C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH43_LEIBR

TriTrypDb:

LbrM.29.0360 , LBRM2903_290010100

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH43

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.673
CLV_NRD_NRD_1	341	343	PF00675	0.654
CLV_NRD_NRD_1	57	59	PF00675	0.585
CLV_PCSK_KEX2_1	341	343	PF00082	0.654
CLV_PCSK_KEX2_1	57	59	PF00082	0.585
CLV_PCSK_SKI1_1	15	19	PF00082	0.664
CLV_PCSK_SKI1_1	226	230	PF00082	0.577
CLV_PCSK_SKI1_1	308	312	PF00082	0.739
DEG_APCC_DBOX_1	225	233	PF00400	0.577
DEG_SPOP_SBC_1	208	212	PF00917	0.595
DOC_CKS1_1	102	107	PF01111	0.731
DOC_CYCLIN_RxL_1	305	313	PF00134	0.605
DOC_CYCLIN_RxL_1	9	22	PF00134	0.665
DOC_MAPK_gen_1	224	232	PF00069	0.421
DOC_MAPK_gen_1	5	13	PF00069	0.678
DOC_MAPK_gen_1	57	68	PF00069	0.582
DOC_MAPK_MEF2A_6	166	174	PF00069	0.583
DOC_MAPK_MEF2A_6	224	232	PF00069	0.421
DOC_MAPK_MEF2A_6	61	70	PF00069	0.580
DOC_USP7_MATH_1	119	123	PF00917	0.615
DOC_USP7_MATH_1	208	212	PF00917	0.671
DOC_USP7_MATH_1	218	222	PF00917	0.660
DOC_USP7_MATH_1	306	310	PF00917	0.623
DOC_USP7_MATH_1	346	350	PF00917	0.532
DOC_USP7_MATH_1	381	385	PF00917	0.535
DOC_USP7_MATH_1	396	400	PF00917	0.606
DOC_USP7_MATH_1	81	85	PF00917	0.589
DOC_USP7_UBL2_3	5	9	PF12436	0.679
DOC_WW_Pin1_4	117	122	PF00397	0.559
DOC_WW_Pin1_4	210	215	PF00397	0.650
DOC_WW_Pin1_4	42	47	PF00397	0.650
DOC_WW_Pin1_4	98	103	PF00397	0.713
LIG_14-3-3_CanoR_1	281	291	PF00244	0.696
LIG_AP2alpha_2	380	382	PF02296	0.519
LIG_FHA_1	12	18	PF00498	0.668
LIG_FHA_1	122	128	PF00498	0.569
LIG_FHA_1	165	171	PF00498	0.629
LIG_FHA_1	22	28	PF00498	0.487
LIG_FHA_1	231	237	PF00498	0.663
LIG_FHA_1	255	261	PF00498	0.566
LIG_FHA_2	281	287	PF00498	0.694
LIG_FHA_2	385	391	PF00498	0.538
LIG_LIR_Apic_2	288	294	PF02991	0.663
LIG_LIR_Gen_1	150	158	PF02991	0.538
LIG_LIR_Gen_1	355	366	PF02991	0.527
LIG_LIR_Gen_1	84	92	PF02991	0.582
LIG_LIR_Nem_3	150	155	PF02991	0.534
LIG_LIR_Nem_3	301	305	PF02991	0.582
LIG_LIR_Nem_3	323	328	PF02991	0.582
LIG_LIR_Nem_3	355	361	PF02991	0.523
LIG_LIR_Nem_3	84	88	PF02991	0.564
LIG_NRBOX	387	393	PF00104	0.655
LIG_Pex14_1	143	147	PF04695	0.543
LIG_SH2_CRK	152	156	PF00017	0.539
LIG_SH2_CRK	325	329	PF00017	0.643
LIG_SH2_CRK	358	362	PF00017	0.529
LIG_SH2_NCK_1	152	156	PF00017	0.539
LIG_SH2_NCK_1	358	362	PF00017	0.529
LIG_SH2_STAP1	358	362	PF00017	0.529
LIG_SH2_STAT3	289	292	PF00017	0.677
LIG_SH2_STAT5	91	94	PF00017	0.636
LIG_SH3_2	102	107	PF14604	0.731
LIG_SH3_3	167	173	PF00018	0.642
LIG_SH3_3	202	208	PF00018	0.701
LIG_SH3_3	211	217	PF00018	0.653
LIG_SH3_3	245	251	PF00018	0.606
LIG_SH3_3	99	105	PF00018	0.837
LIG_SH3_4	5	12	PF00018	0.679
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.630
LIG_SUMO_SIM_par_1	227	233	PF11976	0.563
LIG_TRAF2_1	275	278	PF00917	0.636
LIG_TYR_ITIM	356	361	PF00017	0.524
LIG_TYR_ITIM	89	94	PF00017	0.620
MOD_CDK_SPK_2	98	103	PF00069	0.556
MOD_CDK_SPxK_1	101	107	PF00069	0.728
MOD_CK1_1	120	126	PF00069	0.562
MOD_CK1_1	150	156	PF00069	0.643
MOD_CK1_1	210	216	PF00069	0.596
MOD_CK1_1	285	291	PF00069	0.531
MOD_CK1_1	384	390	PF00069	0.532
MOD_CK2_1	295	301	PF00069	0.622
MOD_GlcNHglycan	129	133	PF01048	0.610
MOD_GlcNHglycan	152	155	PF01048	0.609
MOD_GlcNHglycan	178	181	PF01048	0.643
MOD_GlcNHglycan	185	188	PF01048	0.592
MOD_GlcNHglycan	196	199	PF01048	0.540
MOD_GlcNHglycan	220	223	PF01048	0.588
MOD_GlcNHglycan	264	267	PF01048	0.494
MOD_GlcNHglycan	318	322	PF01048	0.621
MOD_GlcNHglycan	375	379	PF01048	0.611
MOD_GlcNHglycan	397	401	PF01048	0.627
MOD_GSK3_1	117	124	PF00069	0.640
MOD_GSK3_1	150	157	PF00069	0.642
MOD_GSK3_1	172	179	PF00069	0.683
MOD_GSK3_1	194	201	PF00069	0.746
MOD_GSK3_1	208	215	PF00069	0.635
MOD_GSK3_1	224	231	PF00069	0.538
MOD_GSK3_1	254	261	PF00069	0.632
MOD_N-GLC_1	402	407	PF02516	0.541
MOD_NEK2_1	209	214	PF00069	0.600
MOD_NEK2_1	232	237	PF00069	0.450
MOD_NEK2_1	295	300	PF00069	0.622
MOD_NEK2_1	324	329	PF00069	0.645
MOD_NEK2_1	62	67	PF00069	0.585
MOD_PIKK_1	258	264	PF00454	0.677
MOD_PIKK_1	44	50	PF00454	0.620
MOD_PK_1	224	230	PF00069	0.422
MOD_PKA_2	280	286	PF00069	0.696
MOD_Plk_1	164	170	PF00069	0.698
MOD_Plk_1	352	358	PF00069	0.521
MOD_Plk_1	62	68	PF00069	0.638
MOD_Plk_2-3	280	286	PF00069	0.696
MOD_Plk_4	13	19	PF00069	0.699
MOD_Plk_4	306	312	PF00069	0.602
MOD_Plk_4	384	390	PF00069	0.660
MOD_ProDKin_1	117	123	PF00069	0.559
MOD_ProDKin_1	210	216	PF00069	0.645
MOD_ProDKin_1	42	48	PF00069	0.654
MOD_ProDKin_1	98	104	PF00069	0.714
MOD_SUMO_for_1	190	193	PF00179	0.715
MOD_SUMO_rev_2	163	168	PF00179	0.741
MOD_SUMO_rev_2	186	192	PF00179	0.608
TRG_DiLeu_BaEn_4	279	285	PF01217	0.666
TRG_ENDOCYTIC_2	152	155	PF00928	0.540
TRG_ENDOCYTIC_2	325	328	PF00928	0.584
TRG_ENDOCYTIC_2	358	361	PF00928	0.526
TRG_ENDOCYTIC_2	91	94	PF00928	0.636
TRG_ER_diArg_1	340	342	PF00400	0.654
TRG_ER_diArg_1	56	58	PF00400	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X275	Leishmania donovani	68%	100%
A4I496	Leishmania infantum	68%	100%
E9ADP3	Leishmania major	69%	98%
E9AM37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%