Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HH01_LEIBR

TriTrypDb:

LbrM.28.3200 , LBRM2903_280039800

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HH01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HH01

PDB structure(s): 7ane_ay

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	118	120	PF00082	0.362
CLV_PCSK_KEX2_1	26	28	PF00082	0.497
CLV_PCSK_KEX2_1	34	36	PF00082	0.438
CLV_PCSK_KEX2_1	75	77	PF00082	0.332
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.362
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.515
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.421
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.347
CLV_PCSK_SKI1_1	115	119	PF00082	0.366
CLV_PCSK_SKI1_1	141	145	PF00082	0.393
CLV_PCSK_SKI1_1	154	158	PF00082	0.420
CLV_PCSK_SKI1_1	160	164	PF00082	0.413
DOC_MAPK_gen_1	118	126	PF00069	0.372
DOC_MAPK_gen_1	89	97	PF00069	0.374
DOC_USP7_UBL2_3	33	37	PF12436	0.428
LIG_14-3-3_CanoR_1	12	17	PF00244	0.507
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_BRCT_BRCA1_1	1	5	PF00533	0.661
LIG_deltaCOP1_diTrp_1	78	87	PF00928	0.352
LIG_FHA_1	72	78	PF00498	0.430
LIG_FHA_1	97	103	PF00498	0.480
LIG_FHA_2	148	154	PF00498	0.564
LIG_LIR_Nem_3	134	140	PF02991	0.467
LIG_LIR_Nem_3	161	166	PF02991	0.521
LIG_LIR_Nem_3	81	87	PF02991	0.362
LIG_Pex14_1	49	53	PF04695	0.378
LIG_Pex14_1	80	84	PF04695	0.365
LIG_RPA_C_Fungi	54	66	PF08784	0.371
LIG_SH2_STAT5	101	104	PF00017	0.386
LIG_SH2_STAT5	53	56	PF00017	0.385
LIG_SH2_STAT5	68	71	PF00017	0.324
LIG_SH2_STAT5	96	99	PF00017	0.358
LIG_WRPW_2	137	140	PF00400	0.378
MOD_CK1_1	4	10	PF00069	0.632
MOD_CK2_1	147	153	PF00069	0.478
MOD_GSK3_1	154	161	PF00069	0.548
MOD_N-GLC_1	147	152	PF02516	0.559
MOD_NEK2_1	1	6	PF00069	0.546
MOD_NEK2_1	18	23	PF00069	0.434
MOD_NEK2_1	61	66	PF00069	0.373
MOD_NEK2_1	71	76	PF00069	0.373
MOD_Plk_1	152	158	PF00069	0.435
MOD_Plk_4	158	164	PF00069	0.411
MOD_Plk_4	18	24	PF00069	0.407
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.258
TRG_ENDOCYTIC_2	68	71	PF00928	0.355
TRG_ER_diArg_1	11	14	PF00400	0.509
TRG_ER_diArg_1	57	60	PF00400	0.384
TRG_NLS_MonoCore_2	33	38	PF00514	0.424
TRG_NLS_MonoExtC_3	32	37	PF00514	0.427
TRG_NLS_MonoExtN_4	31	38	PF00514	0.426
TRG_Pf-PMV_PEXEL_1	100	104	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J6	Leptomonas seymouri	86%	100%
A0A0S4IVN4	Bodo saltans	66%	84%
A0A1X0NQT8	Trypanosomatidae	75%	100%
A0A3Q8IDF2	Leishmania donovani	95%	100%
A0A3R7KDM2	Trypanosoma rangeli	74%	100%
A4I433	Leishmania infantum	95%	100%
D0A8X5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
E9B0C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q7W4	Leishmania major	95%	100%
V5BDQ9	Trypanosoma cruzi	75%	78%