Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH24_LEIBR

TriTrypDb:

LbrM.29.0170 , LBRM2903_290007000

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HH24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	229	231	PF00675	0.401
CLV_NRD_NRD_1	273	275	PF00675	0.433
CLV_NRD_NRD_1	499	501	PF00675	0.578
CLV_NRD_NRD_1	559	561	PF00675	0.398
CLV_NRD_NRD_1	6	8	PF00675	0.451
CLV_PCSK_FUR_1	227	231	PF00082	0.317
CLV_PCSK_KEX2_1	200	202	PF00082	0.726
CLV_PCSK_KEX2_1	229	231	PF00082	0.398
CLV_PCSK_KEX2_1	273	275	PF00082	0.433
CLV_PCSK_KEX2_1	499	501	PF00082	0.578
CLV_PCSK_KEX2_1	558	560	PF00082	0.398
CLV_PCSK_KEX2_1	6	8	PF00082	0.419
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.726
CLV_PCSK_SKI1_1	277	281	PF00082	0.299
CLV_PCSK_SKI1_1	402	406	PF00082	0.320
CLV_PCSK_SKI1_1	409	413	PF00082	0.317
CLV_PCSK_SKI1_1	7	11	PF00082	0.320
CLV_Separin_Metazoa	202	206	PF03568	0.310
DEG_APCC_DBOX_1	401	409	PF00400	0.584
DEG_APCC_DBOX_1	5	13	PF00400	0.561
DEG_MDM2_SWIB_1	118	125	PF02201	0.444
DEG_SCF_FBW7_1	488	493	PF00400	0.380
DEG_SPOP_SBC_1	475	479	PF00917	0.391
DEG_SPOP_SBC_1	501	505	PF00917	0.521
DEG_SPOP_SBC_1	511	515	PF00917	0.390
DOC_CDC14_PxL_1	303	311	PF14671	0.457
DOC_CKS1_1	42	47	PF01111	0.354
DOC_CYCLIN_RxL_1	399	407	PF00134	0.478
DOC_CYCLIN_RxL_1	4	14	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	125	131	PF00134	0.380
DOC_MAPK_gen_1	165	174	PF00069	0.610
DOC_MAPK_gen_1	273	282	PF00069	0.618
DOC_MAPK_gen_1	341	349	PF00069	0.508
DOC_MAPK_gen_1	558	568	PF00069	0.654
DOC_MAPK_gen_1	59	67	PF00069	0.493
DOC_MAPK_gen_1	6	12	PF00069	0.561
DOC_MAPK_MEF2A_6	165	174	PF00069	0.513
DOC_MAPK_MEF2A_6	314	322	PF00069	0.298
DOC_MAPK_MEF2A_6	341	349	PF00069	0.520
DOC_MAPK_MEF2A_6	453	462	PF00069	0.546
DOC_MAPK_NFAT4_5	341	349	PF00069	0.591
DOC_PP1_RVXF_1	546	553	PF00149	0.650
DOC_PP2B_LxvP_1	125	128	PF13499	0.408
DOC_PP4_FxxP_1	327	330	PF00568	0.420
DOC_USP7_MATH_1	323	327	PF00917	0.423
DOC_USP7_MATH_1	373	377	PF00917	0.357
DOC_USP7_MATH_1	384	388	PF00917	0.304
DOC_USP7_MATH_1	447	451	PF00917	0.472
DOC_USP7_MATH_1	470	474	PF00917	0.430
DOC_USP7_MATH_1	475	479	PF00917	0.422
DOC_USP7_MATH_1	501	505	PF00917	0.461
DOC_USP7_MATH_1	90	94	PF00917	0.541
DOC_WW_Pin1_4	195	200	PF00397	0.429
DOC_WW_Pin1_4	41	46	PF00397	0.349
DOC_WW_Pin1_4	486	491	PF00397	0.505
DOC_WW_Pin1_4	504	509	PF00397	0.372
LIG_14-3-3_CanoR_1	113	117	PF00244	0.481
LIG_14-3-3_CanoR_1	268	272	PF00244	0.560
LIG_14-3-3_CanoR_1	273	277	PF00244	0.522
LIG_14-3-3_CanoR_1	453	460	PF00244	0.565
LIG_14-3-3_CanoR_1	484	489	PF00244	0.430
LIG_14-3-3_CanoR_1	499	508	PF00244	0.444
LIG_APCC_ABBA_1	143	148	PF00400	0.233
LIG_APCC_ABBA_1	27	32	PF00400	0.233
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_CaM_IQ_9	550	566	PF13499	0.666
LIG_Clathr_ClatBox_1	39	43	PF01394	0.495
LIG_eIF4E_1	34	40	PF01652	0.459
LIG_FHA_1	317	323	PF00498	0.374
LIG_FHA_1	42	48	PF00498	0.394
LIG_FHA_1	453	459	PF00498	0.590
LIG_FHA_1	491	497	PF00498	0.505
LIG_FHA_1	526	532	PF00498	0.309
LIG_FHA_2	375	381	PF00498	0.353
LIG_LIR_Apic_2	326	330	PF02991	0.485
LIG_LIR_Gen_1	111	120	PF02991	0.457
LIG_LIR_Gen_1	140	148	PF02991	0.269
LIG_LIR_Gen_1	168	179	PF02991	0.556
LIG_LIR_Gen_1	262	267	PF02991	0.544
LIG_LIR_LC3C_4	319	322	PF02991	0.233
LIG_LIR_LC3C_4	534	538	PF02991	0.233
LIG_LIR_Nem_3	111	117	PF02991	0.477
LIG_LIR_Nem_3	121	125	PF02991	0.355
LIG_LIR_Nem_3	140	146	PF02991	0.295
LIG_LIR_Nem_3	168	174	PF02991	0.560
LIG_LIR_Nem_3	262	266	PF02991	0.617
LIG_LIR_Nem_3	463	469	PF02991	0.429
LIG_NRBOX	345	351	PF00104	0.394
LIG_NRBOX	396	402	PF00104	0.414
LIG_Pex14_1	539	543	PF04695	0.534
LIG_Pex14_2	114	118	PF04695	0.375
LIG_Pex14_2	26	30	PF04695	0.444
LIG_Pex14_2	462	466	PF04695	0.471
LIG_SH2_GRB2like	542	545	PF00017	0.636
LIG_SH2_NCK_1	288	292	PF00017	0.272
LIG_SH2_SRC	288	291	PF00017	0.485
LIG_SH2_SRC	34	37	PF00017	0.408
LIG_SH2_STAP1	288	292	PF00017	0.424
LIG_SH2_STAT5	210	213	PF00017	0.452
LIG_SH2_STAT5	34	37	PF00017	0.368
LIG_SH2_STAT5	77	80	PF00017	0.382
LIG_SH3_3	125	131	PF00018	0.444
LIG_SH3_3	319	325	PF00018	0.443
LIG_SH3_3	39	45	PF00018	0.325
LIG_SH3_3	441	447	PF00018	0.630
LIG_SUMO_SIM_anti_2	356	362	PF11976	0.344
LIG_SUMO_SIM_anti_2	455	461	PF11976	0.381
LIG_SUMO_SIM_anti_2	467	474	PF11976	0.650
LIG_SUMO_SIM_anti_2	519	525	PF11976	0.427
LIG_SUMO_SIM_par_1	38	44	PF11976	0.503
LIG_SUMO_SIM_par_1	519	525	PF11976	0.460
LIG_SUMO_SIM_par_1	8	14	PF11976	0.588
LIG_TRAF2_1	166	169	PF00917	0.697
LIG_TRAF2_1	241	244	PF00917	0.686
LIG_WRC_WIRS_1	263	268	PF05994	0.463
MOD_CDC14_SPxK_1	198	201	PF00782	0.456
MOD_CDK_SPK_2	195	200	PF00069	0.429
MOD_CDK_SPK_2	486	491	PF00069	0.393
MOD_CDK_SPxK_1	195	201	PF00069	0.435
MOD_CK1_1	132	138	PF00069	0.408
MOD_CK1_1	144	150	PF00069	0.392
MOD_CK1_1	246	252	PF00069	0.725
MOD_CK1_1	356	362	PF00069	0.233
MOD_CK1_1	473	479	PF00069	0.524
MOD_CK1_1	504	510	PF00069	0.534
MOD_CK1_1	525	531	PF00069	0.485
MOD_CK2_1	374	380	PF00069	0.348
MOD_Cter_Amidation	339	342	PF01082	0.332
MOD_GlcNHglycan	131	134	PF01048	0.561
MOD_GlcNHglycan	179	182	PF01048	0.436
MOD_GlcNHglycan	222	225	PF01048	0.398
MOD_GlcNHglycan	230	233	PF01048	0.403
MOD_GlcNHglycan	238	241	PF01048	0.505
MOD_GlcNHglycan	252	255	PF01048	0.528
MOD_GlcNHglycan	309	312	PF01048	0.599
MOD_GlcNHglycan	504	507	PF01048	0.674
MOD_GlcNHglycan	80	83	PF01048	0.310
MOD_GSK3_1	137	144	PF00069	0.399
MOD_GSK3_1	173	180	PF00069	0.666
MOD_GSK3_1	246	253	PF00069	0.662
MOD_GSK3_1	379	386	PF00069	0.457
MOD_GSK3_1	46	53	PF00069	0.426
MOD_GSK3_1	470	477	PF00069	0.473
MOD_GSK3_1	486	493	PF00069	0.564
MOD_GSK3_1	500	507	PF00069	0.494
MOD_GSK3_1	512	519	PF00069	0.404
MOD_GSK3_1	525	532	PF00069	0.235
MOD_NEK2_1	1	6	PF00069	0.621
MOD_NEK2_1	11	16	PF00069	0.481
MOD_NEK2_1	118	123	PF00069	0.414
MOD_NEK2_1	299	304	PF00069	0.464
MOD_NEK2_1	309	314	PF00069	0.401
MOD_NEK2_1	353	358	PF00069	0.358
MOD_NEK2_1	404	409	PF00069	0.558
MOD_NEK2_1	460	465	PF00069	0.354
MOD_NEK2_1	60	65	PF00069	0.485
MOD_NEK2_2	141	146	PF00069	0.233
MOD_NEK2_2	522	527	PF00069	0.485
MOD_PKA_2	112	118	PF00069	0.432
MOD_PKA_2	148	154	PF00069	0.615
MOD_PKA_2	228	234	PF00069	0.665
MOD_PKA_2	267	273	PF00069	0.544
MOD_PKA_2	452	458	PF00069	0.411
MOD_PKA_2	60	66	PF00069	0.465
MOD_Plk_1	243	249	PF00069	0.733
MOD_Plk_1	562	568	PF00069	0.690
MOD_Plk_4	118	124	PF00069	0.368
MOD_Plk_4	262	268	PF00069	0.622
MOD_Plk_4	316	322	PF00069	0.405
MOD_Plk_4	323	329	PF00069	0.338
MOD_Plk_4	353	359	PF00069	0.446
MOD_Plk_4	396	402	PF00069	0.394
MOD_Plk_4	516	522	PF00069	0.312
MOD_Plk_4	531	537	PF00069	0.250
MOD_ProDKin_1	195	201	PF00069	0.435
MOD_ProDKin_1	41	47	PF00069	0.350
MOD_ProDKin_1	486	492	PF00069	0.501
MOD_ProDKin_1	504	510	PF00069	0.372
MOD_SUMO_for_1	166	169	PF00179	0.698
MOD_SUMO_for_1	199	202	PF00179	0.345
TRG_DiLeu_BaEn_2	261	267	PF01217	0.617
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.524
TRG_ENDOCYTIC_2	542	545	PF00928	0.576
TRG_ER_diArg_1	228	230	PF00400	0.587
TRG_ER_diArg_1	498	500	PF00400	0.381
TRG_ER_diArg_1	558	560	PF00400	0.518
TRG_ER_diArg_1	58	61	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM9	Leptomonas seymouri	42%	100%
A0A1X0NZT8	Trypanosomatidae	23%	100%
A0A3Q8IH23	Leishmania donovani	73%	100%
A0A3R7KT94	Trypanosoma rangeli	26%	100%
A4I453	Leishmania infantum	73%	100%
C9ZKQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ADL8	Leishmania major	72%	100%
E9AM63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%