Putative U5 snRNP-specific 40 kDa protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U5 snRNP-specific 40 kDa protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HGZ9_LEIBR

TriTrypDb:

LbrM.28.3170 , LBRM2903_280039400

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HGZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HGZ9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0030627	pre-mRNA 5'-splice site binding	6	1
GO:0036002	pre-mRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.379
CLV_PCSK_KEX2_1	144	146	PF00082	0.426
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.407
CLV_PCSK_SKI1_1	211	215	PF00082	0.379
CLV_PCSK_SKI1_1	248	252	PF00082	0.352
CLV_PCSK_SKI1_1	52	56	PF00082	0.540
DEG_SPOP_SBC_1	230	234	PF00917	0.437
DEG_SPOP_SBC_1	4	8	PF00917	0.427
DOC_MAPK_gen_1	144	151	PF00069	0.445
DOC_MAPK_MEF2A_6	292	301	PF00069	0.350
DOC_USP7_MATH_1	158	162	PF00917	0.304
DOC_USP7_MATH_1	230	234	PF00917	0.543
DOC_USP7_MATH_1	4	8	PF00917	0.326
DOC_USP7_MATH_1	75	79	PF00917	0.282
LIG_14-3-3_CanoR_1	211	216	PF00244	0.523
LIG_Actin_WH2_2	89	105	PF00022	0.380
LIG_BIR_II_1	1	5	PF00653	0.411
LIG_BIR_III_3	1	5	PF00653	0.326
LIG_BRCT_BRCA1_1	128	132	PF00533	0.369
LIG_CSL_BTD_1	255	258	PF09270	0.381
LIG_FHA_1	199	205	PF00498	0.392
LIG_FHA_1	39	45	PF00498	0.386
LIG_FHA_1	78	84	PF00498	0.494
LIG_FHA_2	123	129	PF00498	0.366
LIG_FHA_2	90	96	PF00498	0.353
LIG_LIR_Gen_1	164	174	PF02991	0.456
LIG_LIR_Nem_3	115	119	PF02991	0.306
LIG_LIR_Nem_3	16	22	PF02991	0.425
LIG_LIR_Nem_3	164	170	PF02991	0.469
LIG_LIR_Nem_3	177	183	PF02991	0.432
LIG_SH2_GRB2like	19	22	PF00017	0.438
LIG_SH2_STAT5	138	141	PF00017	0.385
LIG_SH2_STAT5	307	310	PF00017	0.351
LIG_SH3_3	152	158	PF00018	0.486
LIG_SH3_3	201	207	PF00018	0.330
LIG_SH3_3	260	266	PF00018	0.451
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.297
LIG_TYR_ITIM	17	22	PF00017	0.252
MOD_CK1_1	161	167	PF00069	0.377
MOD_CK1_1	63	69	PF00069	0.487
MOD_CK1_1	77	83	PF00069	0.339
MOD_CK1_1	9	15	PF00069	0.506
MOD_GlcNHglycan	160	163	PF01048	0.430
MOD_GlcNHglycan	196	199	PF01048	0.433
MOD_GlcNHglycan	217	220	PF01048	0.538
MOD_GlcNHglycan	266	269	PF01048	0.398
MOD_GlcNHglycan	294	297	PF01048	0.355
MOD_GlcNHglycan	77	80	PF01048	0.545
MOD_GlcNHglycan	8	11	PF01048	0.448
MOD_GSK3_1	122	129	PF00069	0.412
MOD_GSK3_1	157	164	PF00069	0.324
MOD_GSK3_1	194	201	PF00069	0.444
MOD_GSK3_1	211	218	PF00069	0.330
MOD_GSK3_1	271	278	PF00069	0.402
MOD_GSK3_1	5	12	PF00069	0.349
MOD_GSK3_1	74	81	PF00069	0.304
MOD_N-GLC_1	297	302	PF02516	0.431
MOD_NEK2_1	217	222	PF00069	0.385
MOD_NEK2_1	223	228	PF00069	0.382
MOD_NEK2_1	229	234	PF00069	0.409
MOD_NEK2_1	297	302	PF00069	0.431
MOD_NEK2_1	3	8	PF00069	0.305
MOD_NEK2_2	165	170	PF00069	0.236
MOD_NEK2_2	284	289	PF00069	0.546
MOD_PIKK_1	123	129	PF00454	0.243
MOD_PIKK_1	205	211	PF00454	0.550
MOD_PIKK_1	223	229	PF00454	0.464
MOD_PKB_1	101	109	PF00069	0.473
MOD_Plk_1	297	303	PF00069	0.444
MOD_Plk_4	126	132	PF00069	0.365
MOD_Plk_4	199	205	PF00069	0.329
MOD_Plk_4	259	265	PF00069	0.277
MOD_Plk_4	271	277	PF00069	0.270
MOD_Plk_4	78	84	PF00069	0.450
MOD_Plk_4	89	95	PF00069	0.410
TRG_DiLeu_BaEn_1	247	252	PF01217	0.492
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.364
TRG_ENDOCYTIC_2	19	22	PF00928	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J8	Leptomonas seymouri	61%	100%
A0A1X0NQJ3	Trypanosomatidae	37%	100%
A0A3S7X1X9	Leishmania donovani	85%	72%
A0A422NG23	Trypanosoma rangeli	39%	100%
A4I431	Leishmania infantum	85%	100%
D0A8X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
E9B0B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O94620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	95%
Q4Q7W6	Leishmania major	87%	100%
V5BDN5	Trypanosoma cruzi	39%	100%