LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HH12_LEIBR
TriTrypDb:
LbrM.29.0050 , LBRM2903_290005800 *
Length:
282

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HH12
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 115 117 PF00675 0.602
CLV_NRD_NRD_1 130 132 PF00675 0.579
CLV_NRD_NRD_1 143 145 PF00675 0.531
CLV_NRD_NRD_1 18 20 PF00675 0.683
CLV_PCSK_FUR_1 116 120 PF00082 0.577
CLV_PCSK_KEX2_1 115 117 PF00082 0.557
CLV_PCSK_KEX2_1 118 120 PF00082 0.595
CLV_PCSK_KEX2_1 130 132 PF00082 0.635
CLV_PCSK_KEX2_1 142 144 PF00082 0.603
CLV_PCSK_KEX2_1 18 20 PF00082 0.683
CLV_PCSK_PC1ET2_1 118 120 PF00082 0.526
CLV_PCSK_PC7_1 139 145 PF00082 0.580
CLV_PCSK_SKI1_1 115 119 PF00082 0.560
CLV_PCSK_SKI1_1 130 134 PF00082 0.458
CLV_PCSK_SKI1_1 166 170 PF00082 0.346
CLV_PCSK_SKI1_1 178 182 PF00082 0.372
CLV_PCSK_SKI1_1 19 23 PF00082 0.474
CLV_PCSK_SKI1_1 213 217 PF00082 0.493
CLV_PCSK_SKI1_1 247 251 PF00082 0.394
DEG_Nend_UBRbox_3 1 3 PF02207 0.563
DOC_CYCLIN_RxL_1 241 254 PF00134 0.367
DOC_MAPK_gen_1 18 26 PF00069 0.686
DOC_USP7_UBL2_3 181 185 PF12436 0.600
LIG_14-3-3_CanoR_1 18 24 PF00244 0.573
LIG_14-3-3_CanoR_1 204 208 PF00244 0.489
LIG_14-3-3_CanoR_1 247 253 PF00244 0.363
LIG_14-3-3_CanoR_1 33 39 PF00244 0.577
LIG_14-3-3_CterR_2 279 282 PF00244 0.455
LIG_Actin_WH2_2 263 281 PF00022 0.468
LIG_Actin_WH2_2 86 104 PF00022 0.369
LIG_AP_GAE_1 77 83 PF02883 0.595
LIG_FHA_1 170 176 PF00498 0.324
LIG_FHA_1 190 196 PF00498 0.372
LIG_FHA_1 35 41 PF00498 0.465
LIG_FHA_1 4 10 PF00498 0.640
LIG_FHA_2 147 153 PF00498 0.448
LIG_FHA_2 249 255 PF00498 0.392
LIG_FHA_2 66 72 PF00498 0.696
LIG_LIR_Gen_1 77 86 PF02991 0.469
LIG_LIR_Gen_1 92 101 PF02991 0.395
LIG_LIR_Nem_3 127 132 PF02991 0.603
LIG_LIR_Nem_3 206 210 PF02991 0.460
LIG_LIR_Nem_3 271 277 PF02991 0.433
LIG_LIR_Nem_3 77 83 PF02991 0.491
LIG_LIR_Nem_3 92 98 PF02991 0.391
LIG_NRBOX 166 172 PF00104 0.332
LIG_PCNA_yPIPBox_3 166 180 PF02747 0.473
LIG_Pex14_2 210 214 PF04695 0.493
LIG_PTB_Apo_2 233 240 PF02174 0.517
LIG_REV1ctd_RIR_1 256 266 PF16727 0.288
LIG_SH2_CRK 129 133 PF00017 0.610
LIG_SH2_CRK 198 202 PF00017 0.491
LIG_SH2_CRK 274 278 PF00017 0.454
LIG_SH2_CRK 29 33 PF00017 0.653
LIG_SH2_CRK 95 99 PF00017 0.437
LIG_SH2_NCK_1 95 99 PF00017 0.437
LIG_SH2_STAP1 34 38 PF00017 0.465
LIG_SH2_STAP1 95 99 PF00017 0.489
LIG_SH2_STAT3 147 150 PF00017 0.373
LIG_SH2_STAT5 160 163 PF00017 0.474
LIG_SH2_STAT5 248 251 PF00017 0.497
LIG_SH2_STAT5 29 32 PF00017 0.562
LIG_SH3_3 22 28 PF00018 0.533
LIG_SH3_3 35 41 PF00018 0.642
LIG_SUMO_SIM_anti_2 165 172 PF11976 0.354
LIG_SUMO_SIM_par_1 165 172 PF11976 0.337
LIG_TRAF2_1 68 71 PF00917 0.686
LIG_TRAF2_1 86 89 PF00917 0.231
LIG_TYR_ITIM 27 32 PF00017 0.440
LIG_TYR_ITIM 93 98 PF00017 0.421
MOD_CK1_1 3 9 PF00069 0.449
MOD_CK1_1 36 42 PF00069 0.608
MOD_CK1_1 60 66 PF00069 0.531
MOD_CK2_1 121 127 PF00069 0.462
MOD_CK2_1 248 254 PF00069 0.354
MOD_CK2_1 65 71 PF00069 0.616
MOD_GlcNHglycan 181 184 PF01048 0.432
MOD_GlcNHglycan 231 234 PF01048 0.564
MOD_NEK2_1 121 126 PF00069 0.497
MOD_NEK2_1 169 174 PF00069 0.344
MOD_NEK2_1 179 184 PF00069 0.443
MOD_NEK2_1 268 273 PF00069 0.448
MOD_NEK2_2 137 142 PF00069 0.605
MOD_NEK2_2 28 33 PF00069 0.576
MOD_PIKK_1 146 152 PF00454 0.410
MOD_PIKK_1 169 175 PF00454 0.417
MOD_PIKK_1 84 90 PF00454 0.348
MOD_PKA_2 121 127 PF00069 0.498
MOD_PKA_2 203 209 PF00069 0.471
MOD_PKA_2 65 71 PF00069 0.542
MOD_Plk_1 137 143 PF00069 0.677
MOD_Plk_4 19 25 PF00069 0.632
MOD_SUMO_rev_2 151 156 PF00179 0.427
TRG_DiLeu_BaEn_4 70 76 PF01217 0.741
TRG_DiLeu_BaLyEn_6 128 133 PF01217 0.558
TRG_DiLeu_BaLyEn_6 22 27 PF01217 0.542
TRG_DiLeu_BaLyEn_6 273 278 PF01217 0.352
TRG_ENDOCYTIC_2 129 132 PF00928 0.607
TRG_ENDOCYTIC_2 274 277 PF00928 0.473
TRG_ENDOCYTIC_2 29 32 PF00928 0.648
TRG_ENDOCYTIC_2 95 98 PF00928 0.475
TRG_ER_diArg_1 115 117 PF00400 0.584
TRG_ER_diArg_1 129 131 PF00400 0.570
TRG_ER_diArg_1 141 144 PF00400 0.524
TRG_ER_diArg_1 17 19 PF00400 0.703
TRG_ER_diArg_1 53 56 PF00400 0.565
TRG_Pf-PMV_PEXEL_1 119 123 PF00026 0.612
TRG_Pf-PMV_PEXEL_1 188 193 PF00026 0.650

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIG8 Leptomonas seymouri 65% 100%
A0A0S4ITL7 Bodo saltans 33% 100%
A0A1X0NZE1 Trypanosomatidae 66% 95%
A0A3Q8IB97 Leishmania donovani 76% 98%
A0A3R7KKG3 Trypanosoma rangeli 63% 100%
A4I441 Leishmania infantum 77% 98%
C9ZKS1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9ADK6 Leishmania major 76% 100%
E9AM75 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 98%
V5BUH7 Trypanosoma cruzi 54% 80%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS