Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH44_LEIBR

TriTrypDb:

LbrM.29.0370 , LBRM2903_290010200

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH44

PDB structure(s): 7ane_ag

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.521
CLV_NRD_NRD_1	24	26	PF00675	0.409
CLV_NRD_NRD_1	368	370	PF00675	0.348
CLV_NRD_NRD_1	395	397	PF00675	0.363
CLV_NRD_NRD_1	51	53	PF00675	0.392
CLV_NRD_NRD_1	520	522	PF00675	0.445
CLV_NRD_NRD_1	532	534	PF00675	0.417
CLV_NRD_NRD_1	537	539	PF00675	0.409
CLV_NRD_NRD_1	540	542	PF00675	0.339
CLV_NRD_NRD_1	71	73	PF00675	0.283
CLV_PCSK_FUR_1	538	542	PF00082	0.517
CLV_PCSK_KEX2_1	394	396	PF00082	0.348
CLV_PCSK_KEX2_1	42	44	PF00082	0.386
CLV_PCSK_KEX2_1	53	55	PF00082	0.391
CLV_PCSK_KEX2_1	537	539	PF00082	0.487
CLV_PCSK_KEX2_1	540	542	PF00082	0.472
CLV_PCSK_KEX2_1	71	73	PF00082	0.412
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.386
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.391
CLV_PCSK_PC7_1	533	539	PF00082	0.529
CLV_PCSK_SKI1_1	383	387	PF00082	0.362
CLV_PCSK_SKI1_1	446	450	PF00082	0.534
DEG_APCC_DBOX_1	445	453	PF00400	0.537
DEG_Nend_UBRbox_3	1	3	PF02207	0.602
DEG_SCF_FBW7_1	186	193	PF00400	0.463
DOC_CYCLIN_yClb1_LxF_4	86	91	PF00134	0.424
DOC_MAPK_gen_1	115	125	PF00069	0.463
DOC_MAPK_gen_1	258	267	PF00069	0.508
DOC_MAPK_gen_1	336	343	PF00069	0.336
DOC_MAPK_gen_1	383	393	PF00069	0.342
DOC_MAPK_gen_1	42	50	PF00069	0.386
DOC_MAPK_gen_1	52	60	PF00069	0.383
DOC_MAPK_gen_1	537	548	PF00069	0.556
DOC_MAPK_MEF2A_6	336	343	PF00069	0.336
DOC_PP1_RVXF_1	86	92	PF00149	0.417
DOC_PP2B_LxvP_1	349	352	PF13499	0.359
DOC_PP4_MxPP_1	412	415	PF00568	0.581
DOC_USP7_MATH_1	190	194	PF00917	0.514
DOC_USP7_MATH_1	229	233	PF00917	0.484
DOC_USP7_MATH_1	448	452	PF00917	0.493
DOC_USP7_MATH_1	503	507	PF00917	0.519
DOC_USP7_MATH_1	81	85	PF00917	0.495
DOC_USP7_UBL2_3	407	411	PF12436	0.380
DOC_USP7_UBL2_3	76	80	PF12436	0.353
DOC_WW_Pin1_4	186	191	PF00397	0.563
DOC_WW_Pin1_4	225	230	PF00397	0.382
DOC_WW_Pin1_4	299	304	PF00397	0.348
DOC_WW_Pin1_4	316	321	PF00397	0.347
LIG_14-3-3_CanoR_1	130	138	PF00244	0.506
LIG_14-3-3_CanoR_1	201	211	PF00244	0.345
LIG_14-3-3_CanoR_1	481	486	PF00244	0.530
LIG_14-3-3_CanoR_1	88	92	PF00244	0.290
LIG_14-3-3_CanoR_1	9	13	PF00244	0.545
LIG_Actin_WH2_2	116	132	PF00022	0.505
LIG_deltaCOP1_diTrp_1	380	388	PF00928	0.351
LIG_FHA_1	148	154	PF00498	0.305
LIG_FHA_1	194	200	PF00498	0.412
LIG_FHA_1	231	237	PF00498	0.321
LIG_FHA_1	242	248	PF00498	0.362
LIG_FHA_1	303	309	PF00498	0.312
LIG_FHA_1	408	414	PF00498	0.431
LIG_FHA_1	473	479	PF00498	0.393
LIG_FHA_2	490	496	PF00498	0.413
LIG_HCF-1_HBM_1	315	318	PF13415	0.361
LIG_LIR_Gen_1	121	129	PF02991	0.516
LIG_LIR_Gen_1	205	215	PF02991	0.331
LIG_LIR_Gen_1	232	242	PF02991	0.366
LIG_LIR_Gen_1	287	298	PF02991	0.515
LIG_LIR_Gen_1	491	500	PF02991	0.412
LIG_LIR_LC3C_4	233	238	PF02991	0.226
LIG_LIR_Nem_3	121	125	PF02991	0.413
LIG_LIR_Nem_3	14	18	PF02991	0.417
LIG_LIR_Nem_3	150	154	PF02991	0.400
LIG_LIR_Nem_3	165	170	PF02991	0.321
LIG_LIR_Nem_3	205	211	PF02991	0.334
LIG_LIR_Nem_3	232	237	PF02991	0.313
LIG_LIR_Nem_3	251	257	PF02991	0.368
LIG_LIR_Nem_3	287	293	PF02991	0.494
LIG_LIR_Nem_3	389	393	PF02991	0.414
LIG_LIR_Nem_3	491	497	PF02991	0.407
LIG_NRBOX	448	454	PF00104	0.524
LIG_OCRL_FandH_1	392	404	PF00620	0.477
LIG_Pex14_1	31	35	PF04695	0.383
LIG_PTB_Apo_2	213	220	PF02174	0.259
LIG_PTB_Apo_2	373	380	PF02174	0.446
LIG_PTB_Phospho_1	213	219	PF10480	0.252
LIG_PTB_Phospho_1	373	379	PF10480	0.448
LIG_REV1ctd_RIR_1	435	442	PF16727	0.387
LIG_SH2_CRK	234	238	PF00017	0.341
LIG_SH2_CRK	270	274	PF00017	0.442
LIG_SH2_CRK	37	41	PF00017	0.448
LIG_SH2_CRK	494	498	PF00017	0.426
LIG_SH2_GRB2like	518	521	PF00017	0.405
LIG_SH2_PTP2	122	125	PF00017	0.463
LIG_SH2_SRC	208	211	PF00017	0.435
LIG_SH2_STAP1	170	174	PF00017	0.476
LIG_SH2_STAP1	234	238	PF00017	0.308
LIG_SH2_STAP1	401	405	PF00017	0.356
LIG_SH2_STAP1	494	498	PF00017	0.407
LIG_SH2_STAT3	59	62	PF00017	0.464
LIG_SH2_STAT5	122	125	PF00017	0.410
LIG_SH2_STAT5	309	312	PF00017	0.306
LIG_SH2_STAT5	318	321	PF00017	0.365
LIG_SH2_STAT5	518	521	PF00017	0.405
LIG_SH2_STAT5	59	62	PF00017	0.464
LIG_SH3_3	416	422	PF00018	0.520
LIG_SH3_3	429	435	PF00018	0.347
LIG_SH3_4	26	33	PF00018	0.430
LIG_Sin3_3	104	111	PF02671	0.274
LIG_SUMO_SIM_anti_2	235	240	PF11976	0.322
LIG_SUMO_SIM_par_1	450	456	PF11976	0.556
MOD_CK1_1	188	194	PF00069	0.419
MOD_CK1_1	302	308	PF00069	0.276
MOD_CK1_1	38	44	PF00069	0.393
MOD_CK1_1	451	457	PF00069	0.477
MOD_CK2_1	474	480	PF00069	0.471
MOD_CK2_1	81	87	PF00069	0.559
MOD_Cter_Amidation	538	541	PF01082	0.464
MOD_GlcNHglycan	174	177	PF01048	0.511
MOD_GlcNHglycan	356	359	PF01048	0.430
MOD_GlcNHglycan	37	40	PF01048	0.390
MOD_GlcNHglycan	427	430	PF01048	0.513
MOD_GSK3_1	125	132	PF00069	0.393
MOD_GSK3_1	186	193	PF00069	0.423
MOD_GSK3_1	225	232	PF00069	0.398
MOD_GSK3_1	417	424	PF00069	0.549
MOD_GSK3_1	7	14	PF00069	0.399
MOD_GSK3_1	90	97	PF00069	0.486
MOD_LATS_1	479	485	PF00433	0.416
MOD_N-GLC_1	407	412	PF02516	0.408
MOD_NEK2_1	1	6	PF00069	0.523
MOD_NEK2_1	125	130	PF00069	0.417
MOD_NEK2_1	172	177	PF00069	0.420
MOD_NEK2_1	199	204	PF00069	0.300
MOD_NEK2_1	241	246	PF00069	0.335
MOD_NEK2_1	256	261	PF00069	0.407
MOD_NEK2_1	354	359	PF00069	0.571
MOD_NEK2_1	406	411	PF00069	0.399
MOD_NEK2_2	147	152	PF00069	0.418
MOD_PIKK_1	1	7	PF00454	0.562
MOD_PIKK_1	190	196	PF00454	0.477
MOD_PIKK_1	417	423	PF00454	0.542
MOD_PIKK_1	90	96	PF00454	0.394
MOD_PK_1	327	333	PF00069	0.469
MOD_PK_1	369	375	PF00069	0.490
MOD_PKA_1	369	375	PF00069	0.490
MOD_PKA_2	129	135	PF00069	0.503
MOD_PKA_2	480	486	PF00069	0.547
MOD_PKA_2	532	538	PF00069	0.524
MOD_PKA_2	8	14	PF00069	0.543
MOD_PKA_2	87	93	PF00069	0.298
MOD_Plk_1	422	428	PF00069	0.522
MOD_Plk_2-3	474	480	PF00069	0.474
MOD_Plk_4	11	17	PF00069	0.417
MOD_Plk_4	448	454	PF00069	0.484
MOD_Plk_4	481	487	PF00069	0.438
MOD_ProDKin_1	186	192	PF00069	0.553
MOD_ProDKin_1	225	231	PF00069	0.380
MOD_ProDKin_1	299	305	PF00069	0.341
MOD_ProDKin_1	316	322	PF00069	0.353
MOD_SUMO_rev_2	330	339	PF00179	0.430
MOD_SUMO_rev_2	469	478	PF00179	0.522
TRG_DiLeu_BaEn_1	103	108	PF01217	0.266
TRG_ENDOCYTIC_2	122	125	PF00928	0.331
TRG_ENDOCYTIC_2	15	18	PF00928	0.421
TRG_ENDOCYTIC_2	208	211	PF00928	0.351
TRG_ENDOCYTIC_2	219	222	PF00928	0.360
TRG_ENDOCYTIC_2	234	237	PF00928	0.310
TRG_ENDOCYTIC_2	270	273	PF00928	0.444
TRG_ENDOCYTIC_2	37	40	PF00928	0.450
TRG_ENDOCYTIC_2	494	497	PF00928	0.401
TRG_ER_diArg_1	257	260	PF00400	0.458
TRG_ER_diArg_1	374	377	PF00400	0.472
TRG_ER_diArg_1	393	396	PF00400	0.348
TRG_ER_diArg_1	536	538	PF00400	0.473
TRG_ER_diArg_1	540	543	PF00400	0.456
TRG_ER_diArg_1	70	72	PF00400	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G0	Leptomonas seymouri	81%	100%
A0A1X0NZI0	Trypanosomatidae	64%	98%
A0A3R7NNT1	Trypanosoma rangeli	64%	97%
A0A3S7X247	Leishmania donovani	93%	100%
A4I497	Leishmania infantum	93%	100%
C9ZKN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	97%
E9ADP4	Leishmania major	92%	100%
E9AM36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DLE3	Trypanosoma cruzi	64%	97%