LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HH29_LEIBR
TriTrypDb:
LbrM.29.0220 , LBRM2903_290007500 *
Length:
268

Annotations

LeishMANIAdb annotations

A protein of unknown function. Rare homologs are found outside Kinetoplastida, but also uncharacterized (e.g. E1ZIK9_CHLVA)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 9, no: 2
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4HH29
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH29

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 105 107 PF00675 0.616
CLV_NRD_NRD_1 259 261 PF00675 0.619
CLV_NRD_NRD_1 41 43 PF00675 0.667
CLV_PCSK_KEX2_1 105 107 PF00082 0.595
CLV_PCSK_KEX2_1 141 143 PF00082 0.611
CLV_PCSK_KEX2_1 259 261 PF00082 0.592
CLV_PCSK_KEX2_1 41 43 PF00082 0.650
CLV_PCSK_PC1ET2_1 141 143 PF00082 0.615
CLV_PCSK_SKI1_1 5 9 PF00082 0.627
DEG_APCC_DBOX_1 104 112 PF00400 0.389
DOC_MAPK_gen_1 105 113 PF00069 0.383
DOC_MAPK_gen_1 41 50 PF00069 0.389
DOC_MAPK_MEF2A_6 105 113 PF00069 0.255
DOC_USP7_MATH_1 150 154 PF00917 0.253
DOC_USP7_MATH_1 29 33 PF00917 0.636
DOC_USP7_MATH_1 76 80 PF00917 0.418
DOC_USP7_UBL2_3 65 69 PF12436 0.340
LIG_14-3-3_CanoR_1 105 109 PF00244 0.418
LIG_14-3-3_CanoR_1 142 151 PF00244 0.411
LIG_14-3-3_CanoR_1 5 15 PF00244 0.611
LIG_BIR_II_1 1 5 PF00653 0.469
LIG_BRCT_BRCA1_1 132 136 PF00533 0.337
LIG_BRCT_BRCA1_1 161 165 PF00533 0.380
LIG_deltaCOP1_diTrp_1 157 165 PF00928 0.358
LIG_FHA_1 20 26 PF00498 0.392
LIG_FHA_1 210 216 PF00498 0.583
LIG_FHA_1 240 246 PF00498 0.454
LIG_FHA_1 7 13 PF00498 0.545
LIG_FHA_1 94 100 PF00498 0.417
LIG_FHA_2 105 111 PF00498 0.364
LIG_FHA_2 141 147 PF00498 0.400
LIG_LIR_Gen_1 171 181 PF02991 0.337
LIG_LIR_Gen_1 242 252 PF02991 0.572
LIG_LIR_Nem_3 171 176 PF02991 0.409
LIG_LIR_Nem_3 195 201 PF02991 0.298
LIG_LIR_Nem_3 203 209 PF02991 0.446
LIG_LIR_Nem_3 242 247 PF02991 0.441
LIG_NRBOX 11 17 PF00104 0.590
LIG_Pex14_1 184 188 PF04695 0.328
LIG_Pex14_2 180 184 PF04695 0.328
LIG_PTB_Apo_2 155 162 PF02174 0.411
LIG_PTB_Phospho_1 155 161 PF10480 0.410
LIG_REV1ctd_RIR_1 84 90 PF16727 0.468
LIG_SH2_CRK 129 133 PF00017 0.335
LIG_SH2_CRK 161 165 PF00017 0.340
LIG_SH2_CRK 67 71 PF00017 0.378
LIG_SH2_CRK 88 92 PF00017 0.478
LIG_SH2_GRB2like 156 159 PF00017 0.409
LIG_SH2_NCK_1 88 92 PF00017 0.459
LIG_SH2_SRC 156 159 PF00017 0.409
LIG_SH2_STAP1 156 160 PF00017 0.351
LIG_SH2_STAP1 161 165 PF00017 0.364
LIG_SH2_STAP1 225 229 PF00017 0.434
LIG_SH2_STAT3 250 253 PF00017 0.429
LIG_SH2_STAT3 71 74 PF00017 0.316
LIG_SH2_STAT5 211 214 PF00017 0.620
LIG_SH2_STAT5 244 247 PF00017 0.408
LIG_SH2_STAT5 88 91 PF00017 0.455
LIG_SUMO_SIM_par_1 236 242 PF11976 0.452
LIG_TYR_ITIM 196 201 PF00017 0.376
LIG_TYR_ITSM 240 247 PF00017 0.475
LIG_UBA3_1 121 126 PF00899 0.344
MOD_CK1_1 163 169 PF00069 0.441
MOD_CK1_1 23 29 PF00069 0.606
MOD_CK2_1 104 110 PF00069 0.405
MOD_CK2_1 140 146 PF00069 0.434
MOD_CK2_1 163 169 PF00069 0.459
MOD_CK2_1 204 210 PF00069 0.605
MOD_GlcNHglycan 202 205 PF01048 0.308
MOD_GlcNHglycan 212 215 PF01048 0.330
MOD_GlcNHglycan 22 25 PF01048 0.655
MOD_GlcNHglycan 78 81 PF01048 0.596
MOD_GSK3_1 140 147 PF00069 0.387
MOD_GSK3_1 159 166 PF00069 0.426
MOD_GSK3_1 19 26 PF00069 0.488
MOD_GSK3_1 200 207 PF00069 0.332
MOD_NEK2_1 20 25 PF00069 0.533
MOD_NEK2_1 239 244 PF00069 0.475
MOD_NEK2_1 86 91 PF00069 0.441
MOD_NEK2_2 130 135 PF00069 0.438
MOD_NEK2_2 160 165 PF00069 0.364
MOD_PKA_2 104 110 PF00069 0.400
MOD_PKB_1 3 11 PF00069 0.656
MOD_Plk_2-3 169 175 PF00069 0.381
MOD_Plk_4 160 166 PF00069 0.361
MOD_Plk_4 239 245 PF00069 0.417
MOD_Plk_4 35 41 PF00069 0.321
MOD_SUMO_rev_2 133 143 PF00179 0.415
MOD_SUMO_rev_2 32 39 PF00179 0.422
TRG_DiLeu_BaEn_1 116 121 PF01217 0.416
TRG_DiLeu_BaLyEn_6 232 237 PF01217 0.449
TRG_DiLeu_BaLyEn_6 95 100 PF01217 0.429
TRG_DiLeu_LyEn_5 116 121 PF01217 0.435
TRG_ENDOCYTIC_2 129 132 PF00928 0.337
TRG_ENDOCYTIC_2 161 164 PF00928 0.332
TRG_ENDOCYTIC_2 198 201 PF00928 0.375
TRG_ENDOCYTIC_2 244 247 PF00928 0.540
TRG_ENDOCYTIC_2 67 70 PF00928 0.375
TRG_ER_diArg_1 104 106 PF00400 0.423
TRG_ER_diArg_1 3 6 PF00400 0.692
TRG_ER_diArg_1 40 42 PF00400 0.461
TRG_Pf-PMV_PEXEL_1 106 110 PF00026 0.569
TRG_Pf-PMV_PEXEL_1 142 146 PF00026 0.623
TRG_Pf-PMV_PEXEL_1 98 102 PF00026 0.580

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3Y7 Leptomonas seymouri 69% 98%
A0A0S4JLZ3 Bodo saltans 37% 82%
A0A1X0NZF4 Trypanosomatidae 49% 100%
A0A3Q8IBA6 Leishmania donovani 85% 100%
A0A422NUT6 Trypanosoma rangeli 46% 100%
A4I474 Leishmania infantum 85% 100%
C9ZKQ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 99%
E9ADM3 Leishmania major 83% 100%
E9AM58 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
V5B4T7 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS