WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH18_LEIBR

TriTrypDb:

LbrM.29.0110 , LBRM2903_290006400

Length:

534

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005868	cytoplasmic dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0030286	dynein complex	3	1
GO:0030990	intraciliary transport particle	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HH18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH18

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0042073	intraciliary transport	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0099111	microtubule-based transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	519	523	PF00656	0.476
CLV_NRD_NRD_1	121	123	PF00675	0.561
CLV_NRD_NRD_1	20	22	PF00675	0.513
CLV_NRD_NRD_1	263	265	PF00675	0.333
CLV_NRD_NRD_1	300	302	PF00675	0.433
CLV_PCSK_FUR_1	20	24	PF00082	0.454
CLV_PCSK_FUR_1	298	302	PF00082	0.415
CLV_PCSK_KEX2_1	20	22	PF00082	0.458
CLV_PCSK_KEX2_1	263	265	PF00082	0.333
CLV_PCSK_KEX2_1	300	302	PF00082	0.465
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.450
CLV_PCSK_SKI1_1	106	110	PF00082	0.403
CLV_PCSK_SKI1_1	267	271	PF00082	0.226
CLV_PCSK_SKI1_1	301	305	PF00082	0.351
CLV_PCSK_SKI1_1	384	388	PF00082	0.388
CLV_PCSK_SKI1_1	468	472	PF00082	0.208
CLV_PCSK_SKI1_1	504	508	PF00082	0.544
DEG_APCC_DBOX_1	403	411	PF00400	0.382
DEG_APCC_DBOX_1	448	456	PF00400	0.425
DOC_CYCLIN_RxL_1	381	392	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.377
DOC_MAPK_gen_1	122	129	PF00069	0.514
DOC_MAPK_gen_1	172	178	PF00069	0.356
DOC_MAPK_gen_1	298	307	PF00069	0.358
DOC_MAPK_MEF2A_6	298	307	PF00069	0.379
DOC_PP1_RVXF_1	466	472	PF00149	0.206
DOC_USP7_MATH_1	108	112	PF00917	0.454
DOC_USP7_MATH_1	273	277	PF00917	0.467
DOC_USP7_MATH_1	373	377	PF00917	0.342
DOC_USP7_MATH_1	434	438	PF00917	0.281
DOC_USP7_MATH_1	459	463	PF00917	0.554
DOC_USP7_MATH_1	470	474	PF00917	0.376
DOC_USP7_UBL2_3	36	40	PF12436	0.538
DOC_WW_Pin1_4	114	119	PF00397	0.634
DOC_WW_Pin1_4	132	137	PF00397	0.243
DOC_WW_Pin1_4	187	192	PF00397	0.387
DOC_WW_Pin1_4	280	285	PF00397	0.354
DOC_WW_Pin1_4	320	325	PF00397	0.322
DOC_WW_Pin1_4	377	382	PF00397	0.258
DOC_WW_Pin1_4	402	407	PF00397	0.409
DOC_WW_Pin1_4	423	428	PF00397	0.307
LIG_14-3-3_CanoR_1	106	116	PF00244	0.483
LIG_14-3-3_CanoR_1	198	208	PF00244	0.456
LIG_14-3-3_CanoR_1	300	306	PF00244	0.442
LIG_14-3-3_CanoR_1	397	406	PF00244	0.418
LIG_14-3-3_CanoR_1	438	445	PF00244	0.345
LIG_14-3-3_CanoR_1	508	512	PF00244	0.527
LIG_14-3-3_CanoR_1	66	72	PF00244	0.586
LIG_Actin_WH2_2	492	510	PF00022	0.426
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BIR_III_3	1	5	PF00653	0.421
LIG_BIR_III_4	482	486	PF00653	0.397
LIG_BRCT_BRCA1_1	109	113	PF00533	0.398
LIG_BRCT_BRCA1_1	202	206	PF00533	0.311
LIG_Clathr_ClatBox_1	331	335	PF01394	0.377
LIG_Clathr_ClatBox_1	407	411	PF01394	0.493
LIG_CSL_BTD_1	281	284	PF09270	0.261
LIG_FHA_1	10	16	PF00498	0.526
LIG_FHA_1	107	113	PF00498	0.589
LIG_FHA_1	228	234	PF00498	0.312
LIG_FHA_1	245	251	PF00498	0.464
LIG_FHA_1	302	308	PF00498	0.344
LIG_FHA_1	32	38	PF00498	0.491
LIG_FHA_1	342	348	PF00498	0.488
LIG_FHA_1	357	363	PF00498	0.431
LIG_FHA_1	455	461	PF00498	0.416
LIG_FHA_1	522	528	PF00498	0.521
LIG_FHA_2	23	29	PF00498	0.597
LIG_FHA_2	388	394	PF00498	0.460
LIG_FHA_2	498	504	PF00498	0.367
LIG_FHA_2	89	95	PF00498	0.518
LIG_HCF-1_HBM_1	265	268	PF13415	0.289
LIG_LIR_Apic_2	344	348	PF02991	0.436
LIG_LIR_Nem_3	110	116	PF02991	0.404
LIG_LIR_Nem_3	311	315	PF02991	0.459
LIG_LIR_Nem_3	422	428	PF02991	0.418
LIG_PDZ_Class_1	529	534	PF00595	0.491
LIG_SH2_CRK	237	241	PF00017	0.402
LIG_SH2_CRK	312	316	PF00017	0.480
LIG_SH2_CRK	79	83	PF00017	0.519
LIG_SH2_PTP2	175	178	PF00017	0.414
LIG_SH2_SRC	77	80	PF00017	0.363
LIG_SH2_STAP1	193	197	PF00017	0.351
LIG_SH2_STAP1	237	241	PF00017	0.419
LIG_SH2_STAP1	456	460	PF00017	0.492
LIG_SH2_STAT3	421	424	PF00017	0.241
LIG_SH2_STAT3	445	448	PF00017	0.217
LIG_SH2_STAT5	131	134	PF00017	0.436
LIG_SH2_STAT5	175	178	PF00017	0.414
LIG_SH2_STAT5	193	196	PF00017	0.498
LIG_SH2_STAT5	268	271	PF00017	0.343
LIG_SH2_STAT5	419	422	PF00017	0.462
LIG_SH2_STAT5	456	459	PF00017	0.421
LIG_SH2_STAT5	77	80	PF00017	0.438
LIG_SH3_2	259	264	PF14604	0.315
LIG_SH3_3	12	18	PF00018	0.492
LIG_SH3_3	205	211	PF00018	0.527
LIG_SH3_3	221	227	PF00018	0.285
LIG_SH3_3	253	259	PF00018	0.453
LIG_SH3_3	424	430	PF00018	0.310
LIG_SUMO_SIM_anti_2	125	132	PF11976	0.498
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.473
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.204
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.326
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.330
LIG_SUMO_SIM_par_1	212	218	PF11976	0.373
LIG_SUMO_SIM_par_1	276	283	PF11976	0.204
LIG_SUMO_SIM_par_1	358	365	PF11976	0.414
LIG_SUMO_SIM_par_1	405	411	PF11976	0.517
LIG_SUMO_SIM_par_1	431	437	PF11976	0.330
LIG_TYR_ITIM	310	315	PF00017	0.455
LIG_WRC_WIRS_1	89	94	PF05994	0.467
LIG_WW_3	17	21	PF00397	0.446
MOD_CDC14_SPxK_1	426	429	PF00782	0.294
MOD_CDK_SPxK_1	423	429	PF00069	0.295
MOD_CDK_SPxxK_3	132	139	PF00069	0.382
MOD_CDK_SPxxK_3	280	287	PF00069	0.399
MOD_CDK_SPxxK_3	377	384	PF00069	0.390
MOD_CK1_1	200	206	PF00069	0.252
MOD_CK1_1	239	245	PF00069	0.400
MOD_CK1_1	296	302	PF00069	0.411
MOD_CK1_1	353	359	PF00069	0.470
MOD_CK1_1	392	398	PF00069	0.346
MOD_CK1_1	413	419	PF00069	0.404
MOD_CK1_1	437	443	PF00069	0.313
MOD_CK1_1	497	503	PF00069	0.491
MOD_CK1_1	510	516	PF00069	0.556
MOD_CK1_1	68	74	PF00069	0.653
MOD_CK2_1	22	28	PF00069	0.610
MOD_CK2_1	225	231	PF00069	0.355
MOD_CK2_1	397	403	PF00069	0.382
MOD_CK2_1	470	476	PF00069	0.462
MOD_CK2_1	497	503	PF00069	0.356
MOD_CK2_1	88	94	PF00069	0.441
MOD_GlcNHglycan	165	169	PF01048	0.472
MOD_GlcNHglycan	199	202	PF01048	0.231
MOD_GlcNHglycan	219	222	PF01048	0.294
MOD_GlcNHglycan	241	244	PF01048	0.525
MOD_GlcNHglycan	271	274	PF01048	0.267
MOD_GlcNHglycan	275	278	PF01048	0.290
MOD_GlcNHglycan	377	380	PF01048	0.449
MOD_GlcNHglycan	393	397	PF01048	0.229
MOD_GlcNHglycan	411	415	PF01048	0.340
MOD_GlcNHglycan	472	475	PF01048	0.454
MOD_GlcNHglycan	79	82	PF01048	0.360
MOD_GSK3_1	114	121	PF00069	0.482
MOD_GSK3_1	125	132	PF00069	0.348
MOD_GSK3_1	187	194	PF00069	0.422
MOD_GSK3_1	196	203	PF00069	0.353
MOD_GSK3_1	225	232	PF00069	0.325
MOD_GSK3_1	235	242	PF00069	0.374
MOD_GSK3_1	244	251	PF00069	0.304
MOD_GSK3_1	269	276	PF00069	0.407
MOD_GSK3_1	301	308	PF00069	0.415
MOD_GSK3_1	373	380	PF00069	0.328
MOD_GSK3_1	388	395	PF00069	0.253
MOD_GSK3_1	402	409	PF00069	0.454
MOD_GSK3_1	521	528	PF00069	0.487
MOD_GSK3_1	60	67	PF00069	0.600
MOD_GSK3_1	9	16	PF00069	0.481
MOD_N-GLC_1	106	111	PF02516	0.467
MOD_NEK2_1	163	168	PF00069	0.485
MOD_NEK2_1	197	202	PF00069	0.379
MOD_NEK2_1	386	391	PF00069	0.266
MOD_NEK2_1	507	512	PF00069	0.503
MOD_NEK2_1	529	534	PF00069	0.491
MOD_NEK2_2	108	113	PF00069	0.530
MOD_NEK2_2	293	298	PF00069	0.475
MOD_NEK2_2	525	530	PF00069	0.353
MOD_PIKK_1	271	277	PF00454	0.349
MOD_PIKK_1	29	35	PF00454	0.503
MOD_PIKK_1	350	356	PF00454	0.527
MOD_PIKK_1	494	500	PF00454	0.457
MOD_PIKK_1	507	513	PF00454	0.634
MOD_PIKK_1	65	71	PF00454	0.377
MOD_PKA_1	122	128	PF00069	0.466
MOD_PKA_1	22	28	PF00069	0.588
MOD_PKA_2	197	203	PF00069	0.450
MOD_PKA_2	22	28	PF00069	0.447
MOD_PKA_2	428	434	PF00069	0.341
MOD_PKA_2	437	443	PF00069	0.325
MOD_PKA_2	507	513	PF00069	0.487
MOD_PKA_2	65	71	PF00069	0.588
MOD_PKB_1	21	29	PF00069	0.447
MOD_Plk_1	13	19	PF00069	0.457
MOD_Plk_1	23	29	PF00069	0.443
MOD_Plk_1	46	52	PF00069	0.555
MOD_Plk_1	521	527	PF00069	0.465
MOD_Plk_1	87	93	PF00069	0.511
MOD_Plk_2-3	88	94	PF00069	0.298
MOD_Plk_4	108	114	PF00069	0.269
MOD_Plk_4	125	131	PF00069	0.496
MOD_Plk_4	248	254	PF00069	0.415
MOD_Plk_4	428	434	PF00069	0.307
MOD_Plk_4	525	531	PF00069	0.433
MOD_Plk_4	88	94	PF00069	0.425
MOD_ProDKin_1	114	120	PF00069	0.635
MOD_ProDKin_1	132	138	PF00069	0.239
MOD_ProDKin_1	187	193	PF00069	0.385
MOD_ProDKin_1	280	286	PF00069	0.358
MOD_ProDKin_1	320	326	PF00069	0.314
MOD_ProDKin_1	377	383	PF00069	0.261
MOD_ProDKin_1	402	408	PF00069	0.407
MOD_ProDKin_1	423	429	PF00069	0.304
TRG_DiLeu_BaEn_2	87	93	PF01217	0.299
TRG_DiLeu_LyEn_5	403	408	PF01217	0.467
TRG_ENDOCYTIC_2	161	164	PF00928	0.317
TRG_ENDOCYTIC_2	175	178	PF00928	0.245
TRG_ENDOCYTIC_2	237	240	PF00928	0.331
TRG_ENDOCYTIC_2	312	315	PF00928	0.467
TRG_ENDOCYTIC_2	399	402	PF00928	0.317
TRG_ENDOCYTIC_2	79	82	PF00928	0.452
TRG_ER_diArg_1	19	21	PF00400	0.455
TRG_ER_diArg_1	262	264	PF00400	0.330
TRG_ER_diArg_1	297	300	PF00400	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUS1	Leptomonas seymouri	64%	100%
A0A0S4INJ7	Bodo saltans	24%	82%
A0A0S4KLW0	Bodo saltans	42%	96%
A0A1X0NJ43	Trypanosomatidae	22%	79%
A0A1X0P0W1	Trypanosomatidae	48%	100%
A0A3S5IRX8	Trypanosoma rangeli	48%	100%
A0A3S7X1Z8	Leishmania donovani	81%	100%
A4I447	Leishmania infantum	80%	100%
C9ZKR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ADL2	Leishmania major	79%	100%
E9AM69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9PYY5	Mus musculus	24%	66%
P54703	Dictyostelium discoideum	21%	82%
Q16959	Heliocidaris crassispina	21%	76%
Q16960	Heliocidaris crassispina	23%	89%
Q32KS2	Bos taurus	21%	76%
Q39578	Chlamydomonas reinhardtii	24%	78%
Q4QR00	Xenopus laevis	24%	91%
Q4V8G4	Rattus norvegicus	22%	67%
Q5U4F6	Mus musculus	30%	99%
Q96EX3	Homo sapiens	31%	100%
Q9UI46	Homo sapiens	21%	76%
V5B145	Trypanosoma cruzi	22%	89%
V5BUI1	Trypanosoma cruzi	48%	100%