STI1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HH33_LEIBR

TriTrypDb:

LbrM.29.0260 , LBRM2903_290009000

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH33

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0009987	cellular process	1	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.671
CLV_NRD_NRD_1	13	15	PF00675	0.584
CLV_NRD_NRD_1	232	234	PF00675	0.543
CLV_NRD_NRD_1	238	240	PF00675	0.555
CLV_PCSK_FUR_1	215	219	PF00082	0.619
CLV_PCSK_KEX2_1	13	15	PF00082	0.492
CLV_PCSK_KEX2_1	217	219	PF00082	0.558
CLV_PCSK_KEX2_1	232	234	PF00082	0.535
CLV_PCSK_KEX2_1	238	240	PF00082	0.518
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.553
CLV_PCSK_SKI1_1	13	17	PF00082	0.565
CLV_PCSK_SKI1_1	149	153	PF00082	0.569
DEG_APCC_DBOX_1	12	20	PF00400	0.589
DOC_CYCLIN_RxL_1	153	163	PF00134	0.466
DOC_PP1_RVXF_1	204	211	PF00149	0.372
DOC_PP4_FxxP_1	145	148	PF00568	0.567
DOC_USP7_MATH_1	321	325	PF00917	0.616
DOC_USP7_MATH_1	359	363	PF00917	0.726
DOC_USP7_MATH_1	41	45	PF00917	0.550
DOC_USP7_MATH_1	7	11	PF00917	0.383
DOC_USP7_MATH_1	97	101	PF00917	0.415
DOC_USP7_UBL2_3	337	341	PF12436	0.544
LIG_14-3-3_CanoR_1	377	384	PF00244	0.583
LIG_APCC_ABBA_1	1	6	PF00400	0.444
LIG_APCC_ABBA_1	106	111	PF00400	0.502
LIG_FHA_1	156	162	PF00498	0.520
LIG_FHA_1	50	56	PF00498	0.621
LIG_FHA_2	377	383	PF00498	0.810
LIG_FHA_2	72	78	PF00498	0.572
LIG_LIR_Apic_2	144	148	PF02991	0.574
LIG_LIR_Gen_1	204	213	PF02991	0.373
LIG_LIR_Gen_1	70	80	PF02991	0.451
LIG_LIR_Nem_3	204	210	PF02991	0.480
LIG_LIR_Nem_3	70	76	PF02991	0.464
LIG_PCNA_yPIPBox_3	330	343	PF02747	0.579
LIG_SH2_NCK_1	4	8	PF00017	0.399
LIG_SH2_NCK_1	87	91	PF00017	0.446
LIG_SH3_3	48	54	PF00018	0.565
LIG_SUMO_SIM_par_1	157	163	PF11976	0.383
LIG_TRAF2_1	245	248	PF00917	0.563
LIG_TRAF2_1	68	71	PF00917	0.570
LIG_WW_3	364	368	PF00397	0.574
MOD_CK1_1	372	378	PF00069	0.777
MOD_CK1_1	88	94	PF00069	0.418
MOD_CK2_1	65	71	PF00069	0.714
MOD_GlcNHglycan	188	192	PF01048	0.589
MOD_GlcNHglycan	258	261	PF01048	0.685
MOD_GlcNHglycan	361	364	PF01048	0.733
MOD_GlcNHglycan	371	374	PF01048	0.822
MOD_GlcNHglycan	8	12	PF01048	0.487
MOD_GlcNHglycan	99	102	PF01048	0.436
MOD_GSK3_1	369	376	PF00069	0.715
MOD_N-GLC_1	155	160	PF02516	0.370
MOD_N-GLC_1	201	206	PF02516	0.553
MOD_NEK2_2	182	187	PF00069	0.618
MOD_PIKK_1	160	166	PF00454	0.386
MOD_PIKK_1	310	316	PF00454	0.455
MOD_PKA_2	171	177	PF00069	0.450
MOD_PKA_2	376	382	PF00069	0.586
MOD_Plk_1	155	161	PF00069	0.374
MOD_Plk_1	182	188	PF00069	0.607
MOD_Plk_1	201	207	PF00069	0.313
MOD_Plk_2-3	56	62	PF00069	0.654
MOD_Plk_2-3	63	69	PF00069	0.647
MOD_Plk_2-3	71	77	PF00069	0.581
MOD_Plk_4	289	295	PF00069	0.587
MOD_Plk_4	321	327	PF00069	0.602
MOD_SUMO_for_1	101	104	PF00179	0.556
MOD_SUMO_rev_2	107	115	PF00179	0.377
MOD_SUMO_rev_2	196	201	PF00179	0.572
MOD_SUMO_rev_2	29	36	PF00179	0.390
MOD_SUMO_rev_2	324	331	PF00179	0.616
MOD_SUMO_rev_2	61	66	PF00179	0.558
TRG_DiLeu_BaEn_1	71	76	PF01217	0.453
TRG_DiLeu_BaEn_2	202	208	PF01217	0.450
TRG_ENDOCYTIC_2	134	137	PF00928	0.500
TRG_ER_diArg_1	12	14	PF00400	0.593
TRG_ER_diArg_1	169	172	PF00400	0.455
TRG_ER_diArg_1	237	239	PF00400	0.535
TRG_NES_CRM1_1	314	328	PF08389	0.616
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I190	Leptomonas seymouri	61%	100%
A0A1X0NZI2	Trypanosomatidae	41%	100%
A0A3Q8III7	Leishmania donovani	73%	100%
A4I484	Leishmania infantum	73%	100%
C4NYP8	Drosophila melanogaster	25%	100%
E9ADN3	Leishmania major	77%	100%
P50502	Homo sapiens	31%	100%
P50503	Rattus norvegicus	31%	100%
Q5RF31	Pongo abelii	31%	100%
Q5ZLF0	Gallus gallus	33%	100%
Q86DS1	Drosophila melanogaster	25%	100%
Q8NFI4	Homo sapiens	32%	100%
Q8VWG7	Arabidopsis thaliana	29%	100%
Q99L47	Mus musculus	31%	100%
V5BUJ8	Trypanosoma cruzi	40%	100%