UBX domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UBX domain-containing protein

Species:

Leishmania braziliensis

UniProt:

A4HH35_LEIBR

TriTrypDb:

LbrM.29.0280 , LBRM2903_290009200

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HH35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH35

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.385
CLV_C14_Caspase3-7	337	341	PF00656	0.561
CLV_PCSK_SKI1_1	121	125	PF00082	0.501
CLV_PCSK_SKI1_1	130	134	PF00082	0.361
CLV_PCSK_SKI1_1	163	167	PF00082	0.531
CLV_PCSK_SKI1_1	400	404	PF00082	0.497
DEG_COP1_1	310	317	PF00400	0.474
DEG_SPOP_SBC_1	265	269	PF00917	0.686
DEG_SPOP_SBC_1	352	356	PF00917	0.516
DOC_CKS1_1	362	367	PF01111	0.383
DOC_CKS1_1	89	94	PF01111	0.615
DOC_MAPK_DCC_7	384	393	PF00069	0.556
DOC_MAPK_MEF2A_6	134	142	PF00069	0.346
DOC_MAPK_MEF2A_6	384	393	PF00069	0.518
DOC_MAPK_MEF2A_6	419	428	PF00069	0.375
DOC_PP1_RVXF_1	119	125	PF00149	0.299
DOC_PP2B_LxvP_1	67	70	PF13499	0.517
DOC_PP2B_PxIxI_1	388	394	PF00149	0.510
DOC_PP4_FxxP_1	110	113	PF00568	0.373
DOC_PP4_FxxP_1	246	249	PF00568	0.580
DOC_USP7_MATH_1	161	165	PF00917	0.508
DOC_USP7_MATH_1	292	296	PF00917	0.497
DOC_USP7_MATH_1	307	311	PF00917	0.775
DOC_USP7_MATH_1	352	356	PF00917	0.579
DOC_USP7_MATH_1	97	101	PF00917	0.556
DOC_WW_Pin1_4	245	250	PF00397	0.499
DOC_WW_Pin1_4	272	277	PF00397	0.562
DOC_WW_Pin1_4	290	295	PF00397	0.712
DOC_WW_Pin1_4	321	326	PF00397	0.515
DOC_WW_Pin1_4	361	366	PF00397	0.410
DOC_WW_Pin1_4	44	49	PF00397	0.720
DOC_WW_Pin1_4	52	57	PF00397	0.719
DOC_WW_Pin1_4	62	67	PF00397	0.642
DOC_WW_Pin1_4	68	73	PF00397	0.626
DOC_WW_Pin1_4	88	93	PF00397	0.699
LIG_14-3-3_CanoR_1	163	171	PF00244	0.522
LIG_14-3-3_CanoR_1	350	360	PF00244	0.516
LIG_14-3-3_CanoR_1	384	388	PF00244	0.524
LIG_14-3-3_CanoR_1	96	106	PF00244	0.607
LIG_AP2alpha_2	244	246	PF02296	0.672
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_BIR_III_4	256	260	PF00653	0.520
LIG_deltaCOP1_diTrp_1	219	223	PF00928	0.538
LIG_FHA_1	151	157	PF00498	0.456
LIG_FHA_1	273	279	PF00498	0.671
LIG_FHA_1	298	304	PF00498	0.505
LIG_FHA_1	309	315	PF00498	0.729
LIG_FHA_1	355	361	PF00498	0.415
LIG_FHA_1	89	95	PF00498	0.521
LIG_FHA_2	235	241	PF00498	0.514
LIG_FHA_2	325	331	PF00498	0.519
LIG_FHA_2	335	341	PF00498	0.572
LIG_FHA_2	401	407	PF00498	0.538
LIG_FHA_2	57	63	PF00498	0.525
LIG_LIR_Apic_2	244	249	PF02991	0.604
LIG_LIR_Apic_2	329	334	PF02991	0.571
LIG_LIR_Apic_2	382	388	PF02991	0.539
LIG_LIR_Nem_3	371	375	PF02991	0.400
LIG_LIR_Nem_3	392	397	PF02991	0.551
LIG_LIR_Nem_3	413	418	PF02991	0.415
LIG_NRBOX	372	378	PF00104	0.376
LIG_PDZ_Class_2	425	430	PF00595	0.509
LIG_SH2_CRK	349	353	PF00017	0.325
LIG_SH2_CRK	385	389	PF00017	0.455
LIG_SH2_NCK_1	331	335	PF00017	0.566
LIG_SH2_NCK_1	385	389	PF00017	0.455
LIG_SH2_STAP1	173	177	PF00017	0.402
LIG_SH2_STAP1	28	32	PF00017	0.412
LIG_SH2_STAT5	115	118	PF00017	0.460
LIG_SH2_STAT5	24	27	PF00017	0.289
LIG_SH2_STAT5	331	334	PF00017	0.551
LIG_SH2_STAT5	372	375	PF00017	0.342
LIG_SH2_STAT5	378	381	PF00017	0.376
LIG_SH3_2	83	88	PF14604	0.591
LIG_SH3_3	239	245	PF00018	0.600
LIG_SH3_3	309	315	PF00018	0.603
LIG_SH3_3	317	323	PF00018	0.559
LIG_SH3_3	359	365	PF00018	0.381
LIG_SH3_3	80	86	PF00018	0.674
LIG_SH3_3	87	93	PF00018	0.622
LIG_SUMO_SIM_par_1	138	144	PF11976	0.434
LIG_SUMO_SIM_par_1	275	281	PF11976	0.616
LIG_SUMO_SIM_par_1	310	316	PF11976	0.630
LIG_SUMO_SIM_par_1	324	330	PF11976	0.360
MOD_CDK_SPK_2	44	49	PF00069	0.479
MOD_CDK_SPxxK_3	361	368	PF00069	0.498
MOD_CK1_1	164	170	PF00069	0.453
MOD_CK1_1	293	299	PF00069	0.707
MOD_CK1_1	324	330	PF00069	0.529
MOD_CK1_1	354	360	PF00069	0.578
MOD_CK1_1	392	398	PF00069	0.502
MOD_CK1_1	413	419	PF00069	0.425
MOD_CK1_1	44	50	PF00069	0.526
MOD_CK1_1	60	66	PF00069	0.658
MOD_CK1_1	68	74	PF00069	0.650
MOD_CK2_1	284	290	PF00069	0.720
MOD_CK2_1	307	313	PF00069	0.762
MOD_CK2_1	324	330	PF00069	0.421
MOD_CK2_1	400	406	PF00069	0.582
MOD_CK2_1	98	104	PF00069	0.604
MOD_DYRK1A_RPxSP_1	361	365	PF00069	0.510
MOD_DYRK1A_RPxSP_1	88	92	PF00069	0.684
MOD_GlcNHglycan	166	169	PF01048	0.522
MOD_GlcNHglycan	192	195	PF01048	0.324
MOD_GlcNHglycan	224	227	PF01048	0.522
MOD_GlcNHglycan	268	271	PF01048	0.727
MOD_GlcNHglycan	297	300	PF01048	0.617
MOD_GlcNHglycan	394	397	PF01048	0.582
MOD_GlcNHglycan	419	422	PF01048	0.463
MOD_GlcNHglycan	67	70	PF01048	0.697
MOD_GSK3_1	293	300	PF00069	0.665
MOD_GSK3_1	376	383	PF00069	0.474
MOD_GSK3_1	413	420	PF00069	0.428
MOD_GSK3_1	52	59	PF00069	0.715
MOD_N-GLC_1	175	180	PF02516	0.421
MOD_N-GLC_1	272	277	PF02516	0.632
MOD_N-GLC_1	400	405	PF02516	0.495
MOD_NEK2_1	234	239	PF00069	0.544
MOD_NEK2_1	98	103	PF00069	0.633
MOD_NEK2_2	389	394	PF00069	0.380
MOD_PIKK_1	203	209	PF00454	0.432
MOD_PKA_2	383	389	PF00069	0.440
MOD_Plk_1	143	149	PF00069	0.467
MOD_Plk_1	329	335	PF00069	0.517
MOD_Plk_1	380	386	PF00069	0.503
MOD_Plk_2-3	329	335	PF00069	0.489
MOD_Plk_4	138	144	PF00069	0.347
MOD_Plk_4	166	172	PF00069	0.432
MOD_ProDKin_1	245	251	PF00069	0.501
MOD_ProDKin_1	272	278	PF00069	0.561
MOD_ProDKin_1	290	296	PF00069	0.713
MOD_ProDKin_1	321	327	PF00069	0.512
MOD_ProDKin_1	361	367	PF00069	0.405
MOD_ProDKin_1	44	50	PF00069	0.725
MOD_ProDKin_1	52	58	PF00069	0.718
MOD_ProDKin_1	62	68	PF00069	0.641
MOD_ProDKin_1	88	94	PF00069	0.700
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.443
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.379
TRG_ER_diArg_1	345	348	PF00400	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T7	Leptomonas seymouri	57%	100%
A0A0S4JDU8	Bodo saltans	27%	83%
A0A1X0NZG7	Trypanosomatidae	27%	97%
A0A3Q8IH33	Leishmania donovani	83%	100%
A0A3R7M3Q4	Trypanosoma rangeli	27%	100%
A4I486	Leishmania infantum	83%	100%
C9ZKP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ADN5	Leishmania major	83%	100%
E9AM45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5B4U5	Trypanosoma cruzi	27%	100%