QA-SNARE protein putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania braziliensis

UniProt:

A4HH15_LEIBR

TriTrypDb:

LbrM.29.0080 , LBRM2903_290006100

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0031982	vesicle	4	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0097014	ciliary plasm	5	1
GO:0098796	membrane protein complex	2	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4HH15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH15

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	11
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0006886	intracellular protein transport	4	2
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.589
CLV_C14_Caspase3-7	197	201	PF00656	0.618
CLV_NRD_NRD_1	105	107	PF00675	0.391
CLV_NRD_NRD_1	218	220	PF00675	0.500
CLV_NRD_NRD_1	28	30	PF00675	0.400
CLV_NRD_NRD_1	33	35	PF00675	0.432
CLV_NRD_NRD_1	62	64	PF00675	0.443
CLV_NRD_NRD_1	7	9	PF00675	0.367
CLV_NRD_NRD_1	83	85	PF00675	0.425
CLV_PCSK_KEX2_1	218	220	PF00082	0.492
CLV_PCSK_KEX2_1	28	30	PF00082	0.389
CLV_PCSK_KEX2_1	33	35	PF00082	0.421
CLV_PCSK_KEX2_1	41	43	PF00082	0.434
CLV_PCSK_KEX2_1	48	50	PF00082	0.345
CLV_PCSK_KEX2_1	7	9	PF00082	0.349
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.494
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.376
CLV_PCSK_PC7_1	29	35	PF00082	0.503
CLV_PCSK_PC7_1	44	50	PF00082	0.507
CLV_PCSK_SKI1_1	231	235	PF00082	0.335
CLV_PCSK_SKI1_1	48	52	PF00082	0.334
CLV_PCSK_SKI1_1	64	68	PF00082	0.339
CLV_PCSK_SKI1_1	71	75	PF00082	0.438
CLV_PCSK_SKI1_1	85	89	PF00082	0.310
DOC_MAPK_gen_1	84	94	PF00069	0.595
DOC_MAPK_MEF2A_6	229	237	PF00069	0.451
DOC_PP1_RVXF_1	147	153	PF00149	0.680
DOC_PP1_RVXF_1	229	235	PF00149	0.488
DOC_USP7_MATH_1	117	121	PF00917	0.552
DOC_USP7_MATH_1	2	6	PF00917	0.547
DOC_USP7_MATH_1	242	246	PF00917	0.391
DOC_WW_Pin1_4	143	148	PF00397	0.647
LIG_14-3-3_CanoR_1	115	123	PF00244	0.582
LIG_14-3-3_CanoR_1	138	142	PF00244	0.571
LIG_14-3-3_CanoR_1	33	40	PF00244	0.616
LIG_14-3-3_CanoR_1	49	56	PF00244	0.582
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_BIR_III_1	1	5	PF00653	0.491
LIG_BIR_III_3	1	5	PF00653	0.491
LIG_FHA_1	166	172	PF00498	0.599
LIG_FHA_2	123	129	PF00498	0.560
LIG_FHA_2	98	104	PF00498	0.599
LIG_LIR_Gen_1	155	162	PF02991	0.666
LIG_LIR_Gen_1	180	189	PF02991	0.578
LIG_LIR_Gen_1	68	75	PF02991	0.565
LIG_LIR_Nem_3	155	160	PF02991	0.666
LIG_LIR_Nem_3	180	185	PF02991	0.572
LIG_LIR_Nem_3	68	72	PF02991	0.576
LIG_SH2_STAP1	157	161	PF00017	0.664
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.630
LIG_SUMO_SIM_par_1	239	245	PF11976	0.325
LIG_TRAF2_1	36	39	PF00917	0.635
LIG_WRC_WIRS_1	123	128	PF05994	0.561
LIG_WRC_WIRS_1	66	71	PF05994	0.644
MOD_CDC14_SPxK_1	146	149	PF00782	0.639
MOD_CDK_SPxK_1	143	149	PF00069	0.645
MOD_CK2_1	122	128	PF00069	0.617
MOD_CK2_1	201	207	PF00069	0.691
MOD_CK2_1	32	38	PF00069	0.691
MOD_Cter_Amidation	82	85	PF01082	0.460
MOD_GlcNHglycan	112	115	PF01048	0.466
MOD_GlcNHglycan	185	188	PF01048	0.411
MOD_GlcNHglycan	203	206	PF01048	0.431
MOD_GSK3_1	207	214	PF00069	0.624
MOD_GSK3_1	28	35	PF00069	0.621
MOD_N-GLC_1	201	206	PF02516	0.437
MOD_N-GLC_1	211	216	PF02516	0.418
MOD_N-GLC_1	54	59	PF02516	0.464
MOD_NEK2_1	75	80	PF00069	0.629
MOD_NEK2_2	122	127	PF00069	0.561
MOD_PIKK_1	211	217	PF00454	0.671
MOD_PK_1	33	39	PF00069	0.643
MOD_PKA_1	28	34	PF00069	0.588
MOD_PKA_1	48	54	PF00069	0.487
MOD_PKA_2	137	143	PF00069	0.566
MOD_PKA_2	165	171	PF00069	0.585
MOD_PKA_2	207	213	PF00069	0.652
MOD_PKA_2	28	34	PF00069	0.612
MOD_PKA_2	48	54	PF00069	0.487
MOD_Plk_1	75	81	PF00069	0.712
MOD_Plk_4	137	143	PF00069	0.667
MOD_ProDKin_1	143	149	PF00069	0.645
MOD_SUMO_for_1	40	43	PF00179	0.630
MOD_SUMO_rev_2	43	50	PF00179	0.670
TRG_DiLeu_BaEn_1	137	142	PF01217	0.663
TRG_DiLeu_BaEn_1	70	75	PF01217	0.618
TRG_ENDOCYTIC_2	157	160	PF00928	0.665
TRG_ER_diArg_1	217	219	PF00400	0.727
TRG_ER_diArg_1	27	29	PF00400	0.587
TRG_ER_diArg_1	6	8	PF00400	0.574
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V3	Leptomonas seymouri	70%	100%
A0A0S4IMX4	Bodo saltans	35%	100%
A0A0S4J7F1	Bodo saltans	25%	85%
A0A1X0NZD7	Trypanosomatidae	43%	97%
A0A3Q8IF56	Leishmania donovani	88%	99%
A0A3R7NXH1	Trypanosoma rangeli	42%	97%
A4I444	Leishmania infantum	88%	99%
C9ZKR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	97%
E9ADK9	Leishmania major	88%	100%
E9AM72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
O70439	Mus musculus	30%	96%
O94651	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	95%
V5BPW1	Trypanosoma cruzi	42%	97%