C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH37_LEIBR

TriTrypDb:

LbrM.29.0300 , LBRM2903_290009400

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH37

PDB structure(s): 7aih_Ay , 7ane_Ay

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.458
CLV_NRD_NRD_1	29	31	PF00675	0.462
CLV_NRD_NRD_1	38	40	PF00675	0.451
CLV_PCSK_KEX2_1	133	135	PF00082	0.458
CLV_PCSK_KEX2_1	38	40	PF00082	0.451
CLV_PCSK_SKI1_1	137	141	PF00082	0.595
CLV_PCSK_SKI1_1	6	10	PF00082	0.569
DEG_APCC_DBOX_1	5	13	PF00400	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.534
DOC_CYCLIN_RxL_1	3	13	PF00134	0.529
DOC_PP1_RVXF_1	82	88	PF00149	0.444
DOC_USP7_MATH_1	20	24	PF00917	0.516
DOC_WW_Pin1_4	141	146	PF00397	0.392
DOC_WW_Pin1_4	168	173	PF00397	0.430
LIG_14-3-3_CanoR_1	137	142	PF00244	0.490
LIG_14-3-3_CanoR_1	38	44	PF00244	0.577
LIG_DCNL_PONY_1	1	4	PF03556	0.587
LIG_deltaCOP1_diTrp_1	108	113	PF00928	0.379
LIG_deltaCOP1_diTrp_1	165	174	PF00928	0.436
LIG_deltaCOP1_diTrp_1	49	53	PF00928	0.414
LIG_FHA_1	17	23	PF00498	0.624
LIG_FHA_2	126	132	PF00498	0.568
LIG_FHA_2	138	144	PF00498	0.457
LIG_LIR_Gen_1	108	118	PF02991	0.416
LIG_LIR_Gen_1	144	154	PF02991	0.399
LIG_LIR_Nem_3	108	113	PF02991	0.377
LIG_LIR_Nem_3	144	150	PF02991	0.439
LIG_SH2_STAT5	102	105	PF00017	0.506
LIG_SH2_STAT5	52	55	PF00017	0.570
LIG_SH3_3	157	163	PF00018	0.531
LIG_SH3_3	166	172	PF00018	0.431
LIG_TRAF2_1	106	109	PF00917	0.524
LIG_UBA3_1	26	34	PF00899	0.460
LIG_ULM_U2AF65_1	30	36	PF00076	0.452
MOD_CDK_SPK_2	168	173	PF00069	0.430
MOD_CK2_1	103	109	PF00069	0.403
MOD_CK2_1	125	131	PF00069	0.505
MOD_CK2_1	137	143	PF00069	0.428
MOD_GlcNHglycan	22	25	PF01048	0.481
MOD_GSK3_1	10	17	PF00069	0.555
MOD_GSK3_1	137	144	PF00069	0.530
MOD_N-GLC_1	15	20	PF02516	0.513
MOD_NEK2_1	2	7	PF00069	0.470
MOD_PKA_1	30	36	PF00069	0.472
MOD_PKA_1	38	44	PF00069	0.463
MOD_PKA_2	2	8	PF00069	0.490
MOD_PKA_2	37	43	PF00069	0.440
MOD_PKA_2	94	100	PF00069	0.430
MOD_PKB_1	28	36	PF00069	0.474
MOD_Plk_1	10	16	PF00069	0.557
MOD_ProDKin_1	141	147	PF00069	0.393
MOD_ProDKin_1	168	174	PF00069	0.435
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.338
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.505
TRG_ER_diArg_1	133	135	PF00400	0.500
TRG_ER_diArg_1	27	30	PF00400	0.486
TRG_ER_diArg_1	84	87	PF00400	0.380
TRG_NLS_MonoExtC_3	29	34	PF00514	0.456
TRG_NLS_MonoExtN_4	28	35	PF00514	0.461
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F9	Leptomonas seymouri	83%	100%
A0A0S4KP62	Bodo saltans	60%	100%
A0A1X0P0Z3	Trypanosomatidae	65%	100%
A0A3Q8IR30	Leishmania donovani	94%	100%
A0A422NUJ5	Trypanosoma rangeli	77%	100%
A4I488	Leishmania infantum	94%	100%
C9ZKP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9ADN7	Leishmania major	94%	100%
E9AM43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%