Tetratricopeptide repeat protein 30

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative intraflagellar transport protein B2

Species:

Leishmania braziliensis

UniProt:

A4HH23_LEIBR

TriTrypDb:

LbrM.29.0160 , LBRM2903_290006900

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005874	microtubule	6	1
GO:0005879	axonemal microtubule	8	1
GO:0005881	cytoplasmic microtubule	7	1
GO:0030990	intraciliary transport particle	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0031514	motile cilium	5	2

Expansion

Sequence features

A4HH23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH23

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	10
GO:0030030	cell projection organization	4	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035720	intraciliary anterograde transport	4	1
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0044877	protein-containing complex binding	2	1
GO:0120170	intraciliary transport particle B binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.406
CLV_NRD_NRD_1	407	409	PF00675	0.428
CLV_NRD_NRD_1	426	428	PF00675	0.455
CLV_NRD_NRD_1	553	555	PF00675	0.422
CLV_NRD_NRD_1	606	608	PF00675	0.431
CLV_PCSK_KEX2_1	426	428	PF00082	0.546
CLV_PCSK_KEX2_1	553	555	PF00082	0.437
CLV_PCSK_KEX2_1	618	620	PF00082	0.396
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.396
CLV_PCSK_PC7_1	422	428	PF00082	0.564
CLV_PCSK_SKI1_1	171	175	PF00082	0.585
CLV_PCSK_SKI1_1	299	303	PF00082	0.460
CLV_PCSK_SKI1_1	4	8	PF00082	0.496
CLV_PCSK_SKI1_1	422	426	PF00082	0.443
CLV_PCSK_SKI1_1	597	601	PF00082	0.400
CLV_PCSK_SKI1_1	608	612	PF00082	0.379
CLV_PCSK_SKI1_1	619	623	PF00082	0.412
CLV_PCSK_SKI1_1	681	685	PF00082	0.411
CLV_Separin_Metazoa	550	554	PF03568	0.451
DEG_APCC_DBOX_1	510	518	PF00400	0.338
DOC_CYCLIN_RxL_1	681	692	PF00134	0.439
DOC_CYCLIN_yClb1_LxF_4	352	358	PF00134	0.379
DOC_MAPK_DCC_7	308	318	PF00069	0.465
DOC_MAPK_gen_1	618	624	PF00069	0.392
DOC_MAPK_gen_1	681	690	PF00069	0.426
DOC_MAPK_gen_1	82	89	PF00069	0.488
DOC_MAPK_MEF2A_6	569	576	PF00069	0.413
DOC_MAPK_MEF2A_6	618	626	PF00069	0.393
DOC_MAPK_MEF2A_6	681	690	PF00069	0.410
DOC_MAPK_NFAT4_5	619	627	PF00069	0.410
DOC_PP4_FxxP_1	660	663	PF00568	0.533
DOC_PP4_MxPP_1	9	12	PF00568	0.720
DOC_USP7_MATH_1	20	24	PF00917	0.776
DOC_USP7_MATH_1	431	435	PF00917	0.527
DOC_USP7_MATH_1	663	667	PF00917	0.558
DOC_USP7_MATH_1	85	89	PF00917	0.570
DOC_WW_Pin1_4	143	148	PF00397	0.616
DOC_WW_Pin1_4	399	404	PF00397	0.453
DOC_WW_Pin1_4	668	673	PF00397	0.646
LIG_14-3-3_CanoR_1	139	144	PF00244	0.558
LIG_14-3-3_CanoR_1	30	36	PF00244	0.766
LIG_14-3-3_CanoR_1	561	565	PF00244	0.626
LIG_14-3-3_CanoR_1	597	603	PF00244	0.394
LIG_14-3-3_CanoR_1	607	616	PF00244	0.389
LIG_14-3-3_CanoR_1	673	677	PF00244	0.379
LIG_14-3-3_CanoR_1	84	90	PF00244	0.495
LIG_Actin_WH2_2	621	638	PF00022	0.420
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_BRCT_BRCA1_1	480	484	PF00533	0.421
LIG_Clathr_ClatBox_1	323	327	PF01394	0.582
LIG_Clathr_ClatBox_1	644	648	PF01394	0.471
LIG_deltaCOP1_diTrp_1	612	621	PF00928	0.396
LIG_EH1_1	592	600	PF00400	0.453
LIG_EVH1_2	347	351	PF00568	0.393
LIG_FHA_1	180	186	PF00498	0.517
LIG_FHA_1	24	30	PF00498	0.670
LIG_FHA_1	268	274	PF00498	0.447
LIG_FHA_1	319	325	PF00498	0.424
LIG_FHA_1	423	429	PF00498	0.446
LIG_FHA_1	444	450	PF00498	0.446
LIG_FHA_1	52	58	PF00498	0.449
LIG_FHA_2	178	184	PF00498	0.604
LIG_FHA_2	255	261	PF00498	0.679
LIG_FHA_2	307	313	PF00498	0.632
LIG_FHA_2	448	454	PF00498	0.532
LIG_FHA_2	561	567	PF00498	0.510
LIG_FHA_2	73	79	PF00498	0.557
LIG_GBD_Chelix_1	624	632	PF00786	0.434
LIG_HCF-1_HBM_1	63	66	PF13415	0.352
LIG_LIR_Apic_2	563	567	PF02991	0.484
LIG_LIR_Gen_1	105	115	PF02991	0.554
LIG_LIR_Gen_1	349	358	PF02991	0.382
LIG_LIR_Gen_1	388	397	PF02991	0.441
LIG_LIR_Gen_1	637	647	PF02991	0.384
LIG_LIR_Gen_1	655	665	PF02991	0.290
LIG_LIR_Nem_3	105	110	PF02991	0.537
LIG_LIR_Nem_3	118	123	PF02991	0.391
LIG_LIR_Nem_3	331	337	PF02991	0.428
LIG_LIR_Nem_3	349	354	PF02991	0.386
LIG_LIR_Nem_3	388	393	PF02991	0.449
LIG_LIR_Nem_3	405	410	PF02991	0.325
LIG_LIR_Nem_3	452	457	PF02991	0.382
LIG_LIR_Nem_3	469	474	PF02991	0.396
LIG_LIR_Nem_3	55	61	PF02991	0.441
LIG_LIR_Nem_3	637	643	PF02991	0.408
LIG_LIR_Nem_3	655	661	PF02991	0.268
LIG_LYPXL_yS_3	471	474	PF13949	0.396
LIG_PCNA_yPIPBox_3	578	588	PF02747	0.395
LIG_PTB_Apo_2	340	347	PF02174	0.441
LIG_SH2_CRK	58	62	PF00017	0.458
LIG_SH2_NCK_1	364	368	PF00017	0.464
LIG_SH2_NCK_1	564	568	PF00017	0.512
LIG_SH2_PTP2	454	457	PF00017	0.375
LIG_SH2_SRC	134	137	PF00017	0.484
LIG_SH2_SRC	454	457	PF00017	0.392
LIG_SH2_SRC	513	516	PF00017	0.314
LIG_SH2_SRC	564	567	PF00017	0.516
LIG_SH2_SRC	66	69	PF00017	0.495
LIG_SH2_STAP1	124	128	PF00017	0.545
LIG_SH2_STAP1	364	368	PF00017	0.464
LIG_SH2_STAP1	447	451	PF00017	0.385
LIG_SH2_STAP1	605	609	PF00017	0.536
LIG_SH2_STAP1	66	70	PF00017	0.495
LIG_SH2_STAT3	123	126	PF00017	0.484
LIG_SH2_STAT3	381	384	PF00017	0.452
LIG_SH2_STAT5	290	293	PF00017	0.339
LIG_SH2_STAT5	358	361	PF00017	0.393
LIG_SH2_STAT5	381	384	PF00017	0.486
LIG_SH2_STAT5	454	457	PF00017	0.375
LIG_SH2_STAT5	513	516	PF00017	0.333
LIG_SH2_STAT5	539	542	PF00017	0.388
LIG_SH2_STAT5	585	588	PF00017	0.416
LIG_SH2_STAT5	60	63	PF00017	0.504
LIG_SH2_STAT5	687	690	PF00017	0.409
LIG_SH2_STAT5	92	95	PF00017	0.487
LIG_SH3_3	341	347	PF00018	0.415
LIG_SUMO_SIM_anti_2	67	75	PF11976	0.494
LIG_SUMO_SIM_par_1	631	639	PF11976	0.438
LIG_TRAF2_1	116	119	PF00917	0.505
LIG_TRAF2_1	197	200	PF00917	0.511
LIG_TRAF2_1	309	312	PF00917	0.540
LIG_TRAF2_1	450	453	PF00917	0.417
LIG_TRAF2_1	639	642	PF00917	0.438
LIG_TYR_ITSM	54	61	PF00017	0.476
LIG_WW_3	305	309	PF00397	0.458
MOD_CDK_SPK_2	668	673	PF00069	0.646
MOD_CK1_1	179	185	PF00069	0.339
MOD_CK1_1	23	29	PF00069	0.744
MOD_CK1_1	523	529	PF00069	0.299
MOD_CK2_1	102	108	PF00069	0.589
MOD_CK2_1	113	119	PF00069	0.509
MOD_CK2_1	169	175	PF00069	0.450
MOD_CK2_1	194	200	PF00069	0.511
MOD_CK2_1	254	260	PF00069	0.538
MOD_CK2_1	306	312	PF00069	0.604
MOD_CK2_1	399	405	PF00069	0.453
MOD_CK2_1	447	453	PF00069	0.527
MOD_CK2_1	635	641	PF00069	0.432
MOD_CK2_1	686	692	PF00069	0.553
MOD_CK2_1	72	78	PF00069	0.585
MOD_GlcNHglycan	18	21	PF01048	0.738
MOD_GlcNHglycan	214	217	PF01048	0.472
MOD_GlcNHglycan	480	483	PF01048	0.413
MOD_GlcNHglycan	527	530	PF01048	0.400
MOD_GSK3_1	139	146	PF00069	0.457
MOD_GSK3_1	16	23	PF00069	0.749
MOD_GSK3_1	190	197	PF00069	0.516
MOD_GSK3_1	208	215	PF00069	0.553
MOD_GSK3_1	25	32	PF00069	0.669
MOD_GSK3_1	263	270	PF00069	0.497
MOD_GSK3_1	314	321	PF00069	0.430
MOD_GSK3_1	395	402	PF00069	0.418
MOD_GSK3_1	443	450	PF00069	0.534
MOD_GSK3_1	49	56	PF00069	0.540
MOD_GSK3_1	535	542	PF00069	0.457
MOD_GSK3_1	580	587	PF00069	0.380
MOD_GSK3_1	663	670	PF00069	0.508
MOD_N-GLC_1	385	390	PF02516	0.461
MOD_N-GLC_2	534	536	PF02516	0.357
MOD_NEK2_1	18	23	PF00069	0.703
MOD_NEK2_1	273	278	PF00069	0.409
MOD_NEK2_1	318	323	PF00069	0.421
MOD_NEK2_1	501	506	PF00069	0.449
MOD_NEK2_1	525	530	PF00069	0.406
MOD_NEK2_1	53	58	PF00069	0.469
MOD_NEK2_1	535	540	PF00069	0.362
MOD_NEK2_1	584	589	PF00069	0.425
MOD_NEK2_1	593	598	PF00069	0.382
MOD_NEK2_1	610	615	PF00069	0.353
MOD_NEK2_1	635	640	PF00069	0.459
MOD_NEK2_1	686	691	PF00069	0.533
MOD_NEK2_1	72	77	PF00069	0.459
MOD_NEK2_2	124	129	PF00069	0.545
MOD_NEK2_2	672	677	PF00069	0.393
MOD_PIKK_1	267	273	PF00454	0.462
MOD_PIKK_1	380	386	PF00454	0.460
MOD_PIKK_1	431	437	PF00454	0.583
MOD_PIKK_1	72	78	PF00454	0.570
MOD_PKA_2	273	279	PF00069	0.513
MOD_PKA_2	29	35	PF00069	0.683
MOD_PKA_2	478	484	PF00069	0.419
MOD_PKA_2	520	526	PF00069	0.500
MOD_PKA_2	560	566	PF00069	0.622
MOD_PKA_2	672	678	PF00069	0.512
MOD_Plk_1	385	391	PF00069	0.460
MOD_Plk_1	447	453	PF00069	0.527
MOD_Plk_1	636	642	PF00069	0.453
MOD_Plk_2-3	102	108	PF00069	0.589
MOD_Plk_2-3	483	489	PF00069	0.427
MOD_Plk_2-3	560	566	PF00069	0.510
MOD_Plk_4	102	108	PF00069	0.589
MOD_Plk_4	124	130	PF00069	0.502
MOD_Plk_4	139	145	PF00069	0.386
MOD_Plk_4	169	175	PF00069	0.480
MOD_Plk_4	385	391	PF00069	0.460
MOD_Plk_4	520	526	PF00069	0.550
MOD_Plk_4	53	59	PF00069	0.446
MOD_Plk_4	535	541	PF00069	0.441
MOD_Plk_4	580	586	PF00069	0.387
MOD_Plk_4	610	616	PF00069	0.397
MOD_Plk_4	85	91	PF00069	0.545
MOD_ProDKin_1	143	149	PF00069	0.610
MOD_ProDKin_1	399	405	PF00069	0.453
MOD_ProDKin_1	668	674	PF00069	0.638
MOD_SUMO_rev_2	601	610	PF00179	0.534
TRG_DiLeu_BaEn_1	68	73	PF01217	0.545
TRG_ENDOCYTIC_2	107	110	PF00928	0.484
TRG_ENDOCYTIC_2	226	229	PF00928	0.415
TRG_ENDOCYTIC_2	363	366	PF00928	0.411
TRG_ENDOCYTIC_2	390	393	PF00928	0.406
TRG_ENDOCYTIC_2	407	410	PF00928	0.351
TRG_ENDOCYTIC_2	454	457	PF00928	0.366
TRG_ENDOCYTIC_2	465	468	PF00928	0.378
TRG_ENDOCYTIC_2	471	474	PF00928	0.377
TRG_ENDOCYTIC_2	513	516	PF00928	0.387
TRG_ENDOCYTIC_2	58	61	PF00928	0.435
TRG_ENDOCYTIC_2	687	690	PF00928	0.409
TRG_ENDOCYTIC_2	94	97	PF00928	0.481
TRG_ER_diArg_1	426	428	PF00400	0.585
TRG_ER_diArg_1	552	554	PF00400	0.443
TRG_ER_diArg_1	81	84	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2B4	Leptomonas seymouri	87%	100%
A0A0S4J480	Bodo saltans	73%	100%
A0A1X0NZF0	Trypanosomatidae	74%	100%
A0A3Q8IE38	Leishmania donovani	94%	100%
A0A3R7MWT3	Trypanosoma rangeli	75%	100%
A2AKQ8	Mus musculus	55%	100%
A2VE45	Bos taurus	54%	100%
A4I452	Leishmania infantum	95%	100%
A4IHR1	Xenopus tropicalis	56%	100%
A6H739	Bos taurus	53%	100%
A7YE96	Danio rerio	55%	100%
A8XBR9	Caenorhabditis briggsae	42%	100%
B2RYD6	Rattus norvegicus	55%	100%
C9ZKR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9ADL7	Leishmania major	94%	100%
E9AM64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q16JL4	Aedes aegypti	45%	100%
Q29L58	Drosophila pseudoobscura pseudoobscura	43%	100%
Q4QQS2	Rattus norvegicus	55%	100%
Q6INU8	Xenopus laevis	55%	100%
Q7PRA4	Anopheles gambiae	45%	100%
Q86WT1	Homo sapiens	55%	100%
Q8I7G4	Caenorhabditis elegans	43%	100%
Q8N4P2	Homo sapiens	55%	100%
Q99J38	Mus musculus	56%	100%
Q9CY00	Mus musculus	55%	100%
Q9VK41	Drosophila melanogaster	43%	100%
V5BKA3	Trypanosoma cruzi	76%	100%