CCHC NOA-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3451), putative

Species:

Leishmania braziliensis

UniProt:

A4HH39_LEIBR

TriTrypDb:

LbrM.29.0320 , LBRM2903_290009700

Length:

963

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005638	lamin filament	7	1
GO:0005815	microtubule organizing center	2	1
GO:0005882	intermediate filament	6	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HH39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH39

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	1
GO:0030527	structural constituent of chromatin	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	545	549	PF00656	0.410
CLV_NRD_NRD_1	302	304	PF00675	0.575
CLV_NRD_NRD_1	375	377	PF00675	0.460
CLV_NRD_NRD_1	428	430	PF00675	0.475
CLV_NRD_NRD_1	433	435	PF00675	0.483
CLV_NRD_NRD_1	447	449	PF00675	0.470
CLV_NRD_NRD_1	49	51	PF00675	0.574
CLV_NRD_NRD_1	56	58	PF00675	0.602
CLV_NRD_NRD_1	599	601	PF00675	0.581
CLV_PCSK_FUR_1	426	430	PF00082	0.574
CLV_PCSK_KEX2_1	133	135	PF00082	0.623
CLV_PCSK_KEX2_1	347	349	PF00082	0.476
CLV_PCSK_KEX2_1	428	430	PF00082	0.477
CLV_PCSK_KEX2_1	433	435	PF00082	0.487
CLV_PCSK_KEX2_1	446	448	PF00082	0.505
CLV_PCSK_KEX2_1	49	51	PF00082	0.484
CLV_PCSK_KEX2_1	510	512	PF00082	0.572
CLV_PCSK_KEX2_1	517	519	PF00082	0.622
CLV_PCSK_KEX2_1	56	58	PF00082	0.443
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.623
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.476
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.663
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.720
CLV_PCSK_PC7_1	429	435	PF00082	0.414
CLV_PCSK_SKI1_1	157	161	PF00082	0.474
CLV_PCSK_SKI1_1	189	193	PF00082	0.472
CLV_PCSK_SKI1_1	278	282	PF00082	0.621
CLV_PCSK_SKI1_1	347	351	PF00082	0.437
CLV_PCSK_SKI1_1	365	369	PF00082	0.418
CLV_PCSK_SKI1_1	433	437	PF00082	0.525
CLV_PCSK_SKI1_1	547	551	PF00082	0.592
CLV_PCSK_SKI1_1	568	572	PF00082	0.432
CLV_PCSK_SKI1_1	596	600	PF00082	0.490
CLV_PCSK_SKI1_1	786	790	PF00082	0.591
CLV_PCSK_SKI1_1	875	879	PF00082	0.402
CLV_PCSK_SKI1_1	931	935	PF00082	0.371
CLV_Separin_Metazoa	597	601	PF03568	0.521
DEG_APCC_DBOX_1	213	221	PF00400	0.542
DEG_APCC_DBOX_1	595	603	PF00400	0.483
DEG_APCC_DBOX_1	785	793	PF00400	0.588
DEG_Nend_UBRbox_3	1	3	PF02207	0.646
DEG_SPOP_SBC_1	124	128	PF00917	0.527
DOC_CYCLIN_RxL_1	343	354	PF00134	0.418
DOC_CYCLIN_RxL_1	428	438	PF00134	0.390
DOC_CYCLIN_RxL_1	928	936	PF00134	0.364
DOC_CYCLIN_yCln2_LP_2	108	111	PF00134	0.661
DOC_CYCLIN_yCln2_LP_2	673	679	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	787	793	PF00134	0.444
DOC_MAPK_gen_1	262	271	PF00069	0.456
DOC_MAPK_gen_1	303	310	PF00069	0.439
DOC_MAPK_gen_1	514	524	PF00069	0.710
DOC_MAPK_gen_1	544	552	PF00069	0.543
DOC_MAPK_HePTP_8	819	831	PF00069	0.348
DOC_MAPK_MEF2A_6	262	271	PF00069	0.435
DOC_MAPK_MEF2A_6	365	374	PF00069	0.335
DOC_MAPK_MEF2A_6	786	793	PF00069	0.463
DOC_MAPK_MEF2A_6	822	831	PF00069	0.344
DOC_MAPK_NFAT4_5	264	272	PF00069	0.429
DOC_PP1_RVXF_1	405	411	PF00149	0.538
DOC_PP1_RVXF_1	898	905	PF00149	0.474
DOC_PP2B_LxvP_1	108	111	PF13499	0.769
DOC_PP2B_LxvP_1	673	676	PF13499	0.534
DOC_PP2B_LxvP_1	787	790	PF13499	0.418
DOC_PP2B_LxvP_1	793	796	PF13499	0.495
DOC_USP7_MATH_1	114	118	PF00917	0.646
DOC_USP7_MATH_1	146	150	PF00917	0.616
DOC_USP7_MATH_1	196	200	PF00917	0.594
DOC_USP7_MATH_1	280	284	PF00917	0.617
DOC_USP7_MATH_1	639	643	PF00917	0.670
DOC_WW_Pin1_4	134	139	PF00397	0.786
DOC_WW_Pin1_4	181	186	PF00397	0.500
DOC_WW_Pin1_4	285	290	PF00397	0.530
DOC_WW_Pin1_4	75	80	PF00397	0.615
DOC_WW_Pin1_4	854	859	PF00397	0.537
DOC_WW_Pin1_4	933	938	PF00397	0.404
LIG_14-3-3_CanoR_1	171	178	PF00244	0.588
LIG_14-3-3_CanoR_1	181	185	PF00244	0.638
LIG_14-3-3_CanoR_1	303	311	PF00244	0.560
LIG_14-3-3_CanoR_1	348	354	PF00244	0.591
LIG_14-3-3_CanoR_1	365	374	PF00244	0.503
LIG_14-3-3_CanoR_1	413	420	PF00244	0.552
LIG_14-3-3_CanoR_1	433	442	PF00244	0.300
LIG_14-3-3_CanoR_1	600	609	PF00244	0.531
LIG_14-3-3_CanoR_1	636	644	PF00244	0.531
LIG_14-3-3_CanoR_1	655	664	PF00244	0.515
LIG_14-3-3_CanoR_1	66	71	PF00244	0.481
LIG_14-3-3_CanoR_1	801	809	PF00244	0.664
LIG_14-3-3_CanoR_1	875	881	PF00244	0.553
LIG_14-3-3_CanoR_1	942	949	PF00244	0.430
LIG_Actin_WH2_2	585	602	PF00022	0.515
LIG_APCC_ABBA_1	909	914	PF00400	0.353
LIG_BRCT_BRCA1_1	677	681	PF00533	0.496
LIG_BRCT_BRCA1_1	873	877	PF00533	0.497
LIG_Clathr_ClatBox_1	350	354	PF01394	0.462
LIG_CtBP_PxDLS_1	291	295	PF00389	0.599
LIG_FHA_1	139	145	PF00498	0.574
LIG_FHA_1	181	187	PF00498	0.637
LIG_FHA_1	644	650	PF00498	0.526
LIG_FHA_1	737	743	PF00498	0.490
LIG_FHA_1	762	768	PF00498	0.466
LIG_FHA_1	804	810	PF00498	0.530
LIG_FHA_1	854	860	PF00498	0.533
LIG_FHA_1	877	883	PF00498	0.394
LIG_FHA_1	942	948	PF00498	0.397
LIG_FHA_1	950	956	PF00498	0.312
LIG_FHA_2	366	372	PF00498	0.382
LIG_FHA_2	382	388	PF00498	0.534
LIG_FHA_2	450	456	PF00498	0.490
LIG_FHA_2	493	499	PF00498	0.579
LIG_FHA_2	606	612	PF00498	0.507
LIG_FHA_2	720	726	PF00498	0.335
LIG_LIR_Gen_1	551	557	PF02991	0.472
LIG_LIR_Gen_1	688	697	PF02991	0.395
LIG_LIR_Gen_1	823	834	PF02991	0.384
LIG_LIR_Gen_1	880	888	PF02991	0.459
LIG_LIR_Gen_1	908	916	PF02991	0.410
LIG_LIR_Nem_3	46	51	PF02991	0.572
LIG_LIR_Nem_3	54	58	PF02991	0.611
LIG_LIR_Nem_3	551	556	PF02991	0.472
LIG_LIR_Nem_3	678	683	PF02991	0.406
LIG_LIR_Nem_3	823	829	PF02991	0.388
LIG_LIR_Nem_3	880	886	PF02991	0.307
LIG_LIR_Nem_3	908	912	PF02991	0.385
LIG_MLH1_MIPbox_1	677	681	PF16413	0.469
LIG_MYND_1	110	114	PF01753	0.701
LIG_PDZ_Class_1	958	963	PF00595	0.453
LIG_SH2_STAP1	689	693	PF00017	0.398
LIG_SH2_STAT5	826	829	PF00017	0.272
LIG_SH2_STAT5	850	853	PF00017	0.349
LIG_SH3_1	97	103	PF00018	0.538
LIG_SH3_3	108	114	PF00018	0.739
LIG_SH3_3	67	73	PF00018	0.703
LIG_SH3_3	866	872	PF00018	0.425
LIG_SH3_3	97	103	PF00018	0.713
LIG_SUMO_SIM_anti_2	306	313	PF11976	0.430
LIG_SUMO_SIM_par_1	816	823	PF11976	0.419
LIG_TRAF2_1	206	209	PF00917	0.586
LIG_TRAF2_1	384	387	PF00917	0.424
LIG_TRAF2_1	722	725	PF00917	0.307
LIG_TRAF2_1	810	813	PF00917	0.388
LIG_TYR_ITIM	824	829	PF00017	0.276
LIG_UBA3_1	332	337	PF00899	0.545
LIG_WRC_WIRS_1	649	654	PF05994	0.398
LIG_WRC_WIRS_1	906	911	PF05994	0.481
MOD_CK1_1	117	123	PF00069	0.803
MOD_CK1_1	125	131	PF00069	0.732
MOD_CK1_1	256	262	PF00069	0.535
MOD_CK1_1	359	365	PF00069	0.568
MOD_CK1_1	394	400	PF00069	0.474
MOD_CK1_1	412	418	PF00069	0.580
MOD_CK1_1	471	477	PF00069	0.524
MOD_CK1_1	62	68	PF00069	0.722
MOD_CK2_1	146	152	PF00069	0.571
MOD_CK2_1	203	209	PF00069	0.405
MOD_CK2_1	279	285	PF00069	0.607
MOD_CK2_1	363	369	PF00069	0.497
MOD_CK2_1	379	385	PF00069	0.569
MOD_CK2_1	605	611	PF00069	0.430
MOD_CK2_1	719	725	PF00069	0.430
MOD_CK2_1	807	813	PF00069	0.599
MOD_CK2_1	87	93	PF00069	0.775
MOD_DYRK1A_RPxSP_1	181	185	PF00069	0.438
MOD_GlcNHglycan	172	175	PF01048	0.483
MOD_GlcNHglycan	197	201	PF01048	0.579
MOD_GlcNHglycan	469	473	PF01048	0.520
MOD_GlcNHglycan	61	64	PF01048	0.677
MOD_GlcNHglycan	641	644	PF01048	0.626
MOD_GlcNHglycan	809	812	PF01048	0.566
MOD_GlcNHglycan	815	818	PF01048	0.477
MOD_GlcNHglycan	83	87	PF01048	0.661
MOD_GlcNHglycan	89	92	PF01048	0.628
MOD_GlcNHglycan	960	963	PF01048	0.547
MOD_GSK3_1	134	141	PF00069	0.713
MOD_GSK3_1	280	287	PF00069	0.659
MOD_GSK3_1	359	366	PF00069	0.552
MOD_GSK3_1	375	382	PF00069	0.619
MOD_GSK3_1	62	69	PF00069	0.621
MOD_GSK3_1	639	646	PF00069	0.488
MOD_GSK3_1	675	682	PF00069	0.406
MOD_GSK3_1	719	726	PF00069	0.436
MOD_GSK3_1	803	810	PF00069	0.629
MOD_GSK3_1	871	878	PF00069	0.467
MOD_GSK3_1	951	958	PF00069	0.378
MOD_N-GLC_1	114	119	PF02516	0.496
MOD_N-GLC_1	189	194	PF02516	0.719
MOD_N-GLC_1	224	229	PF02516	0.353
MOD_NEK2_1	170	175	PF00069	0.444
MOD_NEK2_1	203	208	PF00069	0.435
MOD_NEK2_1	224	229	PF00069	0.378
MOD_NEK2_1	310	315	PF00069	0.509
MOD_NEK2_1	391	396	PF00069	0.438
MOD_NEK2_1	435	440	PF00069	0.508
MOD_NEK2_1	449	454	PF00069	0.525
MOD_NEK2_1	580	585	PF00069	0.421
MOD_NEK2_1	610	615	PF00069	0.651
MOD_NEK2_1	664	669	PF00069	0.441
MOD_NEK2_1	807	812	PF00069	0.664
MOD_PIKK_1	115	121	PF00454	0.506
MOD_PIKK_1	212	218	PF00454	0.530
MOD_PIKK_1	248	254	PF00454	0.526
MOD_PIKK_1	359	365	PF00454	0.333
MOD_PIKK_1	43	49	PF00454	0.619
MOD_PIKK_1	435	441	PF00454	0.398
MOD_PIKK_1	449	455	PF00454	0.580
MOD_PIKK_1	512	518	PF00454	0.467
MOD_PIKK_1	656	662	PF00454	0.607
MOD_PKA_1	303	309	PF00069	0.558
MOD_PKA_1	510	516	PF00069	0.616
MOD_PKA_1	600	606	PF00069	0.612
MOD_PKA_2	170	176	PF00069	0.647
MOD_PKA_2	180	186	PF00069	0.660
MOD_PKA_2	253	259	PF00069	0.561
MOD_PKA_2	375	381	PF00069	0.473
MOD_PKA_2	399	405	PF00069	0.416
MOD_PKA_2	412	418	PF00069	0.438
MOD_PKA_2	420	426	PF00069	0.445
MOD_PKA_2	510	516	PF00069	0.607
MOD_PKA_2	605	611	PF00069	0.424
MOD_PKA_2	65	71	PF00069	0.481
MOD_PKA_2	865	871	PF00069	0.401
MOD_PKA_2	914	920	PF00069	0.541
MOD_PKA_2	941	947	PF00069	0.450
MOD_Plk_1	189	195	PF00069	0.487
MOD_Plk_1	224	230	PF00069	0.577
MOD_Plk_1	468	474	PF00069	0.591
MOD_Plk_1	610	616	PF00069	0.517
MOD_Plk_1	723	729	PF00069	0.401
MOD_Plk_1	737	743	PF00069	0.416
MOD_Plk_1	761	767	PF00069	0.427
MOD_Plk_2-3	605	611	PF00069	0.446
MOD_Plk_4	224	230	PF00069	0.577
MOD_Plk_4	605	611	PF00069	0.448
MOD_Plk_4	622	628	PF00069	0.514
MOD_Plk_4	66	72	PF00069	0.482
MOD_Plk_4	675	681	PF00069	0.415
MOD_Plk_4	723	729	PF00069	0.302
MOD_Plk_4	774	780	PF00069	0.506
MOD_Plk_4	865	871	PF00069	0.382
MOD_Plk_4	905	911	PF00069	0.436
MOD_Plk_4	955	961	PF00069	0.353
MOD_ProDKin_1	134	140	PF00069	0.788
MOD_ProDKin_1	181	187	PF00069	0.503
MOD_ProDKin_1	285	291	PF00069	0.527
MOD_ProDKin_1	75	81	PF00069	0.616
MOD_ProDKin_1	854	860	PF00069	0.549
MOD_ProDKin_1	933	939	PF00069	0.400
MOD_SUMO_for_1	325	328	PF00179	0.405
MOD_SUMO_for_1	464	467	PF00179	0.545
MOD_SUMO_rev_2	334	339	PF00179	0.475
MOD_SUMO_rev_2	36	41	PF00179	0.497
MOD_SUMO_rev_2	810	817	PF00179	0.627
TRG_DiLeu_BaEn_1	263	268	PF01217	0.412
TRG_DiLeu_BaEn_1	328	333	PF01217	0.409
TRG_DiLeu_BaEn_1	387	392	PF01217	0.544
TRG_DiLeu_BaEn_1	605	610	PF01217	0.430
TRG_DiLeu_BaEn_1	738	743	PF01217	0.477
TRG_DiLeu_BaEn_4	611	617	PF01217	0.518
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.362
TRG_DiLeu_BaLyEn_6	763	768	PF01217	0.306
TRG_DiLeu_BaLyEn_6	929	934	PF01217	0.402
TRG_DiLeu_LyEn_5	328	333	PF01217	0.541
TRG_ENDOCYTIC_2	689	692	PF00928	0.396
TRG_ENDOCYTIC_2	710	713	PF00928	0.403
TRG_ENDOCYTIC_2	826	829	PF00928	0.272
TRG_ER_diArg_1	433	435	PF00400	0.447
TRG_ER_diArg_1	445	448	PF00400	0.492
TRG_ER_diArg_1	48	50	PF00400	0.573
TRG_ER_diArg_1	55	57	PF00400	0.603
TRG_ER_diArg_1	616	619	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	434	439	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	655	660	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	698	702	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	891	895	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDE6	Leptomonas seymouri	61%	98%
A0A1X0NZR4	Trypanosomatidae	43%	100%
A0A3Q8IF75	Leishmania donovani	82%	99%
A0A3R7KK73	Trypanosoma rangeli	45%	100%
A4I490	Leishmania infantum	82%	99%
C9ZKP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ADN9	Leishmania major	81%	99%
E9AM41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5BPY2	Trypanosoma cruzi	43%	95%