantum 29% 100%
C9ZQ86 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZRD7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 85%
E9ADP5 Leishmania major 74% 100%
E9AM35 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%
E9AVY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B1A3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q6W1 Leishmania major 31% 100%
Q4QBJ8 Leishmania major 28% 100%
Q8L774 Arabidopsis thaliana 24% 97%
Q944L7 Arabidopsis thaliana 27% 97%
V5ARZ9 Trypanosoma cruzi 24% 100%
V5BPY7 Trypanosoma cruzi 32% 86%
V5BX32 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS