Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH42_LEIBR

TriTrypDb:

LbrM.29.0350 , LBRM2903_290010000

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.648
CLV_C14_Caspase3-7	255	259	PF00656	0.570
CLV_C14_Caspase3-7	538	542	PF00656	0.499
CLV_NRD_NRD_1	494	496	PF00675	0.543
CLV_NRD_NRD_1	528	530	PF00675	0.585
CLV_PCSK_KEX2_1	388	390	PF00082	0.614
CLV_PCSK_KEX2_1	494	496	PF00082	0.543
CLV_PCSK_KEX2_1	527	529	PF00082	0.582
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.675
CLV_PCSK_PC7_1	524	530	PF00082	0.492
CLV_PCSK_SKI1_1	388	392	PF00082	0.595
CLV_PCSK_SKI1_1	443	447	PF00082	0.647
CLV_PCSK_SKI1_1	494	498	PF00082	0.546
CLV_Separin_Metazoa	500	504	PF03568	0.632
DEG_APCC_DBOX_1	556	564	PF00400	0.626
DEG_Nend_Nbox_1	1	3	PF02207	0.489
DEG_SCF_FBW7_1	41	46	PF00400	0.528
DEG_SPOP_SBC_1	69	73	PF00917	0.506
DOC_CDC14_PxL_1	187	195	PF14671	0.498
DOC_CKS1_1	225	230	PF01111	0.529
DOC_CYCLIN_yCln2_LP_2	192	195	PF00134	0.602
DOC_MAPK_gen_1	133	142	PF00069	0.522
DOC_MAPK_gen_1	285	294	PF00069	0.524
DOC_PP1_RVXF_1	477	483	PF00149	0.516
DOC_PP2B_LxvP_1	192	195	PF13499	0.602
DOC_PP2B_LxvP_1	329	332	PF13499	0.507
DOC_PP2B_LxvP_1	50	53	PF13499	0.790
DOC_PP4_FxxP_1	294	297	PF00568	0.496
DOC_PP4_FxxP_1	406	409	PF00568	0.530
DOC_USP7_MATH_1	11	15	PF00917	0.561
DOC_USP7_MATH_1	121	125	PF00917	0.660
DOC_USP7_MATH_1	162	166	PF00917	0.555
DOC_USP7_MATH_1	268	272	PF00917	0.636
DOC_USP7_MATH_1	336	340	PF00917	0.604
DOC_USP7_MATH_1	355	359	PF00917	0.518
DOC_USP7_MATH_1	409	413	PF00917	0.544
DOC_USP7_MATH_1	68	72	PF00917	0.616
DOC_USP7_MATH_1	97	101	PF00917	0.428
DOC_WW_Pin1_4	127	132	PF00397	0.677
DOC_WW_Pin1_4	224	229	PF00397	0.645
DOC_WW_Pin1_4	261	266	PF00397	0.642
DOC_WW_Pin1_4	374	379	PF00397	0.663
DOC_WW_Pin1_4	39	44	PF00397	0.645
DOC_WW_Pin1_4	397	402	PF00397	0.605
DOC_WW_Pin1_4	405	410	PF00397	0.603
DOC_WW_Pin1_4	415	420	PF00397	0.494
DOC_WW_Pin1_4	45	50	PF00397	0.642
DOC_WW_Pin1_4	483	488	PF00397	0.612
DOC_WW_Pin1_4	92	97	PF00397	0.434
LIG_14-3-3_CanoR_1	154	162	PF00244	0.535
LIG_14-3-3_CanoR_1	356	362	PF00244	0.601
LIG_14-3-3_CanoR_1	371	377	PF00244	0.534
LIG_14-3-3_CanoR_1	389	395	PF00244	0.620
LIG_14-3-3_CanoR_1	397	401	PF00244	0.516
LIG_14-3-3_CanoR_1	435	441	PF00244	0.623
LIG_14-3-3_CanoR_1	461	470	PF00244	0.594
LIG_14-3-3_CanoR_1	479	487	PF00244	0.538
LIG_14-3-3_CanoR_1	527	533	PF00244	0.584
LIG_14-3-3_CterR_2	567	571	PF00244	0.507
LIG_APCC_ABBA_1	545	550	PF00400	0.481
LIG_DCNL_PONY_1	1	4	PF03556	0.550
LIG_EVH1_2	504	508	PF00568	0.495
LIG_FHA_1	178	184	PF00498	0.723
LIG_FHA_1	21	27	PF00498	0.418
LIG_FHA_1	225	231	PF00498	0.527
LIG_FHA_1	326	332	PF00498	0.602
LIG_FHA_1	358	364	PF00498	0.543
LIG_FHA_1	389	395	PF00498	0.589
LIG_FHA_1	422	428	PF00498	0.527
LIG_FHA_1	457	463	PF00498	0.506
LIG_FHA_1	71	77	PF00498	0.797
LIG_FHA_2	308	314	PF00498	0.646
LIG_FHA_2	437	443	PF00498	0.557
LIG_FHA_2	495	501	PF00498	0.664
LIG_LIR_Gen_1	452	462	PF02991	0.489
LIG_LIR_Gen_1	546	556	PF02991	0.475
LIG_LIR_Nem_3	126	132	PF02991	0.760
LIG_LIR_Nem_3	452	457	PF02991	0.482
LIG_LIR_Nem_3	546	551	PF02991	0.483
LIG_MYND_1	191	195	PF01753	0.535
LIG_MYND_1	561	565	PF01753	0.574
LIG_NRBOX	107	113	PF00104	0.553
LIG_NRBOX	85	91	PF00104	0.491
LIG_RPA_C_Fungi	351	363	PF08784	0.607
LIG_SH2_CRK	109	113	PF00017	0.402
LIG_SH2_NCK_1	510	514	PF00017	0.485
LIG_SH2_STAT5	417	420	PF00017	0.532
LIG_SH2_STAT5	535	538	PF00017	0.520
LIG_SH3_1	416	422	PF00018	0.520
LIG_SH3_3	138	144	PF00018	0.594
LIG_SH3_3	188	194	PF00018	0.625
LIG_SH3_3	197	203	PF00018	0.536
LIG_SH3_3	219	225	PF00018	0.531
LIG_SH3_3	262	268	PF00018	0.660
LIG_SH3_3	289	295	PF00018	0.665
LIG_SH3_3	329	335	PF00018	0.628
LIG_SH3_3	416	422	PF00018	0.520
LIG_SH3_3	444	450	PF00018	0.495
LIG_SH3_3	46	52	PF00018	0.616
LIG_SH3_3	498	504	PF00018	0.618
LIG_SH3_3	506	512	PF00018	0.545
LIG_SH3_3	562	568	PF00018	0.625
LIG_SUMO_SIM_anti_2	550	555	PF11976	0.612
LIG_SUMO_SIM_anti_2	71	79	PF11976	0.493
LIG_SUMO_SIM_par_1	71	79	PF11976	0.516
LIG_SxIP_EBH_1	402	416	PF03271	0.525
LIG_TRAF2_2	453	458	PF00917	0.488
LIG_WW_3	500	504	PF00397	0.485
MOD_CDC14_SPxK_1	130	133	PF00782	0.675
MOD_CDK_SPK_2	397	402	PF00069	0.512
MOD_CDK_SPxK_1	127	133	PF00069	0.675
MOD_CDK_SPxxK_3	374	381	PF00069	0.526
MOD_CK1_1	100	106	PF00069	0.655
MOD_CK1_1	175	181	PF00069	0.740
MOD_CK1_1	374	380	PF00069	0.561
MOD_CK1_1	441	447	PF00069	0.642
MOD_CK1_1	483	489	PF00069	0.521
MOD_CK1_1	530	536	PF00069	0.597
MOD_CK1_1	75	81	PF00069	0.560
MOD_CK2_1	267	273	PF00069	0.643
MOD_CK2_1	307	313	PF00069	0.628
MOD_CK2_1	436	442	PF00069	0.553
MOD_CK2_1	494	500	PF00069	0.618
MOD_CK2_1	92	98	PF00069	0.558
MOD_DYRK1A_RPxSP_1	261	265	PF00069	0.640
MOD_DYRK1A_RPxSP_1	397	401	PF00069	0.563
MOD_GlcNHglycan	123	126	PF01048	0.602
MOD_GlcNHglycan	183	186	PF01048	0.580
MOD_GlcNHglycan	188	191	PF01048	0.721
MOD_GlcNHglycan	235	238	PF01048	0.578
MOD_GlcNHglycan	270	273	PF01048	0.631
MOD_GlcNHglycan	288	291	PF01048	0.505
MOD_GlcNHglycan	302	307	PF01048	0.496
MOD_GlcNHglycan	357	360	PF01048	0.532
MOD_GlcNHglycan	383	386	PF01048	0.525
MOD_GlcNHglycan	391	394	PF01048	0.522
MOD_GlcNHglycan	463	466	PF01048	0.497
MOD_GlcNHglycan	516	519	PF01048	0.647
MOD_GlcNHglycan	78	81	PF01048	0.493
MOD_GSK3_1	121	128	PF00069	0.523
MOD_GSK3_1	172	179	PF00069	0.784
MOD_GSK3_1	216	223	PF00069	0.643
MOD_GSK3_1	298	305	PF00069	0.568
MOD_GSK3_1	35	42	PF00069	0.622
MOD_GSK3_1	367	374	PF00069	0.636
MOD_GSK3_1	376	383	PF00069	0.624
MOD_GSK3_1	405	412	PF00069	0.534
MOD_GSK3_1	456	463	PF00069	0.609
MOD_GSK3_1	537	544	PF00069	0.581
MOD_GSK3_1	559	566	PF00069	0.484
MOD_GSK3_1	68	75	PF00069	0.611
MOD_N-GLC_2	7	9	PF02516	0.432
MOD_NEK2_1	186	191	PF00069	0.619
MOD_NEK2_1	480	485	PF00069	0.533
MOD_NEK2_2	456	461	PF00069	0.559
MOD_PIKK_1	409	415	PF00454	0.556
MOD_PIKK_1	43	49	PF00454	0.765
MOD_PIKK_1	530	536	PF00454	0.506
MOD_PIKK_1	97	103	PF00454	0.425
MOD_PKA_1	388	394	PF00069	0.526
MOD_PKA_1	494	500	PF00069	0.530
MOD_PKA_1	527	533	PF00069	0.586
MOD_PKA_2	153	159	PF00069	0.541
MOD_PKA_2	20	26	PF00069	0.417
MOD_PKA_2	286	292	PF00069	0.524
MOD_PKA_2	355	361	PF00069	0.741
MOD_PKA_2	380	386	PF00069	0.544
MOD_PKA_2	388	394	PF00069	0.590
MOD_PKA_2	396	402	PF00069	0.485
MOD_PKA_2	460	466	PF00069	0.566
MOD_PKA_2	480	486	PF00069	0.577
MOD_PKA_2	494	500	PF00069	0.592
MOD_PKA_2	527	533	PF00069	0.581
MOD_PKB_1	479	487	PF00069	0.520
MOD_Plk_1	441	447	PF00069	0.642
MOD_Plk_1	59	65	PF00069	0.539
MOD_Plk_1	81	87	PF00069	0.490
MOD_Plk_2-3	541	547	PF00069	0.487
MOD_Plk_4	100	106	PF00069	0.703
MOD_Plk_4	336	342	PF00069	0.563
MOD_Plk_4	72	78	PF00069	0.531
MOD_ProDKin_1	127	133	PF00069	0.677
MOD_ProDKin_1	224	230	PF00069	0.644
MOD_ProDKin_1	261	267	PF00069	0.641
MOD_ProDKin_1	374	380	PF00069	0.664
MOD_ProDKin_1	39	45	PF00069	0.645
MOD_ProDKin_1	397	403	PF00069	0.607
MOD_ProDKin_1	405	411	PF00069	0.597
MOD_ProDKin_1	415	421	PF00069	0.487
MOD_ProDKin_1	483	489	PF00069	0.614
MOD_ProDKin_1	92	98	PF00069	0.433
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.499
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.515
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.544
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.503
TRG_ENDOCYTIC_2	109	112	PF00928	0.404
TRG_ER_diArg_1	478	481	PF00400	0.517
TRG_ER_diArg_1	494	496	PF00400	0.523
TRG_ER_diArg_1	526	529	PF00400	0.583
TRG_ER_diArg_1	567	570	PF00400	0.588
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFI2	Leptomonas seymouri	29%	100%
A0A3Q8IDI0	Leishmania donovani	58%	99%
A4I495	Leishmania infantum	58%	99%
E9ADP2	Leishmania major	56%	99%
E9AM38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	99%