3,2-trans-enoyl-CoA isomerase, mitochondrial-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3,2-trans-enoyl-CoA isomerase, mitochondrial precursor-like protein

Species:

Leishmania braziliensis

UniProt:

A4HH09_LEIBR

TriTrypDb:

LbrM.29.0020 , LBRM2903_290005400

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	1
GO:0020023	kinetoplast	2	1

Expansion

Sequence features

A4HH09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH09

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006629	lipid metabolic process	3	3
GO:0006631	fatty acid metabolic process	4	3
GO:0006635	fatty acid beta-oxidation	6	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009062	fatty acid catabolic process	5	3
GO:0009987	cellular process	1	3
GO:0016042	lipid catabolic process	4	3
GO:0016054	organic acid catabolic process	4	3
GO:0019395	fatty acid oxidation	5	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0030258	lipid modification	4	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0034440	lipid oxidation	5	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044242	cellular lipid catabolic process	4	3
GO:0044248	cellular catabolic process	3	3
GO:0044255	cellular lipid metabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044282	small molecule catabolic process	3	3
GO:0046395	carboxylic acid catabolic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:0072329	monocarboxylic acid catabolic process	6	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0016853	isomerase activity	2	21
GO:0004165	delta(3)-delta(2)-enoyl-CoA isomerase activity	5	9
GO:0016860	intramolecular oxidoreductase activity	3	9
GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds	4	9
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	5	2
GO:0016491	oxidoreductase activity	2	2
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2
GO:0004300	enoyl-CoA hydratase activity	5	3
GO:0016829	lyase activity	2	3
GO:0016835	carbon-oxygen lyase activity	3	3
GO:0016836	hydro-lyase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.406
CLV_NRD_NRD_1	191	193	PF00675	0.304
CLV_NRD_NRD_1	253	255	PF00675	0.297
CLV_NRD_NRD_1	294	296	PF00675	0.564
CLV_NRD_NRD_1	4	6	PF00675	0.567
CLV_PCSK_FUR_1	2	6	PF00082	0.414
CLV_PCSK_KEX2_1	155	157	PF00082	0.407
CLV_PCSK_KEX2_1	253	255	PF00082	0.324
CLV_PCSK_KEX2_1	4	6	PF00082	0.567
CLV_PCSK_PC7_1	151	157	PF00082	0.380
CLV_PCSK_SKI1_1	254	258	PF00082	0.254
CLV_PCSK_SKI1_1	40	44	PF00082	0.343
DEG_APCC_DBOX_1	253	261	PF00400	0.340
DEG_Nend_UBRbox_1	1	4	PF02207	0.595
DEG_SPOP_SBC_1	17	21	PF00917	0.579
DOC_CYCLIN_RxL_1	232	241	PF00134	0.325
DOC_MAPK_gen_1	192	200	PF00069	0.211
DOC_MAPK_JIP1_4	160	166	PF00069	0.236
DOC_MAPK_MEF2A_6	120	129	PF00069	0.294
DOC_MAPK_MEF2A_6	160	168	PF00069	0.380
DOC_MAPK_MEF2A_6	193	202	PF00069	0.173
DOC_PP2B_LxvP_1	125	128	PF13499	0.318
DOC_PP2B_LxvP_1	237	240	PF13499	0.374
DOC_PP2B_LxvP_1	256	259	PF13499	0.190
DOC_PP4_FxxP_1	175	178	PF00568	0.380
DOC_USP7_MATH_1	128	132	PF00917	0.282
DOC_USP7_MATH_1	145	149	PF00917	0.294
DOC_USP7_MATH_1	22	26	PF00917	0.506
DOC_USP7_MATH_1	72	76	PF00917	0.396
DOC_USP7_UBL2_3	292	296	PF12436	0.561
DOC_WW_Pin1_4	33	38	PF00397	0.343
DOC_WW_Pin1_4	83	88	PF00397	0.290
LIG_14-3-3_CanoR_1	120	126	PF00244	0.409
LIG_14-3-3_CanoR_1	16	24	PF00244	0.528
LIG_FHA_1	157	163	PF00498	0.183
LIG_FHA_1	25	31	PF00498	0.450
LIG_FHA_1	260	266	PF00498	0.263
LIG_FHA_1	84	90	PF00498	0.167
LIG_FHA_2	63	69	PF00498	0.259
LIG_Integrin_isoDGR_2	48	50	PF01839	0.328
LIG_LIR_Apic_2	7	12	PF02991	0.402
LIG_LIR_Gen_1	121	130	PF02991	0.328
LIG_LIR_Gen_1	272	282	PF02991	0.341
LIG_LIR_LC3C_4	27	32	PF02991	0.377
LIG_LIR_Nem_3	106	111	PF02991	0.298
LIG_LIR_Nem_3	121	125	PF02991	0.321
LIG_LIR_Nem_3	270	276	PF02991	0.381
LIG_NRBOX	199	205	PF00104	0.161
LIG_Pex14_2	108	112	PF04695	0.287
LIG_Pex14_2	115	119	PF04695	0.295
LIG_Pex14_2	273	277	PF04695	0.318
LIG_Pex14_2	58	62	PF04695	0.323
LIG_SH2_PTP2	9	12	PF00017	0.407
LIG_SH2_STAT3	111	114	PF00017	0.256
LIG_SH2_STAT5	180	183	PF00017	0.343
LIG_SH2_STAT5	9	12	PF00017	0.407
LIG_SH3_1	155	161	PF00018	0.453
LIG_SH3_3	155	161	PF00018	0.337
LIG_SH3_3	173	179	PF00018	0.380
LIG_SH3_3	66	72	PF00018	0.287
LIG_SUMO_SIM_anti_2	29	36	PF11976	0.441
LIG_SUMO_SIM_anti_2	39	45	PF11976	0.337
LIG_SUMO_SIM_par_1	142	149	PF11976	0.237
LIG_SUMO_SIM_par_1	234	241	PF11976	0.401
LIG_SUMO_SIM_par_1	29	36	PF11976	0.321
LIG_SUMO_SIM_par_1	39	45	PF11976	0.210
LIG_WRC_WIRS_1	119	124	PF05994	0.301
MOD_CDK_SPxxK_3	33	40	PF00069	0.250
MOD_CK2_1	33	39	PF00069	0.286
MOD_GlcNHglycan	130	133	PF01048	0.291
MOD_GlcNHglycan	204	207	PF01048	0.345
MOD_GlcNHglycan	240	243	PF01048	0.272
MOD_GlcNHglycan	59	62	PF01048	0.302
MOD_GSK3_1	16	23	PF00069	0.671
MOD_GSK3_1	53	60	PF00069	0.402
MOD_N-GLC_1	101	106	PF02516	0.238
MOD_NEK2_1	118	123	PF00069	0.295
MOD_NEK2_1	277	282	PF00069	0.161
MOD_NEK2_1	62	67	PF00069	0.187
MOD_PIKK_1	264	270	PF00454	0.314
MOD_PIKK_1	277	283	PF00454	0.360
MOD_PIKK_1	72	78	PF00454	0.161
MOD_PKA_1	4	10	PF00069	0.548
MOD_PKA_2	4	10	PF00069	0.550
MOD_PKB_1	2	10	PF00069	0.529
MOD_Plk_4	269	275	PF00069	0.224
MOD_Plk_4	4	10	PF00069	0.614
MOD_ProDKin_1	33	39	PF00069	0.335
MOD_ProDKin_1	83	89	PF00069	0.290
TRG_DiLeu_BaEn_1	39	44	PF01217	0.268
TRG_DiLeu_BaEn_4	195	201	PF01217	0.259
TRG_ENDOCYTIC_2	150	153	PF00928	0.332
TRG_ENDOCYTIC_2	245	248	PF00928	0.320
TRG_ENDOCYTIC_2	274	277	PF00928	0.309
TRG_ER_diArg_1	1	4	PF00400	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z0	Leptomonas seymouri	23%	100%
A0A0N1I4C8	Leptomonas seymouri	32%	84%
A0A0N1PBS2	Leptomonas seymouri	70%	99%
A0A0N1PCQ9	Leptomonas seymouri	30%	100%
A0A0S4IKH3	Bodo saltans	36%	86%
A0A0S4JA19	Bodo saltans	46%	88%
A0A1X0NRI1	Trypanosomatidae	31%	80%
A0A1X0P9A2	Trypanosomatidae	22%	100%
A0A3Q8IE71	Leishmania donovani	78%	100%
A0A3Q8IV04	Leishmania donovani	25%	100%
A0A3S7X4R5	Leishmania donovani	35%	87%
A0A3S7X4T7	Leishmania donovani	33%	87%
A0A422N418	Trypanosoma rangeli	36%	86%
A0A422NUW6	Trypanosoma rangeli	47%	100%
A4HJK3	Leishmania braziliensis	34%	86%
A4HJK8	Leishmania braziliensis	33%	86%
A4HJL5	Leishmania braziliensis	34%	86%
A4HM74	Leishmania braziliensis	30%	100%
A4I438	Leishmania infantum	78%	100%
A4I708	Leishmania infantum	35%	87%
A4I738	Leishmania infantum	34%	85%
A9JS71	Xenopus laevis	25%	100%
C9ZKS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	95%
C9ZLJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZWP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	83%
E9ADK3	Leishmania major	78%	100%
E9AEL3	Leishmania major	26%	100%
E9AHU0	Leishmania infantum	25%	100%
E9AM78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9B226	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	87%
E9B233	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	87%
E9B5S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
F1LU71	Rattus norvegicus	29%	94%
F4JML5	Arabidopsis thaliana	26%	98%
F9XMX6	Zymoseptoria tritici (strain CBS 115943 / IPO323)	24%	97%
O04469	Arabidopsis thaliana	22%	100%
O07137	Mycobacterium leprae (strain TN)	22%	100%
O23300	Arabidopsis thaliana	27%	100%
O34893	Bacillus subtilis (strain 168)	28%	100%
P14604	Rattus norvegicus	22%	100%
P23965	Rattus norvegicus	30%	100%
P30084	Homo sapiens	23%	100%
P42125	Mus musculus	34%	100%
P42126	Homo sapiens	32%	98%
Q13825	Homo sapiens	29%	87%
Q2HJD5	Bos taurus	23%	97%
Q2TBT3	Bos taurus	26%	100%
Q4PEN0	Ustilago maydis (strain 521 / FGSC 9021)	26%	100%
Q4Q628	Leishmania major	35%	85%
Q4Q636	Leishmania major	36%	78%
Q52995	Rhizobium meliloti (strain 1021)	26%	100%
Q589W8	Alternaria alternata	23%	100%
Q58DM8	Bos taurus	23%	100%
Q5R646	Pongo abelii	23%	100%
Q6AYG5	Rattus norvegicus	25%	99%
Q6GAG7	Staphylococcus aureus (strain MSSA476)	26%	100%
Q869N6	Dictyostelium discoideum	28%	99%
Q86YB7	Homo sapiens	27%	100%
Q8BH95	Mus musculus	21%	100%
Q8NXA0	Staphylococcus aureus (strain MW2)	26%	100%
Q96VB3	Alternaria alternata	23%	100%
Q9D9V3	Mus musculus	26%	92%
Q9JLZ3	Mus musculus	29%	94%
Q9P4U7	Alternaria alternata	23%	100%
Q9P4U9	Alternaria alternata	23%	100%
V5B2L9	Trypanosoma cruzi	34%	76%
V5BK92	Trypanosoma cruzi	48%	100%
V5BWB9	Trypanosoma cruzi	24%	81%
V5DTT7	Trypanosoma cruzi	23%	100%