Tryptophan--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryptophanyl-tRNA synthetase, putative

Species:

Leishmania braziliensis

UniProt:

A4HH14_LEIBR

TriTrypDb:

LbrM.29.0070 , LBRM2903_290006000

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HH14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH14

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006418	tRNA aminoacylation for protein translation	6	12
GO:0006436	tryptophanyl-tRNA aminoacylation	7	12
GO:0006520	amino acid metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0004830	tryptophan-tRNA ligase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	450	454	PF00656	0.297
CLV_C14_Caspase3-7	55	59	PF00656	0.405
CLV_NRD_NRD_1	133	135	PF00675	0.323
CLV_NRD_NRD_1	445	447	PF00675	0.407
CLV_PCSK_KEX2_1	133	135	PF00082	0.348
CLV_PCSK_KEX2_1	411	413	PF00082	0.300
CLV_PCSK_KEX2_1	447	449	PF00082	0.410
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.300
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.410
CLV_PCSK_SKI1_1	102	106	PF00082	0.423

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G3	Leptomonas seymouri	84%	100%
A0A0N1HXL2	Leptomonas seymouri	41%	100%
A0A0S4IN16	Bodo saltans	75%	100%
A0A0S4JC70	Bodo saltans	43%	100%
A0A1X0NGJ6	Trypanosomatidae	40%	100%
A0A1X0NZB4	Trypanosomatidae	76%	100%
A0A3R7MPN7	Trypanosoma rangeli	78%	100%
A0A3S7WXL2	Leishmania donovani	45%	100%
A0A3S7X238	Leishmania donovani	90%	100%
A0A422NW64	Trypanosoma rangeli	41%	100%

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