Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania braziliensis

UniProt:

A4HH34_LEIBR

TriTrypDb:

LbrM.29.0270 , LBRM2903_290009100

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH34

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	10
GO:0008047	enzyme activator activity	3	10
GO:0030234	enzyme regulator activity	2	10
GO:0030695	GTPase regulator activity	4	10
GO:0060589	nucleoside-triphosphatase regulator activity	3	10
GO:0098772	molecular function regulator activity	1	10
GO:0140677	molecular function activator activity	2	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.529
CLV_NRD_NRD_1	12	14	PF00675	0.685
CLV_NRD_NRD_1	182	184	PF00675	0.344
CLV_NRD_NRD_1	209	211	PF00675	0.415
CLV_NRD_NRD_1	269	271	PF00675	0.698
CLV_NRD_NRD_1	37	39	PF00675	0.678
CLV_PCSK_KEX2_1	209	211	PF00082	0.403
CLV_PCSK_KEX2_1	247	249	PF00082	0.632
CLV_PCSK_KEX2_1	269	271	PF00082	0.660
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.632

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F7	Leptomonas seymouri	52%	99%
A0A1X0NZE9	Trypanosomatidae	42%	100%
A0A3Q8IE49	Leishmania donovani	68%	97%
A0A422N066	Trypanosoma rangeli	47%	100%
A4I485	Leishmania infantum	69%	97%
C9ZKP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ADN4	Leishmania major	66%	100%
E9AM46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	97%

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