Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate-repressible phosphate permease

Species:

Leishmania braziliensis

UniProt:

A4HH06_LEIBR

TriTrypDb:

LbrM.28.3250 , LBRM2903_030009800

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

A4HH06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH06

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	24
GO:0006811	monoatomic ion transport	4	24
GO:0006817	phosphate ion transport	7	24
GO:0006820	monoatomic anion transport	5	24
GO:0015698	inorganic anion transport	6	24
GO:0051179	localization	1	24
GO:0051234	establishment of localization	2	24
GO:0009987	cellular process	1	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0035435	phosphate ion transmembrane transport	6	3
GO:0055085	transmembrane transport	2	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098661	inorganic anion transmembrane transport	5	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	24
GO:0005315	inorganic phosphate transmembrane transporter activity	4	24
GO:0015291	secondary active transmembrane transporter activity	4	24
GO:0015293	symporter activity	5	24
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	24
GO:0022804	active transmembrane transporter activity	3	24
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.536
CLV_C14_Caspase3-7	358	362	PF00656	0.468
CLV_NRD_NRD_1	138	140	PF00675	0.512
CLV_NRD_NRD_1	247	249	PF00675	0.230
CLV_NRD_NRD_1	302	304	PF00675	0.181
CLV_NRD_NRD_1	305	307	PF00675	0.171
CLV_PCSK_KEX2_1	246	248	PF00082	0.275
CLV_PCSK_KEX2_1	302	304	PF00082	0.181
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.337
CLV_PCSK_SKI1_1	175	179	PF00082	0.320
CLV_PCSK_SKI1_1	213	217	PF00082	0.468
CLV_PCSK_SKI1_1	306	310	PF00082	0.161
CLV_PCSK_SKI1_1	39	43	PF00082	0.318
CLV_PCSK_SKI1_1	522	526	PF00082	0.211
DEG_Nend_Nbox_1	1	3	PF02207	0.323
DEG_ODPH_VHL_1	187	200	PF01847	0.417
DEG_SPOP_SBC_1	497	501	PF00917	0.290
DOC_CKS1_1	471	476	PF01111	0.565
DOC_CYCLIN_RxL_1	172	182	PF00134	0.245
DOC_CYCLIN_RxL_1	210	220	PF00134	0.161
DOC_MAPK_DCC_7	186	196	PF00069	0.417
DOC_MAPK_gen_1	246	254	PF00069	0.522
DOC_MAPK_gen_1	520	527	PF00069	0.447
DOC_MAPK_MEF2A_6	222	230	PF00069	0.161
DOC_MAPK_MEF2A_6	39	48	PF00069	0.506
DOC_MAPK_MEF2A_6	520	529	PF00069	0.563
DOC_MAPK_NFAT4_5	522	530	PF00069	0.561
DOC_MAPK_RevD_3	234	248	PF00069	0.313
DOC_PP1_RVXF_1	518	524	PF00149	0.433
DOC_PP4_FxxP_1	157	160	PF00568	0.331
DOC_PP4_FxxP_1	457	460	PF00568	0.245
DOC_USP7_MATH_1	110	114	PF00917	0.331
DOC_USP7_MATH_1	235	239	PF00917	0.331
DOC_USP7_MATH_1	278	282	PF00917	0.473
DOC_USP7_MATH_1	363	367	PF00917	0.475
DOC_USP7_MATH_1	402	406	PF00917	0.320
DOC_USP7_MATH_1	407	411	PF00917	0.338
DOC_USP7_MATH_1	497	501	PF00917	0.290
DOC_USP7_UBL2_3	300	304	PF12436	0.417
DOC_WW_Pin1_4	156	161	PF00397	0.331
DOC_WW_Pin1_4	352	357	PF00397	0.526
DOC_WW_Pin1_4	470	475	PF00397	0.490
LIG_14-3-3_CanoR_1	139	144	PF00244	0.161
LIG_14-3-3_CanoR_1	279	283	PF00244	0.554
LIG_14-3-3_CanoR_1	364	372	PF00244	0.448
LIG_14-3-3_CanoR_1	39	44	PF00244	0.527
LIG_APCC_ABBA_1	198	203	PF00400	0.166
LIG_BRCT_BRCA1_1	543	547	PF00533	0.385
LIG_FHA_1	180	186	PF00498	0.517
LIG_FHA_1	313	319	PF00498	0.493
LIG_FHA_1	427	433	PF00498	0.313
LIG_FHA_1	454	460	PF00498	0.311
LIG_FHA_1	482	488	PF00498	0.329
LIG_FHA_1	491	497	PF00498	0.347
LIG_FHA_1	499	505	PF00498	0.357
LIG_FHA_1	534	540	PF00498	0.338
LIG_GBD_Chelix_1	165	173	PF00786	0.236
LIG_GBD_Chelix_1	482	490	PF00786	0.245
LIG_HP1_1	83	87	PF01393	0.239
LIG_LIR_Apic_2	155	160	PF02991	0.331
LIG_LIR_Apic_2	456	460	PF02991	0.245
LIG_LIR_Apic_2	492	497	PF02991	0.346
LIG_LIR_Gen_1	203	212	PF02991	0.331
LIG_LIR_Gen_1	82	91	PF02991	0.245
LIG_LIR_Gen_1	97	106	PF02991	0.389
LIG_LIR_LC3C_4	484	488	PF02991	0.360
LIG_LIR_Nem_3	141	146	PF02991	0.275
LIG_LIR_Nem_3	203	209	PF02991	0.331
LIG_LIR_Nem_3	390	396	PF02991	0.479
LIG_LIR_Nem_3	97	103	PF02991	0.376
LIG_MYND_1	189	193	PF01753	0.417
LIG_Pex14_2	197	201	PF04695	0.331
LIG_Pex14_2	204	208	PF04695	0.332
LIG_SH2_CRK	420	424	PF00017	0.217
LIG_SH2_CRK	494	498	PF00017	0.382
LIG_SH2_CRK	88	92	PF00017	0.365
LIG_SH2_NCK_1	420	424	PF00017	0.217
LIG_SH2_SRC	377	380	PF00017	0.417
LIG_SH2_STAP1	420	424	PF00017	0.286
LIG_SH2_STAT5	145	148	PF00017	0.271
LIG_SH2_STAT5	176	179	PF00017	0.565
LIG_SH2_STAT5	190	193	PF00017	0.437
LIG_SH2_STAT5	374	377	PF00017	0.539
LIG_SH2_STAT5	5	8	PF00017	0.323
LIG_SH2_STAT5	78	81	PF00017	0.282
LIG_SH2_STAT5	84	87	PF00017	0.331
LIG_SH3_3	350	356	PF00018	0.410
LIG_SH3_3	468	474	PF00018	0.565
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.565
LIG_SUMO_SIM_par_1	150	155	PF11976	0.313
LIG_SUMO_SIM_par_1	45	51	PF11976	0.320
LIG_SUMO_SIM_par_1	486	493	PF11976	0.320
LIG_SUMO_SIM_par_1	507	512	PF11976	0.346
LIG_SUMO_SIM_par_1	535	540	PF11976	0.357
LIG_TRAF2_1	260	263	PF00917	0.495
LIG_TRAF2_1	317	320	PF00917	0.417
LIG_TYR_ITIM	86	91	PF00017	0.320
LIG_UBA3_1	461	468	PF00899	0.513
LIG_UBA3_1	524	528	PF00899	0.474
LIG_WRC_WIRS_1	283	288	PF05994	0.417
LIG_WRC_WIRS_1	454	459	PF05994	0.388
MOD_CDK_SPxK_1	470	476	PF00069	0.490
MOD_CK1_1	335	341	PF00069	0.467
MOD_CK1_1	35	41	PF00069	0.580
MOD_CK1_1	489	495	PF00069	0.333
MOD_CK2_1	48	54	PF00069	0.342
MOD_CK2_1	74	80	PF00069	0.209
MOD_Cter_Amidation	137	140	PF01082	0.417
MOD_GlcNHglycan	146	149	PF01048	0.594
MOD_GlcNHglycan	162	165	PF01048	0.442
MOD_GlcNHglycan	219	222	PF01048	0.576
MOD_GlcNHglycan	231	234	PF01048	0.301
MOD_GlcNHglycan	254	257	PF01048	0.329
MOD_GlcNHglycan	378	382	PF01048	0.376
MOD_GlcNHglycan	543	546	PF01048	0.343
MOD_GlcNHglycan	70	73	PF01048	0.471
MOD_GSK3_1	105	112	PF00069	0.455
MOD_GSK3_1	152	159	PF00069	0.341
MOD_GSK3_1	248	255	PF00069	0.495
MOD_GSK3_1	278	285	PF00069	0.582
MOD_GSK3_1	31	38	PF00069	0.445
MOD_GSK3_1	348	355	PF00069	0.528
MOD_GSK3_1	397	404	PF00069	0.245
MOD_GSK3_1	407	414	PF00069	0.317
MOD_GSK3_1	486	493	PF00069	0.353
MOD_GSK3_1	498	505	PF00069	0.326
MOD_GSK3_1	533	540	PF00069	0.362
MOD_GSK3_1	60	67	PF00069	0.346
MOD_GSK3_1	90	97	PF00069	0.365
MOD_NEK2_1	102	107	PF00069	0.216
MOD_NEK2_1	179	184	PF00069	0.532
MOD_NEK2_1	216	221	PF00069	0.322
MOD_NEK2_1	32	37	PF00069	0.491
MOD_NEK2_1	426	431	PF00069	0.161
MOD_NEK2_1	48	53	PF00069	0.385
MOD_NEK2_1	486	491	PF00069	0.346
MOD_NEK2_1	509	514	PF00069	0.245
MOD_NEK2_1	90	95	PF00069	0.304
MOD_PIKK_1	287	293	PF00454	0.376
MOD_PIKK_1	60	66	PF00454	0.368
MOD_PKA_1	139	145	PF00069	0.244
MOD_PKA_2	138	144	PF00069	0.161
MOD_PKA_2	252	258	PF00069	0.575
MOD_PKA_2	278	284	PF00069	0.573
MOD_PKA_2	363	369	PF00069	0.438
MOD_Plk_1	179	185	PF00069	0.417
MOD_Plk_2-3	348	354	PF00069	0.532
MOD_Plk_4	278	284	PF00069	0.361
MOD_Plk_4	39	45	PF00069	0.409
MOD_Plk_4	74	80	PF00069	0.215
MOD_Plk_4	94	100	PF00069	0.349
MOD_ProDKin_1	156	162	PF00069	0.331
MOD_ProDKin_1	352	358	PF00069	0.526
MOD_ProDKin_1	470	476	PF00069	0.490
MOD_SUMO_rev_2	326	335	PF00179	0.423
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.320
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.361
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.461
TRG_ENDOCYTIC_2	176	179	PF00928	0.445
TRG_ENDOCYTIC_2	420	423	PF00928	0.219
TRG_ENDOCYTIC_2	5	8	PF00928	0.323
TRG_ENDOCYTIC_2	84	87	PF00928	0.334
TRG_ENDOCYTIC_2	88	91	PF00928	0.327
TRG_ER_diArg_1	247	249	PF00400	0.434
TRG_ER_diArg_1	520	523	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.217
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S5	Leptomonas seymouri	49%	100%
A0A0S4JEW4	Bodo saltans	25%	88%
A0A1X0NXY5	Trypanosomatidae	49%	100%
A0A1X0P0T2	Trypanosomatidae	25%	85%
A0A3Q8I8Y3	Leishmania donovani	49%	100%
A0A3Q8IBK1	Leishmania donovani	47%	100%
A0A3R7K4N2	Trypanosoma rangeli	46%	100%
A0A3R7L5P3	Trypanosoma rangeli	25%	94%
A0A3S5H545	Leishmania donovani	80%	98%
A1A4I1	Bos taurus	28%	87%
A4H5Y5	Leishmania braziliensis	47%	89%
A4H6C2	Leishmania braziliensis	47%	89%
A4HBH2	Leishmania braziliensis	45%	97%
A4HUP5	Leishmania infantum	49%	100%
A4HYJ6	Leishmania infantum	47%	100%
C9ZHT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZHU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ACJ5	Leishmania major	80%	100%
E9AG39	Leishmania infantum	80%	98%
E9AJT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9AN09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9ANE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AUE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	98%
O97596	Felis catus	28%	82%
P15710	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	95%
P38361	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	98%
Q28E01	Xenopus tropicalis	28%	86%
Q4QH82	Leishmania major	49%	89%
Q4QHL7	Leishmania major	50%	89%
Q5BL44	Xenopus tropicalis	25%	82%
Q61609	Mus musculus	26%	82%
Q63488	Rattus norvegicus	28%	86%
Q80UP8	Mus musculus	28%	86%
Q8WUM9	Homo sapiens	27%	83%
Q95L97	Felis catus	28%	86%
Q9ES44	Cricetulus griseus	28%	86%
V5DS90	Trypanosoma cruzi	47%	100%