Ribosomal protein L3-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L3-like protein

Species:

Leishmania braziliensis

UniProt:

A4HH11_LEIBR

TriTrypDb:

LbrM.29.0040 , LBRM2903_290005700

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	12
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HH11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH11

PDB structure(s): 7aih_A , 7am2_A , 7ane_A

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.319
CLV_NRD_NRD_1	17	19	PF00675	0.544
CLV_NRD_NRD_1	2	4	PF00675	0.536
CLV_NRD_NRD_1	271	273	PF00675	0.241
CLV_NRD_NRD_1	28	30	PF00675	0.376
CLV_NRD_NRD_1	424	426	PF00675	0.397
CLV_NRD_NRD_1	428	430	PF00675	0.418
CLV_NRD_NRD_1	432	434	PF00675	0.427
CLV_NRD_NRD_1	435	437	PF00675	0.434
CLV_NRD_NRD_1	455	457	PF00675	0.304
CLV_NRD_NRD_1	98	100	PF00675	0.276
CLV_PCSK_KEX2_1	17	19	PF00082	0.546
CLV_PCSK_KEX2_1	2	4	PF00082	0.538
CLV_PCSK_KEX2_1	271	273	PF00082	0.241
CLV_PCSK_KEX2_1	28	30	PF00082	0.365
CLV_PCSK_KEX2_1	282	284	PF00082	0.278
CLV_PCSK_KEX2_1	455	457	PF00082	0.436
CLV_PCSK_KEX2_1	463	465	PF00082	0.443
CLV_PCSK_KEX2_1	98	100	PF00082	0.276
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.235
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.466
CLV_PCSK_SKI1_1	137	141	PF00082	0.328
CLV_PCSK_SKI1_1	229	233	PF00082	0.235
CLV_PCSK_SKI1_1	366	370	PF00082	0.498
CLV_PCSK_SKI1_1	402	406	PF00082	0.510
CLV_PCSK_SKI1_1	455	459	PF00082	0.464
CLV_PCSK_SKI1_1	463	467	PF00082	0.468
DEG_Nend_UBRbox_1	1	4	PF02207	0.499
DOC_CDC14_PxL_1	315	323	PF14671	0.308
DOC_CDC14_PxL_1	35	43	PF14671	0.438
DOC_CKS1_1	213	218	PF01111	0.478
DOC_MAPK_FxFP_2	156	159	PF00069	0.311
DOC_MAPK_gen_1	229	239	PF00069	0.435
DOC_MAPK_gen_1	433	443	PF00069	0.419
DOC_MAPK_MEF2A_6	130	138	PF00069	0.209
DOC_MAPK_MEF2A_6	232	241	PF00069	0.435
DOC_PP4_FxxP_1	156	159	PF00568	0.311
DOC_PP4_FxxP_1	189	192	PF00568	0.358
DOC_USP7_UBL2_3	426	430	PF12436	0.577
DOC_WW_Pin1_4	212	217	PF00397	0.438
DOC_WW_Pin1_4	347	352	PF00397	0.516
DOC_WW_Pin1_4	373	378	PF00397	0.411
LIG_14-3-3_CanoR_1	28	38	PF00244	0.452
LIG_14-3-3_CanoR_1	429	433	PF00244	0.481
LIG_14-3-3_CterR_2	464	467	PF00244	0.619
LIG_ActinCP_TwfCPI_2	189	199	PF01115	0.306
LIG_AP2alpha_1	383	387	PF02296	0.383
LIG_BRCT_BRCA1_1	127	131	PF00533	0.325
LIG_BRCT_BRCA1_1	208	212	PF00533	0.539
LIG_CSL_BTD_1	156	159	PF09270	0.311
LIG_FHA_1	173	179	PF00498	0.365
LIG_FHA_2	138	144	PF00498	0.342
LIG_FHA_2	222	228	PF00498	0.435
LIG_FHA_2	318	324	PF00498	0.313
LIG_FHA_2	41	47	PF00498	0.390
LIG_FHA_2	82	88	PF00498	0.380
LIG_LIR_Apic_2	111	117	PF02991	0.372
LIG_LIR_Apic_2	154	159	PF02991	0.304
LIG_LIR_Apic_2	188	192	PF02991	0.364
LIG_LIR_Gen_1	122	131	PF02991	0.345
LIG_LIR_Gen_1	143	151	PF02991	0.332
LIG_LIR_Gen_1	258	266	PF02991	0.436
LIG_LIR_Gen_1	328	336	PF02991	0.323
LIG_LIR_Gen_1	84	94	PF02991	0.368
LIG_LIR_Nem_3	102	107	PF02991	0.375
LIG_LIR_Nem_3	122	126	PF02991	0.353
LIG_LIR_Nem_3	128	134	PF02991	0.300
LIG_LIR_Nem_3	143	147	PF02991	0.311
LIG_LIR_Nem_3	217	222	PF02991	0.435
LIG_LIR_Nem_3	245	251	PF02991	0.435
LIG_LIR_Nem_3	258	264	PF02991	0.436
LIG_LIR_Nem_3	299	304	PF02991	0.435
LIG_LIR_Nem_3	32	38	PF02991	0.427
LIG_LIR_Nem_3	328	332	PF02991	0.315
LIG_LIR_Nem_3	350	356	PF02991	0.507
LIG_LIR_Nem_3	48	53	PF02991	0.284
LIG_LIR_Nem_3	65	70	PF02991	0.354
LIG_LIR_Nem_3	84	89	PF02991	0.376
LIG_LIR_Nem_3	91	97	PF02991	0.354
LIG_LYPXL_S_1	66	70	PF13949	0.358
LIG_LYPXL_SIV_4	218	226	PF13949	0.435
LIG_LYPXL_yS_3	38	41	PF13949	0.389
LIG_LYPXL_yS_3	54	57	PF13949	0.326
LIG_LYPXL_yS_3	67	70	PF13949	0.367
LIG_Pex14_1	307	311	PF04695	0.435
LIG_Pex14_1	34	38	PF04695	0.389
LIG_Pex14_2	253	257	PF04695	0.437
LIG_Pex14_2	383	387	PF04695	0.370
LIG_PTB_Apo_2	240	247	PF02174	0.435
LIG_PTB_Phospho_1	240	246	PF10480	0.435
LIG_SH2_CRK	219	223	PF00017	0.446
LIG_SH2_CRK	248	252	PF00017	0.538
LIG_SH2_CRK	301	305	PF00017	0.435
LIG_SH2_CRK	462	466	PF00017	0.488
LIG_SH2_CRK	86	90	PF00017	0.365
LIG_SH2_NCK_1	219	223	PF00017	0.446
LIG_SH2_PTP2	261	264	PF00017	0.446
LIG_SH2_SRC	219	222	PF00017	0.435
LIG_SH2_STAP1	127	131	PF00017	0.309
LIG_SH2_STAT3	246	249	PF00017	0.543
LIG_SH2_STAT5	179	182	PF00017	0.357
LIG_SH2_STAT5	261	264	PF00017	0.446
LIG_SH2_STAT5	317	320	PF00017	0.306
LIG_SH2_STAT5	329	332	PF00017	0.313
LIG_SH2_STAT5	341	344	PF00017	0.353
LIG_SH2_STAT5	382	385	PF00017	0.362
LIG_SH2_STAT5	421	424	PF00017	0.419
LIG_SH2_STAT5	56	59	PF00017	0.333
LIG_SH3_1	348	354	PF00018	0.365
LIG_SH3_3	210	216	PF00018	0.479
LIG_SH3_3	348	354	PF00018	0.365
LIG_SH3_3	65	71	PF00018	0.355
LIG_TRAF2_1	233	236	PF00917	0.435
LIG_TYR_ITIM	460	465	PF00017	0.479
LIG_TYR_ITSM	82	89	PF00017	0.380
LIG_WRC_WIRS_1	353	358	PF05994	0.382
LIG_WW_1	377	380	PF00397	0.381
MOD_CK1_1	297	303	PF00069	0.452
MOD_CK1_1	40	46	PF00069	0.285
MOD_CK2_1	356	362	PF00069	0.430
MOD_GlcNHglycan	20	23	PF01048	0.472
MOD_GlcNHglycan	208	211	PF01048	0.307
MOD_GlcNHglycan	296	299	PF01048	0.268
MOD_GlcNHglycan	402	405	PF01048	0.427
MOD_GlcNHglycan	5	8	PF01048	0.578
MOD_GSK3_1	237	244	PF00069	0.435
MOD_GSK3_1	335	342	PF00069	0.376
MOD_GSK3_1	352	359	PF00069	0.334
MOD_NEK2_1	125	130	PF00069	0.332
MOD_NEK2_1	151	156	PF00069	0.301
MOD_NEK2_1	264	269	PF00069	0.435
MOD_NEK2_1	332	337	PF00069	0.345
MOD_NEK2_2	428	433	PF00069	0.334
MOD_PIKK_1	391	397	PF00454	0.443
MOD_PKA_1	419	425	PF00069	0.463
MOD_PKA_2	332	338	PF00069	0.487
MOD_PKA_2	428	434	PF00069	0.430
MOD_Plk_1	151	157	PF00069	0.306
MOD_Plk_1	235	241	PF00069	0.443
MOD_Plk_4	311	317	PF00069	0.327
MOD_Plk_4	325	331	PF00069	0.315
MOD_Plk_4	339	345	PF00069	0.391
MOD_Plk_4	352	358	PF00069	0.407
MOD_Plk_4	37	43	PF00069	0.391
MOD_Plk_4	62	68	PF00069	0.358
MOD_ProDKin_1	212	218	PF00069	0.438
MOD_ProDKin_1	347	353	PF00069	0.515
MOD_ProDKin_1	373	379	PF00069	0.409
MOD_SUMO_rev_2	394	404	PF00179	0.432
TRG_ENDOCYTIC_2	144	147	PF00928	0.345
TRG_ENDOCYTIC_2	219	222	PF00928	0.435
TRG_ENDOCYTIC_2	248	251	PF00928	0.491
TRG_ENDOCYTIC_2	261	264	PF00928	0.398
TRG_ENDOCYTIC_2	301	304	PF00928	0.435
TRG_ENDOCYTIC_2	329	332	PF00928	0.313
TRG_ENDOCYTIC_2	38	41	PF00928	0.389
TRG_ENDOCYTIC_2	380	383	PF00928	0.404
TRG_ENDOCYTIC_2	438	441	PF00928	0.478
TRG_ENDOCYTIC_2	462	465	PF00928	0.463
TRG_ENDOCYTIC_2	54	57	PF00928	0.326
TRG_ENDOCYTIC_2	67	70	PF00928	0.367
TRG_ENDOCYTIC_2	86	89	PF00928	0.373
TRG_ENDOCYTIC_2	94	97	PF00928	0.340
TRG_ER_diArg_1	1	3	PF00400	0.569
TRG_ER_diArg_1	17	19	PF00400	0.544
TRG_ER_diArg_1	271	273	PF00400	0.435
TRG_ER_diArg_1	28	31	PF00400	0.387
TRG_ER_diArg_1	97	99	PF00400	0.347
TRG_NLS_Bipartite_1	412	430	PF00514	0.405
TRG_NLS_MonoExtC_3	411	417	PF00514	0.426
TRG_NLS_MonoExtC_3	424	429	PF00514	0.455
TRG_NLS_MonoExtC_3	432	437	PF00514	0.444
TRG_NLS_MonoExtN_4	411	416	PF00514	0.447
TRG_NLS_MonoExtN_4	425	430	PF00514	0.435
TRG_NLS_MonoExtN_4	433	440	PF00514	0.440
TRG_NLS_MonoExtN_4	461	467	PF00514	0.605
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAL5	Leptomonas seymouri	90%	100%
A0A0S4IMW0	Bodo saltans	78%	100%
A0A1X0NZZ6	Trypanosomatidae	88%	99%
A0A3Q8IR02	Leishmania donovani	94%	100%
A0A422NUY5	Trypanosoma rangeli	89%	99%
A4I440	Leishmania infantum	94%	100%
C9ZKS2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	89%	99%
E9ADK5	Leishmania major	94%	100%
E9AM76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BPV7	Trypanosoma cruzi	90%	88%