RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH26_LEIBR

TriTrypDb:

LbrM.29.0190 , LBRM2903_290007200

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HH26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH26

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.609
CLV_C14_Caspase3-7	423	427	PF00656	0.519
CLV_NRD_NRD_1	265	267	PF00675	0.687
CLV_NRD_NRD_1	414	416	PF00675	0.581
CLV_NRD_NRD_1	467	469	PF00675	0.569
CLV_NRD_NRD_1	57	59	PF00675	0.696
CLV_NRD_NRD_1	61	63	PF00675	0.709
CLV_PCSK_FUR_1	55	59	PF00082	0.591
CLV_PCSK_KEX2_1	265	267	PF00082	0.562
CLV_PCSK_KEX2_1	333	335	PF00082	0.392
CLV_PCSK_KEX2_1	410	412	PF00082	0.526
CLV_PCSK_KEX2_1	467	469	PF00082	0.569
CLV_PCSK_KEX2_1	57	59	PF00082	0.693
CLV_PCSK_KEX2_1	61	63	PF00082	0.705
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.490
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.526
CLV_PCSK_PC7_1	57	63	PF00082	0.581
CLV_PCSK_SKI1_1	212	216	PF00082	0.471
CLV_PCSK_SKI1_1	315	319	PF00082	0.557
CLV_PCSK_SKI1_1	341	345	PF00082	0.499
CLV_PCSK_SKI1_1	429	433	PF00082	0.672
DEG_SPOP_SBC_1	474	478	PF00917	0.726
DOC_CKS1_1	120	125	PF01111	0.525
DOC_CKS1_1	134	139	PF01111	0.573
DOC_CKS1_1	374	379	PF01111	0.566
DOC_CYCLIN_RxL_1	339	347	PF00134	0.651
DOC_CYCLIN_yCln2_LP_2	519	522	PF00134	0.566
DOC_MAPK_DCC_7	504	513	PF00069	0.686
DOC_MAPK_MEF2A_6	504	513	PF00069	0.686
DOC_PP1_RVXF_1	250	256	PF00149	0.539
DOC_PP2B_LxvP_1	131	134	PF13499	0.691
DOC_PP2B_LxvP_1	169	172	PF13499	0.594
DOC_PP2B_LxvP_1	519	522	PF13499	0.566
DOC_PP4_FxxP_1	105	108	PF00568	0.499
DOC_PP4_FxxP_1	296	299	PF00568	0.525
DOC_PP4_FxxP_1	490	493	PF00568	0.555
DOC_PP4_MxPP_1	109	112	PF00568	0.498
DOC_USP7_MATH_1	199	203	PF00917	0.610
DOC_USP7_MATH_1	307	311	PF00917	0.483
DOC_USP7_MATH_1	350	354	PF00917	0.787
DOC_USP7_MATH_1	389	393	PF00917	0.771
DOC_USP7_MATH_1	474	478	PF00917	0.713
DOC_USP7_UBL2_3	416	420	PF12436	0.454
DOC_WW_Pin1_4	119	124	PF00397	0.624
DOC_WW_Pin1_4	133	138	PF00397	0.645
DOC_WW_Pin1_4	183	188	PF00397	0.558
DOC_WW_Pin1_4	373	378	PF00397	0.649
DOC_WW_Pin1_4	385	390	PF00397	0.695
DOC_WW_Pin1_4	64	69	PF00397	0.707
DOC_WW_Pin1_4	99	104	PF00397	0.764
LIG_14-3-3_CanoR_1	250	256	PF00244	0.545
LIG_14-3-3_CanoR_1	39	44	PF00244	0.729
LIG_14-3-3_CanoR_1	415	422	PF00244	0.603
LIG_BIR_II_1	1	5	PF00653	0.789
LIG_BRCT_BRCA1_1	101	105	PF00533	0.495
LIG_BRCT_BRCA1_1	469	473	PF00533	0.770
LIG_DLG_GKlike_1	39	47	PF00625	0.779
LIG_FHA_1	224	230	PF00498	0.418
LIG_FHA_1	426	432	PF00498	0.527
LIG_FHA_2	134	140	PF00498	0.624
LIG_FHA_2	206	212	PF00498	0.568
LIG_FHA_2	368	374	PF00498	0.654
LIG_LIR_Apic_2	102	108	PF02991	0.527
LIG_LIR_Apic_2	301	305	PF02991	0.544
LIG_LIR_Apic_2	488	493	PF02991	0.696
LIG_LIR_Gen_1	215	222	PF02991	0.329
LIG_LIR_Gen_1	22	31	PF02991	0.772
LIG_LIR_Gen_1	322	331	PF02991	0.502
LIG_LIR_Nem_3	215	219	PF02991	0.317
LIG_LIR_Nem_3	22	27	PF02991	0.771
LIG_LIR_Nem_3	322	328	PF02991	0.484
LIG_MYND_1	108	112	PF01753	0.765
LIG_NRP_CendR_1	533	536	PF00754	0.716
LIG_SH2_CRK	496	500	PF00017	0.632
LIG_SH2_SRC	164	167	PF00017	0.543
LIG_SH2_STAP1	164	168	PF00017	0.533
LIG_SH2_STAP1	174	178	PF00017	0.461
LIG_SH2_STAP1	336	340	PF00017	0.547
LIG_SH2_STAT5	205	208	PF00017	0.490
LIG_SH2_STAT5	216	219	PF00017	0.403
LIG_SH2_STAT5	327	330	PF00017	0.405
LIG_SH2_STAT5	496	499	PF00017	0.553
LIG_SH3_1	303	309	PF00018	0.572
LIG_SH3_3	10	16	PF00018	0.782
LIG_SH3_3	105	111	PF00018	0.716
LIG_SH3_3	117	123	PF00018	0.703
LIG_SH3_3	131	137	PF00018	0.605
LIG_SH3_3	303	309	PF00018	0.537
LIG_SH3_3	371	377	PF00018	0.636
LIG_SH3_3	506	512	PF00018	0.680
LIG_SUMO_SIM_par_1	511	517	PF11976	0.375
LIG_TRAF2_1	221	224	PF00917	0.574
LIG_TRFH_1	255	259	PF08558	0.597
LIG_TYR_ITIM	494	499	PF00017	0.639
LIG_WW_1	96	99	PF00397	0.749
MOD_CK1_1	20	26	PF00069	0.678
MOD_CK1_1	248	254	PF00069	0.487
MOD_CK1_1	30	36	PF00069	0.516
MOD_CK1_1	319	325	PF00069	0.509
MOD_CK1_1	383	389	PF00069	0.745
MOD_CK1_1	42	48	PF00069	0.723
MOD_CK1_1	451	457	PF00069	0.695
MOD_CK1_1	49	55	PF00069	0.658
MOD_CK1_1	88	94	PF00069	0.764
MOD_CK2_1	133	139	PF00069	0.629
MOD_CK2_1	205	211	PF00069	0.590
MOD_CK2_1	217	223	PF00069	0.468
MOD_CK2_1	229	235	PF00069	0.510
MOD_CK2_1	367	373	PF00069	0.572
MOD_CK2_1	48	54	PF00069	0.811
MOD_CK2_1	511	517	PF00069	0.643
MOD_CK2_1	64	70	PF00069	0.542
MOD_DYRK1A_RPxSP_1	64	68	PF00069	0.754
MOD_GlcNHglycan	1	4	PF01048	0.525
MOD_GlcNHglycan	18	22	PF01048	0.757
MOD_GlcNHglycan	309	312	PF01048	0.651
MOD_GlcNHglycan	321	324	PF01048	0.414
MOD_GlcNHglycan	352	355	PF01048	0.629
MOD_GlcNHglycan	378	381	PF01048	0.734
MOD_GlcNHglycan	383	386	PF01048	0.713
MOD_GlcNHglycan	391	394	PF01048	0.661
MOD_GlcNHglycan	416	419	PF01048	0.714
MOD_GlcNHglycan	453	456	PF01048	0.692
MOD_GlcNHglycan	469	472	PF01048	0.525
MOD_GlcNHglycan	90	93	PF01048	0.763
MOD_GSK3_1	144	151	PF00069	0.441
MOD_GSK3_1	19	26	PF00069	0.659
MOD_GSK3_1	27	34	PF00069	0.580
MOD_GSK3_1	344	351	PF00069	0.655
MOD_GSK3_1	35	42	PF00069	0.693
MOD_GSK3_1	376	383	PF00069	0.716
MOD_GSK3_1	384	391	PF00069	0.659
MOD_GSK3_1	425	432	PF00069	0.565
MOD_GSK3_1	43	50	PF00069	0.602
MOD_GSK3_1	62	69	PF00069	0.521
MOD_GSK3_1	81	88	PF00069	0.697
MOD_GSK3_1	91	98	PF00069	0.671
MOD_LATS_1	263	269	PF00433	0.728
MOD_LATS_1	447	453	PF00433	0.795
MOD_N-GLC_1	199	204	PF02516	0.611
MOD_N-GLC_1	357	362	PF02516	0.572
MOD_NEK2_1	1	6	PF00069	0.521
MOD_NEK2_1	114	119	PF00069	0.504
MOD_NEK2_1	229	234	PF00069	0.488
MOD_NEK2_1	253	258	PF00069	0.504
MOD_NEK2_1	317	322	PF00069	0.537
MOD_NEK2_1	344	349	PF00069	0.702
MOD_NEK2_1	37	42	PF00069	0.709
MOD_NEK2_1	494	499	PF00069	0.576
MOD_PIKK_1	475	481	PF00454	0.731
MOD_PKA_1	265	271	PF00069	0.720
MOD_PKA_1	467	473	PF00069	0.572
MOD_PKA_2	153	159	PF00069	0.555
MOD_PKA_2	251	257	PF00069	0.594
MOD_PKA_2	265	271	PF00069	0.489
MOD_PKA_2	414	420	PF00069	0.661
MOD_PKA_2	448	454	PF00069	0.525
MOD_PKA_2	467	473	PF00069	0.569
MOD_PKB_1	64	72	PF00069	0.725
MOD_Plk_1	174	180	PF00069	0.582
MOD_Plk_1	199	205	PF00069	0.608
MOD_Plk_1	85	91	PF00069	0.746
MOD_Plk_2-3	135	141	PF00069	0.342
MOD_Plk_2-3	326	332	PF00069	0.551
MOD_Plk_4	101	107	PF00069	0.668
MOD_Plk_4	114	120	PF00069	0.567
MOD_Plk_4	126	132	PF00069	0.702
MOD_Plk_4	164	170	PF00069	0.506
MOD_ProDKin_1	119	125	PF00069	0.624
MOD_ProDKin_1	133	139	PF00069	0.644
MOD_ProDKin_1	183	189	PF00069	0.548
MOD_ProDKin_1	373	379	PF00069	0.649
MOD_ProDKin_1	385	391	PF00069	0.697
MOD_ProDKin_1	64	70	PF00069	0.707
MOD_ProDKin_1	99	105	PF00069	0.766
MOD_SUMO_rev_2	337	343	PF00179	0.560
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.556
TRG_ENDOCYTIC_2	216	219	PF00928	0.449
TRG_ENDOCYTIC_2	496	499	PF00928	0.627
TRG_ER_diArg_1	249	252	PF00400	0.563
TRG_ER_diArg_1	466	468	PF00400	0.574
TRG_ER_diArg_1	55	58	PF00400	0.672
TRG_ER_diArg_1	61	64	PF00400	0.681
TRG_NLS_MonoExtC_3	408	414	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y5	Leptomonas seymouri	44%	100%
A0A3Q8IE82	Leishmania donovani	79%	100%
A4I471	Leishmania infantum	78%	100%
C9ZKQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ADM0	Leishmania major	80%	100%
E9AM61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5DLD2	Trypanosoma cruzi	26%	100%