Arf-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania braziliensis

UniProt:

A4HH34_LEIBR

TriTrypDb:

LbrM.29.0270 , LBRM2903_290009100

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH34

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	10
GO:0008047	enzyme activator activity	3	10
GO:0030234	enzyme regulator activity	2	10
GO:0030695	GTPase regulator activity	4	10
GO:0060589	nucleoside-triphosphatase regulator activity	3	10
GO:0098772	molecular function regulator activity	1	10
GO:0140677	molecular function activator activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.529
CLV_NRD_NRD_1	12	14	PF00675	0.685
CLV_NRD_NRD_1	182	184	PF00675	0.344
CLV_NRD_NRD_1	209	211	PF00675	0.415
CLV_NRD_NRD_1	269	271	PF00675	0.698
CLV_NRD_NRD_1	37	39	PF00675	0.678
CLV_PCSK_KEX2_1	209	211	PF00082	0.403
CLV_PCSK_KEX2_1	247	249	PF00082	0.632
CLV_PCSK_KEX2_1	269	271	PF00082	0.660
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.632
CLV_PCSK_PC7_1	265	271	PF00082	0.655
CLV_PCSK_SKI1_1	141	145	PF00082	0.264
CLV_PCSK_SKI1_1	196	200	PF00082	0.409
CLV_PCSK_SKI1_1	212	216	PF00082	0.526
DEG_APCC_DBOX_1	133	141	PF00400	0.400
DEG_SCF_FBW7_2	343	348	PF00400	0.509
DEG_SPOP_SBC_1	44	48	PF00917	0.723
DOC_ANK_TNKS_1	217	224	PF00023	0.447
DOC_CYCLIN_yClb5_NLxxxL_5	190	199	PF00134	0.442
DOC_USP7_MATH_1	163	167	PF00917	0.450
DOC_USP7_MATH_1	214	218	PF00917	0.459
DOC_USP7_MATH_1	235	239	PF00917	0.603
DOC_USP7_MATH_1	367	371	PF00917	0.707
DOC_USP7_MATH_1	44	48	PF00917	0.755
DOC_USP7_UBL2_3	10	14	PF12436	0.602
DOC_USP7_UBL2_3	212	216	PF12436	0.566
DOC_USP7_UBL2_3	35	39	PF12436	0.680
DOC_WW_Pin1_4	341	346	PF00397	0.709
DOC_WW_Pin1_4	362	367	PF00397	0.667
DOC_WW_Pin1_4	368	373	PF00397	0.588
LIG_14-3-3_CanoR_1	134	138	PF00244	0.363
LIG_14-3-3_CanoR_1	303	309	PF00244	0.515
LIG_14-3-3_CanoR_1	99	104	PF00244	0.203
LIG_APCC_ABBA_1	177	182	PF00400	0.203
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_deltaCOP1_diTrp_1	301	311	PF00928	0.533
LIG_FHA_1	287	293	PF00498	0.475
LIG_FHA_1	305	311	PF00498	0.643
LIG_FHA_1	348	354	PF00498	0.548
LIG_FHA_1	46	52	PF00498	0.720
LIG_FHA_2	128	134	PF00498	0.308
LIG_FHA_2	170	176	PF00498	0.231
LIG_FHA_2	310	316	PF00498	0.479
LIG_Integrin_RGD_1	248	250	PF01839	0.620
LIG_Integrin_RGD_1	330	332	PF01839	0.543
LIG_LIR_Gen_1	98	108	PF02991	0.284
LIG_LIR_Nem_3	286	290	PF02991	0.561
LIG_LIR_Nem_3	98	103	PF02991	0.284
LIG_PDZ_Class_2	371	376	PF00595	0.641
LIG_SH2_STAP1	155	159	PF00017	0.284
LIG_SH2_STAP1	300	304	PF00017	0.533
LIG_SH3_3	222	228	PF00018	0.559
LIG_SH3_3	290	296	PF00018	0.513
LIG_SH3_3	311	317	PF00018	0.538
LIG_SH3_3	318	324	PF00018	0.622
LIG_SH3_3	366	372	PF00018	0.497
LIG_SUMO_SIM_par_1	222	229	PF11976	0.464
LIG_SUMO_SIM_par_1	306	312	PF11976	0.537
LIG_TRAF2_1	296	299	PF00917	0.677
LIG_TRAF2_1	324	327	PF00917	0.650
LIG_WRC_WIRS_1	287	292	PF05994	0.632
LIG_WRC_WIRS_1	310	315	PF05994	0.421
MOD_CK1_1	226	232	PF00069	0.541
MOD_CK1_1	268	274	PF00069	0.566
MOD_CK1_1	370	376	PF00069	0.619
MOD_CK1_1	46	52	PF00069	0.620
MOD_CK2_1	133	139	PF00069	0.337
MOD_CK2_1	169	175	PF00069	0.255
MOD_CK2_1	309	315	PF00069	0.568
MOD_Cter_Amidation	245	248	PF01082	0.648
MOD_GlcNHglycan	113	116	PF01048	0.306
MOD_GlcNHglycan	166	169	PF01048	0.409
MOD_GSK3_1	12	19	PF00069	0.694
MOD_GSK3_1	122	129	PF00069	0.310
MOD_GSK3_1	210	217	PF00069	0.486
MOD_GSK3_1	337	344	PF00069	0.676
MOD_GSK3_1	34	41	PF00069	0.665
MOD_GSK3_1	361	368	PF00069	0.528
MOD_GSK3_1	45	52	PF00069	0.649
MOD_GSK3_1	95	102	PF00069	0.284
MOD_LATS_1	32	38	PF00433	0.670
MOD_N-GLC_2	88	90	PF02516	0.274
MOD_NEK2_1	50	55	PF00069	0.670
MOD_PIKK_1	273	279	PF00454	0.502
MOD_PK_1	16	22	PF00069	0.532
MOD_PK_1	99	105	PF00069	0.284
MOD_PKA_1	34	40	PF00069	0.652
MOD_PKA_2	111	117	PF00069	0.267
MOD_PKA_2	12	18	PF00069	0.655
MOD_PKA_2	133	139	PF00069	0.400
MOD_PKA_2	163	169	PF00069	0.412
MOD_PKA_2	208	214	PF00069	0.390
MOD_PKA_2	268	274	PF00069	0.662
MOD_Plk_1	16	22	PF00069	0.547
MOD_Plk_2-3	133	139	PF00069	0.400
MOD_Plk_4	46	52	PF00069	0.481
MOD_ProDKin_1	341	347	PF00069	0.709
MOD_ProDKin_1	362	368	PF00069	0.667
MOD_SUMO_rev_2	31	37	PF00179	0.528
TRG_ENDOCYTIC_2	287	290	PF00928	0.646
TRG_ER_diArg_1	208	210	PF00400	0.415
TRG_NLS_MonoExtC_3	34	39	PF00514	0.552
TRG_NLS_MonoExtN_4	34	39	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.284
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F7	Leptomonas seymouri	52%	99%
A0A1X0NZE9	Trypanosomatidae	42%	100%
A0A3Q8IE49	Leishmania donovani	68%	97%
A0A422N066	Trypanosoma rangeli	47%	100%
A4I485	Leishmania infantum	69%	97%
C9ZKP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ADN4	Leishmania major	66%	100%
E9AM46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	97%